268
Views
46
CrossRef citations to date
0
Altmetric
Review

Autoantibodies to glutamate receptors can damage the brain in epilepsy, systemic lupus erythematosus and encephalitis

&
Pages 1141-1160 | Published online: 09 Jan 2014

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (2)

Eisuke Ogawa, Tatsuo Nagai, Yuko Sakuma, Yoshiyuki Arinuma & Shunsei Hirohata. (2016) Association of antibodies to the NR1 subunit of -methyl--aspartate receptors with neuropsychiatric systemic lupus erythematosus. Modern Rheumatology 26:3, pages 377-383.
Read now
Bryan Paul Morgan. (2015) The role of complement in neurological and neuropsychiatric diseases. Expert Review of Clinical Immunology 11:10, pages 1109-1119.
Read now

Articles from other publishers (44)

Maria S. Hadjiagapiou, George Krashias, Christina Christodoulou, Marios Pantzaris & Anastasia Lambrianides. (2023) Serum Reactive Antibodies against the N-Methyl-D-Aspartate Receptor NR2 Subunit—Could They Act as Potential Biomarkers?. International Journal of Molecular Sciences 24:22, pages 16170.
Crossref
Balázs Sonkodi, László Marsovszky, Anita Csorba, Attila Balog, Bence Kopper, Zoltán Zsolt Nagy & Miklós D. Resch. (2023) Neural Regeneration in Dry Eye Secondary to Systemic Lupus Erythematosus Is Also Disrupted like in Rheumatoid Arthritis, but in a Progressive Fashion. International Journal of Molecular Sciences 24:13, pages 10680.
Crossref
George A. Karkashadze, Leyla S. Namazova-Baranova, Leonid M. Yatsik, Olga B. Gordeeva, Elena A. Vishneva, Kamilla E. Efendieva, Elena V. Kaytukova, Natella V. Sukhanova, Natalia S. Sergienko, Julia V. Nesterova, Svetlana E. Kondratova, Madina T. Fatakhova, Alexandr V. Pashkov, Irina V. Naumova, Irina V. Zelenkova, Viktor A. Gankovskiy, Svetlana G. Gubanova, Elizaveta V. Leonova, Alina R. Pankova, Anna A. Alexeeva, Daria A. Bushueva, Tinatin Yu. Gogberashvili, Dmitriy S. Kratko, Safarbegim H. Sadilloeva, Natalia E. Sergeeva, Marina A. Kurakina, Tatiana A. Konstantinidi, Inessa A. Povalyaeva, Margarita A. Soloshenko, Mariya I. Slipka, Viktor V. Altunin, Anastasiya I. Rykunova, Tatiana A. Salimgareeva, Pavel A. Prudnikov, Nadezhda A. Ulkina, Alexey I. Firumyantc, Nikita S. Shilko & Julia E. Kazanceva. (2023) Levels of Neurospecific Peptides, Neurotransmitters and Neuroreceptor Markers in the Serum of Children with Various Sensory Disorders, Mild Cognitive Impairments and Other Neuropathology. Pediatric pharmacology 19:6, pages 459-478.
Crossref
Qingwei Lai, Qingyun Li, Xinyu Li, Heng Wang, Wei Zhang, Xiaotao Song, Peng Hu, Ruiqin Yao, Hongbin Fan & Xingshun Xu. (2022) GluR3B Antibody Was a Biomarker for Drug-Resistant Epilepsy in Patients With Focal to Bilateral Tonic-Clonic Seizures. Frontiers in Immunology 13.
Crossref
Mia Levite & Hadassa Goldberg. (2022) Autoimmune Epilepsy - Novel Multidisciplinary Analysis, Discoveries and Insights. Frontiers in Immunology 12.
Crossref
Ali Alizadeh Khatir, Mahdi Sepidarkish, Mohammad Reza Rajabalizadeh, Solmaz Alizadeh Moghaddam, Saeed Aghapour, Saeed Mehravar, Peter J. Hotez, Robin B. Gasser & Ali Rostami. (2021) Case-Control Study to Assess the Association between Epilepsy and Toxocara Infection/Exposure. Microorganisms 9:10, pages 2091.
