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Expert Opinion on Drug Metabolism & Toxicology Volume 3, 2007 - Issue 2
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Review

Arylamine N-acetyltransferases

Edith Sim University of Oxford, Department of Pharmacology, Mansfield Road, Oxford, OX1 3QT, UK. [email protected]
,
Isaac Westwood University of Oxford, Department of Pharmacology, Mansfield Road, Oxford, OX1 3QT, UK. [email protected]
&
Elizabeth Fullam University of Oxford, Department of Pharmacology, Mansfield Road, Oxford, OX1 3QT, UK. [email protected]
Pages 169-184 | Published online: 11 Apr 2007

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Wolfram Föllmann, Meinolf Blaszkewicz, Claudia Behm, Gisela H. Degen & Klaus Golka. (2012) N-Acetylation of p-Aminobenzoic Acid and p-Phenylenediamine in Primary Porcine Urinary Bladder Epithelial Cells and in the Human Urothelial Cell Line 5637. Journal of Toxicology and Environmental Health, Part A 75:19-20, pages 1206-1215.
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Malika Khelil, Bahia Djerdjouri & Bouchentouf Tayebi. (2010) N-acetyltransferase 2 (Nat2) polymorphism in the sand rat Psammomys obesus. Toxicology Mechanisms and Methods 20:8, pages 440-444.
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Katy Walker, Gary Ginsberg, Dale Hattis, Douglas O. Johns, Kathryn Z. Guyton & Babasaheb Sonawane. (2009) Genetic Polymorphism in N-Acetyltransferase (NAT): Population Distribution of NAT1 and NAT2 Activity. Journal of Toxicology and Environmental Health, Part B 12:5-6, pages 440-472.
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David W Hein. (2009) N-acetyltransferase SNPs: emerging concepts serve as a paradigm for understanding complexities of personalized medicine. Expert Opinion on Drug Metabolism & Toxicology 5:4, pages 353-366.
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Larissa Wakefield, Valerie Cornish, Hilary Long, Akane Kawamura, Xiaoyan Zhang, David W. Hein & Edith Sim. (2008) Mouse arylamine N-acetyltransferase 2 (Nat2) expression during embryogenesis: a potential marker for the developing neuroendocrine system. Biomarkers 13:1, pages 106-118.
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Edith Sim, Kylie Walters & Sotiria Boukouvala. (2008) Arylamine N-acetyltransferases: From Structure to Function. Drug Metabolism Reviews 40:3, pages 479-510.
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Beatriz Carvalho Henriques, Esther H. Yang, Diego Lapetina, Michael S. Carr, Vasyl Yavorskyy, Joshua Hague & Katherine J. Aitchison. (2020) How Can Drug Metabolism and Transporter Genetics Inform Psychotropic Prescribing?. Frontiers in Genetics 11.
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Hong-Yan Qin, Jia-Xin Kou, Zhi Rao, Guo-Qiang Zhang, Xiao-Hua Wang, Li-Ping Bai & Yu-Hui Wei. (2019) N-Acetyltransferase Activity Assay and Inhibitory Compounds Screening by Using Living Human Hepatoma HepaRG Cell Model. International Journal of Pharmacology 15:2, pages 229-237.
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David W. Hein, Giannoulis Fakis & Sotiria Boukouvala. (2018) Functional expression of human arylamine N-acetyltransferase NAT1*10 and NAT1*11 alleles. Pharmacogenetics and Genomics 28:10, pages 238-244.
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N. Laurieri, E. Polycarpou & E. Sim. 2018. Comprehensive Toxicology. Comprehensive Toxicology 429 467 .
Collette S Guy, Esther Tichauer, Gemma L Kay, Daniel J Phillips, Trisha L Bailey, James Harrison, Christopher M Furze, Andrew D Millard, Matthew I Gibson, Mark J Pallen & Elizabeth Fullam. (2017) Identification of the anti‐mycobacterial functional properties of piperidinol derivatives. British Journal of Pharmacology 174:14, pages 2183-2193.
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Romain Duval, Ximing Xu, Linh-Chi Bui, Cécile Mathieu, Emile Petit, Kevin Cariou, Robert H. Dodd, Jean-Marie Dupret & Fernando Rodrigues-Lima. (2016) Identification of cancer chemopreventive isothiocyanates as direct inhibitors of the arylamine N -acetyltransferase-dependent acetylation and bioactivation of aromatic amine carcinogens . Oncotarget 7:8, pages 8688-8699.
