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New methods for the discovery and synthesis of PDE7 inhibitors as new drugs for neurological and inflammatory disorders

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Pages 733-751 | Published online: 09 Apr 2013

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Ana Martinez & Carmen Gil. (2014) cAMP-specific phosphodiesterase inhibitors: promising drugs for inflammatory and neurological diseases. Expert Opinion on Therapeutic Patents 24:12, pages 1311-1321.
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Maria Gabriella Matera, Clive Page & Mario Cazzola. (2014) PDE inhibitors currently in early clinical trials for the treatment of asthma. Expert Opinion on Investigational Drugs 23:9, pages 1267-1275.
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Articles from other publishers (23)

Miaomiao Jiang, Weiheng Yan, Yuyanan Zhang, Zhe Lu, Tianlan Lu, Dai Zhang, Jun Li & Lifang Wang. (2023) Phosphodiesterase and psychiatric disorders: a two-sample Mendelian randomization study. Journal of Translational Medicine 21:1.
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Strahil Berkov, Mariyana Atanasova, Borislav Georgiev, Jaume Bastida & Irini Doytchinova. (2021) The Amaryllidaceae alkaloids: an untapped source of acetylcholinesterase inhibitors. Phytochemistry Reviews 21:5, pages 1415-1443.
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Naoyuki Obokata, Chie Seki, Takeshi Hirata, Jun Maeda, Hideki Ishii, Yuji Nagai, Takehiko Matsumura, Misae Takakuwa, Hajime Fukuda, Takafumi Minamimoto, Kazunori Kawamura, Ming-Rong Zhang, Tatsuo Nakajima, Takeaki Saijo & Makoto Higuchi. (2021) Synthesis and preclinical evaluation of [11C]MTP38 as a novel PET ligand for phosphodiesterase 7 in the brain. European Journal of Nuclear Medicine and Molecular Imaging 48:10, pages 3101-3112.
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Susan McQuown, Dean Paes, Karsten Baumgärtel, Jos Prickaerts & Marco Peters. (2021) Pharmacological inhibition of phosphodiesterase 7 enhances consolidation processes of spatial memory. Neurobiology of Learning and Memory 177, pages 107357.
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Maarten Ooms & Guy Bormans. 2021. PET and SPECT of Neurobiological Systems. PET and SPECT of Neurobiological Systems 851 877 .
Mayasah Y. Al-Nema & Anand Gaurav. (2020) Phosphodiesterase as a Target for Cognition Enhancement in Schizophrenia. Current Topics in Medicinal Chemistry 20:26, pages 2404-2421.
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Yingle Chen, Shunyuan Li, Xianmei Zhong, Zhenming Kang & Rulei Chen. (2020) PDE-7 Inhibitor BRL-50481 Reduces Neurodegeneration and Long-Term Memory Deficits in Mice Following Sevoflurane Exposure. ACS Chemical Neuroscience 11:9, pages 1353-1358.
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Chang Doo Lee, Won Seok Choi, Yong Geon Choi, Hyun Sik Kang, Wang Tae Lee, Hong Jo Kim & Ji-Yun Lee. (2020) Inhibition of phosphodiesterase suppresses allergic lung inflammation by regulating MCP-1 in an OVA-induced asthma murine model with co-exposure to lipopolysaccharide. Journal of International Medical Research 48:2, pages 030006052090366.
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Ling Cao, Weilong Zhang, Xiaoni Liu, Ping Yang, Jing Wang, Kai Hu, Xiuru Zhang, Weiyou Liu, Xue He, Hongmei Jing & Xiaoliang Yuan. (2019) The Prognostic Significance of PDE7B in Cytogenetically Normal Acute Myeloid Leukemia. Scientific Reports 9:1.
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Jesper Fogelholm, Samuel Inkabi, Andrey Höglund, Robin Abbey-Lee, Martin Johnsson, Per Jensen, Rie Henriksen & Dominic Wright. (2019) Genetical Genomics of Tonic Immobility in the Chicken. Genes 10:5, pages 341.
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Haoxiao Zuo, Isabella Cattani-Cavalieri, Nshunge Musheshe, Viacheslav O. Nikolaev & Martina Schmidt. (2019) Phosphodiesterases as therapeutic targets for respiratory diseases. Pharmacology & Therapeutics 197, pages 225-242.
