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Expert Opinion on Drug Discovery Volume 4, 2009 - Issue 3
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Targeting the non-structural proteins of hepatitis C virus: beyond hepatitis C virus protease and polymerase

Tod P Holler Associate Research Fellow Pfizer Global Research and Development, Antiviral Biology, Ramsgate Road, Sandwich, Kent CT13 9NJ, UK +44 130 464 6387; +44 130 465 1819; [email protected]
,
Tanya Parkinson Associate Research Fellow Pfizer Global Research and Development, Antiviral Biology, Ramsgate Road, Sandwich, Kent CT13 9NJ, UK +44 130 464 6387; +44 130 465 1819; [email protected]
&
David C Pryde Associate Research Fellow Pfizer Global Research and Development, Antiviral Chemistry, Ramsgate Road, Sandwich, Kent, CT13 9NJ, UK
Pages 293-314 | Published online: 08 Mar 2009

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Jiachang Gong, Timothy Eley, Bing He, Vinod Arora, Thomas Philip, Hao Jiang, John Easter, W. Griffith Humphreys, Ramaswamy A. Iyer & Wenying Li. (2016) Characterization of ADME properties of [14C]asunaprevir (BMS-650032) in humans. Xenobiotica 46:1, pages 52-64.
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Articles from other publishers (16)