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Joshua W. Knowles, Weijia Xie, Zhongyang Zhang, Indumathi Chennemsetty, Themistocles L. Assimes, Jussi Paananen, Ola Hansson, James Pankow, Mark O. Goodarzi, Ivan Carcamo-Orive, Andrew P. Morris, Yii-Der I. Chen, Ville-Petteri Mäkinen, Andrea Ganna, Anubha Mahajan, Xiuqing Guo, Fahim Abbasi, Danielle M. Greenawalt, Pek Lum, Cliona Molony, Lars Lind, Cecilia Lindgren, Leslie J. Raffel, Philip S. Tsao, Eric E. Schadt, Jerome I. Rotter, Alan Sinaiko, Gerald Reaven, Xia Yang, Chao A. Hsiung, Leif Groop, Heather J. Cordell, Markku Laakso, Ke Hao, Erik Ingelsson, Timothy M. Frayling, Michael N. Weedon, Mark Walker & Thomas Quertermous. (2015) Identification and validation of N-acetyltransferase 2 as an insulin sensitivity gene. Journal of Clinical Investigation 125:4, pages 1739-1751.
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Yumi Endo, Hiroko Yamashita, Satoru Takahashi, Shinya Sato, Nobuyasu Yoshimoto, Tomoko Asano, Yukari Hato, Yu Dong, Yoshitaka Fujii & Tatsuya Toyama. (2014) Immunohistochemical determination of the miR-1290 target arylamine N-acetyltransferase 1 (NAT1) as a prognostic biomarker in breast cancer. BMC Cancer 14:1.
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E Sim, A Abuhammad & A Ryan. (2014) Arylamine N‐acetyltransferases: from drug metabolism and pharmacogenetics to drug discovery. British Journal of Pharmacology 171:11, pages 2705-2725.
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Nicola Laurieri, Julien Dairou, James E. Egleton, Lesley A. Stanley, Angela J. Russell, Jean-Marie Dupret, Edith Sim & Fernando Rodrigues-Lima. (2014) From Arylamine N-Acetyltransferase to Folate-Dependent Acetyl CoA Hydrolase: Impact of Folic Acid on the Activity of (HUMAN)NAT1 and Its Homologue (MOUSE)NAT2. PLoS ONE 9:5, pages e96370.
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Audrey Sabbagh, Julie Marin, Charlotte Veyssi?re, Emilie Lecompte, Sotiria Boukouvala, Estella S Poloni, Pierre Darlu & Brigitte Crouau-Roy. (2013) Rapid birth-and-death evolution of the xenobiotic metabolizing NAT gene family in vertebrates with evidence of adaptive selection. BMC Evolutionary Biology 13:1, pages 62.
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Xin Wang, Lei Cui, Nannan Zhou, Weiping Zhu, Rui Wang, Xuhong Qian & Yufang Xu. (2013) A highly selective and sensitive near-infrared fluorescence probe for arylamine N-acetyltransferase 2 in vitro and in vivo. Chemical Science 4:7, pages 2936.
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Marie Stiborová, Radek Indra, Michaela Moserová, Věra Černá, Martina Rupertová, Václav Martínek, Tomáš Eckschlager, René Kizek & Eva Frei. (2012) Cytochrome b 5 Increases Cytochrome P450 3A4-Mediated Activation of Anticancer Drug Ellipticine to 13-Hydroxyellipticine Whose Covalent Binding to DNA Is Elevated by Sulfotransferases and N , O -Acetyltransferases . Chemical Research in Toxicology 25:5, pages 1075-1085.
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Ibrahim A. Yassine, Loulou Kobeissi, Michel E. Jabbour & Hassan R. Dhaini. (2012) N-Acetyltransferase 1 ( NAT1 ) Genotype: A Risk Factor for Urinary Bladder Cancer in a Lebanese Population . Journal of Oncology 2012, pages 1-10.
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Fernando Rodrigues-Lima, Julien Dairou, Florent Busi & Jean-Marie Dupret. 2012. Cell Signaling & Molecular Targets in Cancer. Cell Signaling & Molecular Targets in Cancer 23 35 .
