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Uric acid administration in patients with acute stroke: a novel approach to neuroprotection

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Pages 259-270 | Published online: 09 Jan 2014

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Yanxin Ren, Bing Wei, Xirui Song, Nan An, Yiying Zhou, Xinxin Jin & Yuyang Zhang. (2015) Edaravone's free radical scavenging mechanisms of neuroprotection against cerebral ischemia: review of the literature. International Journal of Neuroscience 125:8, pages 555-565.
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E. Agabiti-Rosei & G. Grassi. (2013) Beyond gout: uric acid and cardiovascular diseases. Current Medical Research and Opinion 29:sup3, pages 33-39.
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Peter Higgins, Lyn D Ferguson & Matthew R Walters. (2011) Xanthine oxidase inhibition for the treatment of stroke disease: a novel therapeutic approach. Expert Review of Cardiovascular Therapy 9:4, pages 399-401.
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JACEK KURZEPA, JOANNA BIELEWICZ, ZBIGNIEW STELMASIAK & HALINA BARTOSIK-PSUJEK. (2009) SERUM BILIRUBIN AND URIC ACID LEVELS AS THE BAD PROGNOSTIC FACTORS IN THE ISCHEMIC STROKE. International Journal of Neuroscience 119:12, pages 2243-2249.
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Articles from other publishers (41)

