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Immunological aspects of using plant cells as delivery vehicles for oral vaccines

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Abel Ramos-Vega, Elizabeth Monreal-Escalante, Eric Dumonteil, Bernardo Bañuelos-Hernández & Carlos Angulo. (2021) Plant-made vaccines against parasites: bioinspired perspectives to fight against Chagas disease. Expert Review of Vaccines 20:11, pages 1373-1388.
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Omayra C. Bolaños-Martínez & Sergio Rosales-Mendoza. (2020) The potential of plant-made vaccines to fight picornavirus. Expert Review of Vaccines 19:7, pages 599-610.
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Sergio Rosales-Mendoza & Jorge A. Salazar-González. (2017) Do microRNAs play a role in the activity of plant-based vaccines?. Expert Review of Vaccines 16:6, pages 529-533.
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Verónica Araceli Márquez-Escobar. (2017) Current developments and prospects on human metapneumovirus vaccines. Expert Review of Vaccines 16:5, pages 419-431.
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Dania O. Govea-Alonso, Josué Beltrán-López, Jorge A. Salazar-González, Juan Vargas-Morales & Sergio Rosales-Mendoza. (2017) Progress and future opportunities in the development of vaccines against atherosclerosis. Expert Review of Vaccines 16:4, pages 337-350.
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Verónica A. Márquez-Escobar, Sergio Rosales-Mendoza, Josué I. Beltrán-López & Omar González-Ortega. (2017) Plant-based vaccines against respiratory diseases: current status and future prospects. Expert Review of Vaccines 16:2, pages 137-149.
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Jorge Alberto Salazar-González, Omar González-Ortega & Sergio Rosales-Mendoza. (2015) Gold nanoparticles and vaccine development. Expert Review of Vaccines 14:9, pages 1197-1211.
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Sergio Rosales-Mendoza & Dania O Govea-Alonso. (2015) The potential of plants for the production and delivery of human papillomavirus vaccines. Expert Review of Vaccines 14:7, pages 1031-1041.
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Sergio Rosales-Mendoza, Regina Ríos-Huerta & Carlos Angulo. (2015) An overview of tuberculosis plant-derived vaccines. Expert Review of Vaccines 14:6, pages 877-889.
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Articles from other publishers (46)

Hang Su, André van Eerde, Espen Rimstad, Ralph Bock, Norica Branza-Nichita, Igor A. Yakovlev & Jihong Liu Clarke. (2023) Plant-made vaccines against viral diseases in humans and farm animals. Frontiers in Plant Science 14.
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Jia Qi Yip, Jia Choo, Kirthikah Kadiresen, Megan Min Tse Yew, Ying Pei Wong & Anna Pick Kiong Ling. 2023. Plants as Bioreactors for Industrial Molecules. Plants as Bioreactors for Industrial Molecules 57 87 .
Anabel Ortiz Caltempa, Marisela Hernández, Ana Lilia Pérez, Liliana Aguilar, Cynthia Guzmán, Dolores Adriana Ayón-Núñez, Gladis Fragoso, Raúl J. Bobes, Maria Eugenia López, Edda Sciutto & María Luisa Villareal. (2022) Improvement of cell suspension cultures of transformed and untransformed Carica papaya cell lines, towards the development of an antiparasitic product against the gastrointestinal nematode Haemonchus contortus. Frontiers in Cellular and Infection Microbiology 12.
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Omayra C. Bolaños-Martínez, Dania O. Govea-Alonso, Gladis Fragoso, Edda Sciutto & Sergio Rosales-Mendoza. (2022) Carrot cells expressing the VP1 and VP2 poliovirus proteins effectively elicited mucosal immunity. Plant Cell, Tissue and Organ Culture (PCTOC) 148:3, pages 545-556.
