672
Views
123
CrossRef citations to date
0
Altmetric
Review

Sex-specific differences in CYP450 isoforms in humans

, BSc (Hon), , BSc (Hon) & , PhD
Pages 413-424 | Published online: 23 Apr 2008

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (12)

Xiaoyue Qin, Chun’e Li, Wenming Wei, Dan He, Yijing Zhao, Qingqing Cai, Na Zhang, Xiaoge Chu, Sirong Shi & Feng Zhang. (2023) Assessing the association of coffee consumption on the relationship of chronic pain with depression and anxiety. Nutritional Neuroscience 0:0, pages 1-11.
Read now
Junmei Chen, Jinman Liu, Yueyue Huang, Ruoyu Li, Cuiru Ma, Beiping Zhang, Fanchang Wu, Wenqian Yu, Xue Zuo, Yong Liang & Qi Wang. (2021) Insights into oral bioavailability enhancement of therapeutic herbal constituents by cytochrome P450 3A inhibition. Drug Metabolism Reviews 53:4, pages 491-507.
Read now
Wojciech Kuban & Władysława Anna Daniel. (2021) Cytochrome P450 expression and regulation in the brain. Drug Metabolism Reviews 53:1, pages 1-29.
Read now
Huaqiao Tang, Nana Long, Lin Lin, Yao Liu, Jianlong Li, Fenghui Sun, Lijuan Guo, Fen Zhang & Min Dai. (2018) Effect of MRSA on CYP450: dynamic changes of cytokines, oxidative stress, and drug-metabolizing enzymes in mice infected with MRSA. Infection and Drug Resistance 11, pages 229-238.
Read now
Vidya Perera, Annette S Gross, Thomas M Polasek, Yan Qin, Gauri Rao, Alan Forrest, Junzhe Xu & Andrew J McLachlan. (2013) Considering CYP1A2 phenotype and genotype for optimizing the dose of olanzapine in the management of schizophrenia. Expert Opinion on Drug Metabolism & Toxicology 9:9, pages 1115-1137.
Read now
Aarathi Sugathan & David J. Waxman. (2013) Genome-Wide Analysis of Chromatin States Reveals Distinct Mechanisms of Sex-Dependent Gene Regulation in Male and Female Mouse Liver. Molecular and Cellular Biology 33:18, pages 3594-3610.
Read now
Savita Bisht, Georg Feldmann & Peter Brossart. (2013) Pharmacokinetics and pharmacodynamics of sunitinib for the treatment of advanced pancreatic neuroendocrine tumors. Expert Opinion on Drug Metabolism & Toxicology 9:6, pages 777-788.
Read now
Yijing Zhang, Ekaterina V. Laz & David J. Waxman. (2012) Dynamic, Sex-Differential STAT5 and BCL6 Binding to Sex-Biased, Growth Hormone-Regulated Genes in Adult Mouse Liver. Molecular and Cellular Biology 32:4, pages 880-896.
Read now
Shubulade Smith. (2010) Gender differences in antipsychotic prescribing. International Review of Psychiatry 22:5, pages 472-484.
Read now
Alan Boobis, Jean-Baptiste Watelet, Rhys Whomsley, Margherita Strolin Benedetti, Pascal Demoly & Keith Tipton. (2009) Drug interactions. Drug Metabolism Reviews 41:3, pages 486-527.
Read now

Articles from other publishers (111)

Rosana Carvalho Silva, Claudia Pisanu, Elisabetta Maffioletti, Valentina Menesello, Marco Bortolomasi, Massimo Gennarelli, Bernhard T Baune, Alessio Squassina & Alessandra Minelli. (2023) Biological markers of sex-based differences in major depressive disorder and in antidepressant response. European Neuropsychopharmacology 76, pages 89-107.
Crossref
Bodyl A. Brand, Elske J. M. Willemse, Iris M. H. Hamers & Iris E. Sommer. (2023) Evidence-Based Recommendations for the Pharmacological Treatment of Women with Schizophrenia Spectrum Disorders. Current Psychiatry Reports 25:11, pages 723-733.
Crossref
Qing Zhao, Yao Chen, Weihua Huang, Honghao Zhou & Wei Zhang. (2023) Drug-microbiota interactions: an emerging priority for precision medicine. Signal Transduction and Targeted Therapy 8:1.
Crossref
Jinming Fan, Yajun Yuan, Xiaoting Zhang, Wenhan Li, Wuqin Ma, Wenhao Wang, Jinyan Gu & Bin Zhou. (2023) Association between urinary caffeine and caffeine metabolites and stroke in American adults: a cross-sectional study from the NHANES, 2009–2014. Scientific Reports 13:1.
Crossref
Laura MacNairJustyna Kulpa, Melanie L. HillGraham M.L. EglitIrina MosesovaMarcel O. Bonn-Miller & Erica N. Peters. (2023) Sex Differences in the Pharmacokinetics of Cannabidiol and Metabolites Following Oral Administration of a Cannabidiol-Dominant Cannabis Oil in Healthy Adults. Cannabis and Cannabinoid Research.
