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Recent progress concerning CpG DNA and its use as a vaccine adjuvant

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Bin Zhu, Tianbao Wang, Xiaoxia Wei, Yancai Zhou & Jiansheng Li. (2023) CpG DNA-triggered upregulation of TLR9 expression affects apoptosis and immune responses in human plasmacytoid dendritic cells isolated from chronic hepatitis B patients. Archives of Physiology and Biochemistry 129:2, pages 330-337.
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Wenqiang Chen, Mingxia Jiang, Wenjing Yu, Zhiwei Xu, Xinyue Liu, Qingmiao Jia, Xiuwen Guan & Weifen Zhang. (2021) CpG-Based Nanovaccines for Cancer Immunotherapy. International Journal of Nanomedicine 16, pages 5281-5299.
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Kan Chen, Yuqi Fan, Jun Gu, Zhihua Han, Huasu Zeng, Chengyu Mao & Changqian Wang. (2020) In vivo Screening of Natural Products Against Angiogenesis and Mechanisms of Anti-Angiogenic Activity of Deoxysappanone B 7,4ʹ-Dimethyl Ether. Drug Design, Development and Therapy 14, pages 3069-3078.
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Huining Wang, Wenwen Yu, Hongyan Li, Yi Zheng, Zhen Chen, Hongbing Lin & Yuqin Shen. (2020) N-Acetyl-l-Leucine-Polyethyleneimine-Mediated Delivery of CpG Oligodeoxynucleotides 2006 Inhibits RAW264.7 Cell Osteoclastogenesis. Drug Design, Development and Therapy 14, pages 2657-2665.
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Nobutaka Hanagata, Xianglan Li, Min-Hua Chen, Jie Li & Shinya Hattori. (2018) Double-stranded phosphodiester cytosine-guanine oligodeoxynucleotide complexed with calcium phosphate as a potent vaccine adjuvant for activating cellular and Th1-type humoral immunities. International Journal of Nanomedicine 13, pages 43-62.
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Yao Deng, Jiaming Lan, Linlin Bao, Baoying Huang, Fei Ye, Yingzhu Chen, Yanfeng Yao, Wenling Wang, Chuan Qin & Wenjie Tan. (2018) Enhanced protection in mice induced by immunization with inactivated whole viruses compare to spike protein of middle east respiratory syndrome coronavirus. Emerging Microbes & Infections 7:1, pages 1-10.
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Yongping Du, Yao Deng, Ying Zhan, Ren Yang, Jiao Ren, Wen Wang, Baoying Huang & Wenjie Tan. (2023) The recombinant truncated envelope protein of West Nile virus adjuvanted with Alum/CpG induces potent humoral and T cell immunity in mice. Biosafety and Health 5:5, pages 300-307.
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P. Sangeetha Vijayan, Joseph Xavier & Mohanan Parayanthala Valappil. (2023) A review of immune modulators and immunotherapy in infectious diseases. Molecular and Cellular Biochemistry.
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Hongze Ren, Wencong Jia, Yujie Xie, Meihua Yu & Yu Chen. (2023) Adjuvant physiochemistry and advanced nanotechnology for vaccine development. Chemical Society Reviews 52:15, pages 5172-5254.
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Tatiana P. Loginova, Irina A. Khotina, Yurii A. Kabachii, Sergei Yu. Kochev, Vyacheslav M. Abramov, Valentin S. Khlebnikov, Natalia L. Kulikova & Yaroslav O. Mezhuev. (2023) Promising Gene Delivery Properties of Polycations Based on 2-(N,N-dimethylamino)ethyl Methacrylate and Polyethylene Glycol Monomethyl Ether Methacrylate Copolymers. Polymers 15:14, pages 3036.
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Min Hoon Lee, Hong Seok Choi, Na Young Kim, Euni Sim, Jun Young Choi, Sungyoul Hong, Young Kee Shin, Chi Ho Yu, Se Hun Gu, Dong Hyun Song, Gyueng Haeng Hur & Sungho Shin. (2023) Post-Vaccination Delivery of CpG ODNs Enhances the Th2-Associated Protective Immunity of the Smallpox DNA Vaccine. Molecular Biotechnology.
