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An update on microRNAs as colorectal cancer biomarkers: where are we and what’s next?

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You-Yi Huang, Hai-Xing Jiang, Qiu-Yue Shi, Xin Qiu, Xi Wei, Xiang-Lian Zhang & Shan-Yu Qin. (2020) miR-145 Inhibits Th9 Cell Differentiation by Suppressing Activation of the PI3K/Akt/mTOR/p70S6K/HIF-1α Pathway in Malignant Ascites from Liver Cancer. OncoTargets and Therapy 13, pages 3789-3800.
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Yiming Li, Meng Chen, Juan Liu, Lianyun Li, Xiao Yang, Jiao Zhao, Min Wu & Mei Ye. (2017) Upregulation of MicroRNA 18b Contributes to the Development of Colorectal Cancer by Inhibiting CDKN2B. Molecular and Cellular Biology 37:22.
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Manish Pratap Singh, Sandhya Rai, Shradha Suyal, Sunil Kumar Singh, Nand Kumar Singh, Akash Agarwal & Sameer Srivastava. (2017) Genetic and epigenetic markers in colorectal cancer screening: recent advances. Expert Review of Molecular Diagnostics 17:7, pages 665-685.
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Oscar A. Tovar-Camargo, Shusuke Toden & Ajay Goel. (2016) Exosomal microRNA Biomarkers: Emerging Frontiers in Colorectal and Other Human Cancers. Expert Review of Molecular Diagnostics 16:5, pages 553-567.
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Articles from other publishers (37)

Shusuke Toden & Ajay Goel. (2022) Non-coding RNAs as liquid biopsy biomarkers in cancer. British Journal of Cancer 126:3, pages 351-360.
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Aneta L. Zygulska & Piotr Pierzchalski. (2022) Novel Diagnostic Biomarkers in Colorectal Cancer. International Journal of Molecular Sciences 23:2, pages 852.
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Fahimeh Fattahi, Jafar Kiani, Mahdi Alemrajabi, Ahmadreza Soroush, Marzieh Naseri, Mohammad Najafi & Zahra Madjd. (2021) Overexpression of DDIT4 and TPTEP1 are associated with metastasis and advanced stages in colorectal cancer patients: a study utilizing bioinformatics prediction and experimental validation. Cancer Cell International 21:1.
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Norhan A. Sabbah, Wael M. Abdalla, Walid A. Mawla, Nagla AbdAlMonem, Amal F. Gharib, Ahmed Abdul-Saboor, Abdallah S. Abdelazem & Nermin Raafat. (2021) piRNA-823 Is a Unique Potential Diagnostic Non-Invasive Biomarker in Colorectal Cancer Patients. Genes 12:4, pages 598.
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Bene A. Ekine-Afolabi, Anoka A. Njan, Solomon O. Rotimi, Anu R. I.Attia M. Elbehi, Elizabeth Cash & Ademola Adeyeye. (2020) The Impact of Diet on the Involvement of Non-Coding RNAs, Extracellular Vesicles, and Gut Microbiome-Virome in Colorectal Cancer Initiation and Progression. Frontiers in Oncology 10.
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Nahal Eshghifar, Elham Badrlou & Farkhondeh Pouresmaeili. (2020) The roles of miRNAs’ clinical efficiencies in the colorectal cancer pathobiology: A review article. Human Antibodies 28:4, pages 273-285.
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Ye Wu, Wei Wang, An-Gang Yang & Rui Zhang. (2020) The microRNA-424/503 cluster: A master regulator of tumorigenesis and tumor progression with paradoxical roles in cancer. Cancer Letters 494, pages 58-72.
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Makoto Eizuka, Mitsumasa Osakabe, Ayaka Sato, Yasuko Fujita, Yoshihito Tanaka, Koki Otsuka, Akira Sasaki, Takayuki Matsumoto, Hiromu Suzuki & Tamotsu Sugai. (2020) Dysregulation of microRNA expression during the progression of colorectal tumors. Pathology International 70:9, pages 633-643.