Holly M Mortensen, Alain Froment, Godfrey Lema, Jean-Marie Bodo, Muntaser Ibrahim, Thomas B Nyambo, Sabah A Omar & Sarah A Tishkoff. (2011) Characterization of genetic variation and natural selection at the arylamine N -acetyltransferase genes in global human populations . Pharmacogenomics 12:11, pages 1545-1558.
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Elizabeth Fullam, Areej Abuhammad, David L. Wilson, Matthew C. Anderton, Steve G. Davies, Angela J. Russell & Edith Sim. (2011) Analysis of β-amino alcohols as inhibitors of the potential anti-tubercular target N-acetyltransferase. Bioorganic & Medicinal Chemistry Letters 21:4, pages 1185-1190.
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Malika Khelil, Akila Zenati, Mohamed Makrelouf, Amel Otmane & Bouchentouf Tayebi. (2010) Polymorphisms in NAT2 Gene and Atherosclerosis in an Algerian Population. Archives of Medical Research 41:3, pages 215-220.
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Nicola LaurieriMatthew H. J. CrawfordAkane KawamuraIsaac M. WestwoodJames RobinsonAi M. FletcherStephen G. DaviesEdith SimAngela J. Russell. (2010) Small Molecule Colorimetric Probes for Specific Detection of Human Arylamine N -Acetyltransferase 1, a Potential Breast Cancer Biomarker . Journal of the American Chemical Society 132:10, pages 3238-3239.
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Lilian G. Yengi. 2010. Pharmaceutical Sciences Encyclopedia. Pharmaceutical Sciences Encyclopedia 1 23 .
Larissa Wakefield, Sotiria Boukouvala & Edith Sim. (2010) Characterisation of CpG methylation in the upstream control region of mouse Nat2: Evidence for a gene–environment interaction in a polymorphic gene implicated in folate metabolism. Gene 452:1, pages 16-21.
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Lei Cui, Ye Zhong, Weiping Zhu, Yufang Xu & Xuhong Qian. (2010) Selective and sensitive detection and quantification of arylamine N-acetyltransferase 2 by a ratiometric fluorescence probe. Chemical Communications 46:38, pages 7121.
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E. Sim, E. Fullam & L. Wakefield. 2010. Comprehensive Toxicology. Comprehensive Toxicology 385 412 .
Li Liu, Carston R. Wagner & Patrick E. Hanna. (2009) Isoform-Selective Inactivation of Human Arylamine N -Acetyltransferases by Reactive Metabolites of Carcinogenic Arylamines . Chemical Research in Toxicology 22:12, pages 1962-1974.
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Florence Malka, Julien Dairou, Nilusha Ragunathan, Jean‐Marie Dupret & Fernando Rodrigues‐Lima. (2009) Mechanisms and kinetics of human arylamine N ‐acetyltransferase 1 inhibition by disulfiram . The FEBS Journal 276:17, pages 4900-4908.
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Ting Hu, Ruth E. Bailey, Stephen W. Morrall, Marilyn J. Aardema, Lesley A. Stanley & Julie A. Skare. (2009) Dermal penetration and metabolism of p-aminophenol and p-phenylenediamine: Application of the EpiDerm™ human reconstructed epidermis model. Toxicology Letters 188:2, pages 119-129.
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Nathan A. LackAkane KawamuraElizabeth FullamNicola LaurieriStacey BeardAngela J. RussellDimitrios EvangelopoulosIsaac WestwoodEdith Sim. (2009) Temperature stability of proteins essential for the intracellular survival of Mycobacterium tuberculosis. Biochemical Journal 418:2, pages 369-378.
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Terry V. Zenser, Vijaya M. Lakshmi, Herman A.J. Schut, Hui-jia Zhou & P. David Josephy. (2009) Activation of aminoimidazole carcinogens by nitrosation: Mutagenicity and nucleotide adducts. Mutation Research/Genetic Toxicology and Environmental Mutagenesis 673:2, pages 109-115.
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Lilian G. Yengi. 2009. Drug Metabolism Handbook. Drug Metabolism Handbook 65 87 .
