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Drug Discovery Case History

Fluoxetine: a case history of its discovery and preclinical development

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Yitao He, Hui Zhang, Jian Deng, Zhili Cai, Mei Gu, Chenyong Zhao & Yi Guo. (2021) The functions of fluoxetine and identification of fluoxetine-mediated circular RNAs and messenger RNAs in cerebral ischemic stroke. Bioengineered 12:1, pages 2364-2376.
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George Konstantakopoulos, Stefanos Dimitrakopoulos & Panayiota G. Michalopoulou. (2020) The preclinical discovery and development of agomelatine for the treatment of depression. Expert Opinion on Drug Discovery 15:10, pages 1121-1132.
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Liuliu Jiang, Linxia Zheng, K airui Sun, Peng Zhou, Rui Xu, Jingyi Gu & Xin Wei. (2020) In vitro and in vivo evaluation of the antifungal activity of fluoxetine combined with antifungals against Candida albicans biofilms and oral candidiasis. Biofouling 36:5, pages 537-548.
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Daniel J. Clauw, Yvonne D’Arcy, Kevin Gebke, David Semel, Lynne Pauer & Kim D. Jones. (2018) Normalizing fibromyalgia as a chronic illness. Postgraduate Medicine 130:1, pages 9-18.
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Xiang Li, Dan Feng, Shenglu Ma, Mingxing Li, Shulei Zhao & Man Tang. (2024) Ventral hippocampus is more sensitive to fluoxetine-induced changes in extracellular 5-HT concentration, membrane 5-HT transporter level and immobility times. Neuropharmacology 242, pages 109766.
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Aiting Chen, Yanping Wei, Du Tuo, Chuanqin Zhou, Shuting Shi, Nana Tang, Quanguo He & Jun Liu. (2024) Submicromolar electrochemical sensing platform for fast Fluoxetine quantification based on Nb2CTx MXene and nitrogen-doped graphene oxide nanocomposites. Journal of Alloys and Compounds 970, pages 172557.
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Shimeng Lv, Guangheng Zhang, Yufei Huang, Jiamin Li, Ni Yang, Yitong Lu, Haoteng Ma, Yuexiang Ma & Jing Teng. (2023) Antidepressant pharmacological mechanisms: focusing on the regulation of autophagy. Frontiers in Pharmacology 14.
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Lu Qin, Xin Liang, Yingqiang Qi, Yanmin Luo, Qian Xiao, Dujuan Huang, Chunni Zhou, Lin Jiang, Mei Zhou, Yuning Zhou, Jing Tang & Yong Tang. (2023) MPFC PV+ interneurons are involved in the antidepressant effects of running exercise but not fluoxetine therapy. Neuropharmacology 238, pages 109669.
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