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SPECIAL FOCUS: Alzheimer's Disease Therapy - Review

Nutraceuticals and amyloid neurodegenerative diseases: a focus on natural phenols

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Marjan Talebi, Eleni Kakouri, Mohsen Talebi, Petros A. Tarantilis, Tahereh Farkhondeh, Selen İlgün, Ali Mohammad Pourbagher-Shahri & Saeed Samarghandian. (2021) Nutraceuticals-based therapeutic approach: recent advances to combat pathogenesis of Alzheimer’s disease. Expert Review of Neurotherapeutics 21:6, pages 625-642.
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Sunil K. Ravi, Ramesh B. Narasingappa & Bruno Vincent. (2019) Neuro-nutrients as anti-alzheimer's disease agents: A critical review. Critical Reviews in Food Science and Nutrition 59:18, pages 2999-3018.
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Kiran Reddy Kanubaddi, Shin-Han Yang, Li-Wei Wu, Chia-Hung Lee & Ching-Feng Weng. (2018) Nanoparticle-conjugated nutraceuticals exert prospectively palliative of amyloid aggregation. International Journal of Nanomedicine 13, pages 8473-8485.
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Fiorella Casamenti & Massimo Stefani. (2017) Olive polyphenols: new promising agents to combat aging-associated neurodegeneration. Expert Review of Neurotherapeutics 17:4, pages 345-358.
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Diane Stephenson. (2015) Alzheimer’s disease: current and future therapy. Expert Review of Neurotherapeutics 15:1, pages 1-2.
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Caterina Bonfiglio, Francesco Cuccaro, Angelo Campanella, Natalia Rosso, Rossella Tatoli, Gianluigi Giannelli & Rossella Donghia. (2023) Effect of Intake of Extra Virgin Olive Oil on Mortality in a South Italian Cohort with and without NAFLD. Nutrients 15:21, pages 4593.
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Kumar Surya, Nivethitha Manickam, Kesavan Swaminathan Jayachandran, Mahesh Kandasamy & Muthuswamy Anusuyadevi. (2023) Resveratrol Mediated Regulation of Hippocampal Neuroregenerative Plasticity via SIRT1 Pathway in Synergy with Wnt Signaling: Neurotherapeutic Implications to Mitigate Memory Loss in Alzheimer’s Disease. Journal of Alzheimer's Disease 94:s1, pages S125-S140.
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Lingzhi Xiang, Yanan Wang, Shenkui Liu, Beidong Liu, Xuejiao Jin & Xiuling Cao. (2023) Targeting Protein Aggregates with Natural Products: An Optional Strategy for Neurodegenerative Diseases. International Journal of Molecular Sciences 24:14, pages 11275.
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Daniela Impellizzeri, Mario Tomasello, Marika Cordaro, Ramona D’Amico, Roberta Fusco, Ali S. Abdelhameed, Uwe Wenzel, Rosalba Siracusa, Vittorio Calabrese, Salvatore Cuzzocrea & Rosanna Di Paola. (2023) MemophenolTM Prevents Amyloid-β Deposition and Attenuates Inflammation and Oxidative Stress in the Brain of an Alzheimer’s Disease Rat. International Journal of Molecular Sciences 24:8, pages 6938.
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Lidia Ciccone, Susanna Nencetti, Armando Rossello, Lucia Barlettani, Nicolò Tonali, Paola Nieri & Elisabetta Orlandini. (2023) Omega-3 PUFAs as a Dietary Supplement in Senile Systemic Amyloidosis. Nutrients 15:3, pages 749.
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Arash Salehipour, Motahareh Bagheri, Mohammadmahdi Sabahi, Mahsa Dolatshahi & Delphine Boche. (2022) Combination Therapy in Alzheimer’s Disease: Is It Time?. Journal of Alzheimer's Disease 87:4, pages 1433-1449.
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Monica Bucciantini, Manuela Leri, Maria Scuto, Marialaura Ontario, Angela Trovato Salinaro, Edward J. Calabrese, Vittorio Calabrese & Massimo Stefani. (2022) Xenohormesis underlyes the anti-aging and healthy properties of olive polyphenols. Mechanisms of Ageing and Development 202, pages 111620.
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Jyoti V. Vastrad, Pratikhya Badanayak & Giridhar Goudar. 2022. Phenolic Compounds - Chemistry, Synthesis, Diversity, Non-Conventional Industrial, Pharmaceutical and Therapeutic Applications. Phenolic Compounds - Chemistry, Synthesis, Diversity, Non-Conventional Industrial, Pharmaceutical and Therapeutic Applications.
Pablo Arrona Cardoza, Micheil B Spillane & Elisa Morales Marroquin. (2022) Alzheimer’s disease and gut microbiota: does trimethylamine N-oxide (TMAO) play a role?. Nutrition Reviews 80:2, pages 271-281.
