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Lessons from high-throughput protein crystallization screening: 10 years of practical experience

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Pages 465-480 | Published online: 22 Mar 2011

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Yibin Lin. (2018) What’s happened over the last five years with high-throughput protein crystallization screening?. Expert Opinion on Drug Discovery 13:8, pages 691-695.
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Miranda L. Lynch, M. Elizabeth Snell, Stephen A. Potter, Edward H. Snell & Sarah E. J. Bowman. (2023) 20 years of crystal hits: progress and promise in ultrahigh-throughput crystallization screening. Acta Crystallographica Section D Structural Biology 79:3, pages 198-205.
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Jinxu He, Jianhua Zhou, Jianpei Dong, Zhenning Su & Lu Huang. (2022) Revealing the effects of microwell sizes on the crystal growth kinetics of active pharmaceutical ingredients by deep learning. Chemical Engineering Journal 428, pages 131986.
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Johannes Hermann, Daniel Bischoff, Phillip Grob, Robert Janowski, Dariusch Hekmat, Dierk Niessing, Martin Zacharias & Dirk Weuster-Botz. (2021) Controlling Protein Crystallization by Free Energy Guided Design of Interactions at Crystal Contacts. Crystals 11:6, pages 588.
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Ethan T. Holleman, Erica Duguid, Lisa J. Keefe & Sarah E. J. Bowman. (2021) Polo : an open-source graphical user interface for crystallization screening . Journal of Applied Crystallography 54:2, pages 673-679.
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Jitender Mehla, George Liechti, Randy M. Morgenstein, J. Harry Caufield, Ali Hosseinnia, Alla Gagarinova, Sadhna Phanse, Norman Goodacre, Mary Brockett, Neha Sakhawalkar, Mohan Babu, Rong Xiao, Gaetano T. Montelione, Sergey Vorobiev, Tanneke den Blaauwen, John F. Hunt & Peter Uetz. (2021) ZapG (YhcB/DUF1043), a novel cell division protein in gamma-proteobacteria linking the Z-ring to septal peptidoglycan synthesis. Journal of Biological Chemistry 296, pages 100700.
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Geoffrey W. Grime, Oliver B. Zeldin, Mary E. Snell, Edward D. Lowe, John F. Hunt, Gaetano T. Montelione, Liang Tong, Edward H. Snell & Elspeth F. Garman. (2019) High-Throughput PIXE as an Essential Quantitative Assay for Accurate Metalloprotein Structural Analysis: Development and Application. Journal of the American Chemical Society 142:1, pages 185-197.
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Patrick Weber, Cédric Pissis, Rafael Navaza, Ariel E. Mechaly, Frederick Saul, Pedro M. Alzari & Ahmed Haouz. (2019) High-Throughput Crystallization Pipeline at the Crystallography Core Facility of the Institut Pasteur. Molecules 24:24, pages 4451.
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Yanmin Li, Lata Govada, Hodaya Solomon, Richard Gillis, Gary Adams & Naomi Chayen. (2019) Analysis of Glulisine Crystallisation Utilising Phase Diagrams and Nucleants. Crystals 9:9, pages 462.
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Jian-Wei Wang, Jie Gao, Hui-Feng Wang, Qiu-Heng Jin, Bing Rao, Wei Deng, Yu Cao, Ming Lei, Sheng Ye & Qun Fang. (2019) Miniaturization of the Whole Process of Protein Crystallographic Analysis by a Microfluidic Droplet Robot: From Nanoliter-Scale Purified Proteins to Diffraction-Quality Crystals. Analytical Chemistry 91:15, pages 10132-10140.
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Yunxiu Zhang, Yanbin Feng, Yayue Wang, Yinghui Liu, Xupeng Cao & Song Xue. (2019) Positive Effects of Isopropanol as a Co-Precipitant in Glycerol-3-Phosphate Acyltransferase Crystallization. Journal of Ocean University of China 18:1, pages 227-231.
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Fanli Zeng, Zhimin Hao, Pan Li, Yanan Meng, Jingao Dong & Yibin Lin. (2017) A restriction-free method for gene reconstitution using two single-primer PCRs in parallel to generate compatible cohesive ends. BMC Biotechnology 17:1.
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Michael G Malkowski. 2011. Encyclopedia of Inorganic and Bioinorganic Chemistry. Encyclopedia of Inorganic and Bioinorganic Chemistry 1 13 .
Andrew E. Bruno, Alexei S. Soares, Robin L. Owen & Edward H. Snell. (2016) The use of haptic interfaces and web services in crystallography: an application for a `screen to beam' interface. Journal of Applied Crystallography 49:6, pages 2082-2090.
