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Pathophysiological significance of c-jun N-terminal kinase in acetaminophen hepatotoxicity

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Mitchell R. McGill & Jack A. Hinson. (2020) The development and hepatotoxicity of acetaminophen: reviewing over a century of progress. Drug Metabolism Reviews 52:4, pages 472-500.
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Mitchell R. McGill & Hartmut Jaeschke. (2018) Biomarkers of drug-induced liver injury: progress and utility in research, medicine, and regulation. Expert Review of Molecular Diagnostics 18:9, pages 797-807.
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Mitchell R. McGill, Stefanie Kennon-McGill, Dianne Durham & Hartmut Jaeschke. (2016) Hearing, reactive metabolite formation, and oxidative stress in cochleae after a single acute overdose of acetaminophen: an in vivo study. Toxicology Mechanisms and Methods 26:2, pages 104-111.
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Articles from other publishers (48)

Yujie Xu, Haozhe Xu, Tao Ling, Yachao Cui, Junwei Zhang, Xianmin Mu, Desheng Zhou, Ting Zhao, Yingchang Li, Zhongping Su & Qiang You. (2023) Inhibitor of nuclear factor kappa B kinase subunit epsilon regulates murine acetaminophen toxicity via RIPK1/JNK. Cell Biology and Toxicology 39:6, pages 2709-2724.
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Priyanka Ghosh, Nancy Magee, Jephte Y Akakpo, Forkan Ahamed, Natalie Eppler, Elizabeth Jones, Yifan Yu, Lily He, Margitta Lebofsky, Hongyan Dai, Hartmut Jaeschke, Wen-Xing Ding & Yuxia Zhang. (2023) Hepatocyte-specific deletion of small heterodimer partner protects mice against acetaminophen-induced hepatotoxicity via activation of Nrf2. Toxicological Sciences.
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Hee‐Yeon Kim, Hee‐Soo Yoon, Ah Jung Heo, Eui Jung Jung, Chang Hoon Ji, Su Ran Mun, Min Ju Lee, Yong Tae Kwon & Joo‐Won Park. (2023) Mitophagy and endoplasmic reticulum‐phagy accelerated by a p62 ZZ ligand alleviates paracetamol‐induced hepatotoxicity. British Journal of Pharmacology 180:9, pages 1247-1266.
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Tao Yang, Han Wang, Xiao Wang, Jun Li & Longfeng Jiang. (2022) The Dual Role of Innate Immune Response in Acetaminophen-Induced Liver Injury. Biology 11:7, pages 1057.
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Luqi Duan, Giselle Sanchez-Guerrero, Hartmut Jaeschke & Anup Ramachandran. (2022) Activation of the adenosine A2B receptor even beyond the therapeutic window of N-acetylcysteine accelerates liver recovery after an acetaminophen overdose. Food and Chemical Toxicology 163, pages 112911.
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Milos Mihajlovic & Mathieu Vinken. (2022) Mitochondria as the Target of Hepatotoxicity and Drug-Induced Liver Injury: Molecular Mechanisms and Detection Methods. International Journal of Molecular Sciences 23:6, pages 3315.
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Yuanyuan Zhang, Bingke Ma, Shuangshuang Hao, Jiaqi Wang, Ruichen Zhang, Muhammad Ishfaq, Chenxi Shi, Liang Yuan, Rui Li, Changwen Li & Fangping Liu. (2021) Drug‐induced liver injury: Oltipraz and C2‐ceramide intervene HNF‐1α/GSTA1 expression via JNK signaling pathway. Journal of Applied Toxicology 41:12, pages 2011-2020.
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David S. Umbaugh & Hartmut Jaeschke. 2021. 63 125 .
Hartmut Jaeschke, Jephte Y Akakpo, David S Umbaugh & Anup Ramachandran. (2020) Novel Therapeutic Approaches Against Acetaminophen-induced Liver Injury and Acute Liver Failure. Toxicological Sciences 174:2, pages 159-167.
