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Recent advances in targeted therapy for glioblastoma

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Rodney Luwor, Andrew P. Morokoff, Stephanie Amiridis, Giovanna D’Abaco, Lucia Paradiso, Stanley S. Stylli, Hong P. T. Nguyen, Mark Tarleton, Kelly A. Young, Terence J. O’Brien, Phillip J. Robinson, Megan Chircop, Adam McCluskey & Nigel C. Jones. (2019) Targeting Glioma Stem Cells by Functional Inhibition of Dynamin 2: A Novel Treatment Strategy for Glioblastoma. Cancer Investigation 37:3, pages 144-155.
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Xiaohong Yin, Keshun Xia, Song Peng, Bo Tan, Yaohui Huang, Mao Wang & Mingfang He. (2023) ABCF1/CXCL12/CXCR4 Enhances Glioblastoma Cell Proliferation, Migration, and Invasion by Activating the PI3K/AKT Signal Pathway. Developmental Neuroscience, pages 1-10.
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Corina Tamas, Flaviu Tamas, Attila Kovecsi, Georgiana Serban, Cristian Boeriu & Adrian Balasa. (2023) The Role of Ketone Bodies in Treatment Individualization of Glioblastoma Patients. Brain Sciences 13:9, pages 1307.
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Junjun Jing, Zhuoxuan Wu, Jiahe Wang, Guowen Luo, Hengyi Lin, Yi Fan & Chenchen Zhou. (2023) Hedgehog signaling in tissue homeostasis, cancers, and targeted therapies. Signal Transduction and Targeted Therapy 8:1.
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Inês Costa, Daniel José Barbosa, Sofia Benfeito, Vera Silva, Daniel Chavarria, Fernanda Borges, Fernando Remião & Renata Silva. (2023) Molecular mechanisms of ferroptosis and their involvement in brain diseases. Pharmacology & Therapeutics 244, pages 108373.
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Viviane A. O. Silva, Marcela N. Rosa, Izabela N. F. Gomes, Patrik da Silva Vital, Ana Laura V. Alves, Adriane F. Evangelista, Giovanna B. Longato, Adriana C. Carloni, Bruno G. Oliveira, Fernanda E. Pinto, Wanderson Romão, Allisson R. Rezende, Arali A. C. Araújo, Lohanna S. F. M. Oliveira, Alessandra A. M. Souza, Stephanie C. Oliveira, Rosy Iara Maciel A. Ribeiro & Rui M. Reis. (2023) Bio-Prospecting of Crude Leaf Extracts from Thirteen Plants of Brazilian Cerrado Biome on Human Glioma Cell Lines. Molecules 28:3, pages 1394.
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Shangyao Qin, Yimin Yuan, Hong Liu, Yingyan Pu, Kefu Chen, Yulong Wu & Zhida Su. (2022) Identification and characterization of sex‐dependent gene expression profile in glioblastoma. Neuropathology 43:1, pages 72-83.
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Kunlin Zhou, Lei Wang, Zhiyuan Sun, Yuelin Liu, Yufu Zhu, Zhiyi Liu, Bin Zhang & Hengliang Shi. (2022) COP1 Acts as a Ubiquitin Ligase for PCDH9 Ubiquitination and Degradation in Human Glioma. Molecular Neurobiology 59:4, pages 2378-2388.
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Yingyi Xu, Na Zhang, Cheng Chen, Xinke Xu, Ailing Luo, Yaping Yan, Yanhua Lu, Jianhua Liu, Xinxu Ou, Yonghong Tan, Yufeng Liang, Lihe Chen, Xingrong Song & Xiaoping Liu. (2022) Sevoflurane Induces Ferroptosis of Glioma Cells Through Activating the ATF4-CHAC1 Pathway. Frontiers in Oncology 12.
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Shengbiao Li, Yuping He, Kexin Chen, Jiaojiao Sun, Lulu Zhang, Yaxin He, Hong Yu & Qiuhong Li. (2021) RSL3 Drives Ferroptosis through NF-κB Pathway Activation and GPX4 Depletion in Glioblastoma. Oxidative Medicine and Cellular Longevity 2021, pages 1-10.
