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Expert Opinion on Drug Discovery Volume 7, 2012 - Issue 12
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Discovery and therapeutic potential of kinin receptor antagonists

Eric T Whalley 44 Mead Street, Charlestown, MA 02129, USA+1 617 398 6427; [email protected]
, PhD,
Carlos D FigueroaLaboratory of Cellular Pathology, Institute of Anatomy, Histology & Pathology, Universidad Austral de Chile, Valdivia, Chile
, PhD,
Lajos GeraUniversity of Colorado Denver, School of Medicine, Department of Biochemistry and Molecular Genetics, Aurora, CO 80045, USA
, PhD &
Kanti D BhoolaLaboratory of Cellular Pathology, Institute of Anatomy, Histology & Pathology, Universidad Austral de Chile, Valdivia, Chile
, MD PhD FRSSAf
Pages 1129-1148 | Published online: 25 Oct 2012

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Nelly Blaes & Jean-Pierre Girolami. (2013) Targeting the ‘Janus face' of the B2-bradykinin receptor. Expert Opinion on Therapeutic Targets 17:10, pages 1145-1166.
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Articles from other publishers (29)

Indiara Brusco, Maria Fernanda Pessano Fialho, Gabriela Becker, Evelyne Silva Brum, Amanda Favarin, Lara Panazzolo Marquezin, Patrick Tuzi Serafini & Sara Marchesan Oliveira. (2023) Kinins and their B1 and B2 receptors as potential therapeutic targets for pain relief. Life Sciences 314, pages 121302.
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K. Deepak, Pritam Kumar Roy, Prithwish Kola, Budhaditya Mukherjee & Mahitosh Mandal. (2022) An overview of kinin mediated events in cancer progression and therapeutic applications. Biochimica et Biophysica Acta (BBA) - Reviews on Cancer 1877:6, pages 188807.
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Devasahayam Arokiar Balaya Rex, Neelanchal Vaid, K. Deepak, Shobha Dagamajalu & T. S. Keshava Prasad. (2022) A comprehensive review on current understanding of bradykinin in COVID-19 and inflammatory diseases. Molecular Biology Reports 49:10, pages 9915-9927.
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Mona N. Oliveira, Micheli M. Pillat, Juliana Baranova, Roberta Andrejew, Balbino Lino dos Santos, Silvia Lima Costa, Tamara T. Lah & Henning Ulrich. (2022) Glioblastoma cell invasiveness and epithelial-to-mesenchymal transitioning are modulated by kinin receptors. Advances in Cancer Biology - Metastasis 4, pages 100045.
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D. A. B. Rex, K. Deepak, Neelanchal Vaid, Shobha Dagamajalu, Richard Kumaran Kandasamy, Trude Helen Flo & T. S. Keshava Prasad. (2021) A modular map of Bradykinin-mediated inflammatory signaling network. Journal of Cell Communication and Signaling 16:2, pages 301-310.
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Carlos D. Figueroa & Kanti D. Bhoola. 2022. Encyclopedia of Respiratory Medicine. Encyclopedia of Respiratory Medicine 678 693 .
Yiou Wang, Bingxue Zhang, Yibing Huang, Wenjun Yao, Fei Tao & Yuxin Chen. (2021) Novel Bradykinin Receptor Inhibitors Inhibit Proliferation and Promote the Apoptosis of Hepatocellular Carcinoma Cells by Inhibiting the ERK Pathway. Molecules 26:13, pages 3915.
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Gerasimos Rassias, Sofia Leonardi, Dionisia Rigopoulou, Eleanna Vachlioti, Konstantinos Afratis, Zoi Piperigkou, Christos Koutsakis, Nikos K. Karamanos, Haralambos Gavras & Dionissios Papaioannou. (2021) Potent antiproliferative activity of bradykinin B2 receptor selective agonist FR-190997 and analogue structures thereof: A paradox resolved?. European Journal of Medicinal Chemistry 210, pages 112948.
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Joseph Lau, Julie Rousseau, Daniel Kwon, François Bénard & Kuo-Shyan Lin. (2020) A Systematic Review of Molecular Imaging Agents Targeting Bradykinin B1 and B2 Receptors. Pharmaceuticals 13:8, pages 199.
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Anne Lesage, Christoph Gibson, François Marceau, Horst-Dieter Ambrosi, Jörn Saupe, Werner Katzer, Brigitte Loenders, Xavier Charest-Morin & Jochen Knolle. (2020) In Vitro Pharmacological Profile of a New Small Molecule Bradykinin B2 Receptor Antagonist. Frontiers in Pharmacology 11.
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Peiqi Hu, Hua Su, Hong Xiao, Shen-Ju Gou, Carolina A. Herrera, Marco A. Alba, Masao Kakoki, Ronald J. Falk & J. Charles Jennette. (2020) Kinin B1 Receptor Is Important in the Pathogenesis of Myeloperoxidase-Specific ANCA GN. Journal of the American Society of Nephrology 31:2, pages 297-307.
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Ari Rouhiainen, Natalia Kulesskaya, Marie Mennesson, Zuzanna Misiewicz, Tessa Sipilä, Ewa Sokolowska, Kalevi Trontti, Lea Urpa, William McEntegart, Suvi Saarnio, Petri Hyytiä & Iiris Hovatta. (2019) The bradykinin system in stress and anxiety in humans and mice. Scientific Reports 9:1.