Crossref
Fiorella Caputo, Rosario Barranco, Pietrantonio Ricci, Santo Gratteri, Lara Castelletti, Gian Luigi Ravetti & Francesco Ventura. (2020) An unusual case of coma related to glutamate receptor 3 (GluR3) auto-antibodies after a traumatic spinal cord injury: Clinical and pathological aspects. Medico-Legal Journal 89:2, pages 133-136.
Crossref
Chanting He, Xiaoyan Zhao, Huan Li, Fei Wang, Jingsi Zhang, Yanni Wang, Yingchao Han, Chunman Yuan & Qiao Niu. (2021) Regulation of mGluR1 on the Expression of PKC and NMDAR in Aluminum-Exposed PC12 Cells. Neurotoxicity Research 39:3, pages 634-644.
Crossref
Mia Levite, Daniel Zelig, Alon Friedman, Nili Ilouz, Raya Eilam, Zohar Bromberg, Ally Ahmed Ramadhan Lasu, Sagit Arbel-Alon, Shimon Edvardson, Mark Tarshish, Lul P. Riek, Richard Lino Lako, Benjamin Reubinoff, Mario Lebendiker, Dayana Yaish, Alexandra Stavsky & Eithan Galun. (2020) Dual-Targeted Autoimmune Sword in Fatal Epilepsy: Patient's glutamate receptor AMPA GluR3B peptide autoimmune antibodies bind, induce Reactive Oxygen Species (ROS) in, and kill both human neural cells and T cells. Journal of Autoimmunity 112, pages 102462.
Crossref
Baolong Pan, Yaqin Li, Jingsi Zhang, Yue Zhou, Liang Li, Xingli Xue, Huan Li & Qiao Niu. (2020) Role of mGluR 1 in synaptic plasticity impairment induced by maltol aluminium in rats. Environmental Toxicology and Pharmacology 78, pages 103406.
Crossref
Alessandra NicolettiLuis A. Gomez-PuertaGianfranco ArroyoJavier BustosArmando E. GonzalezHector H. Garcia. (2020) Toxocara Brain Infection in Pigs is Not Associated with Visible Lesions on Brain Magnetic Resonance Imaging. The American Journal of Tropical Medicine and Hygiene 103:1, pages 273-275.
Crossref
Irene Meester, Gerardo Francisco Rivera-Silva & Francisco González-Salazar. (2020) Immune System Sex Differences May Bridge the Gap Between Sex and Gender in Fibromyalgia. Frontiers in Neuroscience 13.
Crossref
Deepika Mukhara, Unsong Oh & Gretchen N. Neigh. 2020. Sex Differences in Neurology and Psychiatry. Sex Differences in Neurology and Psychiatry 235 259 .
Russell M. Bauer, Leslie Gaynor, Charles Moreno & Taylor Kuhn. 2019. Handbook on the Neuropsychology of Aging and Dementia. Handbook on the Neuropsychology of Aging and Dementia 619 639 .
Jaime Luna, Calogero Edoardo Cicero, Guillaume Rateau, Graziella Quattrocchi, Benoit Marin, Elisa Bruno, François Dalmay, Michel Druet-Cabanac, Alessandra Nicoletti & Pierre-Marie Preux. (2018) Updated evidence of the association between toxocariasis and epilepsy: Systematic review and meta-analysis. PLOS Neglected Tropical Diseases 12:7, pages e0006665.
Crossref
Shenghua Zong, Carolin Hoffmann, Marina Mané-Damas, Peter Molenaar, Mario Losen & Pilar Martinez-Martinez. (2017) Neuronal Surface Autoantibodies in Neuropsychiatric Disorders: Are There Implications for Depression?. Frontiers in Immunology 8.
Crossref
Barbara Borroni, Marta A. Manes, Antonella Alberici, Maura Cosseddu, Pia Bernasconi, Silvana Archetti, Lorenzo Pinelli, Roberto Gasparotti & Alessandro Padovani. (2017) Autoimmune Frontotemporal Dementia. Alzheimer Disease & Associated Disorders 31:3, pages 259-262.
