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Expert Opinion on Drug Discovery Volume 3, 2008 - Issue 8
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Measuring the tyrosine kinase activity: a review of biochemical and cellular assay technologies

Yong Jia Group Leader Genomics Institute of the Novartis Research Foundation, Department of Kinase Biology, 10675 John J. Hopkins Dr, San Diego, CA 92121, USA +1 858 812 1728; +1 858 812 1918; [email protected]
, PhD,
Xiang-ju Gu Group Leader Genomics Institute of the Novartis Research Foundation, Department of Lead Discovery, 10675 John J. Hopkins Dr, San Diego, CA 92121, USA
, PhD,
Achim Brinker Associate Director Genomics Institute of the Novartis Research Foundation, Department of Lead Discovery, 10675 John J. Hopkins Dr, San Diego, CA 92121, USA
, PhD &
Markus Warmuth Director Genomics Institute of the Novartis Research Foundation, Department of Kinase Biology, 10675 John J. Hopkins Dr, San Diego, CA 92121, USA
, MD
Pages 959-978 | Published online: 16 Jul 2008

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Read on this site (3)

Dominique Perrin, Christèle Frémaux & Adam Shutes. (2010) Capillary microfluidic electrophoretic mobility shift assays: application to enzymatic assays in drug discovery. Expert Opinion on Drug Discovery 5:1, pages 51-63.
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Robert S Ames & Quinn Lu. (2009) Viral-mediated gene delivery for cell-based assays in drug discovery. Expert Opinion on Drug Discovery 4:3, pages 243-256.
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Yong Jia. (2008) Current status of HTRF® technology in kinase assays. Expert Opinion on Drug Discovery 3:12, pages 1461-1474.
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Articles from other publishers (14)

Juan Gao, Jingyi Jian, Zhengjin Jiang & Ann Van Schepdael. (2023) Screening assays for tyrosine kinase inhibitors: A review. Journal of Pharmaceutical and Biomedical Analysis 223, pages 115166.
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Jiahui Wang, Xiaolin Yang, Lin Xi & Xu Na Wu. 2021. Plant Phosphoproteomics. Plant Phosphoproteomics 229 237 .
Monica Kruk, Naomi Widstrom, Sampreeti Jena, Nicole L. Wolter, John F. Blankenhorn, Ibrahim Abdalla, Tzu-Yi Yang & Laurie L. Parker. 2019. Post-translational Modifications That Modulate Enzyme Activity. Post-translational Modifications That Modulate Enzyme Activity 375 406 .
Abigail H. Turner, Michael S. Lebhar, Angela Proctor, Qunzhao Wang, David S. Lawrence & Nancy L. Allbritton. (2015) Rational Design of a Dephosphorylation-Resistant Reporter Enables Single-Cell Measurement of Tyrosine Kinase Activity. ACS Chemical Biology 11:2, pages 355-362.
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Enrico Faggi, Yolanda Pérez, Santiago V. Luis & Ignacio Alfonso. (2016) Supramolecular protection from the enzymatic tyrosine phosphorylation in a polypeptide. Chemical Communications 52:52, pages 8142-8145.
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Yong Jia, Mari Manuia & Jose Juarez. 2016. Kinase Screening and Profiling. Kinase Screening and Profiling 1 18 .
Doriano Fabbro, Sandra W Cowan-Jacob & Henrik Moebitz. (2015) Ten things you should know about protein kinases: IUPHAR Review 14. British Journal of Pharmacology 172:11, pages 2675-2700.
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Taha Azad, Amin Tashakor & Saman Hosseinkhani. (2014) Split-luciferase complementary assay: applications, recent developments, and future perspectives. Analytical and Bioanalytical Chemistry 406:23, pages 5541-5560.
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Guangchang Zhou, Xiaoliang Yan, Ding Wu & Stephen J. Kron. (2010) Photocleavable Peptide-Conjugated Magnetic Beads for Protein Kinase Assays by MALDI-TOF MS. Bioconjugate Chemistry 21:10, pages 1917-1924.
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Daniela E. Achatz, Florian J. Heiligtag, Xiaohua Li, Martin Link & Otto S. Wolfbeis. (2010) Colloidal silica nanoparticles for use in click chemistry-based conjugations and fluorescent affinity assays. Sensors and Actuators B: Chemical 150:1, pages 211-219.
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James E. Ghadiali, Bruce E. Cohen & Molly M. Stevens. (2010) Protein Kinase-Actuated Resonance Energy Transfer in Quantum Dot−Peptide Conjugates. ACS Nano 4:8, pages 4915-4919.
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Hu LiRachel D. TotoritisLeng A. LorBenjamin SchwartzPeter CaprioliAnthony J. JurewiczGuofeng Zhang. (2009) Evaluation of an Antibody-Free ADP Detection Assay: ADP-Glo. ASSAY and Drug Development Technologies 7:6, pages 598-605.
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Lin Hong, Christopher M. Quinn & Yong Jia. (2009) Evaluating the utility of the HTRF® Transcreener™ ADP assay technology: A comparison with the standard HTRF assay technology. Analytical Biochemistry 391:1, pages 31-38.
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Vicki Zhou, Xiaoqi Gao, Shulin Han, Achim Brinker, Jeremy S. Caldwell & Xiang-Ju Gu. (2009) An intracellular conformational sensor assay for Abl T315I. Analytical Biochemistry 385:2, pages 300-308.
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