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Elizabeth Monreal-Escalante, Abel Ramos-Vega, Carlos Angulo & Bernardo Bañuelos-Hernández. (2022) Plant-Based Vaccines: Antigen Design, Diversity, and Strategies for High Level Production. Vaccines 10:1, pages 100.
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Marisela Hernández, Anabel Ortiz Caltempa, Jacquelynne Cervantes, Nelly Villalobos, Cynthia Guzmán, Gladis Fragoso, Edda Sciutto & María Luisa Villareal. 2021. Current State of the Art in Cysticercosis and Neurocysticercosis. Current State of the Art in Cysticercosis and Neurocysticercosis.
Wenshu He, Can Baysal, Maria Lobato Gómez, Xin Huang, Derry Alvarez, Changfu Zhu, Victoria Armario‐Najera, Aamaya Blanco Perera, Pedro Cerda Bennaser, Andrea Saba‐Mayoral, Guillermo Sobrino‐Mengual, Ashwin Vargheese, Rita Abranches, Isabel Alexandra Abreu, Shanmugaraj Balamurugan, Ralph Bock, Johannes F. Buyel, Nicolau B. Cunha, Henry Daniell, Roland Faller, André Folgado, Iyappan Gowtham, Suvi T. Häkkinen, Shashi Kumar, Ramalingam Sathish Kumar, Cristiano Lacorte, George P. Lomonossoff, Ines M. Luís, Julian K.‐C. Ma, Karen A. McDonald, Andre Murad, Somen Nandi, Barry O’Keef, Subramanian Parthiban, Mathew J. Paul, Daniel Ponndorf, Elibio Rech, Julio C.M. Rodrigues, Stephanie Ruf, Stefan Schillberg, Jennifer Schwestka, Priya S. Shah, Rahul Singh, Eva Stoger, Richard M. Twyman, Inchakalody P. Varghese, Giovanni R. Vianna, Gina Webster, Ruud H. P. Wilbers, Paul Christou, Kirsi‐Marja Oksman‐Caldentey & Teresa Capell. (2021) Contributions of the international plant science community to the fight against infectious diseases in humans—part 2: Affordable drugs in edible plants for endemic and re‐emerging diseases. Plant Biotechnology Journal 19:10, pages 1921-1936.
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Srividhya Venkataraman, Kathleen Hefferon, Abdullah Makhzoum & Mounir Abouhaidar. (2021) Combating Human Viral Diseases: Will Plant-Based Vaccines Be the Answer?. Vaccines 9:7, pages 761.
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Manu Kumar, Nisha Kumari, Nishant Thakur, Shashi Kant Bhatia, Ganesh Dattatraya Saratale, Gajanan Ghodake, Bhupendra M. Mistry, Hemasundar Alavilli, D. S. Kishor, Xueshi Du & Sang-Min Chung. (2021) A Comprehensive Overview on the Production of Vaccines in Plant-Based Expression Systems and the Scope of Plant Biotechnology to Combat against SARS-CoV-2 Virus Pandemics. Plants 10:6, pages 1213.
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Elizabeth Monreal-Escalante, Cristhian Sández-Robledo, Amalia León-Gallo, Virginie Roupie, Kris Huygen, Sawako Hori-Oshima, Mario Arce-Montoya, Sergio Rosales-Mendoza & Carlos Angulo. (2021) Alfalfa Plants (Medicago sativa L.) Expressing the 85B (MAP1609c) Antigen of Mycobacterium avium subsp. paratuberculosis Elicit Long-Lasting Immunity in Mice. Molecular Biotechnology 63:5, pages 424-436.
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Martin Kjærulf Rasmussen, Heloisa N. Bordallo, Marcela Aparecida Bordenalli, Milena Apetito Akamatsu, Aryene Góes Trezena, Milene Tino-De-Franco, Osvaldo A. Sant'Anna, Tereza da Silva Martins, José Luiz de Souza Lopes, Márcia Carvalho de Abreu Fantini & Cristiano Luis Pinto Oliveira. (2021) Assessing the efficiency of SBA-15 as a nanocarrier for diphtheria anatoxin. Microporous and Mesoporous Materials 312, pages 110763.