Crossref
Carmen Flores-Pérez, Luis Alfonso Moreno-Rocha, Juan Luis Chávez-Pacheco, Norma Angélica Noguez-Méndez, Janett Flores-Pérez, María Fernanda Alcántara-Morales, Luz Cortés-Vásquez & Lina Sarmiento-Argüello. (2022) Sedation level with midazolam: A pediatric surgery approach. Saudi Pharmaceutical Journal 30:7, pages 906-917.
Crossref
Aldo E. Polettini, Christoph Sauer, Martina Spieß & Wolfgang Schultis. (2022) Evidence for gender differences in the Amphetamine/Methamphetamine ratio in the hair of subjects undergoing Fitness-to-Drive testing. Clinica Chimica Acta 530, pages 87-93.
Crossref
Moumita Dutta, Joe Jongpyo Lim & Julia Yue Cui. (2022) Pregnane X Receptor and the Gut-Liver Axis: A Recent Update. Drug Metabolism and Disposition 50:4, pages 478-491.
Crossref
Bodyl A. Brand, Yudith R. A. Haveman, Franciska de Beer, Janna N. de Boer, Paola Dazzan & Iris E. C. Sommer. (2021) Antipsychotic medication for women with schizophrenia spectrum disorders. Psychological Medicine 52:4, pages 649-663.
Crossref
Kathleen M. Tornatore, Calvin J. Meaney, Kristopher Attwood, Daniel A. Brazeau, Gregory E. Wilding, Joseph D. Consiglio, Aijaz Gundroo, Shirley S. Chang, Vanessa Gray, Louise M. Cooper & Rocco C. Venuto. (2022) Race and sex associations with tacrolimus pharmacokinetics in stable kidney transplant recipients. Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy 42:2, pages 94-105.
Crossref
Caroul Chawar, Alannah Hillmer, Amel Lamri, Flavio Kapczinski, Lehana Thabane, Guillaume Pare & Zainab Samaan. (2021) Implications of OPRM1 and CYP2B6 variants on treatment outcomes in methadone-maintained patients in Ontario: Exploring sex differences. PLOS ONE 16:12, pages e0261201.
Crossref
Jung-Lynn Jonathan Yang, Rukhmani Narayanamurthy, Jerome Y. Yager & Larry D. Unsworth. (2021) How does biological sex affect the physiological response to nanomaterials?. Nano Today 41, pages 101292.
Crossref
Rui Xue, Lianyong Su, Shengyi Lai, Yanyan Wang, Derrick Zhao, Jiangao Fan, Weidong Chen, Phillip B. Hylemon & Huiping Zhou. (2021) Bile Acid Receptors and the Gut–Liver Axis in Nonalcoholic Fatty Liver Disease. Cells 10:11, pages 2806.
Crossref
Seonghae Yoon, Seongmee Jeong, Eben Jung, Ki Soon Kim, Inseung Jeon, Yujin Lee, Joo-Youn Cho, Woo-Yong Oh & Jae-Yong Chung. (2021) Effect of CYP3A4 metabolism on sex differences in the pharmacokinetics and pharmacodynamics of zolpidem. Scientific Reports 11:1.
Crossref
Sanne Hoekstra, Christoffer Bartz-Johannessen, Igne Sinkeviciute, Solveig K. Reitan, Rune A. Kroken, Else-Marie Løberg, Tor K. Larsen, Maria Rettenbacher, Erik Johnsen & Iris E. Sommer. (2021) Sex differences in antipsychotic efficacy and side effects in schizophrenia spectrum disorder: results from the BeSt InTro study. npj Schizophrenia 7:1.
Crossref
Johanna Seifert, Fabienne Führmann, Matthias A. Reinhard, Rolf R. Engel, Xueqiong Bernegger, Stefan Bleich, Susanne Stübner, Eckart Rüther, Sermin Toto, Renate Grohmann, Marcel Sieberer & Waldemar Greil. (2021) Sex differences in pharmacological treatment of major depressive disorder: results from the AMSP pharmacovigilance program from 2001 to 2017. Journal of Neural Transmission 128:6, pages 827-843.
Crossref
Julian C. Gilmore, Lena Serghides & Reina Bendayan. (2021) Differential effects of antiretroviral drug toxicity in male versus female children who are HIV-exposed but uninfected. AIDS 35:1, pages 1-14.
Crossref
Ádám Menus, Ádám Kiss, Katalin Tóth, Dávid Sirok, Máté Déri, Ferenc Fekete, Gábor Csukly & Katalin Monostory. (2020) Association of clozapine-related metabolic disturbances with CYP3A4 expression in patients with schizophrenia. Scientific Reports 10:1.
Crossref
Joshua B. Rubin, Joseph S. Lagas, Lauren Broestl, Jasmin Sponagel, Nathan Rockwell, Gina Rhee, Sarah F. Rosen, Si Chen, Robyn S. Klein, Princess Imoukhuede & Jingqin Luo. (2020) Sex differences in cancer mechanisms. Biology of Sex Differences 11:1.