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Senem Kamiloglu, Esra Capanoglu & Seid Mahdi Jafari. 2022. Retention of Bioactives in Food Processing. Retention of Bioactives in Food Processing 3 36 .
Md. Habibur Rahman, Johny Bajgai, Ailyn Fadriquela, Subham Sharma, Thuy Thi Trinh, Rokeya Akter, Yun Ju Jeong, Seong Hoon Goh, Cheol-Su Kim & Kyu-Jae Lee. (2021) Therapeutic Potential of Natural Products in Treating Neurodegenerative Disorders and Their Future Prospects and Challenges. Molecules 26:17, pages 5327.
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Shofiul Azam, Md. Ezazul Haque, Rengasamy Balakrishnan, In-Su Kim & Dong-Kug Choi. (2021) The Ageing Brain: Molecular and Cellular Basis of Neurodegeneration. Frontiers in Cell and Developmental Biology 9.
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Josephine Trichka & Wen-Quan Zou. (2021) Modulation of Neuroinflammation by the Gut Microbiota in Prion and Prion-Like Diseases. Pathogens 10:7, pages 887.
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Monica Bucciantini, Manuela Leri, Pamela Nardiello, Fiorella Casamenti & Massimo Stefani. (2021) Olive Polyphenols: Antioxidant and Anti-Inflammatory Properties. Antioxidants 10:7, pages 1044.
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Swati Haldar, Souvik Ghosh, Viney Kumar, Saakshi Saini, Debrupa Lahiri & Partha Roy. 2021. Nutraceuticals in Brain Health and Beyond. Nutraceuticals in Brain Health and Beyond 409 439 .
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Nikolaos Stavros Koulakiotis, Pasi Purhonen, Evangelos Gikas, Hans Hebert & Anthony Tsarbopoulos. (2020) Crocus-derived compounds alter the aggregation pathway of Alzheimer’s Disease - associated beta amyloid protein. Scientific Reports 10:1.
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Carolina Pellegrini, Luca Antonioli, Vincenzo Calderone, Rocchina Colucci, Matteo Fornai & Corrado Blandizzi. (2020) Microbiota-gut-brain axis in health and disease: Is NLRP3 inflammasome at the crossroads of microbiota-gut-brain communications?. Progress in Neurobiology 191, pages 101806.
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Lea Pogačnik, Ajda Ota & Nataša Poklar Ulrih. (2020) An Overview of Crucial Dietary Substances and Their Modes of Action for Prevention of Neurodegenerative Diseases. Cells 9:3, pages 576.
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Nur Shafika Mohd Sairazi & K. N. S. Sirajudeen. (2020) Natural Products and Their Bioactive Compounds: Neuroprotective Potentials against Neurodegenerative Diseases. Evidence-Based Complementary and Alternative Medicine 2020, pages 1-30.
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Manuela Leri, Maria Scuto, Maria Laura Ontario, Vittorio Calabrese, Edward J. Calabrese, Monica Bucciantini & Massimo Stefani. (2020) Healthy Effects of Plant Polyphenols: Molecular Mechanisms. International Journal of Molecular Sciences 21:4, pages 1250.
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Alessandra Baldi, Helena Abramovič, Nataša Poklar Ulrih & Maria Daglia. 2020. Handbook of Dietary Phytochemicals. Handbook of Dietary Phytochemicals 1 46 .
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Josef Jampilek, Jiri Kos & Katarina Kralova. (2019) Potential of Nanomaterial Applications in Dietary Supplements and Foods for Special Medical Purposes. Nanomaterials 9:2, pages 296.
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Ruth Hornedo-Ortega, Ana B. Cerezo, Rocío M. de Pablos, Stéphanie Krisa, Tristan Richard, M. Carmen García-Parrilla & Ana M. Troncoso. (2018) Phenolic Compounds Characteristic of the Mediterranean Diet in Mitigating Microglia-Mediated Neuroinflammation. Frontiers in Cellular Neuroscience 12.
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Fangxue Xu, Yujuan Li, Mengmeng Zheng, Xiaozhi Xi, Xuelan Zhang & Chunchao Han. (2018) Structure Properties, Acquisition Protocols, and Biological Activities of Oleuropein Aglycone. Frontiers in Chemistry 6.
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Ioanna Chalatsa, Demetrios A. Arvanitis, Eleni V. Mikropoulou, Athina Giagini, Zeta Papadopoulou-Daifoti, Nektarios Aligiannis, Maria Halabalaki, Anthony Tsarbopoulos, Leandros A. Skaltsounis & Despina Sanoudou. (2018) Beneficial Effects of Sideritis scardica and Cichorium spinosum against Amyloidogenic Pathway and Tau Misprocessing in Alzheimer’s Disease Neuronal Cell Culture Models. Journal of Alzheimer's Disease 64:3, pages 787-800.