Angela J. Russell, Isaac M. Westwood, Matthew H.J. Crawford, James Robinson, Akane Kawamura, Christina Redfield, Nicola Laurieri, Edward D. Lowe, Stephen G. Davies & Edith Sim. (2009) Selective small molecule inhibitors of the potential breast cancer marker, human arylamine N-acetyltransferase 1, and its murine homologue, mouse arylamine N-acetyltransferase 2. Bioorganic & Medicinal Chemistry 17:2, pages 905-918.
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Edith Sim, Nathan Lack, Chan-Ju Wang, Hilary Long, Isaac Westwood, Elizabeth Fullam & Akane Kawamura. (2008) Arylamine N-acetyltransferases: Structural and functional implications of polymorphisms. Toxicology 254:3, pages 170-183.
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Lesley A Stanley & Edith Sim. (2008) Update on the pharmacogenetics of NATs: structural considerations. Pharmacogenomics 9:11, pages 1673-1693.
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Marta Martins, Benjamin Pluvinage, Inès Li de la Sierra-Gallay, Florent Barbault, Julien Dairou, Jean-Marie Dupret & Fernando Rodrigues-Lima. (2008) Functional and Structural Characterization of the Arylamine N-Acetyltransferase from the Opportunistic Pathogen Nocardia farcinica. Journal of Molecular Biology 383:3, pages 549-560.
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Oliver Barbier. 2008. Nuclear Receptors in Drug Metabolism. Nuclear Receptors in Drug Metabolism 61 110 .
Li Liu, Carston R. Wagner & Patrick E. Hanna. (2008) Human Arylamine N -Acetyltransferase 1: In Vitro and Intracellular Inactivation by Nitrosoarene Metabolites of Toxic and Carcinogenic Arylamines . Chemical Research in Toxicology 21:10, pages 2005-2016.
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Francesca Luca, Giuseppina Bubba, Massimo Basile, Radim Brdicka, Emmanuel Michalodimitrakis, Olga Rickards, Galina Vershubsky, Lluis Quintana-Murci, Andrey I. Kozlov & Andrea Novelletto. (2008) Multiple Advantageous Amino Acid Variants in the NAT2 Gene in Human Populations. PLoS ONE 3:9, pages e3136.
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Emilie Simard, Judith Naud, Josée Michaud, Francois A. Leblond, Alain Bonnardeaux, Chantal Guillemette, Edith Sim & Vincent Pichette. (2008) Downregulation of Hepatic Acetylation of Drugs in Chronic Renal Failure. Journal of the American Society of Nephrology 19:7, pages 1352-1359.
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Sotiria BoukouvalaIsaac M Westwood, Neville J Butcher & Giannoulis Fakis. (2008) Current trends in N -acetyltransferase research arising from the 2007 International NAT Workshop . Pharmacogenomics 9:6, pages 765-771.
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Nilusha Ragunathan, Julien Dairou, Benjamin Pluvinage, Marta Martins, Emile Petit, Nathalie Janel, Jean-Marie Dupret & Fernando Rodrigues-Lima. (2008) Identification of the Xenobiotic-Metabolizing Enzyme Arylamine N -Acetyltransferase 1 as a New Target of Cisplatin in Breast Cancer Cells: Molecular and Cellular Mechanisms of Inhibition . Molecular Pharmacology 73:6, pages 1761-1768.
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Akane Kawamura, Isaac Westwood, Larissa Wakefield, Hilary Long, Naixia Zhang, Kylie Walters, Christina Redfield & Edith Sim. (2008) Mouse N-acetyltransferase type 2, the homologue of human N-acetyltransferase type 1. Biochemical Pharmacology 75:7, pages 1550-1560.
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Larissa Wakefield, James Robinson, Hilary Long, J. Claire Ibbitt, Susanna Cooke, Helen C. Hurst & Edith Sim. (2007) Arylamine N ‐acetyltransferase 1 expression in breast cancer cell lines: A potential marker in estrogen receptor‐positive tumors . Genes, Chromosomes and Cancer 47:2, pages 118-126.
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Elizabeth Fullam, Isaac M. Westwood, Matthew C. Anderton, Edward D. Lowe, Edith Sim & Martin E.M. Noble. (2008) Divergence of Cofactor Recognition across Evolution: Coenzyme A Binding in a Prokaryotic Arylamine N-Acetyltransferase. Journal of Molecular Biology 375:1, pages 178-191.
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