1,113
Views
130
CrossRef citations to date
0
Altmetric
Reviews

Rhodanine as a scaffold in drug discovery: a critical review of its biological activities and mechanisms of target modulation

&
Pages 549-560 | Published online: 19 May 2012

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (10)

Akhila Pudipeddi, Sahana Vasudevan, Karthi Shanmugam, Suma Mohan S, Pothiappan Vairaprakash, Prasanna Neelakantan, Alex Stanley Balraj & Adline Princy Solomon. (2023) Design, dynamic docking, synthesis, and in vitro validation of a novel DNA gyrase B inhibitor. Journal of Biomolecular Structure and Dynamics 41:13, pages 6345-6358.
Read now
T. Bensafi, D. Hadji, A. Yahiaoui, K. Argoub, A. Hachemaoui, A. Kenane, B. Baroudi, K. Toubal, A. Djafri & A. M. Benkouider. (2021) Synthesis, characterization and DFT calculations of linear and NLO properties of novel (Z)-5-benzylidene-3-N(4-methylphenyl)-2-thioxothiazolidin-4-one. Journal of Sulfur Chemistry 42:6, pages 645-663.
Read now
Thamires Quadros Froes, Bianca Trindade Chaves, Marina Sena Mendes, Rafael Matos Ximenes, Ivanildo Mangueira da Silva, Priscila Brandão Gomes da Silva, Julianna Ferreira Cavalcanti de Albuquerque & Marcelo Santos Castilho. (2021) Synthesis and biological evaluation of thiazolidinedione derivatives with high ligand efficiency to P. aeruginosa PhzS. Journal of Enzyme Inhibition and Medicinal Chemistry 36:1, pages 1217-1229.
Read now
Seyyed Mojtaba Mousavi, Maryam Zarei, Seyyed Alireza Hashemi, Aziz Babapoor & Ali Mohammad Amani. (2019) A conceptual review of rhodanine: current applications of antiviral drugs, anticancer and antimicrobial activities. Artificial Cells, Nanomedicine, and Biotechnology 47:1, pages 1132-1148.
Read now
Danylo Kaminskyy, Anna Kryshchyshyn & Roman Lesyk. (2017) Recent developments with rhodanine as a scaffold for drug discovery. Expert Opinion on Drug Discovery 12:12, pages 1233-1252.
Read now
Andrii Lozynskyi, Sergii Golota, Borys Zimenkovsky, Dmytro Atamanyuk, Andrzej Gzella & Roman Lesyk. (2016) Synthesis, anticancer and antiviral activities of novel thiopyrano[2,3-d]thiazole-6-carbaldehydes. Phosphorus, Sulfur, and Silicon and the Related Elements 191:9, pages 1245-1249.
Read now
Wael A. A. Arafa, Mervat F. Fareed, Saleh A. Rabeh & Raafat M. Shaker. (2016) Ultrasound mediated green synthesis of rhodanine derivatives: Synthesis, chemical behavior, and antibacterial activity. Phosphorus, Sulfur, and Silicon and the Related Elements 191:8, pages 1129-1136.
Read now
Martin Klumpp. (2016) Non-stoichiometric inhibition in integrated lead finding – a literature review. Expert Opinion on Drug Discovery 11:2, pages 149-162.
Read now
Dmytro Atamanyuk, Borys Zimenkovsky, Vasyl Atamanyuk & Roman Lesyk. (2014) 5-Ethoxymethylidene-4-thioxo-2-thiazolidinone as Versatile Building Block for Novel Biorelevant Small Molecules with Thiopyrano[2,3-d][1,3]thiazole Core. Synthetic Communications 44:2, pages 237-244.
Read now
Stephen P East & Lynn L Silver. (2013) Multitarget ligands in antibacterial research: progress and opportunities. Expert Opinion on Drug Discovery 8:2, pages 143-156.
Read now

Articles from other publishers (120)

Martin Krátký, Karolína Nováčková, Katarína Svrčková, Markéta Švarcová & Šárka Štěpánková. (2023) New 3-amino-2-thioxothiazolidin-4-one-based inhibitors of acetyl- and butyryl-cholinesterase: synthesis and activity. Future Medicinal Chemistry.
Crossref
Ovidiu Teodor Matica, Alina Giorgiana Brotea, Eleonora‐Mihaela Ungureanu, Luisa Roxana Mandoc & Liviu Birzan. (2022) Electrochemical and spectral studies of rhodanine in view of heavy metals determination. Electrochemical Science Advances 3:6.
Crossref
Oleksandr V. Los, Vitalii O. Sinenko, Oleksandr L. Kobzar, Victor V. Zhirnov, Andriy I. Vovk & Volodymyr S. Brovarets. (2023) Synthesis and in vitro anticancer potential of new thiazole-containing derivatives of rhodanine. Chemistry of Heterocyclic Compounds 59:6-7, pages 484-493.
Crossref
Ayman M. Ibrahim, Mai E. Shoman, Mamdouh F. A. Mohamed, Alaa M. Hayallah & Gamal El‐Din A. Abuo‐Rahma. (2023) Chemistry and Applications of Functionalized 2,4‐Thiazolidinediones. European Journal of Organic Chemistry 26:19.
Crossref
Ahmed I. Khodair, Fatimah M. Alzahrani, Mohamed K. Awad, Siham A. Al-Issa, Ghaferah H. Al-Hazmi & Mohamed S. Nafie. (2023) Design, Synthesis, Computational Investigations, and Antitumor Evaluation of N -Rhodanine Glycosides Derivatives as Potent DNA Intercalation and Topo II Inhibition against Cancer Cells . ACS Omega 8:14, pages 13300-13314.
Crossref
Maja Molnar, Melita Lončarić, Teuta Opačak-Bernardi, Ljubica Glavaš-Obrovac & Vesna Rastija. (2023) Rhodanine Derivatives as Anticancer Agents: QSAR and Molecular Docking Studies. Anti-Cancer Agents in Medicinal Chemistry 23:7, pages 839-846.