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Lei She, Lin Su, Liangfang Shen & Chao Liu. (2021) Retrospective Study of the Safety and Efficacy of Anlotinib Combined With Dose-Dense Temozolomide in Patients With Recurrent Glioblastoma. Frontiers in Oncology 11.
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Mayra Colardo, Marco Segatto & Sabrina Di Bartolomeo. (2021) Targeting RTK-PI3K-mTOR Axis in Gliomas: An Update. International Journal of Molecular Sciences 22:9, pages 4899.
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Jolie Bou-Gharios, Sahar Assi, Hisham F. Bahmad, Hussein Kharroubi, Tarek Araji, Reda M. Chalhoub, Farah Ballout, Hayat Harati, Youssef Fares & Wassim Abou-Kheir. (2020) The potential use of tideglusib as an adjuvant radio-therapeutic treatment for glioblastoma multiforme cancer stem-like cells. Pharmacological Reports 73:1, pages 227-239.
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Xue-Yuan Li, Guo-Hui Huang, Qian-Kun Liu, Xi-Tao Yang, Kang Wang, Wen-Zheng Luo, Tian-Song Liang, Shan-Peng Yuan, Ying-Wei Zhen & Dong-Ming Yan. (2020) Porf-2 Inhibits Tumor Cell Migration Through the MMP-2/9 Signaling Pathway in Neuroblastoma and Glioma. Frontiers in Oncology 10.
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Renxin Yi, Handong Wang, Chulei Deng, Xinyue Wang, Lei Yao, Wenhao Niu, Maoxing Fei & Wangdui Zhaba. (2020) Dihydroartemisinin initiates ferroptosis in glioblastoma through GPX4 inhibition. Bioscience Reports 40:6.
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Joseph A. Flores-ToroDefang LuoAdithya GopinathMatthew R. SarkisianJames J. CampbellIsrael F. CharoRajinder SinghThomas J. SchallMeenal DattaRakesh K. Jain, Duane A. Mitchell & Jeffrey K. Harrison. (2019) CCR2 inhibition reduces tumor myeloid cells and unmasks a checkpoint inhibitor effect to slow progression of resistant murine gliomas. Proceedings of the National Academy of Sciences 117:2, pages 1129-1138.
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Huanyu Wang, Qiang Guan, Yang Nan, Quanfeng Ma & Yue Zhong. (2019) Overexpression of human MX2 gene suppresses cell proliferation, migration, and invasion via ERK/P38/NF‐κB pathway in glioblastoma cells. Journal of Cellular Biochemistry 120:11, pages 18762-18770.
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YiHan Wu, Yuan Yao, YongLi Yun, MeiLing Wang & RunXiu Zhu. (2019) MicroRNA-302c enhances the chemosensitivity of human glioma cells to temozolomide by suppressing P-gp expression. Bioscience Reports 39:9, pages BSR20190421.
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Xin Hong, Zhengliang Zhang, Longfei Pan, Wei Ma, Xu Zhai, Changwei Gu, Yaru Zhang, Xiaoju Bi, Wan Huang, Honghong Pei & Zhong Liu. (2019) MicroRNA-301b promotes the proliferation and invasion of glioma cells through enhancing activation of Wnt/β-catenin signaling via targeting Glypican-5. European Journal of Pharmacology 854, pages 39-47.
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Fang Zhang, Anhao Wu, Yinhui Wang & Jianmin Liu. (2019) miR‑490‑3p functions as a tumor suppressor in glioma by inhibiting high‑mobility group AT‑hook 2 expression. Experimental and Therapeutic Medicine.
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Zhenzhen Liu, Hongli Li, Lian He, Yu Xiang, Chengsen Tian, Can Li, Peng Tan, Ji Jing, Yanpin Tian, Lupei Du, Yun Huang, Leng Han, Minyong Li & Yubin Zhou. (2019) Discovery of Small-Molecule Inhibitors of the HSP90-Calcineurin-NFAT Pathway against Glioblastoma. Cell Chemical Biology 26:3, pages 352-365.e7.
