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Aldehyde oxidase and its importance in novel drug discovery: present and future challenges

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Pages 641-654 | Published online: 09 Apr 2013

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Yasuhiro Uno, Shotaro Uehara, Norie Murayama & Hiroshi Yamazaki. (2021) Genetic variants of aldehyde oxidase (AOX) 1 in cynomolgus and rhesus macaques. Xenobiotica 51:4, pages 494-499.
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Christine Beedham. (2020) Aldehyde oxidase; new approaches to old problems. Xenobiotica 50:1, pages 34-50.
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Narges Cheshmazar, Siavoush Dastmalchi, Mineko Terao, Enrico Garattini & Maryam Hamzeh-Mivehroud. (2019) Aldehyde oxidase at the crossroad of metabolism and preclinical screening. Drug Metabolism Reviews 51:4, pages 428-452.
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Mohammad-Reza Rashidi & Somaieh Soltani. (2017) An overview of aldehyde oxidase: an enzyme of emerging importance in novel drug discovery. Expert Opinion on Drug Discovery 12:3, pages 305-316.
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Jinping Gan, Shuguang Ma & Donglu Zhang. (2016) Non-cytochrome P450-mediated bioactivation and its toxicological relevance. Drug Metabolism Reviews 48:4, pages 473-501.
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Thomas A. Baillie, Deepak Dalvie, Ivonne M. C. M. Rietjens & S. Cyrus Khojasteh. (2016) Biotransformation and bioactivation reactions – 2015 literature highlights. Drug Metabolism Reviews 48:2, pages 113-138.
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Yazdan Maghsoud, Chao Dong & G. Andrés Cisneros. (2023) Computational Characterization of the Inhibition Mechanism of Xanthine Oxidoreductase by Topiroxostat. ACS Catalysis 13:9, pages 6023-6043.
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Yasuhiro Uno, Shotaro Uehara & Hiroshi Yamazaki. (2022) Drug-oxidizing and conjugating non-cytochrome P450 (non-P450) enzymes in cynomolgus monkeys and common marmosets as preclinical models for humans. Biochemical Pharmacology 197, pages 114887.
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Yohannes Teffera, Jingzhou Liu, Paul Krolikowski & Zhiyang Zhao. (2021) The Role of Aldehyde Oxidase in the Metabolic Clearance of Substituted Benzothiazoles. Drug Metabolism Letters 14:2, pages 126-136.
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Somaieh Soltani, Somayeh Hallaj-Nezhadi & Mohammad Reza Rashidi. (2021) A comprehensive review of in silico approaches for the prediction and modulation of aldehyde oxidase-mediated drug metabolism: The current features, challenges and future perspectives. European Journal of Medicinal Chemistry 222, pages 113559.
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Ji Hye Kim, Timothée Constantin, Marco Simonetti, Josep Llaveria, Nadeem S. Sheikh & Daniele Leonori. (2021) A radical approach for the selective C–H borylation of azines. Nature 595:7869, pages 677-683.
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Simon J. Mayr, Ralf-R. Mendel & Guenter Schwarz. (2021) Molybdenum cofactor biology, evolution and deficiency. Biochimica et Biophysica Acta (BBA) - Molecular Cell Research 1868:1, pages 118883.
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Pranav Shah, Vishal B. Siramshetty, Alexey V. Zakharov, Noel T. Southall, Xin Xu & Dac-Trung Nguyen. (2020) Predicting liver cytosol stability of small molecules. Journal of Cheminformatics 12:1.
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Yandi Zhang, Yu Yang, Guanwang Shen, Xueqin Mao, Mengyao Jiao & Ying Lin. (2020) Identification and Characterization of Aldehyde Oxidase 5 in the Pheromone Gland of the Silkworm (Lepidoptera: Bombycidae). Journal of Insect Science 20:6.
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Mineko Terao, Enrico Garattini, Maria João Romão & Silke Leimkühler. (2020) Evolution, expression, and substrate specificities of aldehyde oxidase enzymes in eukaryotes. Journal of Biological Chemistry 295:16, pages 5377-5389.
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Nenad Manevski, Lloyd King, William R. Pitt, Fabien Lecomte & Francesca Toselli. (2019) Metabolism by Aldehyde Oxidase: Drug Design and Complementary Approaches to Challenges in Drug Discovery. Journal of Medicinal Chemistry 62:24, pages 10955-10994.
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Shiyan Chen, Karl Austin-Muttitt, Linghua Harris Zhang, Jonathan G. L. Mullins & Aik Jiang Lau. (2019) In Vitro and In Silico Analyses of the Inhibition of Human Aldehyde Oxidase by Bazedoxifene, Lasofoxifene, and Structural Analogues. Journal of Pharmacology and Experimental Therapeutics 371:1, pages 75-86.
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Deepak Dalvie & Li Di. (2019) Aldehyde oxidase and its role as a drug metabolizing enzyme. Pharmacology & Therapeutics 201, pages 137-180.
