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Expert Opinion on Drug Discovery Volume 4, 2009 - Issue 7
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Small-molecule affinity chromatography coupled mass spectrometry for drug target deconvolution

Chaitanya Saxena Integrative Biology, Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, IN 46285, USA +1 317 651 1539; +1 317 433 8767; [email protected]
,
Richard E Higgs Integrative Biology, Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, IN 46285, USA +1 317 651 1539; +1 317 433 8767; [email protected]
,
Eugene Zhen Integrative Biology, Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, IN 46285, USA +1 317 651 1539; +1 317 433 8767; [email protected]
&
John E Hale Integrative Biology, Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, IN 46285, USA +1 317 651 1539; +1 317 433 8767; [email protected]
Pages 701-714 | Published online: 09 Jun 2009

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Chaitanya Saxena. (2016) Identification of protein binding partners of small molecules using label-free methods. Expert Opinion on Drug Discovery 11:10, pages 1017-1025.
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Kui Wang, Tao Yang, Qian Wu, Xia Zhao, Edouard Collins Nice & Canhua Huang. (2012) Chemistry-based functional proteomics for drug target deconvolution. Expert Review of Proteomics 9:3, pages 293-310.
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Bekim Bajrami, Jeffrey G. Martin & Douglas S. Johnson. 2022. Advances in Chemical Proteomics. Advances in Chemical Proteomics 129 156 .
Alan Talevi & Carolina L. Bellera. 2022. Drug Target Selection and Validation. Drug Target Selection and Validation 25 40 .
Junya Kakegawa, Satoshi Ohtsuka, Masahiro Yokoyama, Toru Hosoi, Koichiro Ozawa & Takashi Hatanaka. (2021) Thermal Proteome Profiling Reveals Glutathione Peroxidase 4 as the Target of the Autophagy Inducer Conophylline. Molecular Pharmacology 100:3, pages 181-192.
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Bin Zhao, Ning Liu, Lai Chen, Shuo Geng, Zhijin Fan & Jihong Xing. (2020) Direct label-free methods for identification of target proteins in agrochemicals. International Journal of Biological Macromolecules 164, pages 1475-1483.
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Mei Ding, Hanna Tegel, Åsa Sivertsson, Sophia Hober, Arjan Snijder, Mats Ormö, Per-Erik Strömstedt, Rick Davies & Lovisa Holmberg Schiavone. (2020) Secretome-Based Screening in Target Discovery. SLAS Discovery 25:6, pages 535-551.
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Jiawen Lyu, Keyun Wang & Mingliang Ye. (2020) Modification-free approaches to screen drug targets at proteome level. TrAC Trends in Analytical Chemistry 124, pages 115574.
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Sindhuja Sridharan, Ina Günthner, Isabelle Becher, Mikhail Savitski & Marcus Bantscheff. 2019. Mass Spectrometry‐Based Chemical Proteomics. Mass Spectrometry‐Based Chemical Proteomics 267 291 .
Shao-Yang Zhao, Li-Xi Liao, Peng-Fei Tu, Wei-Wei Li & Ke-Wu Zeng. (2019) Icariin Inhibits AGE-Induced Injury in PC12 Cells by Directly Targeting Apoptosis Regulator Bax. Oxidative Medicine and Cellular Longevity 2019, pages 1-12.
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Jeanette Prinz, Ingo Vogt, Gianluca Adornetto & Mónica Campillos. (2016) A Novel Drug-Mouse Phenotypic Similarity Method Detects Molecular Determinants of Drug Effects. PLOS Computational Biology 12:9, pages e1005111.
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Dries J. H. De Clercq, Jan Tavernier, Sam Lievens & Serge Van Calenbergh. (2016) Chemical Dimerizers in Three-Hybrid Systems for Small Molecule–Target Protein Profiling. ACS Chemical Biology 11:8, pages 2075-2090.
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Si Chen, Hailong Jiang, Yan Cao, Yun Wang, Ziheng Hu, Zhenyu Zhu & Yifeng Chai. (2016) Drug target identification using network analysis: Taking active components in Sini decoction as an example. Scientific Reports 6:1.
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Hossein Hosseinzadeh, Soghra Mehri, Ali Heshmati, Mohammad Ramezani, Amirhossein Sahebkar & Khalil Abnous. (2014) Proteomic screening of molecular targets of crocin. DARU Journal of Pharmaceutical Sciences 22:1.
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. 2013. Bioconjugate Techniques. Bioconjugate Techniques 1017 1094 .
Nico Zinn, Carsten Hopf, Gerard Drewes & Marcus Bantscheff. (2012) Mass spectrometry approaches to monitor protein–drug interactions. Methods 57:4, pages 430-440.
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Quinn Lu, Amy M. Quinn, Mehul P. Patel, Simon F. Semus, Alan P. Graves, Deepak Bandyopadhyay, Andrew J. Pope & Sara H. Thrall. (2012) Perspectives on the Discovery of Small-Molecule Modulators for Epigenetic Processes. SLAS Discovery 17:5, pages 555-571.
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Lianghai Hu, John Paul Fawcett & Jingkai Gu. (2012) Protein target discovery of drug and its reactive intermediate metabolite by using proteomic strategy. Acta Pharmaceutica Sinica B 2:2, pages 126-136.
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Chaitanya Saxena. 2012. Chemical Proteomics. Chemical Proteomics 39 54 .
Debra J Woods, Valerie A Vaillancourt, John A Wendt & Patrick F Meeus. (2011) Discovery and development of veterinary antiparasitic drugs: past, present and future. Future Medicinal Chemistry 3:7, pages 887-896.
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Mikhail M. Savitski, Frank Fischer, Toby Mathieson, Gavain Sweetman, Manja Lang & Marcus Bantscheff. (2010) Targeted data acquisition for improved reproducibility and robustness of proteomic mass spectrometry assays. Journal of the American Society for Mass Spectrometry 21:10, pages 1668-1679.
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Kieran F. Geoghegan & Douglas S. Johnson. 2010. 345 360 .

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