117
Views
55
CrossRef citations to date
0
Altmetric
Original Articles

Advances in the discovery and development of trematocidal drugs

, PhD & , PhD
Pages S9-S23 | Published online: 05 Oct 2007

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (2)

Stefanie Knopp, Sören L Becker, Katrin J Ingram, Jennifer Keiser & Jürg Utzinger. (2013) Diagnosis and treatment of schistosomiasis in children in the era of intensified control. Expert Review of Anti-infective Therapy 11:11, pages 1237-1258.
Read now
Conor R Caffrey & Dietmar Steverding. (2008) Recent initiatives and strategies to developing new drugs for tropical parasitic diseases. Expert Opinion on Drug Discovery 3:2, pages 173-186.
Read now

Articles from other publishers (53)

Ahmad Othman & Rashika El Ridi. 2022. Helminth Infections and their Impact on Global Public Health. Helminth Infections and their Impact on Global Public Health 121 183 .
Shashank M. Patil, Ramith Ramu, Prithvi S. Shirahatti & K. Sumana. 2021. Neglected Tropical Diseases and Phytochemicals in Drug Discovery. Neglected Tropical Diseases and Phytochemicals in Drug Discovery 299 336 .
Melissa J. Buskes, Monica Clements, Kelly A. Bachovchin, Hitesh B. Jalani, Allison Leonard, Seema Bag, Dana M. Klug, Baljinder Singh, Robert F. Campbell, Richard J. Sciotti, Nelly El-Sakkary, Conor R. Caffrey, Michael P. Pollastri & Lori Ferrins. (2020) Structure–Bioactivity Relationships of Lapatinib Derived Analogs against Schistosoma mansoni . ACS Medicinal Chemistry Letters 11:3, pages 258-265.
Crossref
Rafael Toledo, Alba Cortés, Maria Álvarez‐Izquierdo, Carla Muñoz‐Antoli & J. Guillermo Esteban. 2019. Neglected Tropical Diseases. Neglected Tropical Diseases 289 323 .
. 2019. Parasiticide Screening, Volume 2. Parasiticide Screening, Volume 2 1 133 .
Alba Cortés Carbonell & Bernard Fried. 2019. Digenetic Trematodes. Digenetic Trematodes 3 20 .
Rahul Singh, Rachel Beasley, Thavy Long & Conor R. Caffrey. (2018) Algorithmic Mapping and Characterization of the Drug-Induced Phenotypic-Response Space of Parasites Causing Schistosomiasis. IEEE/ACM Transactions on Computational Biology and Bioinformatics 15:2, pages 469-481.
Crossref
Betsaida Bibo-Verdugo, Zhenze Jiang, Conor R. Caffrey & Anthony J. O'Donoghue. (2017) Targeting proteasomes in infectious organisms to combat disease. The FEBS Journal 284:10, pages 1503-1517.
Crossref
. 2017. Utilisation of Bioactive Compounds from Agricultural and Food Waste. Utilisation of Bioactive Compounds from Agricultural and Food Waste 60 85 .
J. Utzinger, S.L. Becker, L. van Lieshout, G.J. van Dam & S. Knopp. (2015) New diagnostic tools in schistosomiasis. Clinical Microbiology and Infection 21:6, pages 529-542.
Crossref
Gordana Panic, Urs Duthaler, Benjamin Speich & Jennifer Keiser. (2014) Repurposing drugs for the treatment and control of helminth infections. International Journal for Parasitology: Drugs and Drug Resistance 4:3, pages 185-200.
Crossref
Amira Taman & Manar Azab. (2014) Present-day anthelmintics and perspectives on future new targets. Parasitology Research 113:7, pages 2425-2433.
Crossref
Nicholas Patocka, Nidhi Sharma, Mohammed Rashid & Paula Ribeiro. (2014) Serotonin Signaling in Schistosoma mansoni: A Serotonin?Activated G Protein-Coupled Receptor Controls Parasite Movement. PLoS Pathogens 10:1, pages e1003878.
