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Recent progress in the development of antagonists to the chemokine receptors CCR3 and CCR4

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Xin-Feng Zhang, Xiao-Li Zhang, Ya-Jing Wang, Yuan Fang, Meng-Li Li, Xing-Yu Liu, Hua-You Luo & Yan Tian. (2023) The regulatory network of the chemokine CCL5 in colorectal cancer. Annals of Medicine 55:1.
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Mauro Alaibac. (2017) Monoclonal antibodies against cutaneous T-cell lymphomas. Expert Opinion on Biological Therapy 17:12, pages 1503-1510.
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Articles from other publishers (51)

Hao Chai, Fangfang Xu, Jixia Wang, Yuxin Zhang, Xiaomin Xie, Han Zhou, Yanfang Liu, Xinmiao Liang & Aoxue Wang. (2023) Profiling CCR3 target pathways for discovering novel antagonists from natural products using label-free cell phenotypic assays. Chemico-Biological Interactions 385, pages 110732.
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Jinxin Miao, Tianfeng Lan, Haoran Guo, Jianyao Wang, Guangtao Zhang, Zheng Wang, Panpan Yang, Haoze Li, Chunyang Zhang, Yaohe Wang, Xiu‐Min Li & Mingsan Miao. (2022) Characterization of SHARPIN knockout Syrian hamsters developed using CRISPR /Cas9 system . Animal Models and Experimental Medicine 6:5, pages 489-498.
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Vithi Hitendra Patel, Srijani Thannir, Maulik Dhanani, Ivan Augustine, S. L Sandeep, Abdulrahim Mehadi, Chaithanya Avanthika & Sharan Jhaveri. (2023) Current Limitations and Recent Advances in the Management of Asthma. Disease-a-Month 69:7, pages 101483.
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Luisa Hueso, Patrice Marques, Brenda Morant, Herminia Gonzalez-Navarro, Joaquin Ortega, José T. Real, María J Sanz & Laura Piqueras. (2023) CCL17 and CCL22 chemokines are upregulated in human obesity and play a role in vascular dysfunction. Frontiers in Endocrinology 14.
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Jinjin Wang, Liheng Bian, Yang Du, Dandan Wang, Ruixuan Jiang, Jingjing Lu & Xingquan Zhao. (2023) The roles of chemokines following intracerebral hemorrhage in animal models and humans. Frontiers in Molecular Neuroscience 15.
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Surya K. De. 2023. Medicines for Cancer. Medicines for Cancer 413 458 .
Sisi Chen, Gaoying Chen, Fang Xu, Beibei Sun, Xinyi Chen, Wei Hu, Fei Li, Madiha Zahra Syeda, Haixia Chen, Youqian Wu, Peng Wu, Ruirui Jing, Xinwei Geng, Lingling Zhang, Longguang Tang, Wen Li, Zhihua Chen, Chao Zhang, Jie Sun, Wei Chen, Huahao Shen & Songmin Ying. (2022) Treatment of allergic eosinophilic asthma through engineered IL-5-anchored chimeric antigen receptor T cells. Cell Discovery 8:1.
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Peter J. Barnes. (2022) Chemokine receptor CCR1: new target for asthma therapy. Trends in Pharmacological Sciences 43:7, pages 539-541.
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Zhehua Shao, Yangxia Tan, Qingya Shen, Li Hou, Bingpeng Yao, Jiao Qin, Peiyu Xu, Chunyou Mao, Li-Nan Chen, Huibing Zhang, Dan-Dan Shen, Chao Zhang, Weijie Li, Xufei Du, Fei Li, Zhi-Hua Chen, Yi Jiang, H. Eric Xu, Songmin Ying, Honglei Ma, Yan Zhang & Huahao Shen. (2022) Molecular insights into ligand recognition and activation of chemokine receptors CCR2 and CCR3. Cell Discovery 8:1.
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Jaqueline Raymondi Silva, Mircea Iftinca, Francisco I. Fernandes Gomes, Julia P. Segal, Olivia M. A. Smith, Courtney A. Bannerman, Atlante Silva Mendes, Manon Defaye, Madeline E. C. Robinson, Ian Gilron, Thiago Mattar Cunha, Christophe Altier & Nader Ghasemlou. (2022) Skin-resident dendritic cells mediate postoperative pain via CCR4 on sensory neurons. Proceedings of the National Academy of Sciences 119:4.
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Julien Catherine & Florence Roufosse. (2021) What does elevated TARC/CCL17 expression tell us about eosinophilic disorders?. Seminars in Immunopathology 43:3, pages 439-458.