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Omayra C. Bolaños-Martínez, Dania O. Govea-Alonso, Jacquelynne Cervantes-Torres, Marisela Hernández, Gladis Fragoso, Edda Sciutto-Conde & Sergio Rosales-Mendoza. (2020) Expression of immunogenic poliovirus Sabin type 1 VP proteins in transgenic tobacco. Journal of Biotechnology 322, pages 10-20.
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Marcelo Lattarulo Campos, Guilherme Souza Prado, Vanessa Olinto dos Santos, Lara Camelo Nascimento, Stephan Machado Dohms, Nicolau Brito da Cunha, Marcelo Henrique Soller Ramada, Maria Fatima Grossi-de-Sa & Simoni Campos Dias. (2020) Mosses: Versatile plants for biotechnological applications. Biotechnology Advances 41, pages 107533.
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Sergio Rosales-Mendoza, Verónica A. Márquez-Escobar, Omar González-Ortega, Ricardo Nieto-Gómez & Jaime I. Arévalo-Villalobos. (2020) What Does Plant-Based Vaccine Technology Offer to the Fight against COVID-19?. Vaccines 8:2, pages 183.
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Mario Rojas, Elizabeth Monreal-Escalante, Gracia Gomez-Anduro, Sergio Rosales-Mendoza, Felipe Ascencio, Julio Hernandez-Gonzalez & Carlos Angulo. (2020) Rapid production in maize seedlings of the Ag85B antigen of Mycobacterium avium subsp. paratuberculosis using an Agrobacterium-mediated transient expression system. Plant Cell, Tissue and Organ Culture (PCTOC) 141:1, pages 31-40.
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Jhonatas Rodrigues Barbosa, Maurício Madson dos Santos Freitas, Luiza Helena da Silva Martins & Raul Nunes de CarvalhoJuniorJunior. (2020) Polysaccharides of mushroom Pleurotus spp.: New extraction techniques, biological activities and development of new technologies. Carbohydrate Polymers 229, pages 115550.
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Abel Ramos-Vega, Sergio Rosales-Mendoza, Bernardo Bañuelos-Hernández & Carlos Angulo. (2018) Prospects on the Use of Schizochytrium sp. to Develop Oral Vaccines. Frontiers in Microbiology 9.
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Sergio Rosales-Mendoza & Ricardo Nieto-Gómez. (2018) Green Therapeutic Biocapsules: Using Plant Cells to Orally Deliver Biopharmaceuticals. Trends in Biotechnology 36:10, pages 1054-1067.
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Jianping Qi, Jie Zhuang, Yongjiu Lv, Yi Lu & Wei Wu. (2018) Exploiting or overcoming the dome trap for enhanced oral immunization and drug delivery. Journal of Controlled Release 275, pages 92-106.
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Samuel Cibulski, Mariana Rivera-Patron, Norma Suárez, Macarena Pirez, Silvina Rossi, Anna Carolina Yendo, Fernanda de Costa, Grace Gosmann, Arthur Fett-Neto, Paulo Michel Roehe & Fernando Silveira. (2018) Leaf saponins of Quillaja brasiliensis enhance long-term specific immune responses and promote dose-sparing effect in BVDV experimental vaccines. Vaccine 36:1, pages 55-65.
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Sergio Rosales-Mendoza, Elizabeth Monreal-Escalante, Omar González-Ortega, Marisela Hernández, Gladis Fragoso, Teresa Garate & Edda Sciutto. (2018) Transplastomic plants yield a multicomponent vaccine against cysticercosis. Journal of Biotechnology 266, pages 124-132.
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Valeria Sander, Sergio O. Angel & Marina Clemente. 2018. Prospects of Plant-Based Vaccines in Veterinary Medicine. Prospects of Plant-Based Vaccines in Veterinary Medicine 89 120 .