Crossref
Yulian Konechnyi, Andrii Lozynskyi, Iryna Ivasechko, Tetiana Dumych, Solomiya Paryzhak, Oksana Hrushka, Ulyana Partyka, Iryna Pasichnyuk, Dmytro Khylyuk & Roman Lesyk. (2023) 3-[5-(1H-Indol-3-ylmethylene)-4-oxo-2-thioxothiazolidin-3-yl]-propionic Acid as a Potential Polypharmacological Agent. Scientia Pharmaceutica 91:1, pages 13.
Crossref
Kunal Mehta, Mihir Khambete, Arundhati Abhyankar & Abdelwahab Omri. (2023) Anti-Tuberculosis Mur Inhibitors: Structural Insights and the Way Ahead for Development of Novel Agents. Pharmaceuticals 16:3, pages 377.
Crossref
Abhishek Chaurasyia, Pooja Chawla, Vikramdeep Monga & Gurpreet Singh. (2022) Rhodanine derivatives: An insight into the synthetic and medicinal perspectives as antimicrobial and antiviral agents. Chemical Biology & Drug Design 101:3, pages 500-549.
Crossref
Noor Alhuda Dakhel Khalaf, Hiba Ali Hasan & Karima Fadhil Ali. (2023) New 3-aminorhodanine derivatives: Synthesis, characterization, docking study and biological activates. F1000Research 12, pages 1365.
Crossref
Rachana Upadhyay, Zebabanu Khalifa, Divyesh Patel & Amit B. Patel. (2022) Rhodanine‐Incorporated Indole Derivatives as Pharmacologically Vital Hybrids. ChemistrySelect 7:45.
Crossref
Julie A. Spicer, Kristiina M. Huttunen, Jiney Jose, Ivo Dimitrov, Hedieh Akhlaghi, Vivien R. Sutton, Ilia Voskoboinik & Joseph Trapani. (2022) Small Molecule Inhibitors of Lymphocyte Perforin as Focused Immunosuppressants for Infection and Autoimmunity. Journal of Medicinal Chemistry 65:21, pages 14305-14325.
Crossref
Timothy K. Beng, Mckenna Sax & Claire Borg. (2022) Serendipitous synthesis of 2-alkenyl- and 2-aryl-4-thiazolidinones using dithiodiglycolic anhydride. New Journal of Chemistry 46:38, pages 18505-18511.
Crossref
Ahmad Khairul Daniel bin Ahmad Kamar, Lim Ju Yin, Chin Tze Liang, Gan Tjin Fung & Vasudeva Rao Avupati. (2022) Rhodanine scaffold: A review of antidiabetic potential and structure–activity relationships (SAR). Medicine in Drug Discovery 15, pages 100131.
Crossref
Yasser M.A. Mohamed & Eirik Solum. (2022) Recent Advances in Rhodanine-Based Compounds as Potential Antimicrobial Agents. Current Bioactive Compounds 18:7.
Crossref
Jacek Szczepański, Helena Tuszewska & Nazar Trotsko. (2022) Anticancer Profile of Rhodanines: Structure–Activity Relationship (SAR) and Molecular Targets—A Review. Molecules 27:12, pages 3750.
Crossref
Michael A. McCoyDominique SpicerNeil WellsKurt Hoogewijs, Marc FiedlerMatthias G. J. Baud. (2022) Biophysical Survey of Small-Molecule β-Catenin Inhibitors: A Cautionary Tale. Journal of Medicinal Chemistry 65:10, pages 7246-7261.
Crossref
Kamila Buzun, Agnieszka Gornowicz, Roman Lesyk, Anna Kryshchyshyn-Dylevych, Andrzej Gzella, Robert Czarnomysy, Gniewomir Latacz, Agnieszka Olejarz-Maciej, Jadwiga Handzlik, Krzysztof Bielawski & Anna Bielawska. (2022) 2-{5-[(Z,2Z)-2-Chloro-3-(4-nitrophenyl)-2-propenylidene]-4-oxo-2-thioxothiazolidin-3-yl}-3-methylbutanoic Acid as a Potential Anti-Breast Cancer Molecule. International Journal of Molecular Sciences 23:8, pages 4091.
Crossref
Fatemeh Jalili, Mahmoud Zarei, Mohammad Ali Zolfigol & Ardeshir Khazaei. (2022) Application of novel metal–organic framework [Zr-UiO-66-PDC-SO 3 H]FeCl 4 in the synthesis of dihydrobenzo[ g ]pyrimido[4,5- b ]quinoline derivatives . RSC Advances 12:15, pages 9058-9068.
Crossref
Ovidiu Teodor Matica, Alina Giorgiana Brotea, Eleonora-Mihaela Ungureanu & Amalia Stefaniu. (2022) Electrochemical and Spectral Studies on Benzylidenerhodanine for Sensor Development for Heavy Metals in Waters. Applied Sciences 12:5, pages 2681.
Crossref
Yajing Xing, Weikai Guo, Min Wu, Jiuqing Xie, Dongxia Huang, Pan Hu, Miaoran Zhou, Lin Zhang, Qiansen Zhang, Peili Wang, Xin Wang, Guixue Wang, Huangan Wu, Cili Zhou, Yihua Chen, Mingyao Liu, Zhengfang Yi & Zhenliang Sun. (2022) An orally available small molecule BCL6 inhibitor effectively suppresses diffuse large B cell lymphoma cells growth in vitro and in vivo. Cancer Letters 529, pages 100-111.
Crossref
Lim Ju Yin, Ahmad Khairul Daniel bin Ahmad Kamar, Gan Tjin Fung, Chin Tze Liang & Vasudeva Rao Avupati. (2022) Review of anticancer potentials and structure-activity relationships (SAR) of rhodanine derivatives. Biomedicine & Pharmacotherapy 145, pages 112406.