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YanPeng Jia, Kun Shi, LiQun Dai, XinLong He, HanZhi Deng, RuXia Han, Fan Yang, BingYang Chu, JinFeng Liao, XiaWei Wei & ZhiYong Qian. (2022) Gold Nanorods and Polymer Micelles Mediated Dual TLR Stimulators Delivery System CPG@Au NRs/M‐R848 Regulate Macrophages Reprogramming and DC Maturation for Enhanced Photothermal Immunotherapy of Melanoma. Small Methods 7:5.
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Nasser Hashemi Goradel, Mahnaz Nemati, Azam Bakhshandeh, Arash Arashkia & Babak Negahdari. (2023) Nanovaccines for cancer immunotherapy: Focusing on complex formation between adjuvant and antigen. International Immunopharmacology 117, pages 109887.
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Meijuan He, Tingting Xiao, Yihui Wang, Hongwei Yu, Zilin Wang, Xiangyang Shi & Han Wang. (2023) Multifunctional PVCL nanogels enable magnetic resonance imaging and immunostimulated radiotherapy of orthotopic glioblastoma. Chemical Engineering Journal 453, pages 139634.
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Anastasia S. Proskurina, Vera S. Ruzanova, Genrikh S. Ritter, Yaroslav R. Efremov, Zakhar S. Mustafin, Sergey A. Lashin, Ekaterina A. Burakova, Alesya A. Fokina, Timofei S. Zatsepin, Dmitry A. Stetsenko, Olga Y. Leplina, Alexandr A. Ostanin, Elena R. Chernykh & Sergey S. Bogachev. (2023) Antitumor efficacy of multi-target <i>in situ</i> vaccinations with CpG oligodeoxynucleotides, anti-OX40, anti-PD1 antibodies, and aptamers. The Journal of Biomedical Research 37:3, pages 194.
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Mohamad Ammar Ayass, Trivendra Tripathi, Natalya Griko, Victor Pashkov, Jun Dai, Jin Zhang, Fabian C. Herbert, Ramya Ramankutty Nair, Tutku Okyay, Kevin Zhu, Jeremiah J. Gassensmith & Lina Abi-Mosleh. (2022) Highly efficacious and safe neutralizing DNA aptamer of SARS-CoV-2 as an emerging therapy for COVID-19 disease. Virology Journal 19:1.
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Dandan Zhao, Anh Thi Tram Tu, Miwako Shobo, Nguyen Bui Thao Le, Chiaki Yoshikawa, Kazuhisa Sugai, Yoji Hakamata & Tomohiko Yamazaki. (2022) Non-Modified CpG Oligodeoxynucleotide Forming Guanine-Quadruplex Structure Complexes with ε-Poly-L-Lysine Induce Antibody Production as Vaccine Adjuvants. Biomolecules 12:12, pages 1868.
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Atsushi Kawai, Toshiro Hirai & Yasushi Yoshioka. (2022) Current Status and Prospects of Vaccines based on DDS TechnologyDDS技術に立脚したワクチン開発の現状. Drug Delivery System 37:5, pages 402-411.
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Dongdong Qiao, Liyan Li, Lixin Liu & Yongming Chen. (2022) Universal and Translational Nanoparticulate CpG Adjuvant. ACS Applied Materials & Interfaces 14:45, pages 50592-50600.
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Eline de Boer, Marina Sokolova, Huy Q. Quach, Karin E. McAdam, Maximilian P. Götz, Viktoriia Chaban, Jarle Vaage, Beatrice Fageräng, Trent M. Woodruff, Peter Garred, Per H. Nilsson, Tom E. Mollnes & Søren E. Pischke. (2022) Synthetic Oligodeoxynucleotide CpG Motifs Activate Human Complement through Their Backbone Structure and Induce Complement-Dependent Cytokine Release. The Journal of Immunology 209:9, pages 1760-1767.