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Mona N. Oliveira, Barbara Breznik, Micheli M. Pillat, Ricardo L. Pereira, Henning Ulrich & Tamara T. Lah. (2019) Kinins in Glioblastoma Microenvironment. Cancer Microenvironment 12:2-3, pages 77-94.
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Céléna Dubuc, Martin Savard, Veronica Bovenzi, Andrée Lessard, Jérôme Côté, Witold Neugebauer, Sameh Geha, Sylvain Chemtob & Fernand GobeilJr.Jr.. (2018) Antitumor activity of cell‐penetrant kinin B1 receptor antagonists in human triple‐negative breast cancer cells. Journal of Cellular Physiology 234:3, pages 2851-2865.
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Patricia Luiza Nunes da Costa, David Wynne, Theodora Fifis, Linh Nguyen, Marcos Perini & Christopher Christophi. (2018) The kallikrein-Kinin system modulates the progression of colorectal liver metastases in a mouse model. BMC Cancer 18:1.
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François Marceau, Marie-Thérèse Bawolak, Jean-Philippe Fortin, Guillaume Morissette, Caroline Roy, Hélène Bachelard, Lajos Gera & Xavier Charest-Morin. (2018) Bifunctional ligands of the bradykinin B 2 and B 1 receptors: An exercise in peptide hormone plasticity. Peptides 105, pages 37-50.
Crossref
Zhenyu Wei, Yi Lyu, XiaoLi Yang, Xin Chen, Ping Zhong & Danhong Wu. (2018) Therapeutic Values of Human Urinary Kallidinogenase on Cerebrovascular Diseases. Frontiers in Neurology 9.
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Valnês S. Rodrigues-Junior, Priscilla B. Pail, Anne D. Villela, Virgínia C.A. Falcão, Adílio S. Dadda, Bruno L. Abbadi, João B. Pesquero, Diógenes S. Santos, Luiz A. Basso & Maria M. Campos. (2018) Effect of the bradykinin 1 receptor antagonist SSR240612 after oral administration in Mycobacterium tuberculosis-infected mice. Tuberculosis 109, pages 1-7.
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Céléna Dubuc, Martin Savard, Veronica Bovenzi, Andrée Lessard, Audrey Fortier, Jérôme Côté, Witold Neugebauer, Flavio Rizzolio, Sameh Geha, Antonio Giordano, Sylvain Chemtob & Fernand Gobeil. (2018) Targeting intracellular B2 receptors using novel cell-penetrating antagonists to arrest growth and induce apoptosis in human triple-negative breast cancer. Oncotarget 9:11, pages 9885-9906.
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Rithwik Ramachandran, Christophe Altier, Katerina Oikonomopoulou & Morley D. Hollenberg. (2016) Proteinases, Their Extracellular Targets, and Inflammatory Signaling. Pharmacological Reviews 68:4, pages 1110-1142.
Crossref
Gloria Valdés, Stephanie Acuña, Alejandro Munizaga, Gloria X. Soto & Carlos D. Figueroa. (2016) Utero-placental cellular and nuclear expression of bradykinin B2 receptors in normal and preeclamptic pregnancies. Pregnancy Hypertension: An International Journal of Women's Cardiovascular Health 6:1, pages 30-37.
Crossref
Natália P. Cignachi, João B. Pesquero, Rogério B. Oliveira, Adriana Etges & Maria M. Campos. (2015) Kinin B 1 Receptor Deletion Affects Bone Healing in Type 1 Diabetic Mice . Journal of Cellular Physiology 230:12, pages 3019-3028.
Crossref
Guillaume Amouroux, Jinhe Pan, Silvia Jenni, Chengcheng Zhang, Zhengxing Zhang, Navjit Hundal-Jabal, Nadine Colpo, Zhibo Liu, François Bénard & Kuo-Shyan Lin. (2015) Imaging Bradykinin B1 Receptor with 68 Ga-Labeled [des-Arg 10 ]Kallidin Derivatives: Effect of the Linker on Biodistribution and Tumor Uptake . Molecular Pharmaceutics 12:8, pages 2879-2888.
Crossref
Mathias Hallberg. (2015) Neuropeptides: Metabolism to Bioactive Fragments and the Pharmacology of Their Receptors. Medicinal Research Reviews 35:3, pages 464-519.
Crossref
Stanislav Avdieiev, Lajos Gera, Dmytro Havrylyuk, Robert S. Hodges, Roman Lesyk, Vincent Ribrag, Yegor Vassetzky & Vadym Kavsan. (2014) Bradykinin antagonists and thiazolidinone derivatives as new potential anti-cancer compounds. Bioorganic & Medicinal Chemistry 22:15, pages 3815-3823.
Crossref
Patrícia L.N. da Costa, Pierre Sirois, Ian F. Tannock & Roger Chammas. (2014) The role of kinin receptors in cancer and therapeutic opportunities. Cancer Letters 345:1, pages 27-38.
Crossref
Fernand GobeilJr.Jr., Pierre Sirois & Domenico Regoli. (2014) Preclinical pharmacology, metabolic stability, pharmacokinetics and toxicology of the peptidic kinin B1 receptor antagonist R-954. Peptides 52, pages 82-89.
Crossref
Menakshi Bhat, Mylène Pouliot, Réjean Couture & Elvire Vaucher. 2014. Recent Developments in the Regulation of Kinins. Recent Developments in the Regulation of Kinins 111 143 .
Hiroshi Maeda. (2013) The link between infection and cancer: Tumor vasculature, free radicals, and drug delivery to tumors via the EPR effect . Cancer Science 104:7, pages 779-789.
Crossref

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