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Expert Review of Neurotherapeutics Volume 13, 2013 - Issue 8
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Review

The fumaric acid ester BG-12: a new option in MS therapy

De-Hyung Lee Department of Neurology, University of Erlangen, Schwabachanlage 6, 91054 Erlangen, Germany. [email protected]; Department of Neurology, University of Erlangen, Schwabachanlage 6, 91054 Erlangen, Germany. [email protected]
,
Martin Stangel Department of Neurology, Clinical Neuroimmunology and Neurochemistry, Hannover Medical School, Germany; Department of Neurology, Clinical Neuroimmunology and Neurochemistry, Hannover Medical School, Germany
,
Ralf Gold Department of Neurology, St. Josef Hospital, Ruhr University Bochum, Germany; Department of Neurology, St. Josef Hospital, Ruhr University Bochum, Germany
&
Ralf Andreas Linker Department of Neurology, University of Erlangen, Schwabachanlage 6, 91054 Erlangen, Germany; Department of Neurology, University of Erlangen, Schwabachanlage 6, 91054 Erlangen, Germany
Pages 951-958 | Published online: 09 Jan 2014

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Bifeng Gao, An Doan & Brooks M Hybertson. (2014) The clinical potential of influencing Nrf2 signaling in degenerative and immunological disorders. Clinical Pharmacology: Advances and Applications 6, pages 19-34.
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Dmitry M. Hushpulian, Navneet Ammal Kaidery, Debashis Dutta, Sudarshana M. Sharma, Irina Gazaryan & Bobby Thomas. (2023) Emerging small molecule inhibitors of Bach1 as therapeutic agents: Rationale, recent advances, and future perspectives. BioEssays.
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Mahmood Ahmad Khan, Gulam Rabbani, Juhi Aggarawal & Rafat Sultana Ahmed. (2023) Divulging the Intricacies of Crosstalk Between NF-kB and Nrf-2/Keap1 Pathway in the Treatment of Arthritis by Dimethyl Fumarate. Applied Biochemistry and Biotechnology.
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Laura Bierhansl, Hans-Peter Hartung, Orhan Aktas, Tobias Ruck, Michael Roden & Sven G. Meuth. (2022) Thinking outside the box: non-canonical targets in multiple sclerosis. Nature Reviews Drug Discovery 21:8, pages 578-600.
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Houman Kahroba, Bahman Ramezani, Hamid Maadi, Mohammad Reza Sadeghi, Hajar Jaberie & Fatemeh Ramezani. (2021) The role of Nrf2 in neural stem/progenitors cells: From maintaining stemness and self-renewal to promoting differentiation capability and facilitating therapeutic application in neurodegenerative disease. Ageing Research Reviews 65, pages 101211.
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Gerardo G. Piroli, Allison M. Manuel, Tulsi Patel, Michael D. Walla, Liang Shi, Scott A. Lanci, Jingtian Wang, Ashley Galloway, Pavel I. Ortinski, Deanna S. Smith & Norma Frizzell. (2019) Identification of Novel Protein Targets of Dimethyl Fumarate Modification in Neurons and Astrocytes Reveals Actions Independent of Nrf2 Stabilization. Molecular & Cellular Proteomics 18:3, pages 504-519.
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Ranran Han, Jinting Xiao, Hui Zhai & Junwei Hao. (2016) Dimethyl fumarate attenuates experimental autoimmune neuritis through the nuclear factor erythroid-derived 2-related factor 2/hemoxygenase-1 pathway by altering the balance of M1/M2 macrophages. Journal of Neuroinflammation 13:1.
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Itzy E. Morales Pantoja, Che-lin Hu, Nora I. Perrone-Bizzozero, Jianzheng Zheng & Oscar A. Bizzozero. (2016) Nrf2-dysregulation correlates with reduced synthesis and low glutathione levels in experimental autoimmune encephalomyelitis. Journal of Neurochemistry 139:4, pages 640-650.
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Izaskun Buendia, Elisa Navarro, Patrycja Michalska, Isabel Gameiro, Javier Egea, Sheila Abril, Alicia López, Laura González-Lafuente, Manuela G López & Rafael León. (2015) New melatonin–cinnamate hybrids as multi-target drugs for neurodegenerative diseases: Nrf2-induction, antioxidant effect and neuroprotection. Future Medicinal Chemistry 7:15, pages 1961-1969.
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Qin Wang, Sergei Chuikov, Sophina Taitano, Qi Wu, Arjun Rastogi, Samuel Tuck, Joseph Corey, Steven Lundy & Yang Mao-Draayer. (2015) Dimethyl Fumarate Protects Neural Stem/Progenitor Cells and Neurons from Oxidative Damage through Nrf2-ERK1/2 MAPK Pathway. International Journal of Molecular Sciences 16:12, pages 13885-13907.
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Ian M. Copple, Luke M. Shelton, Joanne Walsh, Denise V. Kratschmar, Adam Lister, Alex Odermatt, Christopher E. Goldring, Albena T. Dinkova-Kostova, Tadashi Honda & B. Kevin Park. (2014) Chemical Tuning Enhances Both Potency Toward Nrf2 and In Vitro Therapeutic Index of Triterpenoids. Toxicological Sciences 140:2, pages 462-469.
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Michela Rosini, Elena Simoni, Andrea Milelli, Anna Minarini & Carlo Melchiorre. (2013) Oxidative Stress in Alzheimer’s Disease: Are We Connecting the Dots?. Journal of Medicinal Chemistry 57:7, pages 2821-2831.
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Anja Förster, Liane M. Preussner, Jens M. Seeger, Anja Rabenhorst, Hamid Kashkar, Ulrich Mrowietz & Karin Hartmann. (2013) Dimethylfumarate induces apoptosis in human mast cells. Experimental Dermatology 22:11, pages 719-724.
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