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David C. GreenJohannes IhliYi-Yeoun KimSamantha Y. ChongPhillip A. LeeChristopher J. EmpsonFiona C. Meldrum. (2016) Rapid Screening of Calcium Carbonate Precipitation in the Presence of Amino Acids: Kinetics, Structure, and Composition. Crystal Growth & Design 16:9, pages 5174-5183.
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Benjamin J. Orlando & Michael G. Malkowski. (2016) Substrate-selective Inhibition of Cyclooxygeanse-2 by Fenamic Acid Derivatives Is Dependent on Peroxide Tone. Journal of Biological Chemistry 291:29, pages 15069-15081.
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Stephen Whitelam, Yuba Raj Dahal & Jeremy D. Schmit. (2016) Minimal physical requirements for crystal growth self-poisoning. The Journal of Chemical Physics 144:6.
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Guangyu Zhu, Mary Koszelak-Rosenblum, Sara M. Connelly, Mark E. Dumont & Michael G. Malkowski. (2015) The Crystal Structure of an Integral Membrane Fatty Acid α-Hydroxylase. Journal of Biological Chemistry 290:50, pages 29820-29833.
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William J. Bauer, Amit Luthra, Guangyu Zhu, Justin D. Radolf, Michael G. Malkowski & Melissa J. Caimano. (2015) Structural characterization and modeling of the Borrelia burgdorferi hybrid histidine kinase Hk1 periplasmic sensor: A system for sensing small molecules associated with tick feeding. Journal of Structural Biology 192:1, pages 48-58.
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Joseph R. Luft, Jennifer R. Wolfley, Eleanor Cook Franks, Angela M. Lauricella, Ellen J. Gualtieri, Edward H. Snell, Rong Xiao, John K. Everett & Gaetano T. Montelione. (2015) The detection and subsequent volume optimization of biological nanocrystals. Structural Dynamics 2:4, pages 041710.
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Diana Fusco, Timothy J. Barnum, Andrew E. Bruno, Joseph R. Luft, Edward H. Snell, Sayan Mukherjee & Patrick Charbonneau. (2014) Statistical Analysis of Crystallization Database Links Protein Physico-Chemical Features with Crystallization Mechanisms. PLoS ONE 9:7, pages e101123.
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Andrew E. Bruno, Amanda M. Ruby, Joseph R. Luft, Thomas D. Grant, Jayaraman Seetharaman, Gaetano T. Montelione, John F. Hunt & Edward H. Snell. (2014) Comparing Chemistry to Outcome: The Development of a Chemical Distance Metric, Coupled with Clustering and Hierarchal Visualization Applied to Macromolecular Crystallography. PLoS ONE 9:6, pages e100782.
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Ute A. Hellmich & Rachelle Gaudet. 2014. Mammalian Transient Receptor Potential (TRP) Cation Channels. Mammalian Transient Receptor Potential (TRP) Cation Channels 963 990 .
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Guangyu Zhu, Mary Koszelak-Rosenblum & Michael G. Malkowski. (2013) Crystal structures of α-dioxygenase from Oryza sativa : Insights into substrate binding and activation by hydrogen peroxide . Protein Science 22:10, pages 1432-1438.
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E. E. Pryor, P. S. Horanyi, K. M. Clark, N. Fedoriw, S. M. Connelly, M. Koszelak-Rosenblum, G. Zhu, M. G. Malkowski, M. C. Wiener & M. E. Dumont. (2013) Structure of the Integral Membrane Protein CAAX Protease Ste24p. Science 339:6127, pages 1600-1604.
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Christopher C. Goulah, Guangyu Zhu, Mary Koszelak-Rosenblum & Michael G. Malkowski. (2013) The Crystal Structure of α-Dioxygenase Provides Insight into Diversity in the Cyclooxygenase-Peroxidase Superfamily. Biochemistry 52:8, pages 1364-1372.
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Janet Newman, Evan E. Bolton, Jochen M?ller-Dieckmann, Vincent J. Fazio, D. Travis Gallagher, David Lovell, Joseph R. Luft, Thomas S. Peat, David Ratcliffe, Roger A. Sayle, Edward H. Snell, Kerry Taylor, Pascal Vallotton, Sameer Velanker & Frank von Delft. (2012) On the need for an international effort to capture, share and use crystallization screening data. Acta Crystallographica Section F Structural Biology and Crystallization Communications 68:3, pages 253-258.
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