Amrita Saha, Badri Narayan Acharya, Raj Priya, Nagesh K. Tripathi, Ambuj Shrivastava, M. Kameswara Rao, Pooja Kesari, Manju Narwal, Shailly Tomar, Sameer S. Bhagyawant, Manmohan Parida & Paban Kumar Dash. (2018) Development of nsP2 protease based cell free high throughput screening assay for evaluation of inhibitors against emerging Chikungunya virus. Scientific Reports 8:1.
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Kattareeya Kumthip & Niwat Maneekarn. (2015) The role of HCV proteins on treatment outcomes. Virology Journal 12:1.
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Soumendranath Bhakat, Wilson Karubiu, Venkatesan Jayaprakash & Mahmoud E.S. Soliman. (2014) A perspective on targeting non-structural proteins to combat neglected tropical diseases: Dengue, West Nile and Chikungunya viruses. European Journal of Medicinal Chemistry 87, pages 677-702.
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Thien Duc Tran, Florian Wakenhut, Chris Pickford, Stephen Shaw, Mike Westby, Caroline Smith-Burchnell, Lesa Watson, Michael Paradowski, Jared Milbank, Rebecca A. Brimage, Rebecca Halstead, Rebecca Glen, Craig P. Wilson, Fiona Adam, Duncan Hay, Jean-Yves Chiva, Carly Nichols, David C. Blakemore, Iain Gardner, Satish Dayal, Andrew Pike, Rob Webster & David C. Pryde. (2014) The Discovery of Potent Nonstructural Protein 5A (NS5A) Inhibitors with a Unique Resistance Profile-Part 1. ChemMedChem 9:7, pages 1378-1386.
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Makonen Belema, Omar D. Lopez, John A. Bender, Jeffrey L. Romine, Denis R. St. Laurent, David R. Langley, Julie A. Lemm, Donald R. O’BoyleIIII, Jin-Hua Sun, Chunfu Wang, Robert A. Fridell & Nicholas A. Meanwell. (2014) Discovery and Development of Hepatitis C Virus NS5A Replication Complex Inhibitors. Journal of Medicinal Chemistry 57:5, pages 1643-1672.
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Maria Victoria Preciado, Pamela Valva, Alejandro Escobar-Gutierrez, Paula Rahal, Karina Ruiz-Tovar, Lilian Yamasaki, Carlos Vazquez-Chacon, Armando Martinez-Guarneros, Juan Carlos Carpio-Pedroza, Salvador Fonseca-Coronado & Mayra Cruz-Rivera. (2014) Hepatitis C virus molecular evolution: Transmission, disease progression and antiviral therapy. World Journal of Gastroenterology 20:43, pages 15992.
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Donald R. O'Boyle II, Jin-Hua Sun, Peter T. Nower, Julie A. Lemm, Robert A. Fridell, Chunfu Wang, Jeffrey L. Romine, Makonen Belema, Van N. Nguyen, Denis R. St. Laurent, Michael Serrano-Wu, Lawrence B. Snyder, Nicholas A. Meanwell, David R. Langley & Min Gao. (2013) Characterizations of HCV NS5A replication complex inhibitors. Virology 444:1-2, pages 343-354.
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David C. Pryde, Thien-Duc Tran, Mark Gardner, Chris Pickford, Stephen M. Shaw, Mike Westby, Tanya Parkinson, Caroline Smith-Burchnell, Rob Webster & Satish Dayal. (2013) Identification of HCV Inhibitors from a Cell-Based Sub-Genomic Replicon Screen. Open Journal of Medicinal Chemistry 03:01, pages 16-25.
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Tarik Asselah & Patrick Marcellin. (2012) Direct acting antivirals for the treatment of chronic hepatitis C: one pill a day for tomorrow. Liver International 32, pages 88-102.
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Tarik Asselah. (2011) NS5A inhibitors: A new breakthrough for the treatment of chronic hepatitis C. Journal of Hepatology 54:5, pages 1069-1072.
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Frank Narjes, Benedetta Crescenzi, Marco Ferrara, Jörg Habermann, Stefania Colarusso, Maria del Rosario Rico Ferreira, Ian Stansfield, Angela Claire Mackay, Immacolata Conte, Caterina Ercolani, Simone Zaramella, Maria-Cecilia Palumbi, Philip Meuleman, Geert Leroux-Roels, Claudio Giuliano, Fabrizio Fiore, Stefania Di Marco, Paola Baiocco, Uwe Koch, Giovanni Migliaccio, Sergio Altamura, Ralph Laufer, Raffaele De Francesco & Michael Rowley. (2010) Discovery of (7 R )-14-Cyclohexyl-7-{[2-(dimethylamino)ethyl](methyl) amino}-7,8-dihydro-6 H -indolo[1,2- e ][1,5]benzoxazocine-11-carboxylic Acid (MK-3281), a Potent and Orally Bioavailable Finger-Loop Inhibitor of the Hepatitis C Virus NS5B Polymerase . Journal of Medicinal Chemistry 54:1, pages 289-301.
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Nicholas A. Meanwell & Makonen Belema. 2011. 263 282 .
Tanya ParkinsonDavid C Pryde. (2010) Small molecule drug discovery for Dengue and West Nile viruses: applying experience from hepatitis C virus. Future Medicinal Chemistry 2:7, pages 1181-1203.
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Min Gao, Richard E. Nettles, Makonen Belema, Lawrence B. Snyder, Van N. Nguyen, Robert A. Fridell, Michael H. Serrano-Wu, David R. Langley, Jin-Hua Sun, Donald R. O’Boyle II, Julie A. Lemm, Chunfu Wang, Jay O. Knipe, Caly Chien, Richard J. Colonno, Dennis M. Grasela, Nicholas A. Meanwell & Lawrence G. Hamann. (2010) Chemical genetics strategy identifies an HCV NS5A inhibitor with a potent clinical effect. Nature 465:7294, pages 96-100.
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Julie A. Lemm, Donald O'BoyleIIII, Mengping Liu, Peter T. Nower, Richard Colonno, Milind S. Deshpande, Lawrence B. Snyder, Scott W. Martin, Denis R. St. Laurent, Michael H. Serrano-Wu, Jeffrey L. Romine, Nicholas A. Meanwell & Min Gao. (2010) Identification of Hepatitis C Virus NS5A Inhibitors. Journal of Virology 84:1, pages 482-491.
Crossref
Nicholas A. Meanwell, John F. Kadow & Paul M. Scola. 2009. Annual Reports in Medicinal Chemistry Volume 44. Annual Reports in Medicinal Chemistry Volume 44 397 440 .

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