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John J. Lemasters & Hartmut Jaeschke. 2020. The Liver. The Liver 714 727 .
Yoichi Ishitsuka, Yuki Kondo & Daisuke Kadowaki. (2020) Toxicological Property of Acetaminophen: The Dark Side of a Safe Antipyretic/Analgesic Drug?. Biological and Pharmaceutical Bulletin 43:2, pages 195-206.
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Jihong Lu, Hu Wang, Rumeng Zhang, Zhikang Wan, Hang Gao, Jie Cai, Yujia Cheng, Dong Pu, Tengfei Lin, Chenyu Fan & Ying Sun. (2019) Effects of Photoperiod on Acetaminophen-Induced Hepatotoxicity in Mice. Digestive Diseases and Sciences 65:1, pages 178-188.
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Yingqing Chen, Hyeok‐Jun Park, Jeongmin Park, Hyun‐Chul Song, Stefan W. Ryter, Young‐Joon Surh, Uh‐Hyun Kim, Yeonsoo Joe & Hun Taeg Chung. (2019) Carbon monoxide ameliorates acetaminophen‐induced liver injury by increasing hepatic HO‐1 and Parkin expression. The FASEB Journal 33:12, pages 13905-13919.
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Hartmut Jaeschke, Luqi Duan, Nga T. Nguyen & Anup Ramachandran. (2019) Mitochondrial damage and biogenesis in acetaminophen-induced liver injury. Liver Research 3:3-4, pages 150-156.
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Bernard Fromenty. (2019) Inhibition of mitochondrial fatty acid oxidation in drug-induced hepatic steatosis. Liver Research 3:3-4, pages 157-169.
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María Belén Vigo, María Julia Pérez, Fernanda De Fino, Gimena Gómez, Sonia A. Martínez, Veronica Bisagno, María Beatriz Di Carlo, Alejandra Scazziota, José E. Manautou & Carolina I. Ghanem. (2019) Acute acetaminophen intoxication induces direct neurotoxicity in rats manifested as astrogliosis and decreased dopaminergic markers in brain areas associated with locomotor regulation. Biochemical Pharmacology 170, pages 113662.
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Reham Hassan. (2019) Acetaminophen induces programmed necrosis. Archives of Toxicology 93:12, pages 3641-3642.
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Hartmut Jaeschke, Anup Ramachandran, Xiaojuan Chao & Wen-Xing Ding. (2019) Emerging and established modes of cell death during acetaminophen-induced liver injury. Archives of Toxicology 93:12, pages 3491-3502.
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Sanda Win, Robert W.M. Min, Christopher Q. Chen, Jun Zhang, Yibu Chen, Meng Li, Ayako Suzuki, Manal F. Abdelmalek, Ying Wang, Mariam Aghajan, Filbert W.M. Aung, Anna Mae Diehl, Roger J. Davis, Tin A. Than & Neil Kaplowitz. (2019) Expression of mitochondrial membrane–linked SAB determines severity of sex-dependent acute liver injury. Journal of Clinical Investigation 129:12, pages 5278-5293.
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Shan Wang, Yu Tian, Shan Lu, Ruiying Wang, Hai Shang, Xuelian Zhang, Chenyang Zhang, Guibo Sun, Xudong Xu & Xiaobo Sun. (2019) Design and synthesis of acetaminophen probe APAP-P1 for identification of the toxicity targets thioredoxin reductase-1 in HepaRG cells. RSC Advances 9:27, pages 15224-15228.
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Mitchell R. McGill & Hartmut Jaeschke. (2019) Animal models of drug-induced liver injury. Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease 1865:5, pages 1031-1039.
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Yuan Li, Hong-Min Ni, Hartmut Jaeschke & Wen-Xing Ding. (2019) Chlorpromazine protects against acetaminophen-induced liver injury in mice by modulating autophagy and c-Jun N-terminal kinase activation. Liver Research 3:1, pages 65-74.