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Teppei Matsuda, Kazuki Misato, Shigeyuki Tamiya, Yasuhiro Akeda, Ikuhiko Nakase, Etsushi Kuroda, Shokichi Takahama, Motohiro Nonaka, Takuya Yamamoto, Michiko N. Fukuda & Yasuo Yoshioka. (2022) Efficient antigen delivery by dendritic cell-targeting peptide via nucleolin confers superior vaccine effects in mice. iScience 25:11, pages 105324.
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Satoki Kitagawa, Teppei Matsuda, Ayaka Washizaki, Hirotomo Murakami, Takuya Yamamoto & Yasuo Yoshioka. (2022) Elucidation of the role of nucleolin as a cell surface receptor for nucleic acid-based adjuvants. npj Vaccines 7:1.
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Alexandra Correia, Pedro Alves, Ricardo Fróis-Martins, Luzia Teixeira & Manuel Vilanova. (2022) Protective Effect against Neosporosis Induced by Intranasal Immunization with Neospora caninum Membrane Antigens Plus Carbomer-Based Adjuvant. Vaccines 10:6, pages 925.
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Fengyun Shen, Lele Sun, Lihua Wang, Rui Peng, Chunhai Fan & Zhuang Liu. (2022) Framework Nucleic Acid Immune Adjuvant for Transdermal Delivery Based Chemo-immunotherapy for Malignant Melanoma Treatment. Nano Letters 22:11, pages 4509-4518.
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Robert A. Mitchell, Rita Altszuler, Sandra Gonzalez, Roshawn Johnson, Ute Frevert & Elizabeth Nardin. (2022) Innate Immune Responses and P. falciparum CS Repeat-Specific Neutralizing Antibodies Following Vaccination by Skin Scarification. Frontiers in Immunology 13.
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Jing Sui, Wenliang Qiao, Xinrong Xiang & Youfu Luo. (2022) Epigenetic changes in Mycobacterium tuberculosis and its host provide potential targets or biomarkers for drug discovery and clinical diagnosis. Pharmacological Research 179, pages 106195.
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Jingjing Wei, Di Wu, Songsong Zhao, Yu Shao, Yifeng Xia, Dawei Ni, Xinyun Qiu, Jinping Zhang, Jian Chen, Fenghua Meng & Zhiyuan Zhong. (2022) Immunotherapy of Malignant Glioma by Noninvasive Administration of TLR9 Agonist CpG Nano‐Immunoadjuvant. Advanced Science 9:13.
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Angita Shrestha, Rick Meeuws, Jean-Remy Sadeyen, Pengxiang Chang, Marielle Van Hulten & Munir Iqbal. (2022) Haemagglutinin antigen selectively targeted to chicken CD83 overcomes interference from maternally derived antibodies in chickens. npj Vaccines 7:1.
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Chunhong Dong & Bao-Zhong Wang. (2021) Engineered Nanoparticulate Vaccines to Combat Recurring and Pandemic Influenza Threats. Advanced NanoBiomed Research 2:3.
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Yusuke Kawamoto, Wen Liu, Ji Hye Yum, Soyoung Park, Hiroshi Sugiyama, Yuki Takahashi & Yoshinobu Takakura. (2021) Enhanced Immunostimulatory Activity of Covalent DNA Dendrons. ChemBioChem 23:4.
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Chunhong Dong, Ye Wang, Wandi Zhu, Yao Ma, Joo Kim, Lai Wei, Gilbert X. Gonzalez & Bao-Zhong Wang. (2022) Polycationic HA/CpG Nanoparticles Induce Cross-Protective Influenza Immunity in Mice. ACS Applied Materials & Interfaces 14:5, pages 6331-6342.
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Makoto Nagaoka, Wenqing Liao, Kosuke Kusamori & Makiya Nishikawa. (2022) Targeted Delivery of Immunostimulatory CpG Oligodeoxynucleotides to Antigen-Presenting Cells in Draining Lymph Nodes by Stearic Acid Modification and Nanostructurization. International Journal of Molecular Sciences 23:3, pages 1350.