Crossref
Hongbing Sun, Michael Leo Sun & Dana Boyd Barr. (2020) Exposure to organophosphorus insecticides and increased risks of health and cancer in US women. Environmental Toxicology and Pharmacology 80, pages 103474.
Crossref
Hye Jin Jee, Sang Goo Lee, Katrina Joy Bormate & Yi-Sook Jung. (2020) Effect of Caffeine Consumption on the Risk for Neurological and Psychiatric Disorders: Sex Differences in Human. Nutrients 12:10, pages 3080.
Crossref
Daniel A. Brazeau, Kristopher Attwood, Calvin J. Meaney, Gregory E. Wilding, Joseph D. Consiglio, Shirley S. Chang, Aijaz Gundroo, Rocco C. Venuto, Louise Cooper & Kathleen M. Tornatore. (2020) Beyond Single Nucleotide Polymorphisms: CYP3A5∗3∗6∗7 Composite and ABCB1 Haplotype Associations to Tacrolimus Pharmacokinetics in Black and White Renal Transplant Recipients. Frontiers in Genetics 11.
Crossref
Victoria Sarne, Samuel Huter, Sandrina Braunmueller, Lisa Rakob, Nico Jacobi, Melitta Kitzwögerer, Christoph Wiesner, Peter Obrist & Rita Seeboeck. (2020) Promoter Methylation of Selected Genes in Non-Small-Cell Lung Cancer Patients and Cell Lines. International Journal of Molecular Sciences 21:13, pages 4595.
Crossref
Yang Bai, Wei Peng, Cuiping Yang, Wei Zou, Menghua Liu, Hao Wu, Loudi Fan, Peibo Li, Xuan Zeng & Weiwei Su. (2020) Pharmacokinetics and Metabolism of Naringin and Active Metabolite Naringenin in Rats, Dogs, Humans, and the Differences Between Species. Frontiers in Pharmacology 11.
Crossref
Askhi M. Valodara & Kaid Johar SR. (2020) Sexual Dimorphism in Drug Metabolism and Pharmacokinetics. Current Drug Metabolism 20:14, pages 1154-1166.
Crossref
André Farkouh, Thomas Riedl, Roman Gottardi, Martin Czejka & Alexandra Kautzky-Willer. (2019) Sex-Related Differences in Pharmacokinetics and Pharmacodynamics of Frequently Prescribed Drugs: A Review of the Literature. Advances in Therapy 37:2, pages 644-655.
Crossref
Misaki KOJIMA. (2020) Sex and Breed Differences in the Constitutive Gene Expression of Hepatic Drug Metabolizing Enzymes in Meishan and Landrace Pigs: Testosterone-mediated Differences. Japan Agricultural Research Quarterly: JARQ 54:1, pages 7-12.
Crossref
Sophie Gravel, Jean‐Louis Chiasson, Jacques Turgeon, Alexia Grangeon & Veronique Michaud. (2019) Modulation of CYP 450 Activities in Patients With Type 2 Diabetes . Clinical Pharmacology & Therapeutics 106:6, pages 1280-1289.
Crossref
Ji Yoon Shin, Hee Jin Jung & Aree Moon. (2019) Molecular Markers in Sex Differences in Cancer. Toxicological Research 35:4, pages 331-341.
Crossref
Martin Krøyer Rasmussen, Carsten Scavenius, Sabine Gerbal-Chaloin & Jan Enghild. (2019) Sex dictates the constitutive expression of hepatic cytochrome P450 isoforms in Göttingen minipigs. Toxicology Letters 314, pages 181-186.
Crossref
Alejandro GARCÍA & María Dolores SANTOS. (2019) Caracterización in silico de la farmacocinética de clozapina en distintas poblaciones de pacientes.. FarmaJournal 4:2, pages 7.
Crossref
Raju Khatri, John K. Fallon, Rebecca J.B. Rementer, Natasha T. Kulick, Craig R. Lee & Philip C. Smith. (2019) Targeted quantitative proteomic analysis of drug metabolizing enzymes and transporters by nano LC-MS/MS in the sandwich cultured human hepatocyte model. Journal of Pharmacological and Toxicological Methods 98, pages 106590.
Crossref
Victoria Sarne, Sandrina Braunmueller, Lisa Rakob & Rita Seeboeck. (2019) The Relevance of Gender in Tumor-Influencing Epigenetic Traits. Epigenomes 3:1, pages 6.
Crossref
Xuan Zeng, Weiwei Su, Yuying Zheng, Yudong He, Yan He, Hongyu Rao, Wei Peng & Hongliang Yao. (2019) Pharmacokinetics, Tissue Distribution, Metabolism, and Excretion of Naringin in Aged Rats. Frontiers in Pharmacology 10.
Crossref
Julien Tripette, Haruka Murakami, Hidemi Hara, Ryoko Kawakami, Yuko Gando, Harumi Ohno, Nobuyuki Miyatake & Motohiko Miyachi. (2018) Caffeine Consumption Is Associated With Higher Level of Physical Activity in Japanese Women. International Journal of Sport Nutrition and Exercise Metabolism 28:5, pages 474-479.