Crossref
Francesca Curreli, Shahad Ahmed, Sofia M. B. Victor, Aleksandra Drelich, Siva S. Panda, Andrea Altieri, Alexander V. Kurkin, Chien-Te K. Tseng, Christopher D. Hillyer & Asim K. Debnath. (2021) Discovery of Highly Potent Fusion Inhibitors with Potential Pan-Coronavirus Activity That Effectively Inhibit Major COVID-19 Variants of Concern (VOCs) in Pseudovirus-Based Assays. Viruses 14:1, pages 69.
Crossref
Rebecca M. Christoff, Tatiana P. Soares da Costa, Saadi Bayat, Jessica K. Holien, Matthew A. Perugini & Belinda M. Abbott. (2021) Synthesis and structure-activity relationship studies of 2,4-thiazolidinediones and analogous heterocycles as inhibitors of dihydrodipicolinate synthase. Bioorganic & Medicinal Chemistry 52, pages 116518.
Crossref
Marcin Skoreński & Marcin Sieńczyk. (2021) The Fellowship of Privileged Scaffolds—One Structure to Inhibit Them All. Pharmaceuticals 14:11, pages 1164.
Crossref
Miri Choi, Ae-kyeong Kim, Youngwook Ham, Joo-Youn Lee, Daeyong Kim, Ansook Yang, Min Ju Jo, Eunyoung Yoon, Jung-Nyoung Heo, Sang-Bae Han, Min-Hyo Ki, Kyu-Sun Lee & Sungchan Cho. (2021) Aristolactam BIII, a naturally derived DYRK1A inhibitor, rescues Down syndrome-related phenotypes. Phytomedicine 92, pages 153695.
Crossref
Igor José dos Santos Nascimento, Paulo Fernando da Silva Santos-Júnior, Thiago Mendonça de Aquino, João Xavier de Araújo-Júnior & Edeildo Ferreira da Silva-Júnior. (2021) Insights on Dengue and Zika NS5 RNA-dependent RNA polymerase (RdRp) inhibitors. European Journal of Medicinal Chemistry 224, pages 113698.
Crossref
Jianbo Sun, Hui Zhong, Kun Wang, Na Li & Li Chen. (2021) Gains from no real PAINS: Where ‘Fair Trial Strategy’ stands in the development of multi-target ligands. Acta Pharmaceutica Sinica B 11:11, pages 3417-3432.
Crossref
Elizabeth T. Montaño, Jason F. Nideffer, Joseph Sugie, Eray Enustun, Adam B. Shapiro, Hannah Tsunemoto, Alan I. Derman, Kit Pogliano & Joe Pogliano. (2021) Bacterial Cytological Profiling Identifies Rhodanine-Containing PAINS Analogs as Specific Inhibitors of Escherichia coli Thymidylate Kinase In Vivo . Journal of Bacteriology 203:19.
Crossref
Yanghwan Yun, Victor Sukbong Hong, Seungik Jeong, Hyeonseong Choo, Shin Kim & Jinho Lee. (2021) 2-Thioxothiazolidin-4-one Analogs as Pan-PIM Kinase Inhibitors. Chemical and Pharmaceutical Bulletin 69:9, pages 854-861.
Crossref
Heejeong Choi, Il Young Ryu, Inkyu Choi, Sultan Ullah, Hee Jin Jung, Yujin Park, Yeongmu Jeong, YeJi Hwang, Sojeong Hong, In-Soo Yoon, Hwayoung Yun, Min-Soo Kim, Jin-Wook Yoo, Yunjin Jung, Pusoon Chun & Hyung Ryong Moon. (2021) Novel Anti-Melanogenic Compounds, (Z)-5-(Substituted Benzylidene)-4-thioxothiazolidin-2-one Derivatives: In Vitro and In Silico Insights. Molecules 26:16, pages 4963.
Crossref
Lixia Lin, Liping Lu, Caixia Yuan, Ai Wang, Miaoli Zhu, Xueqi Fu & Shu Xing. (2021) The dual inhibition against the activity and expression of tyrosine phosphatase PRL-3 from a rhodanine derivative. Bioorganic & Medicinal Chemistry Letters 41, pages 127981.
Crossref
Angela Fan & Phillip P. Sharp. (2021) Inhibitors of Eukaryotic Translational Machinery as Therapeutic Agents. Journal of Medicinal Chemistry 64:5, pages 2436-2465.
Crossref
Khorshada Jahan, Kaif Rashid Khan, Kawsari Akhter, Umme Kulsum Rowzatur Romman & Ershad Halim. (2021) A convenient approach to synthesize substituted 5-Arylidene-3-m-tolyl thiazolidine-2, 4-diones by using morpholine as a catalyst and its theoretical study. PLOS ONE 16:3, pages e0247619.
Crossref
T.A. Zidan, Ahmed E. Abdelhamid & E.G. Zaki. (2020) N-Aminorhodanine modified chitosan hydrogel for antibacterial and copper ions removal from aqueous solutions. International Journal of Biological Macromolecules 158, pages 32-42.
Crossref
Ze Zhang, Xuan Nie, Fei Wang, Guang Chen, Wei-Qiang Huang, Lei Xia, Wen-Jian Zhang, Zong-Yao Hao, Chun-Yan Hong, Long-Hai Wang & Ye-Zi You. (2020) Rhodanine-based Knoevenagel reaction and ring-opening polymerization for efficiently constructing multicyclic polymers. Nature Communications 11:1.
Crossref
Yu. L. Shepeta, A. V. Lozynskyi, Z. V. Tomkiv, P. Grellier & R. B. Lesyk. (2020) Synthesis and evaluation of biological activity of rhodanine-pyrazoline hybrid molecules with 2-(2,6-dichlorophenylamino)-phenylacetamide fragment. Biopolymers and Cell 36:2, pages 133-145.
Crossref
A. Kryshchyshyn, D. Kaminskyy, O. Roman, R. Kralovics, O. Karpenko & R. Lesyk. (2020) Synthesis and anti-leukemic activity of pyrrolidinedione-thiazolidinone hybrids. The Ukrainian Biochemical Journal 92:2, pages 108-119.