Crossref
Limin Ma, Ruohan Li, Hao Huang, Jinxian Yuan, Shu Ou, Tao Xu, Xinyuan Yu, Xi Liu & Yangmei Chen. (2017) Up-regulated BAFF and BAFF receptor expression in patients with intractable temporal lobe epilepsy and a pilocarpine-induced epilepsy rat model. Seizure 48, pages 79-88.
Crossref
Yongjun Sun, Xiaokun Cheng, Linan Zhang, Jie Hu, You chen, Liying Zhan & Zibin Gao. (2016) The Functional and Molecular Properties, Physiological Functions, and Pathophysiological Roles of GluN2A in the Central Nervous System. Molecular Neurobiology 54:2, pages 1008-1021.
Crossref
A Rosati, R Guerrini & R Cimaz. (2016) Lupus, antiphospholipid syndrome and epilepsy: an update. Lupus 26:1, pages 3-5.
Crossref
Andrey M. Mazarati. 2017. Models of Seizures and Epilepsy. Models of Seizures and Epilepsy 1091 1104 .
Andrew C. Schomer, Wendy Ziai, Mohammed Rehman & Barnett R. Nathan. 2017. Seizures in Critical Care. Seizures in Critical Care 277 290 .
Marco Cosentino, Natasa Kustrimovic & Franca Marino. 2017. Neuroimmune Pharmacology. Neuroimmune Pharmacology 395 406 .
Cassandra A DeMarshall, Abhirup Sarkar & Robert G Nagele. (2015) Serum Autoantibodies as Biomarkers for Parkinsons Disease: Background and Utility. AIMS Medical Science 2:4, pages 316-327.
Crossref
Mia Levite. (2014) GLUTAMATE RECEPTOR ANTIBODIES IN NEUROLOGICAL DISEASES: Anti-AMPA-GluR3 antibodies, Anti-NMDA-NR1 antibodies, Anti-NMDA-NR2A/B antibodies, Anti-mGluR1 antibodies or Anti-mGluR5 antibodies are present in subpopulations of patients with either: Epilepsy, Encephalitis, Cerebellar Ataxia, Systemic Lupus Erythematosus (SLE) and Neuropsychiatric SLE, Sjogren’s syndrome, Schizophrenia, Mania or Stroke. These autoimmune anti-glutamate receptor antibodies can bind neurons in few brain regions, activate glutamate receptors, decrease glutamate receptor’s expression, impair glutamate-induced signaling and function, activate Blood Brain Barrier endothelial cells, kill neurons, damage the brain, induce behavioral/psychiatric/cognitive abnormalities and Ataxia in animal models, and can be removed or silenced in some patients by immunotherapy. Journal of Neural Transmission 121:8, pages 1029-1075.
Crossref
Yonatan Ganor & Mia Levite. (2014) The neurotransmitter glutamate and human T cells: glutamate receptors and glutamate-induced direct and potent effects on normal human T cells, cancerous human leukemia and lymphoma T cells, and autoimmune human T cells. Journal of Neural Transmission 121:8, pages 983-1006.
Crossref
Yonatan Ganor, Hadassa Goldberg-Stern, Ran Cohen, Vivian Teichberg & Mia Levite. (2014) Glutamate receptor antibodies directed against AMPA receptors subunit 3 peptide B (GluR3B) can be produced in DBA/2J mice, lower seizure threshold and induce abnormal behavior. Psychoneuroendocrinology 42, pages 106-117.
Crossref
Hadassa Goldberg-Stern, Yonatan Ganor, Ran Cohen, Lea Pollak, Vivian Teichberg & Mia Levite. (2014) Glutamate receptor antibodies directed against AMPA receptors subunit 3 peptide B (GluR3B) associate with some cognitive/psychiatric/behavioral abnormalities in epilepsy patients. Psychoneuroendocrinology 40, pages 221-231.
Crossref
Philip H. IfflandIIII, Juliana Carvalho-Tavares, Abhishek Trigunaite, Shumei Man, Peter Rasmussen, Andreas Alexopoulos, Chaitali Ghosh, Trine N. Jørgensen & Damir Janigro. (2013) Intracellular and circulating neuronal antinuclear antibodies in human epilepsy. Neurobiology of Disease 59, pages 206-219.