Crossref
Diana M Rydberg, Stefan Mejyr, Desirée Loikas, Karin Schenck-Gustafsson, Mia von Euler & Rickard E Malmström. (2018) Sex differences in spontaneous reports on adverse drug events for common antihypertensive drugs. European Journal of Clinical Pharmacology 74:9, pages 1165-1173.
Crossref
Prasanna Jagannathan, Abel Kakuru, Jaffer Okiring, Mary K. Muhindo, Paul Natureeba, Miriam Nakalembe, Bishop Opira, Peter Olwoch, Felistas Nankya, Isaac Ssewanyana, Kevin Tetteh, Chris Drakeley, James Beeson, Linda Reiling, Tamara D. Clark, Isabel Rodriguez-Barraquer, Bryan Greenhouse, Erika Wallender, Francesca Aweeka, Mary Prahl, Edwin D. Charlebois, Margaret E. Feeney, Diane V. Havlir, Moses R. Kamya & Grant Dorsey. (2018) Dihydroartemisinin-piperaquine for intermittent preventive treatment of malaria during pregnancy and risk of malaria in early childhood: A randomized controlled trial. PLOS Medicine 15:7, pages e1002606.
Crossref
Si Chen, Qiangen Wu, Baitang Ning, Matthew Bryant & Lei Guo. (2018) The role of hepatic cytochrome P450s in the cytotoxicity of dronedarone. Archives of Toxicology 92:6, pages 1969-1981.
Crossref
Lili Wu, Muhammad Zubair Hafiz, Yu Guan, Shuangcheng He, Jing Xiong, Wei Liu, Bingfang Yan, Xiaoping Li & Jian Yang. (2018) 17β-estradiol suppresses carboxylesterases by activating c-Jun/AP-1 pathway in primary human and mouse hepatocytes. European Journal of Pharmacology 819, pages 98-107.
Crossref
I. Castberg, A. A. Westin, E. Skogvoll & O. Spigset. (2017) Effects of age and gender on the serum levels of clozapine, olanzapine, risperidone, and quetiapine. Acta Psychiatrica Scandinavica 136:5, pages 455-464.
Crossref
Geoff Frawley & Md Hamidul Huque. (2017) Infant spinal anesthesia: Do girls need a larger dose of local anesthetic?. Pediatric Anesthesia 27:10, pages 1037-1042.
Crossref
Yuhao Shao, Xiaoxi Yin, Dian Kang, Boyu Shen, Zhangpei Zhu, Xinuo Li, Haofeng Li, Lin Xie, Guangji Wang & Yan Liang. (2017) An integrated strategy for the quantitative analysis of endogenous proteins: A case of gender-dependent expression of P450 enzymes in rat liver microsome. Talanta 170, pages 514-522.
Crossref
Martin O Behm, Ka L Yee, Li Fan & Paul Fackler. (2016) Effect of Gender and Age on the Relative Bioavailability of Doravirine: Results of a Phase I Trial in Healthy Subjects. Antiviral Therapy 22:4, pages 337-344.
Crossref
M. Martín-De Saro, O. Amancio-Chassin, H. Urueta-Cuéllar, L. González-Huerta & S.A. Cuevas-Covarrubias. (2017) Pharmacokinetics of diclofenac in healthy controls with wild-type phenotype for CYP2C9 shows metabolism variability. Revista Médica del Hospital General de México 80:2, pages 92-96.
Crossref
Yani Liu, Jianhong Wu, Zhongfang Li, Ying Luo, Fandian Zeng & Shaojun Shi. (2016) Tolerability and Pharmacokinetics of Hydronidone, an Antifibrotic Agent for Hepatic Fibrosis, after Single and Multiple Doses in Healthy Subjects: an Open-Label, Randomized, Dose-Escalating, First-in-Human Study. European Journal of Drug Metabolism and Pharmacokinetics 42:1, pages 37-48.
Crossref
Michael Gochfeld. (2016) Sex Differences in Human and Animal Toxicology. Toxicologic Pathology 45:1, pages 172-189.
Crossref
Jian Shi, Xinwen Wang, Rachel F. Eyler, Yan Liang, Li Liu, Bruce A. Mueller & Hao-Jie Zhu. (2016) Association of Oseltamivir Activation with Gender and Carboxylesterase 1 Genetic Polymorphisms. Basic & Clinical Pharmacology & Toxicology 119:6, pages 555-561.
Crossref
Misaki Kojima & Masakuni Degawa. (2016) Sex differences in constitutive mRNA levels of CYP2B22, CYP2C33, CYP2C49, CYP3A22, CYP3A29 and CYP3A46 in the pig liver: Comparison between Meishan and Landrace pigs. Drug Metabolism and Pharmacokinetics 31:3, pages 185-192.
Crossref
Lisa Schmölz. (2016) Complexity of vitamin E metabolism. World Journal of Biological Chemistry 7:1, pages 14.
Crossref
Shubulade Smith & Fiona Gaughran. 2016. Comprehensive Women's Mental Health. Comprehensive Women's Mental Health 307 319 .
. 2016. Comprehensive Women's Mental Health. Comprehensive Women's Mental Health 269 347 .
