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PI3K/AKT/mTOR pathway inhibitors: the ideal combination partners for breast cancer therapies?

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Gazmend Temaj, Sarmistha Saha, Shpend Dragusha, Valon Ejupi, Brigitta Buttari, Elisabetta Profumo, Lule Beqa & Luciano Saso. (2022) Ribosomopathies and cancer: pharmacological implications. Expert Review of Clinical Pharmacology 15:6, pages 729-746.
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Fan Yang, Shixu Lyu, Siyang Dong, Yehuan Liu, Xiaohua Zhang & Ouchen Wang. (2016) Expression profile analysis of long noncoding RNA in HER-2-enriched subtype breast cancer by next-generation sequencing and bioinformatics. OncoTargets and Therapy 9, pages 761-772.
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Elif Ulu, İlhan Yaylım, Soykan Arıkan & Canan Cacına. (2022) The evaluation of PIK3CA gene variation and serum PI3K level in breast cancer risk and prognosis in Turkish population . Turkish Journal of Biochemistry 47:3, pages 317-324.
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Xiaoniu Fang, Ya Gao, Chen Wang, Huimin Chen & Tong Zhu. (2022) Exploring the selective mechanism of inhibitors towards different subtypes of class I PI3K. Chemical Physics Letters 786, pages 139174.
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Daniela Miricescu, Alexandra Totan, Iulia-Ioana Stanescu-Spinu, Silviu Constantin Badoiu, Constantin Stefani & Maria Greabu. (2020) PI3K/AKT/mTOR Signaling Pathway in Breast Cancer: From Molecular Landscape to Clinical Aspects. International Journal of Molecular Sciences 22:1, pages 173.
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Fei Xu, Lixin Na, Yanfei Li & Linjun Chen. (2020) RETRACTED ARTICLE: Roles of the PI3K/AKT/mTOR signalling pathways in neurodegenerative diseases and tumours. Cell & Bioscience 10:1.
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Milad Ashrafizadeh, Masoud Najafi, Pooyan Makvandi, Ali Zarrabi, Tahereh Farkhondeh & Saeed Samarghandian. (2020) Versatile role of curcumin and its derivatives in lung cancer therapy. Journal of Cellular Physiology 235:12, pages 9241-9268.
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Nne E. Uko, Osman F. Güner, Diane F. Matesic & J. Phillip Bowen. (2020) Akt Pathway Inhibitors. Current Topics in Medicinal Chemistry 20:10, pages 883-900.
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Li Wang, Kunkun Li, Chen Wang, Xiaoxin Shi & Huiyu Yang. (2019) miR‐107 regulates growth and metastasis of gastric cancer cells via activation of the PI3K‐AKT signaling pathway by down‐regulating FAT4. Cancer Medicine 8:11, pages 5264-5273.
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Guixin Yuan, Zhen Lian, Qian Liu, Xixi Lin, Dantao Xie, Fangming Song, Xinjia Wang, Siyuan Shao, Bo Zhou, Chen Li, Muyan Li & Guanfeng Yao. (2019) Phosphatidyl inositol 3-kinase (PI3K)-mTOR inhibitor PKI-402 inhibits breast cancer induced osteolysis. Cancer Letters 443, pages 135-144.
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OmniaY Bassouny, RashaM AbdRabh & Ahmed Khalil. (2019) Evaluation of expression of Snail and Her2/neu and their clinicopathological significance in serous ovarian tumors: an immunohistochemical study. Egyptian Journal of Pathology 39:2, pages 419.
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Juan Zhou, Yunfeng Pei, Geng Chen, Chunping Cao, Jia Liu, Chen Ding, Duping Wang, Li Sun, Peng Xu & Guoping Niu. (2018) SPC24 Regulates breast cancer progression by PI3K/AKT signaling. Gene 675, pages 272-277.
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M. Orditura, C.M. Della Corte, A. Diana, V. Ciaramella, E. Franzese, V. Famiglietti, I. Panarese, R. Franco, A. Grimaldi, A. Lombardi, M. Caraglia, A. Santoriello, E. Procaccini, E. Lieto, E. Maiello, F. De Vita, F. Ciardiello & F. Morgillo. (2018) Three dimensional primary cultures for selecting human breast cancers that are sensitive to the anti-tumor activity of ipatasertib or taselisib in combination with anti-microtubule cytotoxic drugs. The Breast 41, pages 165-171.
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Songlin Liu, Yunhong Tang, Maomao Yan & Weixi Jiang. (2018) PIK3CA mutation sensitizes breast cancer cells to synergistic therapy of PI3K inhibition and AMPK activation. Investigational New Drugs 36:5, pages 763-772.
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Shan Hu, Yingchun Xu, Liwei Meng, Liming Huang & He Sun. (2018) Curcumin inhibits proliferation and promotes apoptosis of breast cancer cells. Experimental and Therapeutic Medicine.
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Xiao Zhou, Zhen Huang, Huawei Yang, Yi Jiang, Wei Wei, Qiuyun Li, Qinguo Mo & Jianlun Liu. (2017) β-Glucosidase inhibition sensitizes breast cancer to chemotherapy. Biomedicine & Pharmacotherapy 91, pages 504-509.
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Yi Wei Hu, Xiao Man Wu, Shi Si Ren, Lu Cao, Pin Nie & Ming Xian Chang. (2017) NOD1 deficiency impairs CD44a/Lck as well as PI3K/Akt pathway. Scientific Reports 7:1.
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Yu-Fu Zhou, Qian Sun, Ya-Jun Zhang, Geng-Ming Wang, Bin He, Tao Qi, Yan Zhou, Xing-Wang Li, Sheng Li & Lin He. (2017) Targeted inhibition of Notch1 gene enhances the killing effects of paclitaxel on triple negative breast cancer cells. Asian Pacific Journal of Tropical Medicine 10:2, pages 179-183.
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Ingeborg Elisabeth Cernaj. (2016) Simultaneous dual targeting of Par-4 and G6PD: a promising new approach in cancer therapy? Quintessence of a literature review on survival requirements of tumor cells. Cancer Cell International 16:1.
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Yingying Liu, Shanshan Fang, Qiushi Sun & Bo Liu. (2016) Anthelmintic drug ivermectin inhibits angiogenesis, growth and survival of glioblastoma through inducing mitochondrial dysfunction and oxidative stress. Biochemical and Biophysical Research Communications 480:3, pages 415-421.
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Min Yu, Ruishu Li & Juan Zhang. (2016) Repositioning of antibiotic levofloxacin as a mitochondrial biogenesis inhibitor to target breast cancer. Biochemical and Biophysical Research Communications 471:4, pages 639-645.
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Joelle ZambranoElizabeth S. Yeh. (2016) Autophagy and Apoptotic Crosstalk: Mechanism of Therapeutic Resistance in HER2-Positive Breast Cancer. Breast Cancer: Basic and Clinical Research 10, pages BCBCR.S32791.
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Lu Guo, Hua Wu, Jinghong Zhu, Caixia Zhang, Jianxiu Ma, Jianfa Lan & Xiaodong Xie. (2015) Genetic variations in the PI3K/AKT pathway predict platinum-based neoadjuvant chemotherapeutic sensitivity in squamous cervical cancer. Life Sciences 143, pages 217-224.
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Antonio Gentilella, Sara C. Kozma & George Thomas. (2015) A liaison between mTOR signaling, ribosome biogenesis and cancer. Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms 1849:7, pages 812-820.
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