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Novel techniques in the development of osteoporosis drug therapy: the osteoclast ruffled-border vacuolar H+-ATPase as an emerging target

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Luigi Gennari, Daniela Merlotti, Alberto Falchetti, Cristina Eller Vainicher, Roberta Cosso & Iacopo Chiodini. (2020) Emerging therapeutic targets for osteoporosis. Expert Opinion on Therapeutic Targets 24:2, pages 115-130.
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Luigi Gennari & John P. Bilezikian. (2018) New and developing pharmacotherapy for osteoporosis in men. Expert Opinion on Pharmacotherapy 19:3, pages 253-264.
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Luigi Gennari, Stefano Rotatori, Simone Bianciardi, Stefano Gonnelli, Ranuccio Nuti & Daniela Merlotti. (2015) Appropriate models for novel osteoporosis drug discovery and future perspectives. Expert Opinion on Drug Discovery 10:11, pages 1201-1216.
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Jialong Hou, Jian Liu, Zhixian Huang, Yining Wang, Hanbing Yao, Zhenxin Hu, Chengge Shi, Jiake Xu & Qingqing Wang. (2023) Structure and function of the membrane microdomains in osteoclasts. Bone Research 11:1.
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Qian Zhang, Jirong Yang, Nan Hu, Juan Liu, Huan Yu, Haobo Pan, Di Chen & Changshun Ruan. (2023) Small-molecule amines: a big role in the regulation of bone homeostasis. Bone Research 11:1.
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Hanlin Wang & John L. Rubinstein. (2023) CryoEM of V-ATPases: Assembly, disassembly, and inhibition. Current Opinion in Structural Biology 80, pages 102592.
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Natalia Semenova, Olga Shatokhina, Olga Shchagina, Elena Kamenec, Andrey Marakhonov, Anna Degtyareva, Natalia Taran & Tatiana Strokova. (2023) Clinical Presentation of a Patient with a Congenital Disorder of Glycosylation, Type IIs (ATP6AP1), and Liver Transplantation. International Journal of Molecular Sciences 24:8, pages 7449.
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Anh Chu, Yeqi Yao, Golam T. Saffi, Ji Hyun Chung, Roberto J. Botelho, Miroslawa Glibowicka, Charles M. Deber & Morris F. Manolson. (2023) Characterization of a PIP Binding Site in the N-Terminal Domain of V-ATPase a4 and Its Role in Plasma Membrane Association. International Journal of Molecular Sciences 24:5, pages 4867.
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Ari Elson, Anuj Anuj, Maayan Barnea-Zohar & Nina Reuven. (2022) The origins and formation of bone-resorbing osteoclasts. Bone 164, pages 116538.
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Kristine A. Keon, Samir Benlekbir, Susanne H. Kirsch, Rolf Müller & John L. Rubinstein. (2022) Cryo-EM of the Yeast V O Complex Reveals Distinct Binding Sites for Macrolide V-ATPase Inhibitors . ACS Chemical Biology 17:3, pages 619-628.
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Cátia Santos‐Pereira, Lígia R. Rodrigues & Manuela Côrte‐Real. (2021) Emerging insights on the role of V‐ATPase in human diseases: Therapeutic challenges and opportunities. Medicinal Research Reviews 41:4, pages 1927-1964.
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Carolyn Morris & Michael J. O'Donnell. (2021) Vacuolar H+-ATPase and Na+/K+-ATPase energize Na+ uptake mechanisms in the nuchal organ of the hyperregulating freshwater crustacean Daphnia magna . Journal of Experimental Biology 224:12.
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Pingmei Zeng, Yao Fu, Yichuan Pang, Tian He, Yuanyuan Wu, Ruikang Tang, An Qin & Xueqian Kong. (2021) Solid-State Nuclear Magnetic Resonance Identifies Abnormal Calcium Phosphate Formation in Diseased Bones. ACS Biomaterials Science & Engineering 7:3, pages 1159-1168.
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Binhua Zou, Jiehuang Zheng, Wende Deng, Yanhui Tan, Ligang Jie, Yuan Qu, Qin Yang, Minhong Ke, Zongbao Ding, Yan Chen, Qinghong Yu & Xiaojuan Li. (2021) Kirenol inhibits RANKL-induced osteoclastogenesis and prevents ovariectomized-induced osteoporosis via suppressing the Ca2+-NFATc1 and Cav-1 signaling pathways. Phytomedicine 80, pages 153377.