Furong Zhang, Xuming Yu, Chunyan He, Xiufang Ouyang, Jinhua Wu, Jie Li, Junjie Zhang, Xuejiao Duan, Yu Wan & Jiang Yue. (2015) Effects of sexually dimorphic growth hormone secretory patterns on arachidonic acid metabolizing enzymes in rodent heart. Toxicology and Applied Pharmacology 289:3, pages 495-506.
Crossref
M. Reich & N. Kotecki. (2016) Interactions médicamenteuses entre les psychotropes et les thérapies pharmacologiques en oncologie : quelles modalités de prescription ?Drugs interactions between psychotropics and pharmacological treatments in oncology: Which modalities of prescription?. Psycho-Oncologie 9:4, pages 249-266.
Crossref
Jie Li, Yu Wan, Shufang Na, Xiaochan Liu, Guicheng Dong, Zheqiong Yang, Jing Yang & Jiang Yue. (2015) Sex-dependent regulation of hepatic CYP3A by growth hormone: Roles of HNF6, C/EBPα, and RXRα. Biochemical Pharmacology 93:1, pages 92-103.
Crossref
Payman Shahabi, Gérard Siest, Urs A. Meyer & Sophie Visvikis-Siest. (2014) Human cytochrome P450 epoxygenases: Variability in expression and role in inflammation-related disorders. Pharmacology & Therapeutics 144:2, pages 134-161.
Crossref
Lori H. Takahashi, Keith Huie, Daniel A. Spyker, Robert S. Fishman & James V. Cassella. (2014) Effect of Smoking on the Pharmacokinetics of Inhaled Loxapine. Therapeutic Drug Monitoring 36:5, pages 618-623.
Crossref
Pietro Fagiolino, Marta Vázquez, Manuel Ibarra, Laura Magallanes, Natalia Guevara & Nikoletta Fotaki. (2014) Sex- and smoke-related differences in gastrointestinal transit of cyclosporin A microemulsion capsules. European Journal of Pharmaceutical Sciences 63, pages 140-146.
Crossref
Zhong-Ze Fang, Kristopher W Krausz, Kenjiro Nagaoka, Naoki Tanaka, Krishne Gowda, Shantu G Amin, Gary H Perdew & Frank J Gonzalez. (2014) In vivo effects of the pure aryl hydrocarbon receptor antagonist GNF-351 after oral administration are limited to the gastrointestinal tract . British Journal of Pharmacology 171:7, pages 1735-1746.
Crossref
S. Luk, R. S. Atayee, J. D. Ma & B. M. Best. (2014) Urinary Diazepam Metabolite Distribution in a Chronic Pain Population. Journal of Analytical Toxicology 38:3, pages 135-142.
Crossref
A. T. Marinho, P. M. Rodrigues, U. Caixas, A. M. M. Antunes, T. Branco, S. G. Harjivan, M. M. Marques, E. C. Monteiro & S. A. Pereira. (2013) Differences in nevirapine biotransformation as a factor for its sex-dependent dimorphic profile of adverse drug reactions. Journal of Antimicrobial Chemotherapy 69:2, pages 476-482.
Crossref
Svetlana Karakhanova, Yuhui Yang, Julia Link, Sabine Soltek, Katharina von Ahn, Viktor Umansky, Jens Werner & Alexandr V. Bazhin. (2013) Gender-specific immunological effects of the phosphodiesterase 5 inhibitor sildenafil in healthy mice. Molecular Immunology 56:4, pages 649-659.
Crossref
Eva Choong, Irena Loryan, Marja Lindqvist, Åsa Nordling, Samira el Bouazzaoui, Ron H. van Schaik, Inger Johansson, Jan Jakobsson & Magnus Ingelman-Sundberg. (2013) Sex Difference in Formation of Propofol Metabolites: A Replication Study. Basic & Clinical Pharmacology & Toxicology 113:2, pages 126-131.
Crossref
Hubert W. Vesper, Maya R. Sternberg, Tunde Frame & Christine M. Pfeiffer. (2013) Among 10 Sociodemographic and Lifestyle Variables, Smoking Is Strongly Associated with Biomarkers of Acrylamide Exposure in a Representative Sample of the U.S. Population. The Journal of Nutrition 143:6, pages 995S-1000S.
Crossref
Patrick Schrader, Leah M. Panek & Jennifer L. Temple. (2013) Acute and chronic caffeine administration increases physical activity in sedentary adults. Nutrition Research 33:6, pages 457-463.
Crossref
Alexander K. Berg, Sumithra J. Mandrekar, Katie L. Allen Ziegler, Elsa C. Carlson, Eva Szabo, Mathew M. Ames, Daniel Boring, Paul J. Limburg & Joel M. Reid. (2013) Population Pharmacokinetic Model for Cancer Chemoprevention With Sulindac in Healthy Subjects. The Journal of Clinical Pharmacology 53:4, pages 403-412.
