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Technology Evaluation

Monitoring Gq-coupled receptor response through inositol phosphate quantification with the IP-One assay

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Pages 981-994 | Published online: 08 Sep 2011

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Sara Bdioui, Julien Verdi, Nicolas Pierre, Eric Trinquet, Thomas Roux & Terry Kenakin. (2019) The pharmacologic characterization of allosteric molecules: Gq protein activation. Journal of Receptors and Signal Transduction 39:2, pages 106-113.
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Linjie Chen, Lili Jin & Naiming Zhou. (2012) An update of novel screening methods for GPCR in drug discovery. Expert Opinion on Drug Discovery 7:9, pages 791-806.
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John G CummingM Raymond V Finlay, Fabrizio Giordanetto, Martin Hemmerling, Troy Lister, Hitesh Sanganee & Michael J Waring. (2014) Potential strategies for increasing drug-discovery productivity. Future Medicinal Chemistry 6:5, pages 515-527.
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Jurriaan M. Zwier, Hervé Bazin, Laurent Lamarque & Gérard Mathis. (2014) Luminescent Lanthanide Cryptates: from the Bench to the Bedside. Inorganic Chemistry 53:4, pages 1854-1866.
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Lenea Nørskov-Lauritsen, Alex Thomsen & Hans Bräuner-Osborne. (2014) G Protein-Coupled Receptor Signaling Analysis Using Homogenous Time-Resolved Förster Resonance Energy Transfer (HTRF®) Technology. International Journal of Molecular Sciences 15:2, pages 2554-2572.
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Zhan-Guo Gao & Kenneth A. Jacobson. (2013) Allosteric modulation and functional selectivity of G protein-coupled receptors. Drug Discovery Today: Technologies 10:2, pages e237-e243.
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K Siddiquee, J Hampton, D McAnally, LT May & LH Smith. (2013) The apelin receptor inhibits the angiotensin II type 1 receptor via allosteric trans-inhibition. British Journal of Pharmacology 168:5, pages 1104-1117.
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