Dania O. Govea-Alonso, Marlene A. Tello-Olea, Josué Beltrán-López, Elizabeth Monreal-Escalante, Jorge A. Salazar-Gonzalez, Bernardo Bañuelos-Hernández & Sergio Rosales-Mendoza. (2017) Assessment of Carrot Callus as Biofactories of an Atherosclerosis Oral Vaccine Prototype. Molecular Biotechnology 59:11-12, pages 482-489.
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Nguyen-Xuan Huy & Mi-Young Kim. (2017) Overexpression and oral immunogenicity of a dengue antigen transiently expressed in Nicotiana benthamiana. Plant Cell, Tissue and Organ Culture (PCTOC) 131:3, pages 567-577.
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Sean Miletic, Martin Hünerberg, Angelo Kaldis, Jacqueline MacDonald, Antoine Leuthreau, Tim McAllister & Rima Menassa. (2017) A Plant‐Produced Candidate Subunit Vaccine Reduces Shedding of Enterohemorrhagic Escherichia coli in Ruminants . Biotechnology Journal 12:10, pages 1700405.
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Elizabeth Monreal-Escalante, Abel A. Ramos-Vega, Jorge A. Salazar-González, Bernardo Bañuelos-Hernández, Carlos Angulo & Sergio Rosales-Mendoza. (2017) Expression of the VP40 antigen from the Zaire ebolavirus in tobacco plants. Planta 246:1, pages 123-132.
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Sergio Rosales-Mendoza, Cristhian Sández-Robledo, Bernardo Bañuelos-Hernández & Carlos Angulo. (2017) Corn-based vaccines: current status and prospects. Planta 245:5, pages 875-888.
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Gladis Fragoso, Marisela Hernández, Jacquelynne Cervantes-Torres, Rubén Ramírez-Aquino, Héctor Chapula, Nelly Villalobos, René Segura-Velázquez, Alfredo Figueroa, Iván Flores, Herminio Jiménez, Laura Adalid, Gabriela Rosas, Luis Galvez, Elias Pezzat, Elizabeth Monreal-Escalante, Sergio Rosales-Mendoza, Luis G. Vazquez & Edda Sciutto. (2017) Transgenic papaya: a useful platform for oral vaccines. Planta 245:5, pages 1037-1048.
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Matilde Merlin, Mario Pezzotti & Linda Avesani. (2017) Edible plants for oral delivery of biopharmaceuticals. British Journal of Clinical Pharmacology 83:1, pages 71-81.
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María Sol Pérez Aguirreburualde, Silvana Petruccelli, Fernando Bravo Almonacid & Andrés Wigdorovitz. (2016) Plant-Based Vaccine for Livestock: Key Points to Unleash Platform Translation in Developing Countries. Current Molecular Biology Reports 2:4, pages 171-179.
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Young Joung, Se Park, Ki-Beom Moon, Jae-Heung Jeon, Hye-Sun Cho & Hyun-Soon Kim. (2016) The Last Ten Years of Advancements in Plant-Derived Recombinant Vaccines against Hepatitis B. International Journal of Molecular Sciences 17:10, pages 1715.
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Elizabeth Monreal-Escalante, Gabriela Navarro-Tovar, Amalia León-Gallo, Margarita Juárez-Montiel, Alicia Becerra-Flora, Juan Francisco Jiménez-Bremont & Sergio Rosales-Mendoza. (2016) The corn smut-made cholera oral vaccine is thermostable and induces long-lasting immunity in mouse. Journal of Biotechnology 234, pages 1-6.