Crossref
Jin Joo Park, Kyung Woo Park, Jeehoon Kang, Ki-Hyun Jeon, Si-Hyuck Kang, Hyo Suk Ahn, Jung-Kyu Han, Jin-Sin Koh, Sang Eun Lee, Han-Mo Yang, Hae-Young Lee, Hyun-Jae Kang, Bon-Kwon Koo, Byung-Hee Oh, Young-Bae Park & Hyo-Soo Kim. (2013) Genetic determinants of clopidogrel responsiveness in Koreans treated with drug-eluting stents. International Journal of Cardiology 163:1, pages 79-86.
Crossref
A. M. Sandqvist, D. Henrohn, J. Schneede, M. Hedeland, H. C. Egeröd, U. G. Bondesson & B. G. Wikström. (2012) High inter-individual variability of vardenafil pharmacokinetics in patients with pulmonary hypertension. European Journal of Clinical Pharmacology 69:2, pages 197-207.
Crossref
Joo Myung Lee, Jin Joo Park, Hee Won Jung, Young-Seok Cho, Il-Young Oh, Chang-Hwan Yoon, Jung-Won Suh, Eun Ju Chun, Sang Il Choi, Tae-Jin Youn, Cheong Lim, Goo-Yeong Cho, In-Ho Chae, Kay-Hyun Park & Dong-Ju Choi. (2013) Left Ventricular Thrombus and Subsequent Thromboembolism, Comparison of Anticoagulation, Surgical Removal, and Antiplatelet Agents. Journal of Atherosclerosis and Thrombosis 20:1, pages 73-93.
Crossref
Ilaria Campesi, Marco Fois & Flavia Franconi. 2012. Sex and Gender Differences in Pharmacology. Sex and Gender Differences in Pharmacology 265 278 .
Zhong‐Ze Fang, Kristopher W Krausz, Fei Li, Jie Cheng, Naoki Tanaka & Frank J Gonzalez. (2012) Metabolic map and bioactivation of the anti‐tumour drug noscapine. British Journal of Pharmacology 167:6, pages 1271-1286.
Crossref
Alexander V. LyubimovRonald E. White. 2011. Encyclopedia of Drug Metabolism and Interactions. Encyclopedia of Drug Metabolism and Interactions 1 40 .
Renli Teng, Patrick Mitchell & Kathleen Butler. (2012) Effect of age and gender on pharmacokinetics and pharmacodynamics of a single ticagrelor dose in healthy individuals. European Journal of Clinical Pharmacology 68:8, pages 1175-1182.
Crossref
K. Vanhees, F. J. van Schooten, E. J. Moonen, L. M. Maas, S. Barjesteh van & R. W. L. Godschalk. (2012) Maternal intake of quercetin during gestation alters ex vivo benzo[a]pyrene metabolism and DNA adduct formation in adult offspring. Mutagenesis 27:4, pages 445-451.
Crossref
Andreas Benesic, Nora L Rahm, Samuel Ernst & Alexander L Gerbes. (2012) Human monocyte-derived cells with individual hepatocyte characteristics: a novel tool for personalized in vitro studies. Laboratory Investigation 92:6, pages 926-936.
Crossref
Zdenek Dvorak. 2012. Metabolism of Drugs and Other Xenobiotics. Metabolism of Drugs and Other Xenobiotics 223 258 .
Ulrich M. Zanger. 2012. Metabolism of Drugs and Other Xenobiotics. Metabolism of Drugs and Other Xenobiotics 285 300 .
Irena Loryan, Marja Lindqvist, Inger Johansson, Masahiro Hiratsuka, Ilse van der Heiden, Ron HN van Schaik, Jan Jakobsson & Magnus Ingelman-Sundberg. (2011) Influence of sex on propofol metabolism, a pilot study: implications for propofol anesthesia. European Journal of Clinical Pharmacology 68:4, pages 397-406.
Crossref
Bill Speed, Hai-Zhi Bu, William F. Pool, Geoffrey W. Peng, Ellen Y. Wu, Shem Patyna, Carlo Bello & Ping Kang. (2012) Pharmacokinetics, Distribution, and Metabolism of [ 14 C]Sunitinib in Rats, Monkeys, and Humans . Drug Metabolism and Disposition 40:3, pages 539-555.
Crossref
Kyung Woo Park, Jin Joo Park, Ki‐Hyun Jeon, Si‐Hyuk Kang, Il‐Young Oh, Han‐Mo Yang, Hyun‐Jai Cho, Hae‐Young Lee, Hyun‐Jae Kang, Bon‐Kwon Koo, Byung‐Hee Oh, Young‐Bae Park & Hyo‐Soo Kim. (2010) Clinical Predictors of High Posttreatment Platelet Reactivity to Clopidogrel in Koreans. Cardiovascular Therapeutics 30:1, pages 5-11.
Crossref
Alexander V. LyubimovUlrich M. Zanger. 2011. Encyclopedia of Drug Metabolism and Interactions. Encyclopedia of Drug Metabolism and Interactions 1 36 .
Alexander V. LyubimovThomas K. H. Chang & David J. Waxman. 2011. Encyclopedia of Drug Metabolism and Interactions. Encyclopedia of Drug Metabolism and Interactions 1 19 .