Crossref
Yongxi Liang, Mei-Lin Tang, Zhipeng Huo, Chenchen Zhang & Xun Sun. (2020) A Concise Approach to N-Substituted Rhodanines through a Base-Assisted One-Pot Coupling and Cyclization Process. Molecules 25:5, pages 1138.
Crossref
Ahmed I. Khodair, Mohamed K. Awad, Jean-Pierre Gesson & Yaseen A.M.M. Elshaier. (2020) New N-ribosides and N-mannosides of rhodanine derivatives with anticancer activity on leukemia cell line: Design, synthesis, DFT and molecular modelling studies. Carbohydrate Research 487, pages 107894.
Crossref
Brai, Ronzini, Riva, Botta, Zamperini, Borgini, Trivisani, Garbelli, Pennisi, Boccuto, Saladini, Zazzi, Maga & Botta. (2019) Synthesis and Antiviral Activity of Novel 1,3,4-Thiadiazole Inhibitors of DDX3X. Molecules 24:21, pages 3988.
Crossref
Saurabh Loharch & Raman Parkesh. (2019) Epigenetic drug discovery: systematic assessment of chemical space. Future Medicinal Chemistry 11:21, pages 2803-2819.
Crossref
Victor Clausse, Dingyin Tao, Subrata Debnath, Yuhong Fang, Harichandra D. Tagad, Yuhong Wang, Hongmao Sun, Christopher A. LeClair, Sharlyn J. Mazur, Kelly Lane, Zhen-Dan Shi, Olga Vasalatiy, Rebecca Eells, Lynn K. Baker, Mark J. Henderson, Martin R. Webb, Min Shen, Matthew D. Hall, Ettore Appella, Daniel H. Appella & Nathan P. Coussens. (2019) Physiologically relevant orthogonal assays for the discovery of small-molecule modulators of WIP1 phosphatase in high-throughput screens. Journal of Biological Chemistry 294:46, pages 17654-17668.
Crossref
Arundhati Maitra, Tulika Munshi, Jess Healy, Liam T Martin, Waldemar Vollmer, Nicholas H Keep & Sanjib Bhakta. (2019) Cell wall peptidoglycan in Mycobacterium tuberculosis: An Achilles’ heel for the TB-causing pathogen. FEMS Microbiology Reviews 43:5, pages 548-575.
Crossref
Khadidja Khaldoun, Abdelmounaim Safer, Nourdine Boukabcha, Necmi Dege, Sandrine Ruchaud, Mohamed Souab, Stéphane Bach, Abdelkader Chouaih & Salima Saidi-Besbes. (2019) Synthesis and evaluation of new isatin-aminorhodanine hybrids as PIM1 and CLK1 kinase inhibitors. Journal of Molecular Structure 1192, pages 82-90.
Crossref
Sinan Bayindir, Cuneyt Caglayan, Muhammet Karaman & İlhami Gülcin. (2019) The green synthesis and molecular docking of novel N-substituted rhodanines as effective inhibitors for carbonic anhydrase and acetylcholinesterase enzymes. Bioorganic Chemistry 90, pages 103096.
Crossref
Michael Franc, Michal Urban, Ivana Císařová & Jan Veselý. (2019) Highly enantioselective addition of sulfur-containing heterocycles to isatin-derived ketimines. Organic & Biomolecular Chemistry 17:31, pages 7309-7314.
Crossref
Mahamadhanif S. Shaikh, Ashish M. Kanhed, Balakumar Chandrasekaran, Mahesh B. Palkar, Nikhil Agrawal, Christian Lherbet, Girish A. Hampannavar & Rajshekhar Karpoormath. (2019) Discovery of novel N-methyl carbazole tethered rhodanine derivatives as direct inhibitors of Mycobacterium tuberculosis InhA. Bioorganic & Medicinal Chemistry Letters 29:16, pages 2338-2344.
Crossref
Sinan Bayindir & Kemal Yararli. (2019) The easy synthesis of new N -substituted 5-oxindoline-rhodanines and their sensing ability: the recognition of acetate ions in aqueous solution . New Journal of Chemistry 43:21, pages 8168-8178.
Crossref
Bart I. Roman. (2019) Essay: Avoiding unfounded health claims on small molecules in scientific literature. Bioorganic Chemistry 86, pages 273-276.
Crossref
Saurabh Loharch, Vikrant Karmahapatra, Pawan Gupta, Rethi Madathil & Raman Parkesh. 2019. Structural Bioinformatics: Applications in Preclinical Drug Discovery Process. Structural Bioinformatics: Applications in Preclinical Drug Discovery Process 247 269 .
Róbert Kiss, Georgina Csizmadia, Katalin Solti, Attila Keresztes, Max Zhu, Marcus Pickhardt, Eckhard Mandelkow & Gergely Tóth. (2018) Structural Basis of Small Molecule Targetability of Monomeric Tau Protein. ACS Chemical Neuroscience 9:12, pages 2997-3006.
Crossref
Sambasivarao Kotha & Gaddamedi Sreevani. (2018) Diversity‐Oriented Approach to Spirorhodanines via a [2+2+2] Cyclotrimerization. European Journal of Organic Chemistry 2018:43, pages 5935-5941.
Crossref
Dnyandev B. Jarhad, Karishma K. Mashelkar, Hong-Rae Kim, Minsoo Noh & Lak Shin Jeong. (2018) Dual-Specificity Tyrosine Phosphorylation-Regulated Kinase 1A (DYRK1A) Inhibitors as Potential Therapeutics. Journal of Medicinal Chemistry 61:22, pages 9791-9810.
Crossref
Anna Kryshchyshyn, Danylo Kaminskyy, Igor Nektegayev, Philippe Grellier & Roman Lesyk. (2018) Isothiochromenothiazoles—A Class of Fused Thiazolidinone Derivatives with Established Anticancer Activity That Inhibits Growth of Trypanosoma brucei brucei. Scientia Pharmaceutica 86:4, pages 47.
