578
Views
15
CrossRef citations to date
0
Altmetric
Reviews

X-ray structural information of GPCRs in drug design: what are the limitations and where do we go?

Pages 607-620 | Published online: 29 Mar 2013

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (4)

David R. Janero & Ganesh A. Thakur. (2016) Leveraging allostery to improve G protein-coupled receptor (GPCR)-directed therapeutics: cannabinoid receptor 1 as discovery target. Expert Opinion on Drug Discovery 11:12, pages 1223-1237.
Read now
Sid Topiol & Michael Sabio. (2015) The role of experimental and computational structural approaches in 7TM drug discovery. Expert Opinion on Drug Discovery 10:10, pages 1071-1084.
Read now

Articles from other publishers (11)

Alexander Neumann, Christa E. Müller & Vigneshwaran Namasivayam. (2020) P2Y 1 ‐like nucleotide receptors—Structures, molecular modeling, mutagenesis, and oligomerization . WIREs Computational Molecular Science 10:4.
Crossref
Alexander Heifetz, Michelle Southey, Inaki Morao, Andrea Townsend-Nicholson & Mike J. Bodkin. 2018. Computational Methods for GPCR Drug Discovery. Computational Methods for GPCR Drug Discovery 375 394 .
Mélanie Frauli, Christel Franchet, Ismet Dorange, Arturo Mancini, Billy Breton & Stephan Schann. 2016. Allosterism in Drug Discovery. Allosterism in Drug Discovery 65 96 .
Sid Topiol & Michael Sabio. (2016) 7TM X-ray structures for class C GPCRs as new drug-discovery tools. 1. mGluR5. Bioorganic & Medicinal Chemistry Letters 26:2, pages 484-494.
Crossref
Agnieszka A. Kaczor, Ewelina Rutkowska, Damian Bartuzi, Katarzyna M. Targowska-Duda, Dariusz Matosiuk & Jana Selent. 2016. G Protein-Coupled Receptors - Signaling, Trafficking and Regulation. G Protein-Coupled Receptors - Signaling, Trafficking and Regulation 359 399 .
Alessandro Pedretti, Angelica Mazzolari, Chiara Ricci & Giulio Vistoli. (2015) Enhancing the Reliability of GPCR Models by Accounting for Flexibility of Their Pro-Containing Helices: the Case of the Human mAChR1 Receptor. Molecular Informatics 34:4, pages 216-227.
Crossref
Ankit Gupta, Bharat Ramasubramanian Iyer, Deepti Chaturvedi, Svetlana Rajkumar Maurya & Radhakrishnan Mahalakshmi. (2015) Thermodynamic, structural and functional properties of membrane protein inclusion bodies are analogous to purified counterparts: case study from bacteria and humans. RSC Advances 5:2, pages 1227-1234.
Crossref
Christofer S. Tautermann, Daniel Seeliger & Jan M. Kriegl. (2015) What can we learn from molecular dynamics simulations for GPCR drug design?. Computational and Structural Biotechnology Journal 13, pages 111-121.
Crossref
Abel Moreno & Ma Eugenia Mendoza. 2015. Handbook of Crystal Growth. Handbook of Crystal Growth 1277 1315 .
Christofer S. Tautermann. (2014) GPCR structures in drug design, emerging opportunities with new structures. Bioorganic & Medicinal Chemistry Letters 24:17, pages 4073-4079.
Crossref
Trayder Thomas, Kimberley C. McLean, Fiona M. McRobb, David T. Manallack, David K. Chalmers & Elizabeth Yuriev. (2013) Homology Modeling of Human Muscarinic Acetylcholine Receptors. Journal of Chemical Information and Modeling 54:1, pages 243-253.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.