Samanta Yubero-Lahoz, Ricardo Pardo, Magí Farre, Brian Ó Mathuna, Marta Torrens, Cristina Mustata, Clara Perez-Mañá, Klaus Langohr, Marcel-lí Carbó & Rafael de la Torre. (2012) Changes in CYP1A2 Activity in Humans after 3,4-Methylenedioxymethamphetamine (MDMA, Ecstasy) Administration Using Caffeine as a Probe Drug. Drug Metabolism and Pharmacokinetics 27:6, pages 605-613.
Crossref
Michael G. Sugiyama, Luc Hobson, Al B. Agellon & Luis B. Agellon. (2012) Visualization of Sex-Dimorphic Changes in the Intestinal Transcriptome of Fabp2 Gene-Ablated Mice. Journal of Nutrigenetics and Nutrigenomics 5:1, pages 45-55.
Crossref
Paola MatarreseTania ColasantiBarbara AscionePaola MarguttiFlavia FranconiCristiano AlessandriFabrizio ContiValeria RiccieriGiuseppe RosanoElena OrtonaWalter Malorni. (2011) Gender Disparity in Susceptibility to Oxidative Stress and Apoptosis Induced by Autoantibodies Specific to RLIP76 in Vascular Cells. Antioxidants & Redox Signaling 15:11, pages 2825-2836.
Crossref
Hung-Jen Huang, Mei-Ling Tsai, Yen-Wen Chen & Shu-Hui Chen. (2011) Quantitative shot-gun proteomics and MS-based activity assay for revealing gender differences in enzyme contents for rat liver microsome. Journal of Proteomics 74:12, pages 2734-2744.
Crossref
Yijing Zhang, Kathrin Klein, Aarathi Sugathan, Najlla Nassery, Alan Dombkowski, Ulrich M. Zanger & David J. Waxman. (2011) Transcriptional Profiling of Human Liver Identifies Sex-Biased Genes Associated with Polygenic Dyslipidemia and Coronary Artery Disease. PLoS ONE 6:8, pages e23506.
Crossref
Nicholas B Norgard & Gina M Prescott. (2011) Future of personalized pharmacotherapy in chronic heart failure patients. Future Cardiology 7:3, pages 357-379.
Crossref
Nell Tharpe. (2011) Adverse Drug Reactions in Women's Health Care. Journal of Midwifery & Women's Health 56:3, pages 205-213.
Crossref
Catherine Tomicic, Michèle Berode, Anne Oppliger, Vincent Castella, Fabienne Leyvraz, Sophie-Maria Praz-Christinaz & Brigitta Danuser. (2011) Sex differences in urinary levels of several biological indicators of exposure: A human volunteer study. Toxicology Letters 202:3, pages 218-225.
Crossref
Masashi SEKIMOTO. (2011) Sex- and Species-differences on Xenobiotic-induced Toxicity: Differences in Constitutive and Xenobiotic-mediated Expression of Cytochrome P450 1A Subfamily Enzymes (CYP1As)化学物質の毒性発現における種差・性差の解析:シトクロムP450 1A サブファミリー分子種(CYP1As)の発現変動における相違を指標として. YAKUGAKU ZASSHI 131:3, pages 415-422.
Crossref
Wattanaporn Bhadhprasit, Tsutomu Sakuma, Yuki Kawasaki & Nobuo Nemoto. (2011) Hepatocyte Nuclear Factor 4α Regulates Expression of the Mouse Female-Specific Cyp3a41 Gene in the Liver . Drug Metabolism and Disposition 39:3, pages 490-497.
Crossref
Maria Marino, Roberta Masella, Pamela Bulzomi, Ilaria Campesi, Walter Malorni & Flavia Franconi. (2011) Nutrition and human health from a sex–gender perspective. Molecular Aspects of Medicine 32:1, pages 1-70.
Crossref
Eline M. Rodenburg, Bruno H. Ch. Stricker & Loes E. Visser. (2011) Sex-related differences in hospital admissions attributed to adverse drug reactions in the Netherlands. British Journal of Clinical Pharmacology 71:1, pages 95-104.
Crossref
Angelica Francesca Maris, Jeferson Luis Franco, Péricles Aruda Mitozo, Gislaine Paviani, Cristina Borowski, Rafael Trevisan, Marcela Uliano‐Silva, Marcelo Farina & Alcir Luiz Dafre. (2010) Gender Effects of Acute Malathion or Zinc Exposure on the Antioxidant Response of Rat Hippocampus and Cerebral Cortex. Basic & Clinical Pharmacology & Toxicology 107:6, pages 965-970.
Crossref
Maret G. Traber, Debbie J. Mustacich, Laura C. Sullivan, Scott W. Leonard, Amelia Ahern-Rindell & Nancy Kerkvliet. (2010) Vitamin E status and metabolism in adult and aged aryl hydrocarbon receptor null mice. The Journal of Nutritional Biochemistry 21:12, pages 1193-1199.
