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Discovery and development of purine-scaffold Hsp90 inhibitors

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Pages 99-114 | Published online: 19 Dec 2007

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Ghassan Abu Sheikha, Mahmoud A. Al-Sha’er & Mutasem O. Taha. (2011) Some sulfonamide drugs inhibit ATPase activity of heat shock protein 90: investigation by docking simulation and experimental validation. Journal of Enzyme Inhibition and Medicinal Chemistry 26:5, pages 603-609.
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Stanislav S. Shatokhin, Vladislav A. Tuskaev, Svetlana Ch. Gagieva, Alina A. Markova, Dmitry I. Pozdnyakov, Gleb L. Denisov, Elizaveta K. Melnikova, Boris M. Bulychev & Eduard T. Oganesyan. (2022) Synthesis, cytotoxicity and antioxidant activity of new 1,3-dimethyl-8-(chromon-3-yl)-xanthine derivatives containing 2,6-di- tert -butylphenol fragments . New Journal of Chemistry 46:2, pages 621-631.
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Carlos Sanchez-Martin, Stefano A. Serapian, Giorgio Colombo & Andrea Rasola. (2020) Dynamically Shaping Chaperones. Allosteric Modulators of HSP90 Family as Regulatory Tools of Cell Metabolism in Neoplastic Progression. Frontiers in Oncology 10.
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Joseph Berei, Adam Eckburg, Edward Miliavski, Austin D. Anderson, Rachel J. Miller, Joshua Dein, Allison M. Giuffre, Diana Tang, Shreya Deb, Kavya Sri Racherla, Meet Patel, Monica Saravana Vela & Neelu Puri. (2020) Potential Telomere-Related Pharmacological Targets. Current Topics in Medicinal Chemistry 20:6, pages 458-484.
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David Bickel & Holger Gohlke. (2019) C-terminal modulators of heat shock protein of 90 kDa (HSP90): State of development and modes of action. Bioorganic & Medicinal Chemistry 27:21, pages 115080.
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Giovanna Speranza, Larry Anderson, Alice P. Chen, Khanh Do, Michelle Eugeni, Marcie Weil, Larry Rubinstein, Eva Majerova, Jerry Collins, Yvonne Horneffer, Lamin Juwara, Jennifer Zlott, Rachel Bishop, Barbara A. Conley, Howard Streicher, Joseph Tomaszewski, James H. Doroshow & Shivaani Kummar. (2017) First-in-human study of the epichaperome inhibitor PU-H71: clinical results and metabolic profile. Investigational New Drugs 36:2, pages 230-239.
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Liang Yan, Weiming Zhang, Beibei Zhang, Chao Xuan & Daogang Wang. (2017) BIIB021: A novel inhibitor to heat shock protein 90–addicted oncology. Tumor Biology 39:4, pages 101042831769835.
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Younghyun Lee, Huizi Keiko Li, Aya Masaoka, Shigeaki Sunada, Hirokazu Hirakawa, Akira Fujimori, Jac A. Nickoloff & Ryuichi Okayasu. (2016) The purine scaffold Hsp90 inhibitor PU-H71 sensitizes cancer cells to heavy ion radiation by inhibiting DNA repair by homologous recombination and non-homologous end joining. Radiotherapy and Oncology 121:1, pages 162-168.
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Dianrong Li, Chao Li, Lin Li, She Chen, Lei Wang, Qiang Li, Xiaodong Wang, Xiaoguang Lei & Zhirong Shen. (2016) Natural Product Kongensin A is a Non-Canonical HSP90 Inhibitor that Blocks RIP3-dependent Necroptosis. Cell Chemical Biology 23:2, pages 257-266.
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Nasim Shams, Mohammad Hossein Mosslemin & Hossein Anaraki-Ardakani. (2015) An Efficient Synthesis of Bis-Purine Derivatives by a PPh 3 -catalysed Double Addition of Dialkylated Xanthine Derivatives to Alkyl Propiolates . Journal of Chemical Research 39:9, pages 499-501.
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Francesco Massari, Chiara Ciccarese, Antonio Bentito Porcaro, Stefano Ferrero, Giacomo Gazzano, Walter Artibani, Alessandra Modena, Emilio Bria, Teodoro Sava, Anna Caliò, Giacomo Novara, Vincenzo Ficarra, Marco Chilosi, Guido Martignoni, Silvano Bosari, Liang Cheng, Giampaolo Tortora & Matteo Brunelli. (2014) Quantitative score modulation of HSP90 and HSP27 in clear cell renal cell carcinoma. Pathology 46:6, pages 523-526.