Crossref
Jakub Stefaniak, Andrew M. Lewis, Daniel Conole, Sébastien R. G. Galan, Carole J. R. Bataille, Graham M. Wynne, M. Paola Castaldi, Thomas Lundbäck, Angela J. Russell & Kilian V. M. Huber. (2018) Chemical Instability and Promiscuity of Arylmethylidenepyrazolinone-Based MDMX Inhibitors. ACS Chemical Biology 13:10, pages 2849-2854.
Crossref
Arshad Mehmood, Stephanie I. Jones, Peng Tao & Benjamin G. Janesko. (2018) An Orbital-Overlap Complement to Ligand and Binding Site Electrostatic Potential Maps. Journal of Chemical Information and Modeling 58:9, pages 1836-1846.
Crossref
Emilia Zachanowicz, Jacek Pigłowski, Aleksander Zięcina, Krzysztof Rogacki, Błażej Poźniak, Marta Tikhomirov, Monika Marędziak, Krzysztof Marycz, Joanna Kisała, Kinga Hęclik & Robert Pązik. (2018) Polyrhodanine cobalt ferrite (PRHD@CoFe2O4) hybrid nanomaterials - Synthesis, structural, magnetic, cytotoxic and antibacterial properties. Materials Chemistry and Physics 217, pages 553-561.
Crossref
Matthew K. Matlock, Tyler B. Hughes, Jayme L. Dahlin & S. Joshua Swamidass. (2018) Modeling Small-Molecule Reactivity Identifies Promiscuous Bioactive Compounds. Journal of Chemical Information and Modeling 58:8, pages 1483-1500.
Crossref
Hao Shao, Xiaokai Li, Michael A. Moses, Luke A. Gilbert, Chakrapani Kalyanaraman, Zapporah T. Young, Margarita Chernova, Sara N. Journey, Jonathan S. Weissman, Byron Hann, Matthew P. Jacobson, Len Neckers & Jason E. Gestwicki. (2018) Exploration of Benzothiazole Rhodacyanines as Allosteric Inhibitors of Protein–Protein Interactions with Heat Shock Protein 70 (Hsp70). Journal of Medicinal Chemistry 61:14, pages 6163-6177.
Crossref
Remya Ramesh, Swapnil Sonawane, D. Srinivasa Reddy & Rakeshwar Bandichhor. 2018. Protecting‐Group‐Free Organic Synthesis. Protecting‐Group‐Free Organic Synthesis 155 181 .
Issa Yavari, Maryam Naeimabadi & Mohammad R. Halvagar. (2018) A diastereoselective synthesis of functionalized bis-spirorhodanine-linked cyclopentanes via C(sp 3 )–H activation. Tetrahedron 74:30, pages 4145-4150.
Crossref
Dong Zhang, Marios S. Markoulides, Dmitrijs Stepanovs, Anna M. Rydzik, Ahmed El-Hussein, Corentin Bon, Jos J.A.G. Kamps, Klaus-Daniel Umland, Patrick M. Collins, Samuel T. Cahill, David Y. Wang, Frank von Delft, Jürgen Brem, Michael A. McDonough & Christopher J. Schofield. (2018) Structure activity relationship studies on rhodanines and derived enethiol inhibitors of metallo-β-lactamases. Bioorganic & Medicinal Chemistry 26:11, pages 2928-2936.
Crossref
Anna Kryshchyshyn, Oleg Devinyak, Danylo Kaminskyy, Philippe Grellier & Roman Lesyk. (2018) Development of Predictive QSAR Models of 4-Thiazolidinones Antitrypanosomal Activity Using Modern Machine Learning Algorithms. Molecular Informatics 37:5, pages 1700078.
Crossref
S. Brasil, A. Briso-Montiano, A. Gámez, J. Underhaug, M.I. Flydal, L. Desviat, B. Merinero, M. Ugarte, A. Martinez & B. Pérez. (2018) New perspectives for pharmacological chaperoning treatment in methylmalonic aciduria cblB type. Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease 1864:2, pages 640-648.
Crossref
Abbas Babaei Rostam, Majid Peyravi, Mohsen Ghorbani & Mohsen Jahanshahi. (2018) Antibacterial surface modified of novel nanocomposite sulfonated polyethersulfone/polyrhodanine membrane. Applied Surface Science 427, pages 17-28.
Crossref
Giacomo Mari, Lucia De Crescentini, Gianfranco Favi, Stefania Santeusanio, Samuele Lillini & Fabio Mantellini. (2017) Unexpected Synthesis of 2,3,5,6-Tetrahydro-1 H -pyrrolo[3,4- c ]pyridine-1,3,6-triones by a Double Michael Addition/CS 2 Extrusion/Double Cyclization Sequence . European Journal of Organic Chemistry 2017:42, pages 6291-6298.
Crossref
Danylo Kaminskyy, Anna Kryshchyshyn & Roman Lesyk. (2017) 5-Ene-4-thiazolidinones – An efficient tool in medicinal chemistry. European Journal of Medicinal Chemistry 140, pages 542-594.
Crossref
Du Ri Jo, Young-Ok Kim, Ran Kim, Young-Cheol Chang, DuBok Choi & Hoon Cho. (2018) Novel rhodanine derivatives are selective algicides against Microcystis aeruginosa. Biotechnology and Bioprocess Engineering 22:6, pages 748-757.
Crossref
Mika J. Välimäki, Marja A. Tölli, Sini M. Kinnunen, Jani Aro, Raisa Serpi, Lotta Pohjolainen, Virpi Talman, Antti Poso & Heikki J. Ruskoaho. (2017) Discovery of Small Molecules Targeting the Synergy of Cardiac Transcription Factors GATA4 and NKX2-5. Journal of Medicinal Chemistry 60:18, pages 7781-7798.