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Herman D. Lim, J. Robert Lane, Meritxell Canals & Martin J. Stone. (2021) Systematic Assessment of Chemokine Signaling at Chemokine Receptors CCR4, CCR7 and CCR10. International Journal of Molecular Sciences 22:8, pages 4232.
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Adrien Guérard, Victor Laurent, Gaëlle Fromont, David Estève, Julia Gilhodes, Edith Bonnelye, Sophie Le Gonidec, Philippe Valet, Bernard Malavaud, Nicolas Reina, Camille Attané & Catherine Muller. (2021) The Chemokine Receptor CCR3 Is Potentially Involved in the Homing of Prostate Cancer Cells to Bone: Implication of Bone-Marrow Adipocytes. International Journal of Molecular Sciences 22:4, pages 1994.
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So Jin Bing, Phyllis B. Silver, Yingyos Jittayasothorn, Mary J. Mattapallil, Chi-Chao Chan, Reiko Horai & Rachel R. Caspi. (2020) Autoimmunity to neuroretina in the concurrent absence of IFN-γ and IL-17A is mediated by a GM-CSF-driven eosinophilic inflammation. Journal of Autoimmunity 114, pages 102507.
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Omar Robles, Jeffrey J. Jackson, Lisa Marshall, Oezcan Talay, David Chian, Gene Cutler, Raymond Diokno, Dennis X. Hu, Scott Jacobson, Emily Karbarz, Paul D. Kassner, John M. Ketcham, Jenny McKinnell, Cesar Meleza, Maureen K. Reilly, Erin Riegler, Hunter P. Shunatona, Angela Wadsworth, Ashkaan Younai, Dirk G. Brockstedt, David J. Wustrow & Mikhail Zibinsky. (2020) Novel Piperidinyl-Azetidines as Potent and Selective CCR4 Antagonists Elicit Antitumor Response as a Single Agent and in Combination with Checkpoint Inhibitors. Journal of Medicinal Chemistry 63:15, pages 8584-8607.
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Joanna Bogacka, Katarzyna Ciapała, Katarzyna Pawlik, Jan Dobrogowski, Anna Przeklasa-Muszynska & Joanna Mika. (2020) Blockade of CCR4 Diminishes Hypersensitivity and Enhances Opioid Analgesia – Evidence from a Mouse Model of Diabetic Neuropathy. Neuroscience 441, pages 77-92.
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Li Wang, Wei Qin, Yu-Jia Huo, Xiao Li, Qing Shi, John E. J. Rasko, Anne Janin & Wei-Li Zhao. (2020) Advances in targeted therapy for malignant lymphoma. Signal Transduction and Targeted Therapy 5:1.
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Stacy Gelhaus Wendell, Hao Fan & Cheng Zhang. (2019) G Protein–Coupled Receptors in Asthma Therapy: Pharmacology and Drug Action. Pharmacological Reviews 72:1, pages 1-49.
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Jeffrey J. Jackson, John M. Ketcham, Ashkaan Younai, Betty Abraham, Berenger Biannic, Hilary P. Beck, Minna H. T. Bui, David Chian, Gene Cutler, Raymond Diokno, Dennis X. Hu, Scott Jacobson, Emily Karbarz, Paul D. Kassner, Lisa Marshall, Jenny McKinnell, Cesar Meleza, Abood Okal, Deepa Pookot, Maureen K. Reilly, Omar Robles, Hunter P. Shunatona, Oezcan Talay, James R. Walker, Angela Wadsworth, David J. Wustrow & Mikhail Zibinsky. (2019) Discovery of a Potent and Selective CCR4 Antagonist That Inhibits T reg Trafficking into the Tumor Microenvironment . Journal of Medicinal Chemistry 62:13, pages 6190-6213.
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Maria E. Kavanagh, Melissa J. Conroy, Niamh E. Clarke, Niamh T. Gilmartin, Ronan Feighery, Finbar MacCarthy, Dermot O’Toole, Narayanasamy Ravi, John V. Reynolds, Jacintha O’ Sullivan & Joanne Lysaght. (2019) Altered T Cell Migratory Capacity in the Progression from Barrett Oesophagus to Oesophageal Adenocarcinoma. Cancer Microenvironment 12:1, pages 57-66.
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James E. Pease & Timothy J. Williams. (2019) Tipping the balance: A biased nanobody antagonist of CCR3 with potential for the treatment of eosinophilic inflammation. Journal of Allergy and Clinical Immunology 143:2, pages 552-553.