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K P Callahan, M Minhajuddin, C Corbett, E D Lagadinou, R M Rossi, V Grose, M M Balys, L Pan, S Jacob, A Frontier, M R Grever, D M Lucas, A D Kinghorn, J L Liesveld, M W Becker & C T Jordan. (2014) Flavaglines target primitive leukemia cells and enhance anti-leukemia drug activity. Leukemia 28:10, pages 1960-1968.
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TATSUYA SEGAWA, YOSHIHIRO FUJII, AYA TANAKA, SHIN-ICHI BANDO, RYUICHI OKAYASU, KEN OHNISHI & NOBUO KUBOTA. (2014) Radiosensitization of human lung cancer cells by the novel purine-scaffold Hsp90 inhibitor, PU-H71. International Journal of Molecular Medicine 33:3, pages 559-564.
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Pallav D Patel, Pengrong Yan, Paul M Seidler, Hardik J Patel, Weilin Sun, Chenghua Yang, Nanette S Que, Tony Taldone, Paola Finotti, Ralph A Stephani, Daniel T Gewirth & Gabriela Chiosis. (2013) Paralog-selective Hsp90 inhibitors define tumor-specific regulation of HER2. Nature Chemical Biology 9:11, pages 677-684.
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Atul Manvar & Anamik Shah. (2013) Microwave-assisted chemistry of purines and xanthines. An overview. Tetrahedron 69:38, pages 8105-8127.
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Mahmoud A. Al-Sha’er & Mutasem O. Taha. (2012) Application of docking-based comparative intermolecular contacts analysis to validate Hsp90α docking studies and subsequent in silico screening for inhibitors. Journal of Molecular Modeling 18:11, pages 4843-4863.
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Flora Zagouri, Evangelos Bournakis, Konstantinos Koutsoukos & Christos A. Papadimitriou. (2012) Heat Shock Protein 90 (Hsp90) Expression and Breast Cancer. Pharmaceuticals 5:9, pages 1008-1020.
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Sophie E. Jackson. 2013. Molecular Chaperones. Molecular Chaperones 155 240 .
Ramadevi Sanam, Sunita Tajne, Rambabu Gundla, S. Vadivelan, Pavan Kumar Machiraju, Raveendra Dayam, Lakshmi Narasu, Sarma Jagarlapudi & Nouri Neamati. (2010) Combined pharmacophore and structure-guided studies to identify diverse HSP90 inhibitors. Journal of Molecular Graphics and Modelling 28:6, pages 472-477.
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Sofia Barluenga, Jean-Gonzague Fontaine, Cuihua Wang, Kais Aouadi, Ruihong Chen, Kristin Beebe, Len Neckers & Nicolas Winssinger. (2009) Inhibition of HSP90 with Pochoximes: SAR and Structure-Based Insights. ChemBioChem 10:17, pages 2753-2759.
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Cuihua Wang, Sofia Barluenga, Girish K. Koripelly, Jean-Gonzague Fontaine, Ruihong Chen, Jin-Chen Yu, Xiaodong Shen, John C. Chabala, James V. Heck, Allan Rubenstein & Nicolas Winssinger. (2009) Synthesis of pochoxime prodrugs as potent HSP90 inhibitors. Bioorganic & Medicinal Chemistry Letters 19:14, pages 3836-3840.
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Eloisi Caldas-LopesLeandro Cerchietti, James H. AhnCristina C. ClementAna I. Robles, Anna RodinaKamalika MoulickTony TaldoneAlexander GozmanYunke GuoNian WuElisa de StanchinaJulie WhiteSteven S. Gross, Yuliang Ma, Lyuba Varticovski, Ari Melnick & Gabriela Chiosis. (2009) Hsp90 inhibitor PU-H71, a multimodal inhibitor of malignancy, induces complete responses in triple-negative breast cancer models. Proceedings of the National Academy of Sciences 106:20, pages 8368-8373.
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Hui Tao, Yanlong Kang, Tony Taldone & Gabriela Chiosis. (2009) Microwave-assisted one step synthesis of 8-arylmethyl-9H-purin-6-amines. Bioorganic & Medicinal Chemistry Letters 19:2, pages 415-417.
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Teresa Semeraro, Claudia Mugnaini, Fabrizio Manetti, Serena Pasquini & Federico Corelli. (2008) Practical synthesis of novel purine analogues as Hsp90 inhibitors. Tetrahedron 64:49, pages 11249-11255.
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Teresa Semeraro, Claudia Mugnaini & Federico Corelli. (2008) Preparation of a set of 4,5-dihydro-3H-pyrrolo[3,2-d]pyrimidin-4-ones as potential Hsp90 ligands. Tetrahedron Letters 49:41, pages 5965-5967.
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