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Review

Understanding the role of reactive metabolites in drug-induced hepatotoxicity: state of the science

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Pages 1415-1427 | Published online: 25 Oct 2008

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Reza Heidari, Fatemeh Ahmadi, Hamid Reza Rahimi, Negar Azarpira, Massood Hosseinzadeh, Asma Najibi & Hossein Niknahad. (2019) Exacerbated liver injury of antithyroid drugs in endotoxin-treated mice. Drug and Chemical Toxicology 42:6, pages 615-623.
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Nathalie K. Zgheib & Robert A. Branch. (2017) Drug metabolism and liver disease: a drug–gene–environment interaction. Drug Metabolism Reviews 49:1, pages 35-55.
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Lydia Kwast, Daniëlle Fiechter, Laura Kruijssen, Rob Bleumink, Irene Ludwig, Marianne Bol-Schoenmakers, Joost Smit & Raymond Pieters. (2016) Oral exposure to immunostimulating drugs results in early changes in innate immune parameters in the spleen. Journal of Immunotoxicology 13:4, pages 535-547.
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Edgar Rincón-Villamizar & Guillermo Restrepo. (2014) Rules relating hepatotoxicity with structural attributes of drugs. Toxicological & Environmental Chemistry 96:4, pages 594-613.
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Robert A. Roth & Patricia E. Ganey. (2011) Animal models of idiosyncratic drug-induced liver injury—Current status. Critical Reviews in Toxicology 41:9, pages 723-739.
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Gordon Liss & James H Lewis. (2009) Drug-induced liver injury: what was new in 2008?. Expert Opinion on Drug Metabolism & Toxicology 5:8, pages 843-860.
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