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Shuang Pan, Wei Wu, Fu Ren, Lei Li, Yao Li, Weihong Li, Aimei Wang, Dahua Liu & Yongyan Dong. (2020) MiR-346-5p promotes colorectal cancer cell proliferation in vitro and in vivo by targeting FBXL2 and activating the β-catenin signaling pathway. Life Sciences 244, pages 117300.
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Zheng Xiao, Shi Chen, Shujun Feng, Yukun Li, Juan Zou, Hui Ling, Ying Zeng & Xi Zeng. (2020) Function and mechanisms of microRNA‑20a in colorectal cancer (Review). Experimental and Therapeutic Medicine.
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Wen-Cui Li, Yan-Qiong Wu, Bo Gao, Chao-Yun Wang & Juan-Juan Zhang. (2019) MiRNA-574-3p inhibits cell progression by directly targeting CCND2 in colorectal cancer. Bioscience Reports 39:12.
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Veronika Vymetalkova, Pavel Vodicka, Sona Vodenkova, Sergio Alonso & Regine Schneider-Stock. (2019) DNA methylation and chromatin modifiers in colorectal cancer. Molecular Aspects of Medicine 69, pages 73-92.
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Yoshinaga Okugawa, Yuji Toiyama, Keun Hur, Akira Yamamoto, Chengzeng Yin, Shozo Ide, Takahito Kitajima, Hiroyuki Fujikawa, Hiromi Yasuda, Yuhki Koike, Yoshiki Okita, Junichiro Hiro, Shigeyuki Yoshiyama, Toshimitsu Araki, Chikao Miki, Donald C. McMillan, Ajay Goel & Masato Kusunoki. (2019) Circulating miR‐203 derived from metastatic tissues promotes myopenia in colorectal cancer patients. Journal of Cachexia, Sarcopenia and Muscle 10:3, pages 536-548.
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Antja-Voy Hartley, Matthew Martin & Tao Lu. 2019. Advances in the Molecular Understanding of Colorectal Cancer. Advances in the Molecular Understanding of Colorectal Cancer.
Antonio Francavilla, Sonia Tarallo, Barbara Pardini & Alessio Naccarati. (2019) Fecal microRNAs as non-invasive biomarkers for the detection of colorectal cancer: a systematic review. Minerva Biotecnologica 31:1.
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Pierre Laurent-Puig, Marie-Lise Grisoni, Volker Heinemann, François Liebaert, Daniel Neureiter, Andreas Jung, François Montestruc, Yann Gaston-Mathe, Raphaële Thiébaut & Sebastian Stintzing. (2019) Validation of miR-31-3p Expression to Predict Cetuximab Efficacy When Used as First-Line Treatment in RAS Wild-Type Metastatic Colorectal Cancer . Clinical Cancer Research 25:1, pages 134-141.
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Marzieh Ghanbarian, Ali Afgar, Reza Yadegarazari, Rezvan Najafi & Ladan Teimoori-Toolabi. (2018) Through oxaliplatin resistance induction in colorectal cancer cells, increasing ABCB1 level accompanies decreasing level of miR-302c-5p, miR-3664-5p and miR-129-5p. Biomedicine & Pharmacotherapy 108, pages 1070-1080.
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Petra Vychytilova-Faltejskova, Karolina Stitkovcova, Lenka Radova, Milana Sachlova, Zdenka Kosarova, Katerina Slaba, Zdenek Kala, Marek Svoboda, Igor Kiss, Rostislav Vyzula, William C. Cho & Ondrej Slaby. (2018) Circulating PIWI-Interacting RNAs piR-5937 and piR-28876 Are Promising Diagnostic Biomarkers of Colon Cancer. Cancer Epidemiology, Biomarkers & Prevention 27:9, pages 1019-1028.