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Milica Grozdanovic, Kimberly G. Laffey, Hazem Abdelkarim, Ben Hitchinson, Anantha Harijith, Hyung-Geon Moon, Gye Young Park, Lee K. Rousslang, Joanne C. Masterson, Glenn T. Furuta, Nadya I. Tarasova, Vadim Gaponenko & Steven J. Ackerman. (2019) Novel peptide nanoparticle–biased antagonist of CCR3 blocks eosinophil recruitment and airway hyperresponsiveness. Journal of Allergy and Clinical Immunology 143:2, pages 669-680.e12.
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Kim A. T. Verheijden, Saskia Braber, Thea Leusink-Muis, Prescilla V. Jeurink, Suzan Thijssen, Aletta D. Kraneveld, Johan Garssen, Gert Folkerts & Linette E. M. Willemsen. (2018) The Combination Therapy of Dietary Galacto-Oligosaccharides With Budesonide Reduces Pulmonary Th2 Driving Mediators and Mast Cell Degranulation in a Murine Model of House Dust Mite Induced Asthma. Frontiers in Immunology 9.
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H. Hönigsmann. (2018) Commentary to “Mogamulizumab-induced photosensitivity in patients with mycosis fungoides and other T-cell neoplasms” by Y. Masuda et al . . Journal of the European Academy of Dermatology and Venereology 32:10, pages 1626-1626.
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Peter J. Barnes. (2018) Targeting cytokines to treat asthma and chronic obstructive pulmonary disease. Nature Reviews Immunology 18:7, pages 454-466.
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Kathryn DeFea. (2018) Arresting CCR4: A New Look at an Old Approach to Combating Asthma. American Journal of Respiratory Cell and Molecular Biology 58:6, pages 673-675.
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James E. Pease & Timothy J. Williams. (2018) Eosinophils on trial. Clinical & Experimental Allergy 48:5, pages 490-492.
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Yanzhuo Song, Baosheng Ge, Jun Lao, Zhencai Wang, Bin Yang, Xiaojuan Wang, Hua He, Jiqiang Li & Fang Huang. (2017) Regulation of the Oligomeric Status of CCR3 with Binding Ligands Revealed by Single-Molecule Fluorescence Imaging. Biochemistry 57:5, pages 852-860.
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Priscila M. Ferri, Ana C. Simões e Silva, Karen C.L. Torres, Soraya L.C. Silva, Diego J.Q. Aquino, Maria L.M. Ferreira, Eleonora D.T. Fagundes, Débora M. Miranda & Alexandre R. Ferreira. (2018) Autoimmune Hepatitis and Autoimmune Hepatitis Overlap With Sclerosing Cholangitis: Immunophenotype Markers in Children and Adolescents. Journal of Pediatric Gastroenterology & Nutrition 66:2, pages 204-211.
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Dan-Dan Liu, Xiu-Yun Song, Peng-Fei Yang, Qi-Di Ai, Ying-Ying Wang, Xiao-Ye Feng, Xin He & Nai-Hong Chen. (2018) Progress in pharmacological research of chemokine like factor 1 (CKLF1). Cytokine 102, pages 41-50.
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Timothy John Williams & James Edward Pease. 2018. Encyclopedia of Signaling Molecules. Encyclopedia of Signaling Molecules 1554 1558 .
Stefanie Scheu, Shafaqat Ali, Christina Ruland, Volker Arolt & Judith Alferink. (2017) The C-C Chemokines CCL17 and CCL22 and Their Receptor CCR4 in CNS Autoimmunity. International Journal of Molecular Sciences 18:11, pages 2306.
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Afjal H. Miah, Aurelie C. Champigny, Rebecca H. Graves, Simon T. Hodgson, Jonathan M. Percy & Panayiotis A. Procopiou. (2017) Identification of pyrazolopyrimidine arylsulfonamides as CC-chemokine receptor 4 (CCR4) antagonists. Bioorganic & Medicinal Chemistry 25:20, pages 5327-5340.
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Zhi-Jun Zhang, Bao-Chun Jiang & Yong-Jing Gao. (2017) Chemokines in neuron–glial cell interaction and pathogenesis of neuropathic pain. Cellular and Molecular Life Sciences 74:18, pages 3275-3291.
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Elin Kindstedt, Cecilia Koskinen Holm, Rima Sulniute, Irene Martinez-Carrasco, Richard Lundmark & Pernilla Lundberg. (2017) CCL11, a novel mediator of inflammatory bone resorption. Scientific Reports 7:1.
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Brooke I. Polk & Lanny J. Rosenwasser. (2017) Biological Therapies of Immunologic Diseases. Immunology and Allergy Clinics of North America 37:2, pages 247-259.