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Jiarong Xie, Nur Fazilah Saburulla, Shiyan Chen, Siew Ying Wong, Ze Ping Yap, Linghua Harris Zhang & Aik Jiang Lau. (2019) Evaluation of Carbazeran 4-Oxidation and O 6 -Benzylguanine 8-Oxidation as Catalytic Markers of Human Aldehyde Oxidase: Impact of Cytosolic Contamination of Liver Microsomes . Drug Metabolism and Disposition 47:1, pages 26-37.
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Huadong Tang & Michael Mayersohn. (2018) Porcine Prediction of Pharmacokinetic Parameters in People: A Pig in a Poke?. Drug Metabolism and Disposition 46:11, pages 1712-1724.
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Cristiano Mota, Catarina Coelho, Silke Leimkühler, Enrico Garattini, Mineko Terao, Teresa Santos-Silva & Maria João Romão. (2018) Critical overview on the structure and metabolism of human aldehyde oxidase and its role in pharmacokinetics. Coordination Chemistry Reviews 368, pages 35-59.
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Naoki Takaoka, Seigo Sanoh, Katsuhiro Okuda, Yaichiro Kotake, Go Sugahara, Ami Yanagi, Yuji Ishida, Chise Tateno, Yoshitaka Tayama, Kazumi Sugihara, Shigeyuki Kitamura, Mami Kurosaki, Mineko Terao, Enrico Garattini & Shigeru Ohta. (2018) Inhibitory effects of drugs on the metabolic activity of mouse and human aldehyde oxidases and influence on drug–drug interactions. Biochemical Pharmacology 154, pages 28-38.
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Raj Kumar, Gaurav Joshi, Harveen Kler, Sourav Kalra, Manpreet Kaur & Ramandeep Arya. (2018) Toward an Understanding of Structural Insights of Xanthine and Aldehyde Oxidases: An Overview of their Inhibitors and Role in Various Diseases. Medicinal Research Reviews 38:4, pages 1073-1125.
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Priyadeep Bhutani, Senthilkumar Murugesan, Anoop Kumar, Murali Subramanian & Koiram Rajanna Prabhakar. (2018) Offline derivatization LC–MS/MS method for simultaneous estimation of vanillin and vanillic acid in guinea pig plasma. Bioanalysis 10:3, pages 131-142.
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David J. Wilkinson, Rosalind L. Southall, Mingguang Li, Lisa M. Wright, Lindsay J. Corfield, Thomas A. Heeley, Benjamin Bratby, Ranbir Mannu, Sarah L. Johnson, Victoria Shaw, Holly L. Friett, Louise A. Blakeburn, John S. Kendrick & Michael B. Otteneder. (2017) Minipig and Human Metabolism of Aldehyde Oxidase Substrates: In Vitro–In Vivo Comparisons. The AAPS Journal 19:4, pages 1163-1174.
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Ayman F. El-Kattan. 2017. Oral Bioavailability Assessment. Oral Bioavailability Assessment 35 76 .
Yuan Xu, Liang Li, Yulan Wang, Jing Xing, Lei Zhou, Dafang Zhong, Xiaomin Luo, Hualiang Jiang, Kaixian Chen, Mingyue Zheng, Pan Deng & Xiaoyan Chen. (2017) Aldehyde Oxidase Mediated Metabolism in Drug-like Molecules: A Combined Computational and Experimental Study. Journal of Medicinal Chemistry 60:7, pages 2973-2982.
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Maria João Romão, Catarina Coelho, Teresa Santos-Silva, Alessandro Foti, Mineko Terao, Enrico Garattini & Silke Leimkühler. (2017) Structural basis for the role of mammalian aldehyde oxidases in the metabolism of drugs and xenobiotics. Current Opinion in Chemical Biology 37, pages 39-47.
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Silke Leimkühler, Martin Bühning & Lena Beilschmidt. (2017) Shared Sulfur Mobilization Routes for tRNA Thiolation and Molybdenum Cofactor Biosynthesis in Prokaryotes and Eukaryotes. Biomolecules 7:4, pages 5.
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Maryam Hamzeh-Mivehroud, Seifullah Rahmani, Mohammad-Reza Rashidi & Siavoush Dastmalchi. (2016) Structural features of guinea pig aldehyde oxidase inhibitory activities of flavonoids explored using QSAR and molecular modeling studies. Medicinal Chemistry Research 25:12, pages 2773-2786.
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Tahereh Valadbeigi. (2016) Chemical Composition and Enzymes Inhibitory, Brine Shrimp Larvae Toxicity, Antimicrobial and Antioxidant Activities of Caloplaca biatorina. Zahedan Journal of Research in Medical Sciences In Press:In Press.
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Mineko Terao, Maria João Romão, Silke Leimkühler, Marco Bolis, Maddalena Fratelli, Catarina Coelho, Teresa Santos-Silva & Enrico Garattini. (2016) Structure and function of mammalian aldehyde oxidases. Archives of Toxicology 90:4, pages 753-780.
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