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Haroon Khan, Hammad Ullah & Seyed M. Nabavi. (2019) Mechanistic insights of hepatoprotective effects of curcumin: Therapeutic updates and future prospects. Food and Chemical Toxicology 124, pages 182-191.
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Ben-Wen Cui, Ting Bai, Yong Yang, Yu Zhang, Min Jiang, Hong-Xu Yang, Mei Wu, Jian Liu, Chun-Ying Qiao, Zi-Ying Zhan, Yan-Ling Wu, Dong-Zhou Kang, Li-Hua Lian & Ji-Xing Nan. (2019) Thymoquinone Attenuates Acetaminophen Overdose-Induced Acute Liver Injury and Inflammation Via Regulation of JNK and AMPK Signaling Pathway. The American Journal of Chinese Medicine 47:03, pages 577-594.
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Melissa M. Clemens, Mitchell R. McGill & Udayan Apte. 2019. Drug-induced Liver Injury. Drug-induced Liver Injury 241 262 .
JY Akakpo, A Ramachandran, SE Kandel, HM Ni, SC Kumer, BH Rumack & H Jaeschke. (2018) 4-Methylpyrazole protects against acetaminophen hepatotoxicity in mice and in primary human hepatocytes. Human & Experimental Toxicology 37:12, pages 1310-1322.
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Sandeep Subramanya, Balaji Venkataraman, Mohamed Meeran, Sameer Goyal, Chandragouda Patil & Shreesh Ojha. (2018) Therapeutic Potential of Plants and Plant Derived Phytochemicals against Acetaminophen-Induced Liver Injury. International Journal of Molecular Sciences 19:12, pages 3776.
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Rafael Gustavo Castellanos Garzón, Elkin Rene Barrios Peralta, Alberto Adolfo Vides Velásquez & Maria Francisca Olarte. (2018) Actualización en la comprensión y manejo de la intoxicación por acetaminofén. Universitas Médica 59:4, pages 1-11.
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Hartmut Jaeschke, Luqi Duan, Jephte Y. Akakpo, Anwar Farhood & Anup Ramachandran. (2018) The role of apoptosis in acetaminophen hepatotoxicity. Food and Chemical Toxicology 118, pages 709-718.
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Ming-Shiun Tsai, Ying-Han Wang, Yan-Yun Lai, Hsi-Kai Tsou, Gan-Guang Liou, Jiunn-Liang Ko & Sue-Hong Wang. (2018) Kaempferol protects against propacetamol-induced acute liver injury through CYP2E1 inactivation, UGT1A1 activation, and attenuation of oxidative stress, inflammation and apoptosis in mice. Toxicology Letters 290, pages 97-109.
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Anna Moles, Sandra Torres, Anna Baulies, Carmen Garcia-Ruiz & Jose C. Fernandez-Checa. (2018) Mitochondrial–Lysosomal Axis in Acetaminophen Hepatotoxicity. Frontiers in Pharmacology 9.
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Sanda Win, Tin Aung Than, Jun Zhang, Christina Oo, Robert Win Maw Min & Neil Kaplowitz. (2018) New insights into the role and mechanism of c‐Jun‐N‐terminal kinase signaling in the pathobiology of liver diseases. Hepatology 67:5, pages 2013-2024.
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Steven R McGreal, Bharat Bhushan, Chad Walesky, Mitchell R McGill, Margitta Lebofsky, Sylvie E Kandel, Robert D Winefield, Hartmut Jaeschke, Natasha E Zachara, Zhen Zhang, Ee Phie Tan, Chad Slawson & Udayan Apte. (2018) Modulation of O-GlcNAc Levels in the Liver Impacts Acetaminophen-Induced Liver Injury by Affecting Protein Adduct Formation and Glutathione Synthesis. Toxicological Sciences 162:2, pages 599-610.
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Amy L. Ball, Laleh Kamalian, Carol E. Jolly & Amy E. Chadwick. 2018. Mitochondrial Dysfunction Caused by Drugs and Environmental Toxicants. Mitochondrial Dysfunction Caused by Drugs and Environmental Toxicants 73 92 .
