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Drug Evaluations

Polyvinylpyrrolidone–sodium hyaluronate gel (Gelclair®): a bioadherent oral gel for the treatment of oral mucositis and other painful oral lesions

, RN MSN FAAN & , PhD
Pages 1449-1454 | Published online: 25 Oct 2008

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Read on this site (4)

Veronika Walicová, Jan Gajdziok, Sylvie Pavloková & David Vetchý. (2017) Design and evaluation of mucoadhesive oral films containing sodium hyaluronate using multivariate data analysis. Pharmaceutical Development and Technology 22:2, pages 229-236.
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Alessandro Villa & Stephen T. Sonis. (2016) Pharmacotherapy for the management of cancer regimen-related oral mucositis. Expert Opinion on Pharmacotherapy 17:13, pages 1801-1807.
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Moshe Ehrenberg, Eyal Zolotariov, Emmanuel Loeb, Vadim Poliansky & Aharon Levy. (2015) Combining Sodium Hyaluronate and Polyvinylpyrrolidone Therapies for the Rabbit Cornea: A New Approach to Relief of the Human Dry Eye Syndrome. Current Eye Research 40:9, pages 913-922.
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Anna Yuan & Stephen Sonis. (2014) Emerging therapies for the prevention and treatment of oral mucositis. Expert Opinion on Emerging Drugs 19:3, pages 343-351.
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Barbara Vigani, Silvia Rossi, Giuseppina Sandri, Maria Cristina Bonferoni & Carla M. Caramella. (2023) Mucoadhesive polymers in substance-based medical devices: functional ingredients or what else?. Frontiers in Drug Safety and Regulation 3.
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Hsiao-Lei Chin, Kuo-Piao Chung, Hsin-Cheng Liu, Rung-Shu Chen, Hao-Hueng Chang & Min-Huey Chen. (2023) Efficacy of polyacrylate silver salt/polyvinylpyrrolidone-based liquid oral gel in management of concurrence chemoradiotherapy-induced oral mucositis. Journal of the Formosan Medical Association 122:8, pages 723-730.
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Ali I. Mohammed, Antonio Celentano, Rita Paolini, Jun T. Low, John Silke, Lorraine A. O’ Reilly, Michael McCullough & Nicola Cirillo. (2023) High molecular weight hyaluronic acid drastically reduces chemotherapy-induced mucositis and apoptotic cell death. Cell Death & Disease 14:7.
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Monika Furko, Katalin Balázsi & Csaba Balázsi. (2023) Calcium Phosphate Loaded Biopolymer Composites—A Comprehensive Review on the Most Recent Progress and Promising Trends. Coatings 13:2, pages 360.
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Claudio Romano & Carmelo Scarpignato. (2022) Pharmacologic treatment of GERD in adolescents: Is esophageal mucosal protection an option?. Therapeutic Advances in Gastroenterology 15, pages 175628482211153.
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Inna V. Fadeeva, Elena S. Trofimchuk, Anna A. Forysenkova, Abdulrahman I. Ahmed, Oleg I. Gnezdilov, Galina A. Davydova, Svetlana G. Kozlova, Aurora Antoniac & Julietta V. Rau. (2021) Composite Polyvinylpyrrolidone–Sodium Alginate—Hydroxyapatite Hydrogel Films for Bone Repair and Wound Dressings Applications. Polymers 13:22, pages 3989.
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Jonathan T Peters, Marissa E Wechsler & Nicholas A Peppas. (2021) Advanced biomedical hydrogels: molecular architecture and its impact on medical applications. Regenerative Biomaterials 8:6.
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Christina Winter, Roman Keimel, Markus Gugatschka, Dagmar Kolb, Gerd Leitinger & Eva Roblegg. (2021) Investigation of Changes in Saliva in Radiotherapy-Induced Head Neck Cancer Patients. International Journal of Environmental Research and Public Health 18:4, pages 1629.
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Melike ONGUN, Emre TUNÇEL, Esra KODAN, Fatma Nur TUĞCU DEMİRÖZ & Fahriye Figen TIRNAKSIZ. (2020) DEVELOPMENT AND CHARACTERIZATION OF MUCOADHESIVE-THERMOSENSITIVE BUCCAL GEL CONTAINING METRONIDAZOLE FOR THE TREATMENT OF ORAL MUCOSITIS. Ankara Universitesi Eczacilik Fakultesi Dergisi, pages 517-539.
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Yu. V. Alymov, А. М. Mudunov, S. B. Alieva, А. V. Ignatova, R. R. Kaledin & А. М. Avanesov. (2019) Role of hyaluronic acid in the prevention and treatment of radiation-induced oropharyngeal mucositis. Head and Neck Tumors (HNT) 9:3, pages 29-37.
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Carlos J Roldan, Thomas Chai, Jennifer Erian & John Welker. (2018) Oral pain associated with cancer therapy, a pain medicine perspective. Pain Management 8:6, pages 487-493.
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João C. Campos, João D. Cunha, Domingos C. Ferreira, Salette Reis & Paulo J. Costa. (2018) Challenges in the local delivery of peptides and proteins for oral mucositis management. European Journal of Pharmaceutics and Biopharmaceutics 128, pages 131-146.