Crossref
Sahar A. Abd El-Aziz & Hesham El-Serogy. (2013) Antinuclear antibodies and glutamic acid decarboxylase antibodies in children with refractory epilepsy. Egyptian Pediatric Association Gazette 61:1, pages 46-51.
Crossref
Taylor Kuhn & Russell M. Bauer. 2013. Handbook on the Neuropsychology of Aging and Dementia. Handbook on the Neuropsychology of Aging and Dementia 401 419 .
Faith Dickerson, Cassie Stallings, Crystal Vaughan, Andrea Origoni, Sunil Khushalani & Robert Yolken. (2012) Antibodies to the glutamate receptor in mania. Bipolar Disorders 14:5, pages 547-553.
Crossref
Christiane S. Hampe. (2012) B Cells in Autoimmune Diseases. Scientifica 2012, pages 1-18.
Crossref
Yonatan Ganor & Mia Levite. 2012. Nerve-Driven Immunity. Nerve-Driven Immunity 121 161 .
Sharifia Wills, Christy C Rossi, Jeffrey Bennett, Veronica Martinez-Cerdeño, Paul Ashwood, David G Amaral & Judy Van de Water. (2011) Further characterization of autoantibodies to GABAergic neurons in the central nervous system produced by a subset of children with autism. Molecular Autism 2:1.
Crossref
IRLAPATI RAJENDRA VARAPRASAD, SUMEET AGRAWAL, VADIVELMURUGAN NAGASUBRAMANI NAGA PRABU, LIZA RAJASEKHAR, MEENA ANGAMUTHU KANIKANNAN & GUMDAL NARSIMULU. (2011) Posterior Reversible Encephalopathy Syndrome in Systemic Lupus Erythematosus. The Journal of Rheumatology 38:8, pages 1607-1611.
Crossref
Milo Careaga, Judy Water & Paul Ashwood. (2010) Immune dysfunction in autism: A pathway to treatment. Neurotherapeutics 7:3, pages 283-292.
Crossref
Suvi Liimatainen, Maria Peltola, Lidia Sabater, Mahdi Fallah, Elham Kharazmi, Anna‐Maija Haapala, Prasun Dastidar, Mikael Knip, Albert Saiz & Jukka Peltola. (2010) Clinical significance of glutamic acid decarboxylase antibodies in patients with epilepsy. Epilepsia 51:5, pages 760-767.
Crossref
Angela Vincent, Sarosh R Irani & Bethan Lang. (2010) The growing recognition of immunotherapy-responsive seizure disorders with autoantibodies to specific neuronal proteins. Current Opinion in Neurology 23:2, pages 144-150.
Crossref
Wendy C. Ziai & Mohammed Rehman. 2010. Seizures in Critical Care. Seizures in Critical Care 233 261 .
Kenichi Kashihara, Sanami Kawada & Yukitoshi Takahashi. (2009) Autoantibodies to glutamate receptor GluRε2 in a patient with limbic encephalitis associated with relapsing polychondritis. Journal of the Neurological Sciences 287:1-2, pages 275-277.
Crossref
Robert B. Darnell & Jerome B. Posner. (2009) Autoimmune encephalopathy: The spectrum widens. Annals of Neurology 66:1, pages 1-2.
Crossref
Yukitoshi Takahashi, Jyun Mine, Yuko Kubota, Etsuko Yamazaki & Tateki Fujiwara. (2009) A substantial number of Rasmussen syndrome patients have increased IgG, CD4 + T cells, TNFα, and Granzyme B in CSF . Epilepsia 50:6, pages 1419-1431.
Crossref
S. Balosso, T. Ravizza, M. Pierucci, E. Calcagno, R. Invernizzi, G. Di Giovanni, E. Esposito & A. Vezzani. (2009) Molecular and functional interactions between tumor necrosis factor-alpha receptors and the glutamatergic system in the mouse hippocampus: Implications for seizure susceptibility. Neuroscience 161:1, pages 293-300.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.