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Mohammad Zaki Ahmad, Devyani Bhatnagar, Shreya Ladhe, Dileep Kumar, Kalyani Pathak, Ratna Jyoti Das, Himanghsu Sarma & Gulam Mustafa. 2022. Pharmaceutical Nanobiotechnology for Targeted Therapy. Pharmaceutical Nanobiotechnology for Targeted Therapy 337 359 .
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Guohui Bai, Hang Yu, Xiaoyan Guan, Fengjiao Zeng, Xia Liu, Bin Chen, Jianguo Liu & Yuan Tian. (2021) CpG immunostimulatory oligodeoxynucleotide 1826 as a novel nasal ODN adjuvant enhanced the protective efficacy of the periodontitis gene vaccine in a periodontitis model in SD rats. BMC Oral Health 21:1.
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Haitao Liu, Chenliang Zhou, Jiao An, Yujiao Song, Pin Yu, Jiadai Li, Chenjian Gu, Dongdong Hu, Yuanxiang Jiang, Lingli Zhang, Chuanqi Huang, Chao Zhang, Yunqi Yang, Qianjun Zhu, Dekui Wang, Yuqiang Liu, Chenyang Miao, Xiayao Cao, Longfei Ding, Yuanfei Zhu, Hua Zhu, Linlin Bao, Lingyun Zhou, Huan Yan, Jiang Fan, Jianqing Xu, Zhongyu Hu, Youhua Xie, Jiangning Liu & Ge Liu. (2021) Development of recombinant COVID-19 vaccine based on CHO-produced, prefusion spike trimer and alum/CpG adjuvants. Vaccine 39:48, pages 7001-7011.
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Lucille F. van Beek, Pascal L. W. Welzen, Lisa U. Teufel, Irma Joosten, Dimitri A. Diavatopoulos, Jan van Hest & Marien I. de Jonge. (2021) Bimodal Targeting of Human Leukocytes by Fc- and CpG-Decorated Polymersomes to Tune Immune Induction. Biomacromolecules 22:10, pages 4422-4433.
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Meito Shibuya, Shigeyuki Tamiya, Atsushi Kawai, Toshiro Hirai, Mark S. Cragg & Yasuo Yoshioka. (2021) Synergistic effect of non-neutralizing antibodies and interferon-γ for cross-protection against influenza. iScience 24:10, pages 103131.
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Cassie CaudillJillian L. Perry, Kimon IliadisAddis T. TessemaBrian J. Lee, Beverly S. MechamShaomin Tian & Joseph M. DeSimone. (2021) Transdermal vaccination via 3D-printed microneedles induces potent humoral and cellular immunity. Proceedings of the National Academy of Sciences 118:39.
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Alireza Hassani Najafabadi, Zeynab Izadi Najaf Abadi, Marisa E. Aikins, Kathryn E. Foulds, Mitzi M. Donaldson, Wenmin Yuan, Emeka B. Okeke, Jutaek Nam, Yao Xu, Priyan Weerappuli, Taryn Hetrick, David Adams, Patrick A. Lester, Andres M. Salazar, Dan H. Barouch, Anna Schwendeman, Robert A. Seder & James J. Moon. (2021) Vaccine nanodiscs plus polyICLC elicit robust CD8+ T cell responses in mice and non-human primates. Journal of Controlled Release 337, pages 168-178.
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Qiuyan Guo, Chufan Wang, Qiang Zhang, Keman Cheng, Wenjun Shan, Xiumin Wang, Jun Yang, Yunlong Wang & Lei Ren. (2021) Enhanced cancer immunotherapy by microneedle patch-assisted delivery of HBc VLPs based cancer vaccine. Applied Materials Today 24, pages 101110.
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Angita Shrestha, Jean-Remy Sadeyen, Deimante Lukosaityte, Pengxiang Chang, Marielle Van Hulten & Munir Iqbal. (2021) Targeting Haemagglutinin Antigen of Avian Influenza Virus to Chicken Immune Cell Receptors Dec205 and CD11c Induces Differential Immune-Potentiating Responses. Vaccines 9:7, pages 784.