Crossref
Malihe Akhavan, Naser Foroughifar, Hoda Pasdar, Alireza Khajeh-Amiri & Ahmadreza Bekhradnia. (2017) Copper(II)-complex functionalized magnetite nanoparticles: a highly efficient heterogeneous nanocatalyst for the synthesis of 5-arylidenthiazolidine-2,4-diones and 5-arylidene-2-thioxothiazolidin-4-one. Transition Metal Chemistry 42:6, pages 543-552.
Crossref
Trung Vu Quoc, Linh Nguyen Ngoc, Cong Nguyen Tien, Chien Thang Pham & Luc Van Meervelt. (2017) Crystal structure of N -(4-oxo-2-sulfanylidene-1,3-thiazolidin-3-yl)-2-(thiophen-3-yl)acetamide . Acta Crystallographica Section E Crystallographic Communications 73:6, pages 901-904.
Crossref
Waldemar Tejchman, Izabela Korona-Glowniak, Anna Malm, Marek Zylewski & Piotr Suder. (2017) Antibacterial properties of 5-substituted derivatives of rhodanine-3-carboxyalkyl acids. Medicinal Chemistry Research 26:6, pages 1316-1324.
Crossref
Nataliya Zelisko, Olexandr Karpenko, Volodymyr Muzychenko, Andrzej Gzella, Philippe Grellier & Roman Lesyk. (2017) trans -Aconitic acid-based hetero -Diels-Alder reaction in the synthesis of thiopyrano[2,3- d ][1,3]thiazole derivatives. Tetrahedron Letters 58:18, pages 1751-1754.
Crossref
Giovanni Capranico, Jessica Marinello & Giovanni Chillemi. (2017) Type I DNA Topoisomerases. Journal of Medicinal Chemistry 60:6, pages 2169-2192.
Crossref
Camille Déliko Dago, Christelle N’ta Ambeu, Wacothon Karime Coulibaly, Yves-Alain Békro, Janat A. Mamyrbekova-Bekro, Rémy Le Guével, Anne Corlu & Jean-Pierre Bazureau. (2017) Investigation on the synthesis of new 3-[4-(arylalkoxy)phenylethyl]-2-thioxo-1,3-thiazolidin-4-ones and their biological evaluation against cancer cells. Chemistry of Heterocyclic Compounds 53:3, pages 341-349.
Crossref
Paul A. Jackson, John C. Widen, Daniel A. Harki & Kay M. Brummond. (2016) Covalent Modifiers: A Chemical Perspective on the Reactivity of α,β-Unsaturated Carbonyls with Thiols via Hetero-Michael Addition Reactions. Journal of Medicinal Chemistry 60:3, pages 839-885.
Crossref
Patricia Yuste-Checa, Sandra Brasil, Alejandra Gámez, Jarl Underhaug, Lourdes R Desviat, Magdalena Ugarte, Celia Pérez-Cerdá, Aurora Martinez & Belén Pérez. (2017) Pharmacological Chaperoning: A Potential Treatment for PMM2-CDG. Human Mutation 38:2, pages 160-168.
Crossref
Kodai Iijima, Yann Le Gal, Toshiki Higashino, Dominique Lorcy & Takehiko Mori. (2017) Birhodanines and their sulfur analogues for air-stable n-channel organic transistors. Journal of Materials Chemistry C 5:35, pages 9121-9127.
Crossref
Guang-cheng Wang, Ya-ping Peng, Zhen-zhen Xie, Jing Wang & Ming Chen. (2017) Synthesis, α-glucosidase inhibition and molecular docking studies of novel thiazolidine-2,4-dione or rhodanine derivatives. MedChemComm 8:7, pages 1477-1484.
Crossref
Konrad A. Szychowski, Marcin L. Leja, Danylo V. Kaminskyy, Urszula E. Binduga, Oleh R. Pinyazhko, Roman B. Lesyk & Jan Gmiński. (2017) Study of novel anticancer 4-thiazolidinone derivatives. Chemico-Biological Interactions 262, pages 46-56.
Crossref
Tanja Štular, Samo Lešnik, Kaja Rožman, Julia Schink, Mitja Zdouc, An Ghysels, Feng Liu, Courtney C. Aldrich, V. Joachim Haupt, Sebastian Salentin, Simone Daminelli, Michael Schroeder, Thierry Langer, Stanislav Gobec, Dušanka Janežič & Janez Konc. (2016) Discovery of Mycobacterium tuberculosis InhA Inhibitors by Binding Sites Comparison and Ligands Prediction . Journal of Medicinal Chemistry 59:24, pages 11069-11078.
Crossref
Marta P. Carrasco, Marta Machado, Lídia Gonçalves, Moni Sharma, Jiri Gut, Amanda K. Lukens, Dyann F. Wirth, Vânia André, Maria Teresa Duarte, Rita C. Guedes, Daniel J. V. A. dos Santos, Philip J. Rosenthal, Ralph Mazitschek, Miguel Prudêncio & Rui Moreira. (2016) Probing the Azaaurone Scaffold against the Hepatic and Erythrocytic Stages of Malaria Parasites. ChemMedChem 11:19, pages 2194-2204.
Crossref
Martin Krátký, Šárka Štěpánková, Katarína Vorčáková & Jarmila Vinšová. (2016) Synthesis and in vitro evaluation of novel rhodanine derivatives as potential cholinesterase inhibitors. Bioorganic Chemistry 68, pages 23-29.
Crossref
A.Z. El-Sonbati, I.M. El-Deen & M.A. El-Bindary. (2016) Molecular docking, potentiometric and thermodynamic studies of azo rhodanines. Journal of Molecular Liquids 221, pages 51-60.
Crossref
Julia Senkiv, Nataliya Finiuk, Danylo Kaminskyy, Dmytro Havrylyuk, Magdalena Wojtyra, Iryna Kril, Andrzej Gzella, Rostyslav Stoika & Roman Lesyk. (2016) 5-Ene-4-thiazolidinones induce apoptosis in mammalian leukemia cells. European Journal of Medicinal Chemistry 117, pages 33-46.