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Joaquín G. Cordero, Ramón García-Escudero, Jesús Avila, Ricardo Gargini & Vega García-Escudero. (2018) Benefit of Oleuropein Aglycone for Alzheimer’s Disease by Promoting Autophagy. Oxidative Medicine and Cellular Longevity 2018, pages 1-12.
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Zohra Dhouafli, Stefania Rigacci, Manuela Leri, Monica Bucciantini, Borhane Mahjoub, Moufida Saidani Tounsi, Wissem Aidi Wannes, Massimo Stefani & El Akrem Hayouni. (2018) Screening for amyloid-β aggregation inhibitor and neuronal toxicity of eight Tunisian medicinal plants. Industrial Crops and Products 111, pages 823-833.
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Madhurantakam C. Preethi Pallavi & Halmuthur M. Sampath Kumar. 2018. Discovery and Development of Neuroprotective Agents from Natural Products. Discovery and Development of Neuroprotective Agents from Natural Products 359 376 .
Andreia Granja, Alexandre C. Vieira, Luíse L. Chaves, Cláudia Nunes, Ana Rute Neves, Marina Pinheiro & Salette Reis. (2017) Folate-targeted nanostructured lipid carriers for enhanced oral delivery of epigallocatechin-3-gallate. Food Chemistry 237, pages 803-810.
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Mathieu Bourdenx, Nikolaos Stavros Koulakiotis, Despina Sanoudou, Erwan Bezard, Benjamin Dehay & Anthony Tsarbopoulos. (2017) Protein aggregation and neurodegeneration in prototypical neurodegenerative diseases: Examples of amyloidopathies, tauopathies and synucleinopathies. Progress in Neurobiology 155, pages 171-193.
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Daniela Pantano, Ilaria Luccarini, Pamela Nardiello, Maurizio Servili, Massimo Stefani & Fiorella Casamenti. (2017) Oleuropein aglycone and polyphenols from olive mill waste water ameliorate cognitive deficits and neuropathology. British Journal of Clinical Pharmacology 83:1, pages 54-62.
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Michelle Briffa, Stephanie Ghio, Johanna Neuner, Alison J. Gauci, Rebecca Cacciottolo, Christelle Marchal, Mario Caruana, Christophe Cullin, Neville Vassallo & Ruben J. Cauchi. (2017) Extracts from two ubiquitous Mediterranean plants ameliorate cellular and animal models of neurodegenerative proteinopathies. Neuroscience Letters 638, pages 12-20.
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Sergio Davinelli, Michael Maes, Graziamaria Corbi, Armando Zarrelli, Donald Craig Willcox & Giovanni Scapagnini. (2016) Dietary phytochemicals and neuro-inflammaging: from mechanistic insights to translational challenges. Immunity & Ageing 13:1.
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Francesca Pistollato, Sandra Sumalla Cano, Iñaki Elio, Manuel Masias Vergara, Francesca Giampieri & Maurizio Battino. (2016) Role of gut microbiota and nutrients in amyloid formation and pathogenesis of Alzheimer disease. Nutrition Reviews 74:10, pages 624-634.
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Susana Almeida, Marco G. Alves, Mário Sousa, Pedro F. Oliveira & Branca M. Silva. (2016) Are Polyphenols Strong Dietary Agents Against Neurotoxicity and Neurodegeneration?. Neurotoxicity Research 30:3, pages 345-366.
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Mario Caruana, Ruben Cauchi & Neville Vassallo. (2016) Putative Role of Red Wine Polyphenols against Brain Pathology in Alzheimer’s and Parkinson’s Disease. Frontiers in Nutrition 3.
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Stefania Rigacci & Massimo Stefani. (2016) Nutraceutical Properties of Olive Oil Polyphenols. An Itinerary from Cultured Cells through Animal Models to Humans. International Journal of Molecular Sciences 17:6, pages 843.
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Andreia Granja, Marina Pinheiro & Salette Reis. (2016) Epigallocatechin Gallate Nanodelivery Systems for Cancer Therapy. Nutrients 8:5, pages 307.
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Jun Jin, Gayrat Sheraliev, Dan Xie, Wei Zhang, Qingzhe Jin & Xingguo Wang. (2015) Characteristics of Specialty Natural Micronutrients in Certain Oilseeds and Oils: Plastochromanol-8, Resveratrol, 5-Hydroxytryptamine Phenylpropanoid Amides, Lanosterol, Ergosterol and Cyclolinopeptides. Journal of the American Oil Chemists' Society 93:2, pages 155-170.
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Stefania Rigacci, Caterina Miceli, Chiara Nediani, Andrea Berti, Roberta Cascella, Daniela Pantano, Pamela Nardiello, Ilaria Luccarini, Fiorella Casamenti & Massimo Stefani. (2015) Oleuropein aglycone induces autophagy via the AMPK/mTOR signalling pathway: a mechanistic insight . Oncotarget 6:34, pages 35344-35357.
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