Crossref
Katrin Ingram-Sieber, Noemi Cowan, Gordana Panic, Mireille Vargas, Nuha R. Mansour, Quentin D. Bickle, Timothy N. C. Wells, Thomas Spangenberg & Jennifer Keiser. (2014) Orally Active Antischistosomal Early Leads Identified from the Open Access Malaria Box. PLoS Neglected Tropical Diseases 8:1, pages e2610.
Crossref
Ahmad Othman & Rashika El Ridi. 2014. Helminth Infections and their Impact on Global Public Health. Helminth Infections and their Impact on Global Public Health 49 92 .
Paula Ribeiro & Nicholas Patocka. (2013) Neurotransmitter transporters in schistosomes: Structure, function and prospects for drug discovery. Parasitology International 62:6, pages 629-638.
Crossref
M. M. Kamel, M. M. Anwar, A. M. Soliman & H. F. Abdel-Hamid. (2012) In vitro antischistosomal evaluation of some newly synthesized praziquantel derivatives. Research on Chemical Intermediates 39:7, pages 3417-3426.
Crossref
Clarissa Campos Barbosa de Castro, Mirna Meana Dias, Túlio Pessoa de Rezende, Lizandra Guidi Magalhães & Ademar A. Da Silva Filho. 2013. Fighting Multidrug Resistance with Herbal Extracts, Essential Oils and Their Components. Fighting Multidrug Resistance with Herbal Extracts, Essential Oils and Their Components 109 134 .
Alaa Hammad Ali Abou-Zeid, Tigani Abdullah Abkar & Rashid Osman Mohamed. (2012) Schistosomiasis and soil-transmitted helminths among an adult population in a war affected area, Southern Kordofan state, Sudan. Parasites & Vectors 5:1.
Crossref
Hyokyeong Lee, Asher Moody-Davis, Utsab Saha, Brian M Suzuki, Daniel Asarnow, Steven Chen, Michelle Arkin, Conor R Caffrey & Rahul Singh. (2012) Quantification and clustering of phenotypic screening data using time-series analysis for chemotherapy of schistosomiasis. BMC Genomics 13:S1.
Crossref
Jennifer Keiser, Mireille Vargas & Rolf Winter. (2012) Anthelminthic properties of mangostin and mangostin diacetate. Parasitology International 61:2, pages 369-371.
Crossref
Thomas Fürst, Urs Duthaler, Banchop Sripa, Jürg Utzinger & Jennifer Keiser. (2012) Trematode Infections. Infectious Disease Clinics of North America 26:2, pages 399-419.
Crossref
Paula Ribeiro, Vandana Gupta & Nelly El-Sakkary. (2012) Biogenic amines and the control of neuromuscular signaling in schistosomes. Invertebrate Neuroscience 12:1, pages 13-28.
Crossref
Shu-hua Xiao, Jian Xue, Jing-yan Mei & Pei-ying Jiao. (2011) Effectiveness of synthetic trioxolane OZ78 against Schistosoma japonicum in mice and rabbits. Parasitology Research 110:6, pages 2307-2314.
Crossref
Jennifer Keiser, Katrin Ingram, Mireille Vargas, Jacques Chollet, Xiaofang Wang, Yuxiang Dong & Jonathan L. Vennerstrom. (2012) In Vivo Activity of Aryl Ozonides against Schistosoma Species . Antimicrobial Agents and Chemotherapy 56:2, pages 1090-1092.
Crossref
JENNIFER KEISER, KATRIN INGRAM & JÜRG UTZINGER. (2011) Antiparasitic drugs for paediatrics: systematic review, formulations, pharmacokinetics, safety, efficacy and implications for control. Parasitology 138:12, pages 1620-1632.
Crossref
Xiaofang Wang, Qingjie Zhao, Mireille Vargas, Yuxiang Dong, Kamaraj Sriraghavan, Jennifer Keiser & Jonathan L. Vennerstrom. (2011) The activity of dispiro peroxides against Fasciola hepatica. Bioorganic & Medicinal Chemistry Letters 21:18, pages 5320-5323.