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Aishik Chakraborty, Shruthi Polla Ravi, Yasmeen Shamiya, Caroline Cui & Arghya Paul. (2021) Harnessing the physicochemical properties of DNA as a multifunctional biomaterial for biomedical and other applications. Chemical Society Reviews 50:13, pages 7779-7819.
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Caroline R. Champion. (2020) Heplisav-B: A Hepatitis B Vaccine With a Novel Adjuvant. Annals of Pharmacotherapy 55:6, pages 783-791.
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Lampouguin Yenkoidiok-Douti, Carolina Barillas-Mury & Christopher M. Jewell. (2021) Design of Dissolvable Microneedles for Delivery of a Pfs47-Based Malaria Transmission-Blocking Vaccine. ACS Biomaterials Science & Engineering 7:5, pages 1854-1862.
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Zili Gu, Candido Da Silva, Koen Van der Maaden, Ferry Ossendorp & Luis Cruz. (2020) Liposome-Based Drug Delivery Systems in Cancer Immunotherapy. Pharmaceutics 12:11, pages 1054.
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Tete Li, Cong Hua, Wenjun Yue, Jing Wu, Xinping Lv, Qiuyu Wei, Shan Zhu, Guoxia Zang, Jiuwei Cui, Yong-Jun Liu & Jingtao Chen. (2020) Discrepant antitumor efficacies of three CpG oligodeoxynucleotide classes in monotherapy and co-therapy with PD-1 blockade. Pharmacological Research 161, pages 105293.
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A. A. Ostanin, O. Y. Leplina, E. A. Burakova, T. V. Tyrinova, A. A. Fokina, A. S. Proskurina, S. S. Bogachev, D. A. Stetsenko & E. R. Chernykh. (2020) Phosphate-modified CpG oligonucleotides induce in vitro maturation of human myeloid dendritic cells. Vavilov Journal of Genetics and Breeding 24:6, pages 653-660.
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MingRui Dai, XueJian Feng, ZengShuo Mo, Yao Sun, Lu Fu, Yong Zhang, Jiaxin Wu, Bin Yu, Haihong Zhang, Xianghui Yu, Hui Wu & Wei Kong. (2020) Stimulation Effects and Mechanisms of Different Adjuvants on a Norovirus P Particle-Based Active Amyloid-β Vaccine. Journal of Alzheimer's Disease 77:4, pages 1717-1732.
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Oluwaseyi T. Shofolawe-Bakare, Larry D. Stokes, Mehjabeen Hossain, Adam E. Smith & Thomas A. Werfel. (2020) Immunostimulatory biomaterials to boost tumor immunogenicity. Biomaterials Science 8:20, pages 5516-5537.
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Sachiko Ezoe, Nirianne Marie Q. Palacpac, Kohhei Tetsutani, Kouji Yamamoto, Kiyoshi Okada, Masaki Taira, Sumiyuki Nishida, Haruhiko Hirata, Atsushi Ogata, Tomomi Yamada, Masanori Yagi, Jyotheeswara R. Edula, Yuko Oishi, Takahiro Tougan, Ken J. Ishii, Akira Myoui & Toshihiro Horii. (2020) First-in-human randomised trial and follow-up study of Plasmodium falciparum blood-stage malaria vaccine BK-SE36 with CpG-ODN(K3). Vaccine 38:46, pages 7246-7257.
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Oksana Babii, Zhenggang Wang, Guangyu Liu, Elisa C. Martinez, Sylvia van Drunen Littel-van den Hurk & Lingyun Chen. (2020) Low molecular weight chitosan nanoparticles for CpG oligodeoxynucleotides delivery: Impact of molecular weight, degree of deacetylation, and mannosylation on intracellular uptake and cytokine induction. International Journal of Biological Macromolecules 159, pages 46-56.
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Seiki Shirai, Atsushi Kawai, Meito Shibuya, Lisa Munakata, Daiki Omata, Ryo Suzuki & Yasuo Yoshioka. (2020) Lipid Nanoparticle Acts as a Potential Adjuvant for Influenza Split Vaccine without Inducing Inflammatory Responses. Vaccines 8:3, pages 433.