Crossref
Luisana Astudillo, Thiago G. Da Silva, Zhiqiang Wang, Xiaoqing Han, Ke Jin, Jeffrey VanWye, Xiaoxia Zhu, Kelly Weaver, Taiji Oashi, Pedro E.M. Lopes, Darren Orton, Leif R. Neitzel, Ethan Lee, Ralf Landgraf, David J. Robbins, Alexander D. MacKerellJrJr & Anthony J. Capobianco. (2016) The Small Molecule IMR-1 Inhibits the Notch Transcriptional Activation Complex to Suppress Tumorigenesis. Cancer Research 76:12, pages 3593-3603.
Crossref
Danylo Kaminskyy, Gertjan J.M. den Hartog, Magdalena Wojtyra, Maryan Lelyukh, Andrzej Gzella, Aalt Bast & Roman Lesyk. (2016) Antifibrotic and anticancer action of 5-ene amino/iminothiazolidinones. European Journal of Medicinal Chemistry 112, pages 180-195.
Crossref
Martin Pouliot & Stephane Jeanmart. (2015) Pan Assay Interference Compounds (PAINS) and Other Promiscuous Compounds in Antifungal Research. Journal of Medicinal Chemistry 59:2, pages 497-503.
Crossref
A. Ciogli, S. Vivek Kumar, M. Mancinelli, A. Mazzanti, S. Perumal, C. Severi & C. Villani. (2016) Atropisomerism in 3-arylthiazolidine-2-thiones. A combined dynamic NMR and dynamic HPLC study. Organic & Biomolecular Chemistry 14:47, pages 11137-11147.
Crossref
Simiao Gao, Yu Zhang, Jun Dong, Ning Chen & Jiaxi Xu. (2016) Synthesis of functionalized 5-substituted thiazolidine-2-thiones via adscititious xanthate-promoted radical cyclization of allyl(alkyl/aryl)dithiocarbamates. Organic & Biomolecular Chemistry 14:3, pages 1002-1012.
Crossref
Duong Nhu, Guillaume Lessene, David C. S. Huang & Christopher J. Burns. (2016) Small molecules targeting Mcl-1: the search for a silver bullet in cancer therapy. MedChemComm 7:5, pages 778-787.
Crossref
Petra Hirsova, Jan Dolezel, Marta Kucerova-Chlupacova, Jiri Kunes, Veronika Pilarova, Lucie Novakova & Veronika Opletalova. (2015) (Z)-3-Amino-5-(pyridin-2-ylmethylidene)-2-thioxo-1,3-thiazolidin-4-one. Molbank 2015:4, pages M872.
Crossref
Shi Qing Tang, Yong Yang Irvin Lee, David Sheela Packiaraj, Han Kiat Ho & Christina Li Lin Chai. (2015) Systematic Evaluation of the Metabolism and Toxicity of Thiazolidinone and Imidazolidinone Heterocycles. Chemical Research in Toxicology 28:10, pages 2019-2033.
Crossref
Fangrui Wu, Hong Jiang, Baisong Zheng, Mari Kogiso, Yuan Yao, Chao Zhou, Xiao-Nan Li & Yongcheng Song. (2015) Inhibition of Cancer-Associated Mutant Isocitrate Dehydrogenases by 2-Thiohydantoin Compounds. Journal of Medicinal Chemistry 58:17, pages 6899-6908.
Crossref
Andrej Perdih, Martina Hrast, Kaja Pureber, Hélène Barreteau, Simona Golič Grdadolnik, Darko Kocjan, Stanislav Gobec, Tom Solmajer & Gerhard Wolber. (2015) Furan-based benzene mono- and dicarboxylic acid derivatives as multiple inhibitors of the bacterial Mur ligases (MurC–MurF): experimental and computational characterization. Journal of Computer-Aided Molecular Design 29:6, pages 541-560.
Crossref
Allan M. Jordan, Ian D. Waddell & Donald J. Ogilvie. (2015) Rethinking ‘academic’ drug discovery: the Manchester Institute perspective. Drug Discovery Today 20:5, pages 525-535.
Crossref
A. V. Lozynskyi, D. V. Kaminskyy, Kh. B. Romanchyshyn, N. G. Semenciv, V. V. Ogurtsov, I. O. Nektegayev & R. B. Lesyk. (2015) Screening of antioxidant and anti-inflammatory activities among thiopyrano[2,3-d]thiazoles. Biopolymers and Cell 31:2, pages 131-137.
Crossref
Sundaravel Vivek Kumar, Shanmugam Muthusubramanian & Subbu Perumal. (2015) A solvent- and catalyst-free domino reaction for the efficient synthesis of 3-arylthiazolidine-2-thiones under microwave irradiation. RSC Advances 5:110, pages 90451-90456.
Crossref
Jürgen Brem, Sander S. van Berkel, WeiShen Aik, Anna M. Rydzik, Matthew B. Avison, Ilaria Pettinati, Klaus-Daniel Umland, Akane Kawamura, James Spencer, Timothy D. W. Claridge, Michael A. McDonough & Christopher J. Schofield. (2014) Rhodanine hydrolysis leads to potent thioenolate mediated metallo-β-lactamase inhibition. Nature Chemistry 6:12, pages 1084-1090.
Crossref
Somaye Seraj, Behruz Mirzayi & Ali Nematollahzadeh. (2014) Superparamagnetic maghemite/polyrhodanine core/shell nanoparticles: Synthesis and characterization. Advanced Powder Technology 25:5, pages 1520-1526.
Crossref
Jayme L Dahlin & Michael A Walters. (2014) The essential roles of chemistry in high-throughput screening triage . Future Medicinal Chemistry 6:11, pages 1265-1290.
Crossref
Jayant Sindhu, Harjinder Singh & J. M. Khurana. (2014) A green, multicomponent, regio- and stereo-selective 1,3-dipolar cycloaddition of azides and azomethine ylides generated in situ with bifunctional dipolarophiles using PEG-400. Molecular Diversity 18:2, pages 345-355.