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Dae Jin SongMun Hee ShimNahyun LeeYoung YooJi Tae Choung. (2017) CCR3 Monoclonal Antibody Inhibits Eosinophilic Inflammation and Mucosal Injury in a Mouse Model of Eosinophilic Gastroenteritis. Allergy, Asthma & Immunology Research 9:4, pages 360.
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Jianmin Zhang, Huaishan Wang, Omar Sherbini, Emily Ling-lin Pai, Sung-Ung Kang, Ji-Sun Kwon, Jia Yang, Wei He, Hong Wang, Stephen M. Eacker, Zhikai Chi, Xiaobo Mao, Jinchong Xu, Haisong Jiang, Shaida A. Andrabi, Ted M. Dawson & Valina L. Dawson. (2016) High-Content Genome-Wide RNAi Screen Reveals CCR3 as a Key Mediator of Neuronal Cell Death . eneuro 3:5, pages ENEURO.0185-16.2016.
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Toshio Morikawa, Ikuko Hachiman, Kazuhiko Matsuo, Eriko Nishida, Kiyofumi Ninomiya, Takao Hayakawa, Osamu Yoshie, Osamu Muraoka & Takashi Nakayama. (2016) Neolignans from the Arils of Myristica fragrans as Potent Antagonists of CC Chemokine Receptor 3 . Journal of Natural Products 79:8, pages 2005-2013.
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Min Tian, Lina Chen, Li Ma, Dandan Wang, Bin Shao, Jianyu Wu, Hangyu Wu & Yimin Jin. (2016) Expression and prognostic significance of CCL11/CCR3 in glioblastoma. Oncotarget 7:22, pages 32617-32627.
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Susan L. Baldwin, Valerie A. Reese, Po-wei D. Huang, Elyse A. Beebe, Brendan K. Podell, Steven G. Reed & Rhea N. Coler. (2016) Protection and Long-Lived Immunity Induced by the ID93/GLA-SE Vaccine Candidate against a Clinical Mycobacterium tuberculosis Isolate. Clinical and Vaccine Immunology 23:2, pages 137-147.
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Leena George & Christopher E. Brightling. (2015) Eosinophilic airway inflammation: role in asthma and chronic obstructive pulmonary disease. Therapeutic Advances in Chronic Disease 7:1, pages 34-51.
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Zoltán Szekanecz & Alisa E. Koch. (2015) Successes and failures of chemokine-pathway targeting in rheumatoid arthritis. Nature Reviews Rheumatology 12:1, pages 5-13.
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Timothy John Williams & James Edward Pease. 2017. Encyclopedia of Signaling Molecules. Encyclopedia of Signaling Molecules 1 5 .
Roberto Solari & James E. Pease. (2015) Targeting chemokine receptors in disease ? a case study of CCR4. European Journal of Pharmacology 763, pages 169-177.
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Osamu Yoshie & Kouji Matsushima. (2015) CCR4 and its ligands: from bench to bedside. International Immunology 27:1, pages 11-20.
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Changdev G. Gadhe & Mi-hyun Kim. (2015) Insights into the binding modes of CC chemokine receptor 4 (CCR4) inhibitors: a combined approach involving homology modelling, docking, and molecular dynamics simulation studies. Molecular BioSystems 11:2, pages 618-634.
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Roberto Solari, James E. Pease & Malcolm Begg. (2015) “Chemokine receptors as therapeutic targets: Why aren’t there more drugs?”. European Journal of Pharmacology 746, pages 363-367.
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Jan M. Kriegl, Domnic Martyres, Marc A. Grundl, Ralf Anderskewitz, Horst Dollinger, Georg Rast, Bernhard Schmid, Peter Seither & Christofer S. Tautermann. (2015) Rodent selectivity of piperidine-4-yl-1H-indoles, a series of CC chemokine receptor-3 (CCR3) antagonists: Insights from a receptor model. Bioorganic & Medicinal Chemistry Letters 25:2, pages 229-235.
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Masao Nakagawa, Roland Schmitz, Wenming Xiao, Carolyn K. Goldman, Weihong Xu, Yandan Yang, Xin Yu, Thomas A. Waldmann & Louis M. Staudt. (2014) Gain-of-function CCR4 mutations in adult T cell leukemia/lymphoma . Journal of Experimental Medicine 211:13, pages 2497-2505.
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L. Pelletier, N. Rosa & M. Savignac. (2014) La singularit? de la signalisation calcique dans les lymphocytes?: possibles implications th?rapeutiques dans l?allergie. Revue Fran?aise d'Allergologie 54:7, pages 519-528.
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