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Shushan Yan, Guoyan Liu, Chengwen Jin, Zengfang Wang, Quanhong Duan, Jiang Xu & Donghua Xu. (2018) MicroRNA‐6869‐5p acts as a tumor suppressor via targeting TLR4/NF‐κB signaling pathway in colorectal cancer. Journal of Cellular Physiology 233:9, pages 6660-6668.
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Gianluca Pellino, Gaetano Gallo, Pierlorenzo Pallante, Raffaella Capasso, Alfonso De Stefano, Isacco Maretto, Umberto Malapelle, Shengyang Qiu, Stella Nikolaou, Andrea Barina, Giuseppe Clerico, Alfonso Reginelli, Antonio Giuliani, Guido Sciaudone, Christos Kontovounisios, Luca Brunese, Mario Trompetto & Francesco Selvaggi. (2018) Noninvasive Biomarkers of Colorectal Cancer: Role in Diagnosis and Personalised Treatment Perspectives. Gastroenterology Research and Practice 2018, pages 1-21.
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Adriano Angelucci, Simona Delle Monache, Alessio Cortellini, Monica Di Padova & Corrado Ficorella. (2018) “Vessels in the Storm”: Searching for Prognostic and Predictive Angiogenic Factors in Colorectal Cancer. International Journal of Molecular Sciences 19:1, pages 299.
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Lucas Ramon, Catherine David, Karine Fontaine, Elodie Lallet, Charles Marcaillou, Séverine Martin-Lannerée, Virginie Decaulne, Céline Vazart, Anne-Héloise Gélibert, Raouf Ben Abdelali, Jean-Marc Costa, Francis Rousseau, Raphaële Thiébaut, Larry Yost & Yann Gaston-Mathé. (2018) Technical Validation of a Reverse-Transcription Quantitative Polymerase Chain Reaction In Vitro Diagnostic Test for the Determination of MiR-31-3p Expression Levels in Formalin-Fixed Paraffin-Embedded Metastatic Colorectal Cancer Tumor Specimens. Biomarker Insights 13, pages 117727191876335.
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Farid E. Ahmed, Nancy C. Ahmed, Mostafa M. Gouda, Paul W. Vos & Chris Bonnerup. 2018. Colorectal Cancer. Colorectal Cancer 203 215 .
Edita Baltruskeviciene, Diana Schveigert, Vaidotas Stankevicius, Ugnius Mickys, Tadas Zvirblis, Jaroslav Bublevic, Kestutis Suziedelis & Eduardas Aleknavicius. (2017) Down-regulation of miRNA-148a and miRNA-625-3p in colorectal cancer is associated with tumor budding. BMC Cancer 17:1.
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Chung-Wei Fan, Yung-Bin Kuo, Geng-Pin Lin, Si-Min Chen, Shih-Hsien Chang, Bo-An Li & Err-Cheng Chan. (2017) Development of a multiplexed tumor-associated autoantibody-based blood test for the detection of colorectal cancer. Clinica Chimica Acta 475, pages 157-163.
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Yang Li, Zheng Sun, Bing Liu, Yujia Shan, Lifen Zhao & Li Jia. (2017) Tumor-suppressive miR-26a and miR-26b inhibit cell aggressiveness by regulating FUT4 in colorectal cancer. Cell Death & Disease 8:6, pages e2892-e2892.
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Tommaso Colangelo, Giovanna Polcaro, Livio Muccillo, Giovanna D'Agostino, Valeria Rosato, Pamela Ziccardi, Angelo Lupo, Gianluigi Mazzoccoli, Lina Sabatino & Vittorio Colantuoni. (2017) Friend or foe?. Biochimica et Biophysica Acta (BBA) - Reviews on Cancer 1867:1, pages 1-18.
