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Expert Opinion on Drug Metabolism & Toxicology Volume 4, 2008 - Issue 4
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Review

Metabolic activation of carboxylic acids

Christian Skonberg Assistant Professor University of Copenhagen, Department of Pharmaceutics and Analytical Chemistry, Faculty of Pharmaceutical Sciences, Universitetsparken 2, 2100 Copenhagen, Denmark 45 35 33 62 58; 45 35 33 60 01; [email protected]
, PhD,
Jrgen Olsen Principal Scientist ADME and Assay Technology, Novo Nordisk A/S, Mlv, Denmark
, PhD,
Kim Grimstrup Madsen PhD student University of Copenhagen, Department of Pharmaceutics and Analytical Chemistry, Faculty of Pharmaceutical Sciences, Denmark
, MSc,
Steen Honor Hansen Professor University of Copenhagen, Department of Pharmaceutics and Analytical Chemistry, Faculty of Pharmaceutical Sciences, Denmark
, Dr Pharm &
Mark P Grillo Principal Scientist AmGen Inc., Department of Pharmacokinetics and Drug Metabolism, South San Francisco, CA 94080, USA
, PhD
Pages 425-438 | Published online: 23 Apr 2008

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Hiroyuki Ikuta, Hiroaki Shimada, Kenjiro Sakamoto, Rena Nakamura, Atsushi Kawase & Masahiro Iwaki. (2022) Species differences in liver microsomal hydrolysis of acyl glucuronide in humans and rats. Xenobiotica 52:7, pages 653-660.
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Chunyong He & Hong Wan. (2018) Drug metabolism and metabolite safety assessment in drug discovery and development. Expert Opinion on Drug Metabolism & Toxicology 14:10, pages 1071-1085.
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Zheng Li, Qianqian Qiu, Xinqian Geng, Jianyong Yang, Wenlong Huang & Hai Qian. (2016) Free fatty acid receptor agonists for the treatment of type 2 diabetes: drugs in preclinical to phase II clinical development. Expert Opinion on Investigational Drugs 25:8, pages 871-890.
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Kathryn Pickup, Jonathan Wills, Alison Rodrigues, Huw B. Jones, Chris Page, Scott Martin, Sunil Sarda & Ian Wilson. (2014) The metabolic fate of [14C]-fenclozic acid in the hepatic reductase null (HRN) mouse. Xenobiotica 44:2, pages 164-173.
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Xiaoyu Niu, Inge A. M. de Graaf & Geny M. M. Groothuis. (2013) Evaluation of the intestinal toxicity and transport of xenobiotics utilizing precision-cut slices. Xenobiotica 43:1, pages 73-83.
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Louis Leung, Amit S. Kalgutkar & R. Scott Obach. (2012) Metabolic activation in drug-induced liver injury. Drug Metabolism Reviews 44:1, pages 18-33.
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