Crossref
Oleg Devinyak, Dmytro Havrylyuk, Borys Zimenkovsky & Roman Lesyk. (2014) Computational Search for Possible Mechanisms of 4-Thiazolidinones Anticancer Activity: The Power of Visualization. Molecular Informatics 33:3, pages 216-229.
Crossref
Tobias Strittmatter, Anette Brockmann, Moritz Pott, Annika Hantusch, Thomas Brunner & Andreas Marx. (2013) Expanding the Scope of Human DNA Polymerase λ and β Inhibitors. ACS Chemical Biology 9:1, pages 282-290.
Crossref
Huanrui Zhang, Baomin Wang, Longchen Cui, Ying Li, Jingping Qu & Yuming Song. (2014) Organocatalytic enantioselective α-amination of 5-substituted rhodanines: an efficient approach to chiral N,S-acetals. Org. Biomol. Chem. 12:45, pages 9097-9100.
Crossref
Zhi Jian Song, Mei Ying Ng, Zheng-Wei Lee, Weilu Dai, Thilo Hagen, Philip K. Moore, Dejian Huang, Lih-Wen Deng & Choon-Hong Tan. (2014) Hydrogen sulfide donors in research and drug development. Med. Chem. Commun. 5:5, pages 557-570.
Crossref
Nataliya Zelisko, Dmytro Atamanyuk, Olexandr Vasylenko, Andriy Bryhas, Vasyl Matiychuk, Andrzej Gzella & Roman Lesyk. (2014) Crotonic, cynnamic, and propiolic acids motifs in the synthesis of thiopyrano[2,3-d][1,3]thiazoles via hetero-Diels–Alder reaction and related tandem processes. Tetrahedron 70:3, pages 720-729.
Crossref
Julie A. Spicer, Gersande Lena, Dani M. Lyons, Kristiina M. Huttunen, Christian K. Miller, Patrick D. O’Connor, Matthew Bull, Nuala Helsby, Stephen M. F. Jamieson, William A. Denny, Annette Ciccone, Kylie A. Browne, Jamie A. Lopez, Jesse Rudd-Schmidt, Ilia Voskoboinik & Joseph A. Trapani. (2013) Exploration of a Series of 5-Arylidene-2-thioxoimidazolidin-4-ones as Inhibitors of the Cytolytic Protein Perforin. Journal of Medicinal Chemistry 56:23, pages 9542-9555.
Crossref
Tuomo Kalliokoski, Christian Kramer & Anna Vulpetti. (2013) Quality Issues with Public Domain Chemogenomics Data. Molecular Informatics 32:11-12, pages 898-905.
Crossref
Cristina Esteva-Font, Puay-Wah Phuan, Marc O. Anderson & A.S. Verkman. (2013) A Small Molecule Screen Identifies Selective Inhibitors of Urea Transporter UT-A. Chemistry & Biology 20:10, pages 1235-1244.
Crossref
Ianire Martin, Jarl Underhaug, Garbiñe Celaya, Fernando Moro, Knut Teigen, Aurora Martinez & Arturo Muga. (2013) Screening and Evaluation of Small Organic Molecules as ClpB Inhibitors and Potential Antimicrobials. Journal of Medicinal Chemistry 56:18, pages 7177-7189.
Crossref
Chris J. Vickers, Gonzalo E. González-Páez, Jeffrey C. Umotoy, Charmagne Cayanan-Garrett, Steven J. Brown & Dennis W. Wolan. (2013) Small-Molecule Procaspase Activators Identified Using Fluorescence Polarization. ChemBioChem 14:12, pages 1419-1422.
Crossref
Garam Min, Su-Kyung Lee, Hye-Nan Kim, Young-Min Han, Rhan-Hee Lee, Dae Gwin Jeong, Dong Cho Han & Byoung-Mog Kwon. (2013) Rhodanine-based PRL-3 inhibitors blocked the migration and invasion of metastatic cancer cells. Bioorganic & Medicinal Chemistry Letters 23:13, pages 3769-3774.
Crossref
Huabo Wang, Jay Chauhan, Angela Hu, Kelsey Pendleton, Jeremy L. Yap, Philip E. Sabato, Jace W. Jones, Mariarita Perri, Jianshi Yu, Erika Cione, Maureen A. Kane, Steven Fletcher & Edward V. Prochownik. (2013) Disruption of Myc-Max Heterodimerization with Improved Cell-Penetrating Analogs of the Small Molecule 10074-G5. Oncotarget 4:6, pages 936-949.
Crossref
Yongqiang Zhang, Shengzheng Wang, Shanchao Wu, Shiping Zhu, Guoqiang Dong, Zhenyuan Miao, Jianzhong Yao, Wannian Zhang, Chunquan Sheng & Wei Wang. (2013) Facile Construction of Structurally Diverse Thiazolidinedione-Derived Compounds via Divergent Stereoselective Cascade Organocatalysis and Their Biological Exploratory Studies. ACS Combinatorial Science 15:6, pages 298-308.
Crossref
Jonathan B. Baell. (2012) Broad Coverage of Commercially Available Lead-like Screening Space with Fewer than 350,000 Compounds. Journal of Chemical Information and Modeling 53:1, pages 39-55.
Crossref
Lynn L. Silver. (2013) Viable screening targets related to the bacterial cell wall. Annals of the New York Academy of Sciences 1277:1, pages 29-53.
Crossref
Jonathan B. Baell, Lori Ferrins, Hendrik Falk & George Nikolakopoulos. (2013) PAINS: Relevance to Tool Compound Discovery and Fragment-Based Screening. Australian Journal of Chemistry 66:12, pages 1483.
Crossref
Nataliya Zelisko, Dmytro Atamanyuk, Olexandr Vasylenko, Philippe Grellier & Roman Lesyk. (2012) Synthesis and antitrypanosomal activity of new 6,6,7-trisubstituted thiopyrano[2,3-d][1,3]thiazoles. Bioorganic & Medicinal Chemistry Letters 22:23, pages 7071-7074.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.