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Alessandro Villa & Sunday O. Akintoye. (2018) Dental Management of Patients Who Have Undergone Oral Cancer Therapy. Dental Clinics of North America 62:1, pages 131-142.
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Nora Šiupšinskienė, Asta Aukštakalnienė & Sigutė Norkienė. (2017) DIRGLIŲ GERKLŲ SINDROMAS: ŠIUOLAIKINĖ DIAGNOSTIKA IR GYDYMAS. Visuomenės sveikata 27:6, pages 98-104.
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Kristina Bertl, Klaus Gotfredsen, Simon S. Jensen, Corinna Bruckmann & Andreas Stavropoulos. (2017) Adverse reaction after hyaluronan injection for minimally invasive papilla volume augmentation. A report on two cases. Clinical Oral Implants Research 28:7, pages 871-876.
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Ahmed Abdel Moneim, Ana Guerra-Librero, Javier Florido, Ying-Qiang Shen, Beatriz Fernández-Gil, Darío Acuña-Castroviejo & Germaine Escames. (2017) Oral Mucositis: Melatonin Gel an Effective New Treatment. International Journal of Molecular Sciences 18:5, pages 1003.
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Isabel Bernad Alonso, Leire Juez Viana, Jos? Miguel Lera Imbuluzqueta & Marta Ivars Lle?. (2015) ?lceras genitales en la mujer. Piel 30:7, pages 424-436.
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Nicola Cirillo, Antonio Vicidomini, Michael McCullough, Antonio Gambardella, Yazan Hassona, Stephen S. Prime & Giuseppe Colella. (2015) A hyaluronic acid-based compound inhibits fibroblast senescence induced by oxidative stress in vitro and prevents oral mucositis in vivo. Journal of Cellular Physiology 230:7, pages 1421-1429.
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Alessandro Villa & Stephen T. Sonis. (2015) Mucositis. Current Opinion in Oncology 27:3, pages 159-164.
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Kenneth R Goldschneider, Julie Good, Emily Harrop, Christina Liossi, Anne Lynch-Jordan, Anna E Martinez, Lynne G Maxwell & Danette Stanko-Lopp. (2014) Pain care for patients with epidermolysis bullosa: best care practice guidelines. BMC Medicine 12:1.
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Hannah R. Wardill & Joanne M. Bowen. (2013) Chemotherapy-induced mucosal barrier dysfunction. Current Opinion in Supportive & Palliative Care 7:2, pages 155-161.
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M.F. Sfondrini, D. Fraticelli, M. Barbati, A. Scribante & P. Gandini. (2012) Effetti di un nuovo preparato farmaceutico sulla guarigione di lesioni aftosiche in pazienti di et? pediatrica. Dental Cadmos 80:6, pages 334-339.
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Rachel J. Gibson & Joanne M. Bowen. (2011) Biomarkers of regimen-related mucosal injury. Cancer Treatment Reviews 37:6, pages 487-493.
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Samuel Vokurka, Jana Skardova, Renata Hruskova, Klara Kabatova-Maxova, Tomas Svoboda, Eva Bystricka, Katerina Steinerova & Vladimir Koza. (2011) The effect of polyvinylpyrrolidone-sodium hyaluronate gel (Gelclair) on oral microbial colonization and pain control compared with other rinsing solutions in patients with oral mucositis after allogeneic stem cells transplantation. Medical Science Monitor 17:10, pages CR572-CR576.
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Matthias C. Schauer, Bernhard Holzmann, Matthias Peiper, Helmut Friess, Wolfram Trudo Knoefel & Joerg Theisen. (2010) Interleukin-10 and -12 Predict Chemotherapy-Associated Toxicity in Esophageal Adenocarcinoma. Journal of Thoracic Oncology 5:11, pages 1849-1854.
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Grace D. Bandow. (2010) Diagnosis and Management of Vulvar Ulcers. Dermatologic Clinics 28:4, pages 753-763.
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Pia López-Jornet, Fabio Camacho-Alonso & Ascensión Martinez-Canovas. (2010) Clinical Evaluation of Polyvinylpyrrolidone Sodium Hyalonurate Gel and 0.2% Chlorhexidine Gel for Pain After Oral Mucosa Biopsy: A Preliminary Study. Journal of Oral and Maxillofacial Surgery 68:9, pages 2159-2163.
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Pedro Diz Dios & Juan Seoane Lest?n. (2010) Oral cancer pain. Oral Oncology 46:6, pages 448-451.
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G. Colella, R. Cannavale, A. Vicidomini, G. Rinaldi, D. Compilato & G. Campisi. (2010) Efficacy of a Spray Compound Containing a Pool of Collagen Precursor Synthetic Amino Acids (L-Proline, L-Leucine, L-Lysine and Glycine) Combined with Sodium Hyaluronate to Manage Chemo/Radiotherapy-Induced Oral Mucositis: Preliminary Data of an Open Clinical Trial. International Journal of Immunopathology and Pharmacology 23:1, pages 143-151.
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María José Fuente González, Lorena Leal Canosa & Miquel Ribera Pibernat. (2009) Efectos secundarios cutáneos de los tratamientos sistémicos del cáncer (I): quimioterapia y hormonoterapia. Piel 24:7, pages 368-379.
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