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Stephan Wilkens, Rebecca A. Oot, Md. Murad Khan & Kassidy Zimmer. 2021. Encyclopedia of Biological Chemistry III. Encyclopedia of Biological Chemistry III 581 593 .
Qiaoyun Song, Bo Meng, Haidong Xu & Zixu Mao. (2020) The emerging roles of vacuolar-type ATPase-dependent Lysosomal acidification in neurodegenerative diseases. Translational Neurodegeneration 9:1.
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Laura Gambari, Francesco Grassi, Livia Roseti, Brunella Grigolo & Giovanna Desando. (2020) Learning from Monocyte-Macrophage Fusion and Multinucleation: Potential Therapeutic Targets for Osteoporosis and Rheumatoid Arthritis. International Journal of Molecular Sciences 21:17, pages 6001.
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Peter Göttle, Moritz Förster, Joel Gruchot, David Kremer, Hans Peter Hartung, Hervé Perron & Patrick Küry. (2019) Rescuing the negative impact of human endogenous retrovirus envelope protein on oligodendroglial differentiation and myelination. Glia 67:1, pages 160-170.
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Sahithi Pamarthy, Arpita Kulshrestha, Gajendra K. Katara & Kenneth D. Beaman. (2018) The curious case of vacuolar ATPase: regulation of signaling pathways. Molecular Cancer 17:1.
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Soung-Hun Roh, Nicholas J. Stam, Corey F. Hryc, Sergio Couoh-Cardel, Grigore Pintilie, Wah Chiu & Stephan Wilkens. (2018) The 3.5-Å CryoEM Structure of Nanodisc-Reconstituted Yeast Vacuolar ATPase Vo Proton Channel. Molecular Cell 69:6, pages 993-1004.e3.
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Rebecca A. Oot, Sergio Couoh-Cardel, Stuti Sharma, Nicholas J. Stam & Stephan Wilkens. (2017) Breaking up and making up: The secret life of the vacuolar H + -ATPase . Protein Science 26:5, pages 896-909.
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Stuti Sharma & Stephan Wilkens. (2017) Biolayer interferometry of lipid nanodisc-reconstituted yeast vacuolar H + -ATPase . Protein Science 26:5, pages 1070-1079.
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Nicholas J. Stam & Stephan Wilkens. (2017) Structure of the Lipid Nanodisc-reconstituted Vacuolar ATPase Proton Channel. Journal of Biological Chemistry 292:5, pages 1749-1761.
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Bin'en Nie, Teng Long, Haiyong Ao, Jianliang Zhou, Tingting Tang & Bing Yue. (2017) Covalent Immobilization of Enoxacin onto Titanium Implant Surfaces for Inhibiting Multiple Bacterial Species Infection and In Vivo Methicillin-Resistant Staphylococcus aureus Infection Prophylaxis . Antimicrobial Agents and Chemotherapy 61:1.
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Rebecca A Oot, Patricia M Kane, Edward A Berry & Stephan Wilkens. (2016) Crystal structure of yeast V 1 ‐ ATP ase in the autoinhibited state . The EMBO Journal 35:15, pages 1694-1706.
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Sipin Zhu, Sarah L. Rea, Taksum Cheng, Hao Tian Feng, John P. Walsh, Thomas Ratajczak, Jennifer Tickner, Nathan Pavlos, Hua‐Zi Xu & Jiake Xu. (2015) Bafilomycin A1 Attenuates Osteoclast Acidification and Formation, Accompanied by Increased Levels of SQSTM1/p62 Protein. Journal of Cellular Biochemistry 117:6, pages 1464-1470.
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Norbert Kartner & Morris F. Manolson. 2016. Regulation of Ca2+-ATPases,V-ATPases and F-ATPases. Regulation of Ca2+-ATPases,V-ATPases and F-ATPases 407 437 .
Sergio Couoh-Cardel, Elena Milgrom & Stephan Wilkens. (2015) Affinity Purification and Structural Features of the Yeast Vacuolar ATPase Vo Membrane Sector. Journal of Biological Chemistry 290:46, pages 27959-27971.
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