Benjamin L. Woolbright & Hartmut Jaeschke. 2018. Mitochondrial Dysfunction Caused by Drugs and Environmental Toxicants. Mitochondrial Dysfunction Caused by Drugs and Environmental Toxicants 373 382 .
Zhenyu Shen, Yu Wang, Zhenhui Su, Ruirui Kou, Keqin Xie & Fuyong Song. (2018) Activation of p62-keap1-Nrf2 antioxidant pathway in the early stage of acetaminophen-induced acute liver injury in mice. Chemico-Biological Interactions 282, pages 22-28.
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H. Jaeschke, M.L. Bajt & A. Ramachandran. 2018. Comprehensive Toxicology. Comprehensive Toxicology 460 482 .
Hiromi Kusama, Kazuyoshi Kon, Kenichi Ikejima, Kumiko Arai, Tomonori Aoyama, Akira Uchiyama, Shunhei Yamashina & Sumio Watanabe. (2016) Sodium 4-phenylbutyric acid prevents murine acetaminophen hepatotoxicity by minimizing endoplasmic reticulum stress. Journal of Gastroenterology 52:5, pages 611-622.
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Vivekkumar P. Dadhania, Bharat Bhushan, Udayan Apte & Harihara M. Mehendale. (2017) Wnt/β-Catenin Signaling Drives Thioacetamide-Mediated Heteroprotection Against Acetaminophen-Induced Lethal Liver Injury. Dose-Response 15:1, pages 155932581769028.
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Kuo Du, Anwar Farhood & Hartmut Jaeschke. (2016) Mitochondria-targeted antioxidant Mito-Tempo protects against acetaminophen hepatotoxicity. Archives of Toxicology 91:2, pages 761-773.
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Benjamin L. Woolbright & Hartmut Jaeschke. 2017. Cellular Injury in Liver Diseases. Cellular Injury in Liver Diseases 55 76 .
Kuo Du, Anup Ramachandran, James L. Weemhoff, Hemantkumar Chavan, Yuchao Xie, Partha Krishnamurthy & Hartmut Jaeschke. (2016) Editor’s Highlight: Metformin Protects Against Acetaminophen Hepatotoxicity by Attenuation of Mitochondrial Oxidant Stress and Dysfunction. Toxicological Sciences 154:2, pages 214-226.
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Kuo Du, Anup Ramachandran & Hartmut Jaeschke. (2016) Oxidative stress during acetaminophen hepatotoxicity: Sources, pathophysiological role and therapeutic potential. Redox Biology 10, pages 148-156.
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Chun Pang, Liang Shi, Yuchen Sheng, Zhiyong Zheng, Hai Wei, Zhengtao Wang & Lili Ji. (2016) Caffeic acid attenuated acetaminophen-induced hepatotoxicity by inhibiting ERK1/2-mediated early growth response-1 transcriptional activation. Chemico-Biological Interactions 260, pages 186-195.
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Hartmut Jaeschke. (2016) Mechanisms of Acetaminophen Hepatotoxicity: Do We Need JNK for Cell Death?. Gastroenterology 151:2, pages 371-372.
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Carolina I. Ghanem, María J. Pérez, José E. Manautou & Aldo D. Mottino. (2016) Acetaminophen from liver to brain: New insights into drug pharmacological action and toxicity. Pharmacological Research 109, pages 119-131.
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Madison Davis & Brendan D. Stamper. (2016) TAMH: A Useful In Vitro Model for Assessing Hepatotoxic Mechanisms. BioMed Research International 2016, pages 1-9.
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Fu-Chao Liu, Hung-Chen Lee, Chia-Chih Liao, Allen H. Li & Huang-Ping Yu. (2016) Tropisetron Protects Against Acetaminophen-Induced Liver Injury via Suppressing Hepatic Oxidative Stress and Modulating the Activation of JNK/ERK MAPK Pathways. BioMed Research International 2016, pages 1-9.
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