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Review

Molecularly targeted therapies for malignant gliomas: advances and challenges

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Pages 641-661 | Published online: 10 Jan 2014

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E. Anderson, R. Grant, S. C. Lewis & I. R. Whittle. (2008) Randomized Phase III controlled trials of therapy in malignant glioma: where are we after 40 years?. British Journal of Neurosurgery 22:3, pages 339-349.
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Riccardo Soffietti, Barbara Leoncini & Roberta Rudà. (2007) New developments in the treatment of malignant gliomas. Expert Review of Neurotherapeutics 7:10, pages 1313-1326.
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Articles from other publishers (28)

Logan Muzyka, Nicolas K. Goff, Nikita Choudhary & Michael T. Koltz. (2023) Systematic Review of Molecular Targeted Therapies for Adult-Type Diffuse Glioma: An Analysis of Clinical and Laboratory Studies. International Journal of Molecular Sciences 24:13, pages 10456.
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Dandan Kou, Yun Gao, Cang Li, Dandan Zhou, Kuan Lu, Ning Wang, Ruru Zhang, Zhe Yang, Yi Zhou, Lei Chen, Jianxian Ge, Jianfeng Zeng & Mingyuan Gao. (2023) Intranasal Pathway for Nanoparticles to Enter the Central Nervous System. Nano Letters 23:11, pages 5381-5390.
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Qi Liu, Zhiming Ma, Qian Cao, Hongyu Zhao, Yu Guo, Tongjun Liu & Jiannan Li. (2022) Perineural invasion-associated biomarkers for tumor development. Biomedicine & Pharmacotherapy 155, pages 113691.
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Fangfang Zhang, Xuelei Ruan, Jun Ma, Xiaobai Liu, Jian Zheng, Yunhui Liu, Libo Liu, Shuyuan Shen, Lianqi Shao, Di Wang, Chunqing Yang, Heng Cai, Zhen Li, Ziyi Feng & Yixue Xue. (2020) DGCR8/ZFAT-AS1 Promotes CDX2 Transcription in a PRC2 Complex-Dependent Manner to Facilitate the Malignant Biological Behavior of Glioma Cells. Molecular Therapy 28:2, pages 613-630.
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Yusuke Tomita, Kazuhiko Kurozumi, Ji Young Yoo, Kentaro Fujii, Tomotsugu Ichikawa, Yuji Matsumoto, Atsuhito Uneda, Yasuhiko Hattori, Toshihiko Shimizu, Yoshihiro Otani, Tetsuo Oka, Balveen Kaur & Isao Date. (2019) Oncolytic Herpes Virus Armed with Vasculostatin in Combination with Bevacizumab Abrogates Glioma Invasion via the CCN1 and AKT Signaling Pathways. Molecular Cancer Therapeutics 18:8, pages 1418-1429.
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Mingjun Yu, Shijia Yu, Yixue Xue, Hai Yu, Duo Chen, Xiangtai Wei & Yunhui Liu. (2018) Over-Expressed FEZF1 Predicts a Poor Prognosis in Glioma and Promotes Glioma Cell Malignant Biological Properties by Regulating Akt-ERK Pathway. Journal of Molecular Neuroscience 65:4, pages 411-419.
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Hu-yin Yang, Da-zhao Fang, Lian-shu Ding, Xiao-bo Hui & Dai Liu. (2017) Overexpression of Protease Serine 8 Inhibits Glioma Cell Proliferation, Migration, and Invasion via Suppressing the Akt/mTOR Signaling Pathway. Oncology Research Featuring Preclinical and Clinical Cancer Therapeutics 25:6, pages 923-930.
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Ling Zhang, Xin Liang & Yuxiong Li. (2017) Long non-coding RNA MEG3 inhibits cell growth of gliomas by targeting miR-93 and inactivating PI3K/AKT pathway. Oncology Reports 38:4, pages 2408-2416.
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Tetsuo Oka, Kazuhiko Kurozumi, Yosuke Shimazu, Tomotsugu Ichikawa, Joji Ishida, Yoshihiro Otani, Toshihiko Shimizu, Yusuke Tomita, Masakiyo Sakaguchi, Masami Watanabe, Yasutomo Nasu, Hiromi Kumon & Isao Date. (2016) A super gene expression system enhances the anti-glioma effects of adenovirus-mediated REIC/Dkk-3 gene therapy. Scientific Reports 6:1.
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Qiao-Li Lv, Lei Hu, Shu-Hui Chen, Bao Sun, Meng-Long Fu, Chong-Zhen Qin, Qiang Qu, Gui-Hua Wang, Chen-Jie He & Hong-Hao Zhou. (2016) A Long Noncoding RNA ZEB1-AS1 Promotes Tumorigenesis and Predicts Poor Prognosis in Glioma. International Journal of Molecular Sciences 17:9, pages 1431.
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Toshihiko Shimizu, Kazuhiko Kurozumi, Joji Ishida, Tomotsugu Ichikawa & Isao Date. (2016) Adhesion molecules and the extracellular matrix as drug targets for glioma. Brain Tumor Pathology 33:2, pages 97-106.
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Guanzhong Qiu, Wei Sun, Yongxiang Zou, Zheng Cai, Peng Wang, Xianbin Lin, Jinxiang Huang, Lei Jiang, Xuehua Ding & Guohan Hu. (2015) RNA interference against TMEM97 inhibits cell proliferation, migration, and invasion in glioma cells. Tumor Biology 36:10, pages 8231-8238.
