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Discovery DMPK: changing paradigms in the eighties, nineties and noughties

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Pages 207-218 | Published online: 08 Mar 2009

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Simon Taylor, James R. J. Gray, Robert Willis, Nigel Deeks, Andrea Haynes, Colin Campbell, Pam Gaskin, Karen Leavens, Emmanuel Demont, Simon Dowell, Jenni Cryan, Mary Morse, Aarti Patel, Helen Garden & Jason Witherington. (2012) The utility of pharmacokinetic–pharmacodynamic modeling in the discovery and optimization of selective S1P1 agonists. Xenobiotica 42:7, pages 671-686.
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Ken M. Page. (2016) Validation of Early Human Dose Prediction: A Key Metric for Compound Progression in Drug Discovery. Molecular Pharmaceutics 13:2, pages 609-620.
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Andreas Reichel. 2015. Blood-Brain Barrier in Drug Discovery. Blood-Brain Barrier in Drug Discovery 5 41 .
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Mads H. Rønnest, Felix Nissen, Palle J. Pedersen, Thomas O. Larsen, Walter Mier & Mads H. Clausen. (2013) A Mild Method for Regioselective Labeling of Aromatics with Radioactive Iodine. European Journal of Organic Chemistry 2013:19, pages 3970-3973.
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Chun Li, Bo Liu, Jonathan Chang, Todd Groessl, Matthew Zimmerman, You-Qun He, John Isbell & Tove Tuntland. (2013) A modern in vivo pharmacokinetic paradigm: combining snapshot, rapid and full PK approaches to optimize and expedite early drug discovery. Drug Discovery Today 18:1-2, pages 71-78.
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David Lagorce, Christelle Reynes, Anne‐Claude Camproux, Maria A. Miteva, Olivier Sperandio & Bruno O. Villoutreix. 2011. ADMET for Medicinal Chemists. ADMET for Medicinal Chemists 29 124 .
Andreas Baumann. (2009) Nonclinical development of biopharmaceuticals. Drug Discovery Today 14:23-24, pages 1112-1122.
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Andreas Reichel. (2009) Addressing Central Nervous System (CNS) Penetration in Drug Discovery: Basics and Implications of the Evolving New Concept. Chemistry & Biodiversity 6:11, pages 2030-2049.
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