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Studying cytochrome P450 kinetics in drug metabolism

, PhD & , PhD
Pages 591-603 | Published online: 18 May 2008

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Junmei Chen, Jinman Liu, Yueyue Huang, Ruoyu Li, Cuiru Ma, Beiping Zhang, Fanchang Wu, Wenqian Yu, Xue Zuo, Yong Liang & Qi Wang. (2021) Insights into oral bioavailability enhancement of therapeutic herbal constituents by cytochrome P450 3A inhibition. Drug Metabolism Reviews 53:4, pages 491-507.
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Ahmed A. El-Sherbeni & Ayman O. S. El-Kadi. (2017) Microsomal cytochrome P450 as a target for drug discovery and repurposing. Drug Metabolism Reviews 49:1, pages 1-17.
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P. Aracena, C. Lazo-Hernández, A. Molina-Berríos, D. R. Sepúlveda, C. Reinoso, J. I. Larraín, J. Navarro & M. E. Letelier. (2014) Microsomal oxidative stress induced by NADPH is inhibited by nitrofurantoin redox biotranformation. Free Radical Research 48:2, pages 129-136.
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Miyoung Yoon, Jerry L. Campbell, Melvin E. Andersen & Harvey J. Clewell. (2012) Quantitative in vitro to in vivo extrapolation of cell-based toxicity assay results. Critical Reviews in Toxicology 42:8, pages 633-652.
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Articles from other publishers (15)

Katarína Vavrová, Radek Indra, Petr Pompach, Zbyněk Heger & Petr Hodek. (2022) The impact of individual human cytochrome P450 enzymes on oxidative metabolism of anticancer drug lenvatinib. Biomedicine & Pharmacotherapy 145, pages 112391.
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Ying Jiang, Zichao Yang, Lishun Zhang, Ruohong Yan, Siming Liu, Haikui Yang, Shanhe Wan, Zhonghuang Li, Zhengguang Zhu, Ling Ye & Jiajie Zhang. (2020) The cytochrome P450 metabolic profiling of SMU-B in vitro, a novel small molecule tyrosine kinase inhibitor. Journal of Pharmaceutical and Biomedical Analysis 188, pages 113400.
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Hannu Raunio, Olli Pentikäinen & Risto O. Juvonen. (2020) Coumarin-Based Profluorescent and Fluorescent Substrates for Determining Xenobiotic-Metabolizing Enzyme Activities In Vitro. International Journal of Molecular Sciences 21:13, pages 4708.
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Patrick C. F. Buchholz, Rüdiger Ohs, Antje C. Spiess & Jürgen Pleiss. (2019) Progress Curve Analysis Within BioCatNet: Comparing Kinetic Models for Enzyme-Catalyzed Self-Ligation. Biotechnology Journal 14:3, pages 1800183.
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Marie Stiborová, Radek Indra, Michaela Moserová, Lucie Bořek-Dohalská, Petr Hodek, Eva Frei, Klaus Kopka, Heinz H. Schmeiser & Volker M. Arlt. (2017) Comparison of human cytochrome P450 1A1-catalysed oxidation of benzo[a]pyrene in prokaryotic and eukaryotic expression systems. Monatshefte für Chemie - Chemical Monthly 148:11, pages 1959-1969.
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T. Bohnert, A. Patel, I. Templeton, Y. Chen, C. Lu, G. Lai, L. Leung, S. Tse, H. J. Einolf, Y.-H. Wang, M. Sinz, R. Stearns, R. Walsky, W. Geng, S. Sudsakorn, D. Moore, L. He, J. Wahlstrom, J. Keirns, R. Narayanan, D. Lang & X. Yang. (2016) Evaluation of a New Molecular Entity as a Victim of Metabolic Drug-Drug Interactions--an Industry Perspective. Drug Metabolism and Disposition 44:8, pages 1399-1423.
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Ahmed A. El-Sherbeni & Ayman O. S. El-Kadi. (2016) Repurposing Resveratrol and Fluconazole To Modulate Human Cytochrome P450-Mediated Arachidonic Acid Metabolism. Molecular Pharmaceutics 13:4, pages 1278-1288.
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Sharad S. Singhal, Jyotsana Singhal, James Figarola, David Horne & Sanjay Awasthi. (2015) RLIP76 Targeted Therapy for Kidney Cancer. Pharmaceutical Research 32:10, pages 3123-3136.
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Ahmed A. El-Sherbeni & Ayman O.S. El-Kadi. (2014) Characterization of Arachidonic Acid Metabolism by Rat Cytochrome P450 Enzymes: The Involvement of CYP1As. Drug Metabolism and Disposition 42:9, pages 1498-1507.
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Paul M. van Midwoud, Marjolijn T. Merema, Niek Verweij, Geny M.M. Groothuis & Elisabeth Verpoorte. (2011) Hydrogel embedding of precision-cut liver slices in a microfluidic device improves drug metabolic activity. Biotechnology and Bioengineering 108:6, pages 1404-1412.
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W. Griffith Humphreys. 2011. Mass Spectrometry in Drug Metabolism and Disposition. Mass Spectrometry in Drug Metabolism and Disposition 229 253 .
Paul M. van Midwoud, Elisabeth Verpoorte & Geny M. M. Groothuis. (2011) Microfluidic devices for in vitro studies on liver drug metabolism and toxicity. Integrative Biology 3:5, pages 509.
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Sean C Gay, Arthur G Roberts & James R Halpert. (2010) Structural features of cytochromes P450 and ligands that affect drug metabolism as revealed by x-ray crystallography and NMR. Future Medicinal Chemistry 2:9, pages 1451-1468.
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Tonika Bohnert & Liang‐Shang Gan. 2009. Enzyme Inhibition in Drug Discovery and Development. Enzyme Inhibition in Drug Discovery and Development 91 176 .
Jae H. Chang, Phillip Yoo, Theresa Lee, Wendy Klopf & Denise Takao. (2009) The Role of pH in the Glucuronidation of Raloxifene, Mycophenolic Acid and Ezetimibe. Molecular Pharmaceutics 6:4, pages 1216-1227.
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