Mohamed S. Abdel-Bakky, Anas S. A. Aldakhili, Hussein M. Ali, Ali Y. Babiker, Ahmad H. Alhowail & Salman A. A. Mohammed. (2023) Evaluation of Cisplatin-Induced Acute Renal Failure Amelioration Using Fondaparinux and Alteplase. Pharmaceuticals 16:7, pages 910.
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Qiu-hong Tan, Lin Liu, Yu-qing Huang, Yu-ling Yu, Jia-yi Huang, Chao-lei Chen, Song-tao Tang & Ying-qing Feng. (2021) Relationship Between Change in Serum Uric Acid and Ischemic Stroke in Chinese Hypertensive Patients. Frontiers in Cardiovascular Medicine 8.
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Wenwei Ren, Qiqi Huang, Kaili Fan, Jingjie Hu, Qianqian Cheng, Minjie Xu, Ruoting Xu, Yuntao Liu, Liping Wang, Siyan Chen, Wanli Zhang, Zhenguo Zhu, Chunxue Wu, Langlang Xue, Yanman Dai, Feifan Yan, Guiqian Huang & Jincai He. (2021) Uric acid played a role in the association between gender and deep vein thrombosis in patients with stroke. Nutrition, Metabolism and Cardiovascular Diseases 31:9, pages 2700-2706.
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Heng Wan, Yuying Wang, Yi Chen, Sijie Fang, Wen Zhang, Fangzhen Xia, Ningjian Wang & Yingli Lu. (2020) Different associations between serum urate and diabetic complications in men and postmenopausal women. Diabetes Research and Clinical Practice 160, pages 108005.
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Hefei Tang, Jinglin Mo, Zimo Chen, Jie Xu, Anxin Wang, Liye Dai, Aichun Cheng & Yongjun Wang. (2019) Uric Acid Contributes to Obesity-Paradox of the Outcome of Ischemic Stroke. Frontiers in Neurology 10.
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Evgeny Sidorov, Dharambir K. Sanghera & Jairam K. P. Vanamala. (2019) Biomarker for Ischemic Stroke Using Metabolome: A Clinician Perspective. Journal of Stroke 21:1, pages 31-41.
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Sergi Amaro, Francesc Jiménez-Altayó & Ángel Chamorro. (2019) Uric acid therapy for vasculoprotection in acute ischemic stroke. Brain Circulation 5:2, pages 55.
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Przemyslaw Swiatkowski, Emily Sewell, Eric S. Sweet, Samantha Dickson, Rachel A. Swanson, Sara A. McEwan, Nicholas Cuccolo, Mark E. McDonnell, Mihir V. Patel, Nevin Varghese, Barclay Morrison, Allen B. Reitz, David F. Meaney & Bonnie L. Firestein. (2018) Cypin: A novel target for traumatic brain injury. Neurobiology of Disease 119, pages 13-25.
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Yacouba Njankouo Mapoure, Chia Mark Ayeah, Hamadou Ba, Romuald Hentchoya & Henry Namme Luma. (2018) The Prognostic Value of Serum Uric Acid in the Acute Phase of Ischemic Stroke in Black Africans. Journal of Stroke and Cerebrovascular Diseases 27:3, pages 783-792.
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Shuolin Wu, Yuesong Pan, Ning Zhang, Wang Yong Jun & Chunxue Wang. (2017) Lower serum uric acid level strongly predict short-term poor functional outcome in acute stroke with normoglycaemia: a cohort study in China. BMC Neurology 17:1.
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Bin Zhang, Ning Yang, Shao-peng Lin & Feng Zhang. (2016) Suitable Concentrations of Uric Acid Can Reduce Cell Death in Models of OGD and Cerebral Ischemia–Reperfusion Injury. Cellular and Molecular Neurobiology 37:5, pages 931-939.
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Yacouba N. Mapoure, Chia Mark Ayeah, M. S. Doualla, H. Ba, Hugo B. Mbatchou Ngahane, Salomon Mbahe & Henry N. Luma. (2017) Serum Uric Acid Is Associated with Poor Outcome in Black Africans in the Acute Phase of Stroke. Stroke Research and Treatment 2017, pages 1-9.
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Sergio Amaro, Xabier Urra & Ángel Chamorro. 2017. Neuroprotective Therapy for Stroke and Ischemic Disease. Neuroprotective Therapy for Stroke and Ischemic Disease 401 414 .
Sergio AmaroCarlos LaredoArturo RenúLaura LlullSalvatore RudilossoVíctor ObachXabier UrraAnna M. PlanasÁngel Chamorro. (2016) Uric Acid Therapy Prevents Early Ischemic Stroke Progression. Stroke 47:11, pages 2874-2876.
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Zhihui Yang, Andong Zhao, Zhongdong Li, Hua Ge, Tonghua Li, Fucheng Zhang, Hao Zhan & Jianchang Wang. (2016) Metabolomics reveals positive acceleration(+Gz)-induced metabolic perturbations and the protective effect of Ginkgo biloba extract in a rat model based on ultra high-performance liquid chromatography coupled with quadrupole time-of-flight mass spectrometry. Journal of Pharmaceutical and Biomedical Analysis 125, pages 77-84.
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Xia Zhang, Zhi-Chao Huang, Tao-Sheng Lu, Shou-Jiang You, Yong-Jun Cao & Chun-Feng Liu. (2015) Prognostic Significance of Uric Acid Levels in Ischemic Stroke Patients. Neurotoxicity Research 29:1, pages 10-20.
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Laura Llull, Sergio Amaro & Ángel Chamorro. (2015) Administration of Uric Acid in the Emergency Treatment of Acute Ischemic Stroke. Current Neurology and Neuroscience Reports 16:1.
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Laura LlullCarlos LaredoArturo RenúBelén PérezElisabet VilaVíctor ObachXabier UrraAnna PlanasSergio AmaroÁngel Chamorro. (2015) Uric Acid Therapy Improves Clinical Outcome in Women With Acute Ischemic Stroke. Stroke 46:8, pages 2162-2167.
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Xuan Liu, Ming Liu, Miao Chen, Qin-Min Ge & Shu-Ming Pan. (2015) Serum Uric Acid Is Neuroprotective in Chinese Patients with Acute Ischemic Stroke Treated with Intravenous Recombinant Tissue Plasminogen Activator. Journal of Stroke and Cerebrovascular Diseases 24:5, pages 1080-1086.
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Sergio Amaro, Laura Llull, Arturo Renú, Carlos Laredo, Belén Perez, Elisabet Vila, Ferrán Torres, Anna M. Planas & Ángel Chamorro. (2015) Uric acid improves glucose-driven oxidative stress in human ischemic stroke. Annals of Neurology 77:5, pages 775-783.
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Yara OnettiAna P. DantasBelén PérezRoger CugotaAngel Chamorro, Anna M. Planas, Elisabet VilaFrancesc Jiménez-Altayó. (2015) Middle cerebral artery remodeling following transient brain ischemia is linked to early postischemic hyperemia: A target of uric acid treatment. American Journal of Physiology-Heart and Circulatory Physiology 308:8, pages H862-H874.
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Min Liu, Kaige Zhou, Hailong Li, Xin Dong, Guangguo Tan, Yifeng Chai, Weizhong Wang & Xiaoying Bi. (2015) Potential of serum metabolites for diagnosing post-stroke cognitive impairment. Molecular BioSystems 11:12, pages 3287-3296.
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Steven R. Levine, Syed Faraz Kazim, Pirouz Piran & Frank C. Barone. 2015. Thrombolytic Therapy for Acute Stroke. Thrombolytic Therapy for Acute Stroke 27 64 .
Zhenzhen Zheng, Xiaoyan Guo, Qianqian Wei, Wei Song, Bei Cao, Rui Huang, Ruwei Ou, Xueping Chen & Huifang Shang. (2014) Serum uric acid level is associated with the prevalence but not with survival of amyotrophic lateral sclerosis in a Chinese population. Metabolic Brain Disease 29:3, pages 771-775.
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O. V. Tovchiga & S. Yu. Shtrygol’. (2014) Uric acid and central nervous system functioning (a literature review). Biology Bulletin Reviews 4:3, pages 210-221.
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Ali Akbar Taheraghdam, Ehsan Sharifipour, Ali Pashapour, Shahryar Namdar, Abolfazl Hatami, Samaneh Houshmandzad, Elyar Sadeghihokmabadi, Mokhtar Tazik, Reza Rikhtegar & Ata Mahmoodpoor. (2014) Allopurinol as a Preventive Contrivance after Acute Ischemic Stroke in Patients with a High Level of Serum Uric Acid: A Randomized, Controlled Trial. Medical Principles and Practice 23:2, pages 134-139.
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Sang-Hwa Lee, Sung Hyuk Heo, Jun-Hyun Kim, Dokyung Lee, Ji Sung Lee, Young Seo Kim, Hyun Young Kim, Seong-Ho Koh & Dae-Il Chang. (2014) Effects of Uric Acid Levels on Outcome in Severe Ischemic Stroke Patients Treated with Intravenous Recombinant Tissue Plasminogen Activator. European Neurology 71:3-4, pages 132-139.
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Wi-Sun Ryu, Chi Kyung Kim, Beom Joon Kim & Seung-Hoon Lee. (2013) Serum Uric Acid Levels and Cerebral Microbleeds in Patients with Acute Ischemic Stroke. PLoS ONE 8:1, pages e55210.
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Sabrina Paganoni, May Zhang, Alejandro Quiroz Zárate, Matthew Jaffa, Hong Yu, Merit E. Cudkowicz & Anne-Marie Wills. (2012) Uric acid levels predict survival in men with amyotrophic lateral sclerosis. Journal of Neurology 259:9, pages 1923-1928.
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C.Y. Shih, C.Y. Chen, C.J. Wen, H.M. Liu & H.K. Kuo. (2012) Relationship between serum uric acid and cerebral white matter lesions in the elderly. Nutrition, Metabolism and Cardiovascular Diseases 22:2, pages 154-159.
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