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Wenqing Liao, Sakiko Akahira, Rintaro Iwata Hara, Takeshi Wada, Kosuke Kusamori, Yoshinobu Takakura & Makiya Nishikawa. (2020) Enhanced Immunostimulatory Activity of CpG Oligodeoxynucleotide by the Combination of Mannose Modification and Incorporation into Nanostructured DNA. Biological and Pharmaceutical Bulletin 43:8, pages 1188-1195.
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Meito Shibuya, Taiki Aoshi, Etsushi Kuroda & Yasuo Yoshioka. (2020) Murine Cross-Reactive Nonneutralizing Polyclonal IgG1 Antibodies Induced by Influenza Vaccine Inhibit the Cross-Protective Effect of IgG2 against Heterologous Virus in Mice. Journal of Virology 94:12.
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Atsushi Kawai, Yasuyuki Yamamoto & Yasuo Yoshioka. (2020) Vaccine effect of recombinant single-chain hemagglutinin protein as an antigen. Heliyon 6:6, pages e04301.
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Yi Zheng, Wenwen Yu, Hongyan Li, Hongbing Lin, Zhen Chen, Huishan Chen, Peipei Zhang, Yue Tian, Xiaowei Xu & Yuqin Shen. (2020) CpG oligodeoxynucleotides inhibit the proliferation and osteoclastic differentiation of RAW264.7 cells. RSC Advances 10:25, pages 14885-14891.
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Yumiko Tsukamoto, Toshiki Tamura, Yumi Maeda, Kensuke Miyake & Manabu Ato. (2020) N6-methylated adenine on the target sites of mamA from Mycobacterium bovis BCG enhances macrophage activation by CpG DNA in mice. Tuberculosis 121, pages 101890.
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Tete Li, Jing Wu, Shan Zhu, Guoxia Zang, Shuang Li, Xinping Lv, Wenjun Yue, Yuan Qiao, Jiuwei Cui, Yan Shao, Jun Zhang, Yong-Jun Liu & Jingtao Chen. (2020) A Novel C Type CpG Oligodeoxynucleotide Exhibits Immunostimulatory Activity In Vitro and Enhances Antitumor Effect In Vivo. Frontiers in Pharmacology 11.
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Seiki Shirai, Meito Shibuya, Atsushi Kawai, Shigeyuki Tamiya, Lisa Munakata, Daiki Omata, Ryo Suzuki, Taiki Aoshi & Yasuo Yoshioka. (2020) Lipid Nanoparticles Potentiate CpG-Oligodeoxynucleotide-Based Vaccine for Influenza Virus. Frontiers in Immunology 10.
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Haiqing Dong, Yan Li, Yiqiong Liu, Ya Wen, Zui Zou, Tianshu Yang, Zheng Cui, Donglu Shi & Yongyong Li. (2019) A nano-immunotraining strategy to enhance the tumor targeting of neutrophils via in vivo pathogen-mimicking stimulation . Biomaterials Science 7:12, pages 5238-5246.
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Youzhi Wang, Xinxin Li, Yiming Zhang, Ling Wang & Zhimou Yang. (2019) A supramolecular hydrogel to boost the production of antibodies for phosphorylated proteins. Chemical Communications 55:82, pages 12388-12391.
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Fahimeh Zahednezhad, Maryam Saadat, Hadi Valizadeh, Parvin Zakeri-Milani & Behzad Baradaran. (2019) Liposome and immune system interplay: Challenges and potentials. Journal of Controlled Release 305, pages 194-209.
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Gabsik Yang, Jung Eun Koo, Hye Eun Lee, Seung Won Shin, Soong Ho Um & Joo Young Lee. (2019) Immunostimulatory activity of Y-shaped DNA nanostructures mediated through the activation of TLR9. Biomedicine & Pharmacotherapy 112, pages 108657.