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Adriana Lori, Stephanie A. Maddox, Sumeet Sharma, Raül Andero, Kerry J. Ressler & Alicia K. Smith. (2019) Dynamic Patterns of Threat-Associated Gene Expression in the Amygdala and Blood. Frontiers in Psychiatry 9.
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Fernando Bartolome, Macarena de la Cueva, Consuelo Pascual, Desiree Antequera, Tamara Fernandez, Carmen Gil, Ana Martinez & Eva Carro. (2018) Amyloid β-induced impairments on mitochondrial dynamics, hippocampal neurogenesis, and memory are restored by phosphodiesterase 7 inhibition. Alzheimer's Research & Therapy 10:1.
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Irini Doytchinova, Mariyana Atanasova, Georgi Stavrakov, Irena Philipova & Dimitrina Zheleva-Dimitrova. 2018. Computational Modeling of Drugs Against Alzheimer’s Disease. Computational Modeling of Drugs Against Alzheimer’s Disease 163 176 .
Anand Gaurav, Ming Xing & Mayasah Al‐Nema. 2017. Quantitative Structure-activity Relationship. Quantitative Structure-activity Relationship.
Georgi Stavrakov, Irena Philipova, Dimitrina Zheleva, Mariyana Atanasova, Spiro Konstantinov & Irini Doytchinova. (2016) Docking-based Design of Galantamine Derivatives with Dual-site Binding to Acetylcholinesterase. Molecular Informatics 35:6-7, pages 278-285.
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Elena Cichero, Chiara Brullo, Olga Bruno & Paola Fossa. (2016) Exhaustive 3D-QSAR analyses as a computational tool to explore the potency and selectivity profiles of thieno[3,2-d]pyrimidin-4(3H)-one derivatives as PDE7 inhibitors. RSC Advances 6:66, pages 61088-61108.
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David Thomae, Stijn Servaes, Naiara Vazquez, Leonie wyffels, Stefanie Dedeurwaerdere, Pieter Van der Veken, Jurgen Joossens, Koen Augustyns, Sigrid Stroobants & Steven Staelens. (2015) Synthesis and preclinical evaluation of an 18 F labeled PDE7 inhibitor for PET neuroimaging. Nuclear Medicine and Biology 42:12, pages 975-981.
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NORIKO YAMAMOTO, RIKA NISHIKAWA, TAKESHI CHIYOMARU, YUSUKE GOTO, ICHIRO FUKUMOTO, HIROKAZU USUI, AKIRA MITSUHASHI, HIDEKI ENOKIDA, MASAYUKI NAKAGAWA, MAKIO SHOZU & NAOHIKO SEKI. (2015) The tumor-suppressive microRNA-1/133a cluster targets PDE7A and inhibits cancer cell migration and invasion in endometrial cancer. International Journal of Oncology 47:1, pages 325-334.
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F Ahmad, T Murata, K Shimizu, E Degerman, D Maurice & V Manganiello. (2014) Cyclic Nucleotide Phosphodiesterases: important signaling modulators and therapeutic targets. Oral Diseases 21:1.
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Maria Gabriella Matera, Paola Rogliani, Luigino Calzetta & Mario Cazzola. (2014) Phosphodiesterase Inhibitors for Chronic Obstructive Pulmonary Disease: What Does the Future Hold?. Drugs 74:17, pages 1983-1992.
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Michael D. Brooks, Erin Jackson, Nicole M. Warrington, Jingqin Luo, Jason T. Forys, Sara Taylor, Diane D. Mao, Jeffrey R. Leonard, Albert H. Kim, David Piwnica-Worms, Robi D. Mitra & Joshua B. Rubin. (2014) PDE7B Is a Novel, Prognostically Significant Mediator of Glioblastoma Growth Whose Expression Is Regulated by Endothelial Cells. PLoS ONE 9:9, pages e107397.
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Ana I. Sánchez, Ricardo Meneses, José M. Mínguez, Araceli Núñez, Rafael R. Castillo, Fabiana Filace, Carolina Burgos, Juan J. Vaquero, Julio Álvarez-Builla, Alvaro Cortés-Cabrera, Federico Gago, Emma Terricabras & Víctor Segarra. (2014) Microwave-assisted synthesis of potent PDE7 inhibitors containing a thienopyrimidin-4-amine scaffold. Org. Biomol. Chem. 12:24, pages 4233-4242.
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