293
Views
22
CrossRef citations to date
0
Altmetric
Review

Ubiquitin proteasome system as a pharmacological target in neurodegeneration

, , &
Pages 1337-1347 | Published online: 10 Jan 2014

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (1)

Saima Nusrat & Rizwan Hasan Khan. (2018) Exploration of ligand-induced protein conformational alteration, aggregate formation, and its inhibition: A biophysical insight. Preparative Biochemistry & Biotechnology 48:1, pages 43-56.
Read now

Articles from other publishers (21)

Melanie Hüttenrauch, José Sócrates Lopez-Noguerola & Susana Castro-Obregón. (2021) Connecting Mind-Body Therapy-Mediated Effects to Pathological Features of Alzheimer’s Disease. Journal of Alzheimer's Disease 82:s1, pages S65-S90.
Crossref
W.M.A.D. Binosha Fernando, Veer B. Gupta, Vijay Jayasena, Charles S. Brennan & Ralph N. Martins. 2019. Neurodegeneration and Alzheimer's Disease. Neurodegeneration and Alzheimer's Disease 149 187 .
Cynthia L. Bethea, Arubala P. Reddy & Fernanda Lima Christian. (2017) How Studies of the Serotonin System in Macaque Models of Menopause Relate to Alzheimer’s Disease1. Journal of Alzheimer's Disease 57:4, pages 1001-1015.
Crossref
Francesca Pistollato, Sandra Sumalla Cano, Iñaki Elio, Manuel Masias Vergara, Francesca Giampieri & Maurizio Battino. (2016) Associations between Sleep, Cortisol Regulation, and Diet: Possible Implications for the Risk of Alzheimer Disease. Advances in Nutrition 7:4, pages 679-689.
Crossref
C L Bethea & A P Reddy. (2015) Ovarian steroids regulate gene expression related to DNA repair and neurodegenerative diseases in serotonin neurons of macaques. Molecular Psychiatry 20:12, pages 1565-1578.
Crossref
Lanhai Lü, Xiqiang Liu, Cheng Wang, Fengchun Hu, Jianning Wang & Hongzhang Huang. (2015) Dissociation of E-cadherin/β-catenin complex by MG132 and bortezomib enhances CDDP induced cell death in oral cancer SCC-25 cells. Toxicology in Vitro 29:8, pages 1965-1976.
Crossref
SHOTA MORIYA, SEIICHIRO KOMATSU, KAHO YAMASAKI, YUSUKE KAWAI, HIROKO KOKUBA, AYAKO HIROTA, XIAO-FANG CHE, MASATO INAZU, AKIHIKO GOTOH, MASAKI HIRAMOTO & KEISUKE MIYAZAWA. (2015) Targeting the integrated networks of aggresome formation, proteasome, and autophagy potentiates ER stress-mediated cell death in multiple myeloma cells. International Journal of Oncology 46:2, pages 474-486.
Crossref
Suzanne M. de la Monte. (2014) Relationships Between Diabetes and Cognitive Impairment. Endocrinology and Metabolism Clinics of North America 43:1, pages 245-267.
Crossref
Suzanne M. de la Monte & Ming Tong. 2013. Metabolic Syndrome and Neurological Disorders. Metabolic Syndrome and Neurological Disorders 1 30 .
Márcio S. Baptista, Carlos B. Duarte & Patrícia Maciel. (2012) Role of the ubiquitin–proteasome system in nervous system function and disease: using C. elegans as a dissecting tool. Cellular and Molecular Life Sciences 69:16, pages 2691-2715.
Crossref
Qian Huang & Maria E. Figueiredo-Pereira. (2010) Ubiquitin/proteasome pathway impairment in neurodegeneration: therapeutic implications. Apoptosis 15:11, pages 1292-1311.
Crossref
Le Zhang, Philip J. Ebenezer, Kalavathi Dasuri, Annadora J. Bruce-Keller, Sun Ok Fernandez-Kim, Ying Liu & Jeffrey N. Keller. (2010) Activation of PERK kinase in neural cells by proteasome inhibitor treatment. Journal of Neurochemistry 112:1, pages 238-245.
Crossref
David F. Fischer, Renske van Dijk, Paula van Tijn, Barbara Hobo, Marian C. Verhage, Roel C. van der Schors, Ka Wan Li, Jan van Minnen, Elly M. Hol & Fred W. van Leeuwen. (2009) Long-term proteasome dysfunction in the mouse brain by expression of aberrant ubiquitin. Neurobiology of Aging 30:6, pages 847-863.
Crossref
Jeroen J.M. Hoozemans & Wiep Scheper. 2009. Protein Folding and Misfolding: Neurodegenerative Diseases. Protein Folding and Misfolding: Neurodegenerative Diseases 111 132 .
Hsin-Mei Chen, Lulu Wang & Santosh R. D’Mello. (2008) A chemical compound commonly used to inhibit PKR, {8-(imidazol-4-ylmethylene)-6H-azolidino[5,4-g] benzothiazol-7-one}, protects neurons by inhibiting cyclin-dependent kinase. European Journal of Neuroscience 28:10, pages 2003-2016.
Crossref
Paula van Tijn, Elly M. Hol, Fred W. van Leeuwen & David F. Fischer. (2008) The neuronal ubiquitin-proteasome system: Murine models and their neurological phenotype. Progress in Neurobiology 85:2, pages 176-193.
Crossref
Francisco Lázaro-Diéguez, Carmen Aguado, Eugenia Mato, Yován Sánchez-Ruíz, Inmaculada Esteban, Jordi Alberch, Erwin Knecht & Gustavo Egea. (2008) Dynamics of an F-actin aggresome generated by the actin-stabilizing toxin jasplakinolide. Journal of Cell Science 121:9, pages 1415-1425.
Crossref
Donghui Zhang, G. Jean Harry, Perry J. Blackshear & Darryl C. Zeldin. (2008) G-protein Pathway Suppressor 2 (GPS2) Interacts with the Regulatory Factor X4 Variant 3 (RFX4_v3) and Functions as a Transcriptional Co-activator. Journal of Biological Chemistry 283:13, pages 8580-8590.
Crossref
E. M. Hol & W. Scheper. (2007) Protein Quality Control in Neurodegeneration: Walking the Tight Rope Between Health and Disease. Journal of Molecular Neuroscience 34:1, pages 23-33.
Crossref
Eduardo Gonzalez-Couto, Silvia Matteoni, Stefano Gotta, Letizia Magnoni, Freddy Heitz, Roberto Raggiaschi, Georg C Terstappen & Andreas Kremer. (2007) Huntington's disease: from experimental results to interaction networks, patho-pathway construction and disease hypothesis. BMC Systems Biology 1:S1.
Crossref
Paula van Tijn, Femke M. S. de Vrij, Karianne G. Schuurman, Nico P. Dantuma, David F. Fischer, Fred W. van Leeuwen & Elly M. Hol. (2007) Dose-dependent inhibition of proteasome activity by a mutant ubiquitin associated with neurodegenerative disease. Journal of Cell Science 120:9, pages 1615-1623.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.