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Edward Topp, Rebecca Irwin, Tim McAllister, Martin Lessard, Jussi J. Joensuu, Igor Kolotilin, Udo Conrad, Eva Stöger, Tsafrir Mor, Heribert Warzecha, J. Chris Hall, Michael D. McLean, Eric Cox, Bert Devriendt, Andrew Potter, Ann Depicker, Vikram Virdi, Larry Holbrook, Ketan Doshi, Marike Dussault, Robert Friendship, Oksana Yarosh, Han Sang Yoo, Jacqueline MacDonald & Rima Menassa. (2016) The case for plant-made veterinary immunotherapeutics. Biotechnology Advances 34:5, pages 597-604.
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Elizabeth Monreal-Escalante, Dania O. Govea-Alonso, Marisela Hernández, Jacquelynne Cervantes, Jorge A. Salazar-González, Andrea Romero-Maldonado, Gabriela Rosas, Teresa Garate, Gladis Fragoso, Edda Sciutto & Sergio Rosales-Mendoza. (2015) Towards the development of an oral vaccine against porcine cysticercosis: expression of the protective HP6/TSOL18 antigen in transgenic carrots cells. Planta 243:3, pages 675-685.
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Samuel Paulo Cibulski, Gustavo Mourglia-Ettlin, Thais Fumaco Teixeira, Lenora Quirici, Paulo Michel Roehe, Fernando Ferreira & Fernando Silveira. (2016) Novel ISCOMs from Quillaja brasiliensis saponins induce mucosal and systemic antibody production, T-cell responses and improved antigen uptake. Vaccine 34:9, pages 1162-1171.
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Sergio Rosales-Mendoza, Carlos Angulo & Beatriz Meza. (2016) Food-Grade Organisms as Vaccine Biofactories and Oral Delivery Vehicles. Trends in Biotechnology 34:2, pages 124-136.
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Sergio Rosales-MendozaSergio Rosales-Mendoza. 2016. Algae-Based Biopharmaceuticals. Algae-Based Biopharmaceuticals 41 63 .
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Jian Yao, Yunqi Weng, Alexia Dickey & Kevin Wang. (2015) Plants as Factories for Human Pharmaceuticals: Applications and Challenges. International Journal of Molecular Sciences 16:12, pages 28549-28565.
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Sergio Rosales-Mendoza. (2015) Current Developments and Future Prospects for Plant-Made Biopharmaceuticals Against Rabies. Molecular Biotechnology 57:10, pages 869-879.
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Margarita Juárez-Montiel, Andrea Romero-Maldonado, Elizabeth Monreal-Escalante, Alicia Becerra-Flora, Schuyler S. Korban, Sergio Rosales-Mendoza & Juan Francisco Jiménez-Bremont. (2015) The Corn Smut (‘Huitlacoche’) as a New Platform for Oral Vaccines. PLOS ONE 10:7, pages e0133535.
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Jorge A. Salazar-González, Carlos Angulo & Sergio Rosales-Mendoza. (2015) Chikungunya virus vaccines: Current strategies and prospects for developing plant-made vaccines. Vaccine 33:31, pages 3650-3658.
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Hartinio N. Nahampun, Brad Bosworth, Joan Cunnick, Mark Mogler & Kan Wang. (2015) Expression of H3N2 nucleoprotein in maize seeds and immunogenicity in mice. Plant Cell Reports 34:6, pages 969-980.
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Jorge A. Salazar-González, Bernardo Bañuelos-Hernández & Sergio Rosales-Mendoza. (2015) Current status of viral expression systems in plants and perspectives for oral vaccines development. Plant Molecular Biology 87:3, pages 203-217.
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Ana S. Pérez-Martínez, Sergio A. Acevedo-Padilla, Martha Bibbins-Martínez, Jenifer Galván-Alonso & Sergio Rosales-Mendoza. (2015) A perspective on the use of Pleurotus for the development of convenient fungi-made oral subunit vaccines. Vaccine 33:1, pages 25-33.
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Jianfeng Xu & Ningning Zhang. (2014) On the way to commercializing plant cell culture platform for biopharmaceuticals: present status and prospect. Pharmaceutical Bioprocessing 2:6, pages 499-518.
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