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Limei Shen, Stefan Tenzer, Wiebke Storck, Dominika Hobernik, Verena Katherina Raker, Karl Fischer, Sandra Decker, Andrzej Dzionek, Susanne Krauthäuser, Mustafa Diken, Alexej Nikolaev, Joachim Maxeiner, Petra Schuster, Cinja Kappel, Admar Verschoor, Hansjörg Schild, Stephan Grabbe & Matthias Bros. (2018) Protein corona–mediated targeting of nanocarriers to B cells allows redirection of allergic immune responses. Journal of Allergy and Clinical Immunology 142:5, pages 1558-1570.
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Ana L. Chiodetti, María F. Sánchez Vallecillo, Joseph S. Dolina, María I. Crespo, Constanza Marin, Stephen P. Schoenberger, Daniel A. Allemandi, Santiago D. Palma, María C. Pistoresi-Palencia, Gabriel Morón & Belkys A. Maletto. (2018) Class-B CpG-ODN Formulated With a Nanostructure Induces Type I Interferons-Dependent and CD4+ T Cell-Independent CD8+ T-Cell Response Against Unconjugated Protein Antigen. Frontiers in Immunology 9.
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Neal Van Hoeven, Steven Wiley, Emily Gage, Andrew Fiore-Gartland, Brian Granger, Sean Gray, Christopher Fox, David E. Clements, D. Elliot Parks, Scott Winram, Dan T. Stinchcomb, Steven G. Reed & Rhea N. Coler. (2018) A combination of TLR-4 agonist and saponin adjuvants increases antibody diversity and protective efficacy of a recombinant West Nile Virus antigen. npj Vaccines 3:1.
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Michelle L. Bookstaver, Krystina L. Hess & Christopher M. Jewell. (2018) Self‐Assembly of Immune Signals Improves Codelivery to Antigen Presenting Cells and Accelerates Signal Internalization, Processing Kinetics, and Immune Activation. Small 14:38, pages 1802202.
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Matthias Bros, Lutz Nuhn, Johanna Simon, Lorna Moll, Volker Mailänder, Katharina Landfester & Stephan Grabbe. (2018) The Protein Corona as a Confounding Variable of Nanoparticle-Mediated Targeted Vaccine Delivery. Frontiers in Immunology 9.
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I. Tosi, F. Bureau, F. Farnir, J.M. Denoix, P. Lekeux & T. Art. (2018) Effects of a P-class CpG-ODN administered by intramuscular injection on plasma cytokines and on white blood cells of healthy horses. Veterinary Immunology and Immunopathology 201, pages 57-61.
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Hongxia ZhangXiaojun Xia. (2018) A CpG fever for cancer nanovaccine. Immunotherapy 10:8, pages 631-633.
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Yan Li, Lianghua He, Haiqing Dong, Yiqiong Liu, Kun Wang, Ang Li, Tianbin Ren, Donglu Shi & Yongyong Li. (2018) Fever‐Inspired Immunotherapy Based on Photothermal CpG Nanotherapeutics: The Critical Role of Mild Heat in Regulating Tumor Microenvironment. Advanced Science 5:6.
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Naru Zhang & Kutty Selva Nandakumar. (2018) Recent advances in the development of vaccines for chronic inflammatory autoimmune diseases. Vaccine 36:23, pages 3208-3220.
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Hideki Takahashi, Kazuki Misato, Taiki Aoshi, Yasuyuki Yamamoto, Yui Kubota, Xin Wu, Etsushi Kuroda, Ken J. Ishii, Hirofumi Yamamoto & Yasuo Yoshioka. (2018) Carbonate Apatite Nanoparticles Act as Potent Vaccine Adjuvant Delivery Vehicles by Enhancing Cytokine Production Induced by Encapsulated Cytosine-Phosphate-Guanine Oligodeoxynucleotides. Frontiers in Immunology 9.
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Caixing Wu, Xiaofei Xiang, Yang Yue, Lin Li, Yesen Li, Chong Zhang & Yuhong Xu. (2018) CpG-PEG Conjugates and their Immune Modulating Effects after Systemic Administration. Pharmaceutical Research 35:4.
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Masoud Foroutan & Fatemeh Ghaffarifar. (2018) Calcium-dependent protein kinases are potential targets for Toxoplasma gondii vaccine . Clinical and Experimental Vaccine Research 7:1, pages 24.
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