Crossref
V. A. Sukhanov & L. A. Piruzyan. (2010) Role of physiological factors in predicting the risk of oncological diseases on the basis of the polymorphism of the xenobiotic metabolism enzyme system. Human Physiology 36:6, pages 723-736.
Crossref
H.-S. Kang, B.J. Kwon, J.E. Kim & M.H. Han. (2010) Preinterventional Clopidogrel Response Variability for Coil Embolization of Intracranial Aneurysms: Clinical Implications. American Journal of Neuroradiology 31:7, pages 1206-1210.
Crossref
Xia Yang, Bin Zhang, Cliona Molony, Eugene Chudin, Ke Hao, Jun Zhu, Andrea Gaedigk, Christine Suver, Hua Zhong, J. Steven Leeder, F. Peter Guengerich, Stephen C. Strom, Erin Schuetz, Thomas H. Rushmore, Roger G. Ulrich, J. Greg Slatter, Eric E. Schadt, Andrew Kasarskis & Pek Yee Lum. (2010) Systematic genetic and genomic analysis of cytochrome P450 enzyme activities in human liver. Genome Research 20:8, pages 1020-1036.
Crossref
Jackson K Mukonzo, Paul Waako, Jasper Ogwal-Okeng, Lars L Gustafsson & Eleni Aklillu. (2010) Genetic Variations in ABCB1 and CYP3A5 as well as Sex Influence Quinine Disposition Among Ugandans. Therapeutic Drug Monitoring 32:3, pages 346-352.
Crossref
Shinichiro Hanada, Natasha T. Snider, Elizabeth M. Brunt, Paul F. Hollenberg & M. Bishr Omary. (2010) Gender Dimorphic Formation of Mouse Mallory–Denk Bodies and the Role of Xenobiotic Metabolism and Oxidative Stress. Gastroenterology 138:4, pages 1607-1617.
Crossref
Salvador Fudio, Alberto M. Borobia, Enrique Piñana, Elena Ramírez, Beatriz Tabarés, Pedro Guerra, Antonio Carcas & Jesús Frías. (2010) Evaluation of the influence of sex and CYP2C19 and CYP2D6 polymorphisms in the disposition of citalopram. European Journal of Pharmacology 626:2-3, pages 200-204.
Crossref
Sabrina Peterson, Yvonne Schwarz, Shuying S. Li, Lin Li, Irena B. King, Chu Chen, David L. Eaton, John D. Potter & Johanna W. Lampe. (2009) CYP1A2, GSTM1 , and GSTT1 Polymorphisms and Diet Effects on CYP1A2 Activity in a Crossover Feeding Trial . Cancer Epidemiology, Biomarkers & Prevention 18:11, pages 3118-3125.
Crossref
G.L. Pereno & C.A. Beltramino. (2009) Differential role of gonadal hormones on kainic acid–induced neurodegeneration in medial amygdaloid nucleus of female and male rats. Neuroscience 163:3, pages 952-963.
Crossref
Hao-Jie Zhu, David I. Appel, Yan Jiang & John S. Markowitz. (2009) Age- and Sex-Related Expression and Activity of Carboxylesterase 1 and 2 in Mouse and Human Liver. Drug Metabolism and Disposition 37:9, pages 1819-1825.
Crossref
David J. Waxman & Minita G. Holloway. (2009) Sex Differences in the Expression of Hepatic Drug Metabolizing Enzymes. Molecular Pharmacology 76:2, pages 215-228.
Crossref
Matthew J. Price, Keshav R. Nayak, Colin M. Barker, David E. Kandzari & Paul S. Teirstein. (2009) Predictors of Heightened Platelet Reactivity Despite Dual-Antiplatelet Therapy in Patients Undergoing Percutaneous Coronary Intervention. The American Journal of Cardiology 103:10, pages 1339-1343.
Crossref
Tsutomu Sakuma, Yuki Kawasaki, Kanokwan Jarukamjorn & Nobuo Nemoto. (2009) Sex Differences of Drug-metabolizing Enzyme: Female Predominant Expression of Human and Mouse Cytochrome P450 3A Isoforms. JOURNAL OF HEALTH SCIENCE 55:3, pages 325-337.
Crossref
G. Zamaratskaia, V. Zlabek, G. Chen & A. Madej. (2009) Modulation of porcine cytochrome P450 enzyme activities by surgical castration and immunocastration. Animal 3:8, pages 1124-1132.
Crossref
Ondřej ZENDULKA, Lucia ZAHRADNÍKOVÁ, Jan JUŘICA & Jiří TOTUŠEK. (2008) The influence of trans-resveratrol and quercetin on the activity of CYP1A2 in rat. Czech Journal of Food Sciences 26:Special Issue, pages S60-S64.
Crossref
MJ Kennedy. (2008) Hormonal Regulation of Hepatic Drug-Metabolizing Enzyme Activity During Adolescence. Clinical Pharmacology & Therapeutics 84:6, pages 662-673.
Crossref
David J. Greenblatt & Lisa L. von Moltke. (2008) Gender Has a Small but Statistically Significant Effect on Clearance of CYP3A Substrate Drugs. The Journal of Clinical Pharmacology 48:11, pages 1350-1355.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.