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New opportunities in drug design of metalloproteinase inhibitors: combination between structure–function experimental approaches and systems biology

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Pages 527-542 | Published online: 21 Apr 2011

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Luiz G.N. de Almeida, Hayley Thode, Yekta Eslambolchi, Sameeksha Chopra, Daniel Young, Sean Gill, Laurent Devel & Antoine Dufour. (2022) Matrix Metalloproteinases: From Molecular Mechanisms to Physiology, Pathophysiology, and Pharmacology. Pharmacological Reviews 74:3, pages 714-770.
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Patricia Llorente, Soraia Martins, Isabel Sastre, Jesús Aldudo, María Recuero, James Adjaye & Maria J. Bullido. (2020) Matrix Metalloproteinase 14 Mediates APP Proteolysis and Lysosomal Alterations Induced by Oxidative Stress in Human Neuronal Cells. Oxidative Medicine and Cellular Longevity 2020, pages 1-13.
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Amel F. El‐Husseiny, Hammed H.A.M. Hassan, Firas M. Fadhil & Tarek E. Khalil. (2020) Nanometer‐sized, rod‐like, ligand‐containing tryptophan complexes: Anion influence–structural geometry–antitumor activity correlations. Applied Organometallic Chemistry 34:8.
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Alexandra Bertran, Danylo Khomiak, Anna Konopka, Emilia Rejmak, Ewa Bulska, Jesús Seco, Leszek Kaczmarek, Teresa Tarragó & Roger Prades. (2020) Design and synthesis of selective and blood-brain barrier-permeable hydroxamate-based gelatinase inhibitors. Bioorganic Chemistry 94, pages 103365.
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Gregg B. Fields. (2019) The Rebirth of Matrix Metalloproteinase Inhibitors: Moving Beyond the Dogma. Cells 8:9, pages 984.
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Nikolaos A. Afratis & Irit Sagi. 2019. The Extracellular Matrix. The Extracellular Matrix 261 275 .
Suellen Herbster, Andressa Paladino, Sumara de Freitas & Enrique Boccardo. (2018) Alterations in the expression and activity of extracellular matrix components in HPV-associated infections and diseases. Clinics 73, pages e551s.
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Varsha Thakur & Barbara Bedogni. (2016) The membrane tethered matrix metalloproteinase MT1-MMP at the forefront of melanoma cell invasion and metastasis. Pharmacological Research 111, pages 17-22.
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Charuvaka Muvva, Sanjukta Patra & Subramanian Venkatesan. (2016) MMpI: A WideRange of Available Compounds of Matrix Metalloproteinase Inhibitors. PLOS ONE 11:8, pages e0159321.
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Ulrich Eckhard, Pitter F. Huesgen, Oliver Schilling, Caroline L. Bellac, Georgina S. Butler, Jennifer H. Cox, Antoine Dufour, Verena Goebeler, Reinhild Kappelhoff, Ulrich auf dem Keller, Theo Klein, Philipp F. Lange, Giada Marino, Charlotte J. Morrison, Anna Prudova, David Rodriguez, Amanda E. Starr, Yili Wang & Christopher M. Overall. (2016) Active site specificity profiling of the matrix metalloproteinase family: Proteomic identification of 4300 cleavage sites by nine MMPs explored with structural and synthetic peptide cleavage analyses. Matrix Biology 49, pages 37-60.
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Marco Fragai & Claudio Luchinat. 2015. Matrix Metalloproteinase Biology. Matrix Metalloproteinase Biology 41 60 .
Gemma Shay, Conor C. Lynch & Barbara Fingleton. (2015) Moving targets: Emerging roles for MMPs in cancer progression and metastasis. Matrix Biology 44-46, pages 200-206.
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Gregg B. Fields. (2015) New strategies for targeting matrix metalloproteinases. Matrix Biology 44-46, pages 239-246.
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Roosmarijn E. Vandenbroucke & Claude Libert. (2014) Is there new hope for therapeutic matrix metalloproteinase inhibition?. Nature Reviews Drug Discovery 13:12, pages 904-927.
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Dong Hyun Nam & Xin Ge. (2013) Development of a periplasmic FRET screening method for protease inhibitory antibodies. Biotechnology and Bioengineering 110:11, pages 2856-2864.
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Stamatia Vassiliou & Eirini Tzouma. (2013) Mapping the Pathway toward Thiophosphinic Pseudopeptides. Synthesis of Suitably Protected PG-Phe-Ψ[P(S)(OX)CH 2 ]-Gly-OY Analogues as Thiophosphinyl Dipeptide Isosters (TDI), a Comparative Study for Selective Deprotection and Further Elongation . The Journal of Organic Chemistry 78:20, pages 10069-10076.
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Yael Udi, Marco Fragai, Moran Grossman, Simon Mitternacht, Rina Arad-Yellin, Vito Calderone, Maxime Melikian, Mirco Toccafondi, Igor N. Berezovsky, Claudio Luchinat & Irit Sagi. (2013) Unraveling Hidden Regulatory Sites in Structurally Homologous Metalloproteases. Journal of Molecular Biology 425:13, pages 2330-2346.
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Chunxiang Xiong, Xinli Zhan & Zengming Xiao. (2013) Transcript levels of major MMPs and ADAMTS-4 in relation to the clinicopathological profile of patients with tuberculous intervertebral discs and healthy controls. Clinical Biochemistry 46:7-8, pages 603-611.
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Dong Xia, Hui Yao, Qing Liu & Liang Xu. (2012) Preparation of Microspheres Encapsulating a Recombinant TIMP-1 Adenovirus and their Inhibition of Proliferation of Hepatocellular Carcinoma Cells. Asian Pacific Journal of Cancer Prevention 13:12, pages 6363-6368.
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Margaret Ndinguri, Manishabrata Bhowmick, Dorota Tokmina-Roszyk, Trista Robichaud & Gregg Fields. (2012) Peptide-Based Selective Inhibitors of Matrix Metalloproteinase-Mediated Activities. Molecules 17:12, pages 14230-14248.
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Christian Gege, Bagna Bao, Harald Bluhm, Jürgen Boer, Brian M. GallagherJr.Jr., Brian Korniski, Timothy S. Powers, Christoph Steeneck, Arthur G. Taveras & Vijaykumar M. Baragi. (2012) Discovery and Evaluation of a Non-Zn Chelating, Selective Matrix Metalloproteinase 13 (MMP-13) Inhibitor for Potential Intra-articular Treatment of Osteoarthritis. Journal of Medicinal Chemistry 55:2, pages 709-716.
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Netta Sela-Passwell, Raghavendra Kikkeri, Orly Dym, Haim Rozenberg, Raanan Margalit, Rina Arad-Yellin, Miriam Eisenstein, Ori Brenner, Tsipi Shoham, Tamar Danon, Abraham Shanzer & Irit Sagi. (2011) Antibodies targeting the catalytic zinc complex of activated matrix metalloproteinases show therapeutic potential. Nature Medicine 18:1, pages 143-147.
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Krishnamoorthy Ganesan, Praveen Kumar Sehgal, Asit Baran Mandal & Sadulla Sayeed. (2011) Protective Effect of Withania somnifera and Cardiospermum halicacabum Extracts Against Collagenolytic Degradation of Collagen. Applied Biochemistry and Biotechnology 165:3-4, pages 1075-1091.
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