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Anna-Maria Pehserl, Anna Ress, Stefanie Stanzer, Margit Resel, Michael Karbiener, Elke Stadelmeyer, Verena Stiegelbauer, Armin Gerger, Christian Mayr, Marcel Scheideler, Georg Hutterer, Thomas Bauernhofer, Tobias Kiesslich & Martin Pichler. (2016) Comprehensive Analysis of miRNome Alterations in Response to Sorafenib Treatment in Colorectal Cancer Cells. International Journal of Molecular Sciences 17:12, pages 2011.
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Ryo Uratani, Yuji Toiyama, Takahito Kitajima, Mikio Kawamura, Junichiro Hiro, Minako Kobayashi, Koji Tanaka, Yasuhiro Inoue, Yasuhiko Mohri, Takao Mori, Toshio Kato, Ajay Goel & Masato Kusunoki. (2016) Diagnostic Potential of Cell-Free and Exosomal MicroRNAs in the Identification of Patients with High-Risk Colorectal Adenomas. PLOS ONE 11:10, pages e0160722.
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H. Imaoka, Y. Toiyama, H. Fujikawa, J. Hiro, S. Saigusa, K. Tanaka, Y. Inoue, Y. Mohri, T. Mori, T. Kato, S. Toden, A. Goel & M. Kusunoki. (2016) Circulating microRNA-1290 as a novel diagnostic and prognostic biomarker in human colorectal cancer. Annals of Oncology 27:10, pages 1879-1886.
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Martha L. Slattery, Jennifer S. Herrick, Daniel F. Pellatt, Lila E. Mullany, John R. Stevens, Erica Wolff, Michael D. Hoffman, Roger K. Wolff & Wade Samowitz. (2016) Site-specific associations between miRNA expression and survival in colorectal cancer cases. Oncotarget 7:37, pages 60193-60205.
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Francesco Sclafani, Ian Chau, David Cunningham, Andrea Lampis, Jens Claus Hahne, Michele Ghidini, Hazel Lote, Domenico Zito, Josep Tabernero, Bengt Glimelius, Andres Cervantes, Ruwaida Begum, David Gonzalez De Castro, Sanna Hulkki Wilson, Clare Peckitt, Zakaria Eltahir, Andrew Wotherspoon, Diana Tait, Gina Brown, Jacqueline Oates, Chiara Braconi & Nicola Valeri. (2016) Sequence variation in mature microRNA-608 and benefit from neo-adjuvant treatment in locally advanced rectal cancer patients. Carcinogenesis 37:9, pages 852-857.
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Yang Longqiu, Luo Pengcheng, Fei Xuejie & Zhang Peng. (2016) A mi RNA s panel promotes the proliferation and invasion of colorectal cancer cells by targeting GABBR 1 . Cancer Medicine 5:8, pages 2022-2031.
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Tomofumi Noguchi, Yuji Toiyama, Takahito Kitajima, Hiroki Imaoka, Junichiro Hiro, Susumu Saigusa, Koji Tanaka, Yasuhiro Inoue, Yasuhiko Mohri, Shusuke Toden & Masato Kusunoki. (2016) miRNA-503 Promotes Tumor Progression and Is Associated with Early Recurrence and Poor Prognosis in Human Colorectal Cancer. Oncology 90:4, pages 221-231.
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Xiaohua Zhong, Yipin Xiao, Chao Chen, Xiuwen Wei, Chen Hu, Xukun Ling & Xinbin Liu. (2015) MicroRNA-203-mediated posttranscriptional deregulation of CPEB4 contributes to colorectal cancer progression. Biochemical and Biophysical Research Communications 466:2, pages 206-213.
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Jun Wang, Yong-Xi Song, Bin Ma, Jia-Jun Wang, Jing-Xu Sun, Xiao-Wan Chen, Jun-Hua Zhao, Yu-Chong Yang & Zhen-Ning Wang. (2015) Regulatory Roles of Non-Coding RNAs in Colorectal Cancer. International Journal of Molecular Sciences 16:8, pages 19886-19919.
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