Crossref
Jürg Utzinger, Eliézer K. N’Goran, Conor R. Caffrey & Jennifer Keiser. (2011) From innovation to application: Social–ecological context, diagnostics, drugs and integrated control of schistosomiasis. Acta Tropica 120, pages S121-S137.
Crossref
J. Keiser, T. Manneck & M. Vargas. (2011) Interactions of mefloquine with praziquantel in the Schistosoma mansoni mouse model and in vitro. Journal of Antimicrobial Chemotherapy 66:8, pages 1791-1797.
Crossref
I.Z. Abdel Aziz, Ayman A. El-bady & Sabah H. El-Gayed. (2011) In vitro Anti-schistosomal Activity of "Plectranthus tenuiflorus" on Miracidium, Cercaria and Schistosomula Stages of Schistosoma mansoni. Research Journal of Parasitology 6:2, pages 74-82.
Crossref
Shu-hua Xiao, Jian Xue, Xu Li-li, Yong-nian Zhang & Hui-qing Qiang. (2010) Effectiveness of mefloquine against Clonorchis sinensis in rats and Paragonimus westermani in dogs. Parasitology Research 107:6, pages 1391-1397.
Crossref
Saša Štefanić, Jan Dvořák, Martin Horn, Simon Braschi, Daniel Sojka, Debbie S. Ruelas, Brian Suzuki, Kee-Chong Lim, Stephanie D. Hopkins, James H. McKerrow & Conor R. Caffrey. (2010) RNA Interference in Schistosoma mansoni Schistosomula: Selectivity, Sensitivity and Operation for Larger-Scale Screening. PLoS Neglected Tropical Diseases 4:10, pages e850.
Crossref
Jennifer Keiser, Urs Duthaler & Jürg Utzinger. (2010) Update on the diagnosis and treatment of food-borne trematode infections. Current Opinion in Infectious Diseases 23:5, pages 513-520.
Crossref
A. HEMPHILL. (2010) Development and applications of cestode and trematode laboratory models. Parasitology 137:3, pages 329-333.
Crossref
Jennifer Keiser, Vincenzo Veneziano, Laura Rinaldi, Laura Mezzino, Urs Duthaler & Giuseppe Cringoli. (2010) Anthelmintic activity of artesunate against Fasciola hepatica in naturally infected sheep. Research in Veterinary Science 88:1, pages 107-110.
Crossref
T. MANNECK, Y. HAGGENMÜLLER & J. KEISER. (2009) Morphological effects and tegumental alterations induced by mefloquine on schistosomula and adult flukes of Schistosoma mansoni . Parasitology 137:1, pages 85-98.
Crossref
Jennifer Keiser & Jürg Utzinger. 2010. Important Helminth Infections in Southeast Asia: Diversity and Potential for Control and Elimination, Part B. Important Helminth Infections in Southeast Asia: Diversity and Potential for Control and Elimination, Part B 197 230 .
Jürg Utzinger, Robert Bergquist, Remigio Olveda & Xiao-Nong Zhou. 2010. Important Helminth Infections in Southeast Asia: Diversity and Potential for Control and Elimination, Part A. Important Helminth Infections in Southeast Asia: Diversity and Potential for Control and Elimination, Part A 1 30 .
Sanaa S. Botros, Samia William, James R. Beadle, Nadejda Valiaeva & Karl Y. Hostetler. (2009) Antischistosomal Activity of Hexadecyloxypropyl Cyclic 9-( S )-[3-Hydroxy-2-(Phosphonomethoxy)Propyl]Adenine and Other Alkoxyalkyl Esters of Acyclic Nucleoside Phosphonates Assessed by Schistosome Worm Killing In Vitro . Antimicrobial Agents and Chemotherapy 53:12, pages 5284-5287.
Crossref
J. UTZINGER, G. RASO, S. BROOKER, D. DE SAVIGNY, M. TANNER, N. ØRNBJERG, B. H. SINGER & E. K. N'GORAN. (2009) Schistosomiasis and neglected tropical diseases: towards integrated and sustainable control and a word of caution. Parasitology 136:13, pages 1859-1874.
