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Expert Opinion on Drug Metabolism & Toxicology Volume 4, 2008 - Issue 2
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Review

The use of hepatocytes in evaluating time-dependent inactivation of P450 in vivo

Ping Zhao Sonus Pharmaceuticals, Bothell, WA 98021, USA +1 425 487 9500; +1 425 398 8433; [email protected]
Pages 151-164 | Published online: 18 Mar 2008

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. (2014) ABSTRACTS FROM THE 10TH INTERNATIONAL ISSX MEETING. Drug Metabolism Reviews 45:sup1, pages 1-286.
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Dandan Luo, Yinsi Lin, Jiannan Chen, Xiaoqi Huang, Youliang Xie, Yuhong Liu, Suiqin Ni, Ziren Su, Yucui Li & Zhenbiao Zhang. (2023) Stereoisomers of octahydrocurcumin, the hydrogenated metabolites of curcumin, display stereoselective activity on the CYP2E1 enzyme in L-02 cells. Food & Function 14:6, pages 2822-2835.
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Paresh P. Chothe, Rachel Pemberton & Niresh Hariparsad. (2021) Function and Expression of Bile Salt Export Pump in Suspension Human Hepatocytes . Drug Metabolism and Disposition, pages DMD-AR-2020-000057.
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Jaydeep Yadav, Erickson Paragas, Ken Korzekwa & Swati Nagar. (2020) Time-dependent enzyme inactivation: Numerical analyses of in vitro data and prediction of drug-drug interactions. Pharmacology & Therapeutics 206, pages 107449.
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C. Zetterberg, F. Maltais, L. Laitinen, S. Liao, H. Tsao, A. Chakilam & N. Hariparsad. (2016) VX-509 (Decernotinib)-Mediated CYP3A Time-Dependent Inhibition: An Aldehyde Oxidase Metabolite as a Perpetrator of Drug-Drug Interactions. Drug Metabolism and Disposition 44:8, pages 1286-1295.
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A. A. Sprouse & R. B. van Breemen. (2015) Pharmacokinetic Interactions between Drugs and Botanical Dietary Supplements. Drug Metabolism and Disposition 44:2, pages 162-171.
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Katharina Mertsch, Martin Will, Werngard Czechtizky, Niels Griesang, Alexander Marker & Jacob Olsen. 2015. Small Molecule Medicinal Chemistry. Small Molecule Medicinal Chemistry 353 377 .
Patrik Lundquist, Gunilla Englund, Cristine Skogastierna, Johan Lööf, Jenny Johansson, Janet Hoogstraate, Lovisa Afzelius & Tommy B. Andersson. (2014) Functional ATP-Binding Cassette Drug Efflux Transporters in Isolated Human and Rat Hepatocytes Significantly Affect Assessment of Drug Disposition. Drug Metabolism and Disposition 42:3, pages 448-458.
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Tonika Bohnert & Lawrence L. Gan. 2014. Handbook of Metabolic Pathways of Xenobiotics. Handbook of Metabolic Pathways of Xenobiotics 1 61 .
Jialin Mao, Theodore R. Johnson, Zhongzhou Shen & Shinji Yamazaki. (2013) Prediction of Crizotinib-Midazolam Interaction Using the Simcyp Population-Based Simulator: Comparison of CYP3A Time-Dependent Inhibition between Human Liver Microsomes versus Hepatocytes. Drug Metabolism and Disposition 41:2, pages 343-352.
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Daniel R. Albaugh, Cody L. Fullenwider, Michael B. Fisher & J. Matthew Hutzler. (2012) Time-Dependent Inhibition and Estimation of CYP3A Clinical Pharmacokinetic Drug-Drug Interactions Using Plated Human Cell Systems. Drug Metabolism and Disposition 40:7, pages 1336-1344.
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Brian J. Kirby, Ann C. Collier, Evan D. Kharasch, Dale Whittington, Kenneth E. Thummel & Jashvant D. Unadkat. (2011) Complex Drug Interactions of HIV Protease Inhibitors 1: Inactivation, Induction, and Inhibition of Cytochrome P450 3A by Ritonavir or Nelfinavir. Drug Metabolism and Disposition 39:6, pages 1070-1078.
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J. Matthew Hutzler, Jack Cook & Joseph C. Fleishaker. 2011. Pharmacokinetics in Drug Development. Pharmacokinetics in Drug Development 21 56 .
Lei Zhang, Kellie S. Reynolds, Ping Zhao & Shiew-Mei Huang. (2010) Drug interactions evaluation: An integrated part of risk assessment of therapeutics. Toxicology and Applied Pharmacology 243:2, pages 134-145.
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Tonika Bohnert & Liang‐Shang Gan. 2009. Enzyme Inhibition in Drug Discovery and Development. Enzyme Inhibition in Drug Discovery and Development 91 176 .
Ping Zhao. 2009. Enzyme Inhibition in Drug Discovery and Development. Enzyme Inhibition in Drug Discovery and Development 345 362 .
Lei Zhang, Yuanchao Zhang, Ping Zhao & Shiew-Mei Huang. (2009) Predicting Drug–Drug Interactions: An FDA Perspective. The AAPS Journal 11:2, pages 300-306.
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Kenneth H. Grime, James Bird, Douglas Ferguson & Robert J. Riley. (2009) Mechanism-based inhibition of cytochrome P450 enzymes: An evaluation of early decision making in vitro approaches and drug–drug interaction prediction methods. European Journal of Pharmaceutical Sciences 36:2-3, pages 175-191.
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