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Yujiao Gong, Yucui Dong, Jingru Cui, Quanye Sun, Ziqi Zhen, Yifan Gao, Jun Su & Huan Ren. 2019. Glioma - Contemporary Diagnostic and Therapeutic Approaches. Glioma - Contemporary Diagnostic and Therapeutic Approaches.
Yihai Lin & Zhangyi Wu. (2018) MicroRNA-128 inhibits proliferation and invasion of glioma cells by targeting COX-2. Gene 658, pages 63-69.
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Tengfei Song, Mengxuan Chen, Weiyun Chai, Zhizhen Zhang & Xiao-Yuan Lian. (2018) New bioactive pyrrospirones C−I from a marine-derived fungus Penicillium sp. ZZ380. Tetrahedron 74:8, pages 884-891.
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Xiaoyan He, Mayinur Maimaiti, Yan Jiao, Xuegang Meng & Hongyan Li. (2018) Sinomenine Induces G1-Phase Cell Cycle Arrest and Apoptosis in Malignant Glioma Cells Via Downregulation of Sirtuin 1 and Induction of p53 Acetylation. Technology in Cancer Research & Treatment 17, pages 153303461877030.
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Feng Jin, Guang-Kui Han, Hao Zhang, Ran Zhang, Gen-Hua Li, Song Feng, Xian-Yun Qin, Ling-Sheng Kong, Quan-Min Nie, Hua-Rong Li & Lei Zhao. (2017) Difference in the Inhibitory Effect of Temozolomide on TJ905 Glioma Cells and Stem Cells. Frontiers in Neurology 8.
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Xuejiao Liu, Ning Liu, Chenglong Yue, Dacheng Wang, Zhenglei Qi, Yiming Tu, Guokun Zhuang, Di Zhou, Shangfeng Gao, Mingshan Niu & Rutong Yu. (2017) FoxR2 promotes glioma proliferation by suppression of the p27 pathway. Oncotarget 8:34, pages 56255-56266.
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Xuewei Ye, Komal Anjum, Tengfei Song, Wenling Wang, Ying Liang, Mengxuan Chen, Haocai Huang, Xiao-Yuan Lian & Zhizhen Zhang. (2017) Antiproliferative cyclodepsipeptides from the marine actinomycete Streptomyces sp. P11-23B downregulating the tumor metabolic enzymes of glycolysis, glutaminolysis, and lipogenesis. Phytochemistry 135, pages 151-159.
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Jagriti Pal, Vikas Patil & Kumaravel Somasundaram. 2017. Advances in Biology and Treatment of Glioblastoma. Advances in Biology and Treatment of Glioblastoma 161 190 .
Huanli Xu, Qunying Chen, Hong Wang, Pingxiang Xu, Ru Yuan, Xiaorong Li, Lu Bai & Ming Xue. (2016) Inhibitory effects of lapachol on rat C6 glioma in vitro and in vivo by targeting DNA topoisomerase I and topoisomerase II. Journal of Experimental & Clinical Cancer Research 35:1.
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S A Kaliberov, L N Kaliberova, H Yan, V Kapoor & D E Hallahan. (2016) Retargeted adenoviruses for radiation-guided gene delivery. Cancer Gene Therapy 23:9, pages 303-314.
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Jun Yang, Yan Li, Tianlu Zhang & Xin Zhang. (2016) Development of bioactive materials for glioblastoma therapy. Bioactive Materials 1:1, pages 29-38.
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Arabinda Das, Daniel G. McDonald, Yaenette N. Dixon-Mah, Dustin J. Jacqmin, Vikram N. Samant, William A. Vandergrift, Scott M. Lindhorst, David Cachia, Abhay K. Varma, Kenneth N. Vanek, Naren L. Banik, Joseph M. Jenrette, Jeffery J. Raizer, Pierre Giglio & Sunil J. Patel. (2015) RIP1 and RIP3 complex regulates radiation-induced programmed necrosis in glioblastoma. Tumor Biology 37:6, pages 7525-7534.
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