Crossref
Shu-Hua Xiao, Jacques Chollet, Jürg Utzinger, Jin-Yan Mei, Pei-Yin Jiao, Jennifer Keiser & Marcel Tanner. (2009) Effect of single-dose oral mefloquine on the morphology of adult Schistosoma japonicum in mice. Parasitology Research 105:3, pages 853-861.
Crossref
Christophe Chassaing & Harald Sekljic. 2009. Antiparasitic and Antibacterial Drug Discovery. Antiparasitic and Antibacterial Drug Discovery 117 133 .
Conor R. Caffrey, David L. Williams, Matthew H. Todd, David L. Nelson, Jennifer Keiser & Jürg Utzinger. 2009. Antiparasitic and Antibacterial Drug Discovery. Antiparasitic and Antibacterial Drug Discovery 299 321 .
Conor R. Caffrey, Andreas Rohwer, Frank Oellien, Richard J. Marhöfer, Simon Braschi, Guilherme Oliveira, James H. McKerrow & Paul M. Selzer. (2009) A Comparative Chemogenomics Strategy to Predict Potential Drug Targets in the Metazoan Pathogen, Schistosoma mansoni. PLoS ONE 4:2, pages e4413.
Crossref
Jennifer Keiser, Jacques Chollet, Shu-Hua Xiao, Jin-Yan Mei, Pei-Ying Jiao, J?rg Utzinger & Marcel Tanner. (2009) Mefloquine?An Aminoalcohol with Promising Antischistosomal Properties in Mice. PLoS Neglected Tropical Diseases 3:1, pages e350.
Crossref
Jasmina Saric, Jia V. Li, Yulan Wang, Elaine Holmes, Jürg Utzinger & Jennifer Keiser*. 2009. The Biology of Echinostomes. The Biology of Echinostomes 295 324 .
Qin Liu, Li-Guang Tian, Shu-Hua Xiao, Zhen Qi, Peter Steinmann, Tippi K Mak, Jürg Utzinger & Xiao-Nong Zhou. (2008) Harnessing the wealth of Chinese scientific literature: schistosomiasis research and control in China. Emerging Themes in Epidemiology 5:1.
Crossref
Michael J Doenhoff, Donato Cioli & Jürg Utzinger. (2008) Praziquantel: mechanisms of action, resistance and new derivatives for schistosomiasis. Current Opinion in Infectious Diseases 21:6, pages 659-667.
Crossref
Marcus Luiz de Oliveira Penido, Paulo Marcos Zech Coelho, Rômulo Teixeira de Mello, Dorila Piló-Veloso, Mônica Cristina de Oliveira, John Robert Kusel & David Lee Nelson. (2008) Antischistosomal activity of aminoalkanethiols, aminoalkanethiosulfuric acids and the corresponding disulfides. Acta Tropica 108:2-3, pages 249-255.
Crossref
Jennifer Keiser, Laura Rinaldi, Vincenzo Veneziano, Laura Mezzino, Marcel Tanner, Jürg Utzinger & Giuseppe Cringoli. (2008) Efficacy and safety of artemether against a natural Fasciola hepatica infection in sheep. Parasitology Research 103:3, pages 517-522.
Crossref
Shu-Hua Xiao, Xue Jian, Marcel Tanner, Zhang Yong-Nian, Jennifer Keiser, Jürg Utzinger & Qiang Hui-Qiang. (2008) Artemether, artesunate, praziquantel and tribendimidine administered singly at different dosages against Clonorchis sinensis: A comparative in vivo study. Acta Tropica 106:1, pages 54-59.
Crossref
Jennifer Keiser, Jürg Utzinger, Shu-Hua Xiao, Peter Odermatt & Smarn Tesana. (2008) Opisthorchis viverrini: efficacy and tegumental alterations following administration of tribendimidine in vivo and in vitro. Parasitology Research 102:4, pages 771-776.
Crossref
Jian Xue, Jürg Utzinger, Yong-Nian Zhang, Marcel Tanner, Jennifer Keiser & Shu-Hua Xiao. (2007) Artemether and tribendimidine lack activity in experimental treatment of Paragonimus westermani in the dog. Parasitology Research 102:3, pages 537-540.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.