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Marta Penas-Prado, Kenneth R. Hess, Michael J. Fisch, Lore W. Lagrone, Morris D. Groves, Victor A. Levin, John F. De Groot, Vinay K. Puduvalli, Howard Colman, Gena Volas-Redd, Pierre Giglio, Charles A. Conrad, Michael E. Salacz, Justin D. Floyd, Monica E. Loghin, Sigmund H. Hsu, Javier Gonzalez, Eric L. Chang, Shiao Y. Woo, Anita Mahajan, Kenneth D. Aldape, W. K. Alfred Yung & Mark R. Gilbert. (2015) Randomized phase II adjuvant factorial study of dose-dense temozolomide alone and in combination with isotretinoin, celecoxib, and/or thalidomide for glioblastoma. Neuro-Oncology 17:2, pages 266-273.
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Y Shimazu, K Kurozumi, T Ichikawa, K Fujii, M Onishi, J Ishida, T Oka, M Watanabe, Y Nasu, H Kumon & I Date. (2014) Integrin antagonist augments the therapeutic effect of adenovirus-mediated REIC/Dkk-3 gene therapy for malignant glioma. Gene Therapy 22:2, pages 146-154.
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Alok R Singh, Shweta Joshi, Elizabeth George & Donald L Durden. (2014) Anti-tumor effect of a novel PI3-kinase inhibitor, SF1126, in 12 V-Ha-Ras transgenic mouse glioma model. Cancer Cell International 14:1.
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Kazuhiko KUROZUMI, Tomotsugu ICHIKAWA, Manabu ONISHI, Kentaro FUJII & Isao DATE. (2012) Cilengitide Treatment for Malignant Glioma: Current Status and Future Direction. Neurologia medico-chirurgica 52:8, pages 539-547.
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Marta Penas-Prado, Terri S. Armstrong & Mark R. Gilbert. 2012. Neuro-Oncology Part II. Neuro-Oncology Part II 485 506 .
Jihong Xu, Deepa Sampath, Frederick F. Lang, Sujit Prabhu, Ganesh Rao, Gregory N. Fuller, Yuanfang Liu & Vinay K. Puduvalli. (2011) Vorinostat modulates cell cycle regulatory proteins in glioma cells and human glioma slice cultures. Journal of Neuro-Oncology 105:2, pages 241-251.
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Xue-yuan Li, Lian-qun Zhang, Xue-guang Zhang, Xin Li, Yu-bo Ren, Xiang-yu Ma, Xin-gang Li & Le-xin Wang. (2010) Association between AKT/mTOR signalling pathway and malignancy grade of human gliomas. Journal of Neuro-Oncology 103:3, pages 453-458.
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Michal Grzmil & Brian A. Hemmings. (2010) Deregulated signalling networks in human brain tumours. Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics 1804:3, pages 476-483.
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Betty Herrington & Mark W. Kieran. (2009) Small molecule inhibitors in children with malignant gliomas. Pediatric Blood & Cancer 53:3, pages 312-317.
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Robert H. Mach, Farrokh Dehdashti & Kenneth T. Wheeler. (2009) PET Radiotracers for Imaging the Proliferative Status of Solid Tumors. PET Clinics 4:1, pages 1-15.
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Paul E. Milbury. 2009. Complementary and Alternative Therapies and the Aging Population. Complementary and Alternative Therapies and the Aging Population 347 370 .
Robert M. Sharkey & David M. Goldenberg. (2008) Use of antibodies and immunoconjugates for the therapy of more accessible cancers. Advanced Drug Delivery Reviews 60:12, pages 1407-1420.
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Ruty Mehrian ShaiJuergen KV ReichardtThomas C Chen. (2008) Pharmacogenomics of brain cancer and personalized medicine in malignant gliomas. Future Oncology 4:4, pages 525-534.
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Natalia Vykhodtseva, Nathan McDannold & Kullervo Hynynen. (2008) Progress and problems in the application of focused ultrasound for blood–brain barrier disruption. Ultrasonics 48:4, pages 279-296.
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Janine Masri, Andrew Bernath, Jheralyn Martin, Oak D. Jo, Raffi Vartanian, Alexander Funk & Joseph Gera. (2007) mTORC2 Activity Is Elevated in Gliomas and Promotes Growth and Cell Motility via Overexpression of Rictor. Cancer Research 67:24, pages 11712-11720.
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Kazuhiko Kurozumi, Jayson Hardcastle, Roopa Thakur, Ming Yang, Gregory Christoforidis, Giulia Fulci, Fred H. Hochberg, Ralph Weissleder, William Carson, E. Antonio Chiocca & Balveen Kaur. (2007) Effect of Tumor Microenvironment Modulation on the Efficacy of Oncolytic Virus Therapy. JNCI: Journal of the National Cancer Institute 99:23, pages 1768-1781.
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