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Genetically detoxified pertussis toxin (PT-9K/129G): implications for immunization and vaccines

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Geraldine Blanchard-Rohner. (2022) Novel approaches to reactivate pertussis immunity. Expert Review of Vaccines 21:12, pages 1787-1797.
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Naveen Surendran & Michael Pichichero. (2019) Genetically detoxified pertussis toxin induces superior antigen specific CD4 T cell responses compared to chemically detoxified pertussis toxin. Human Vaccines & Immunotherapeutics 15:5, pages 1167-1170.
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Geert Leroux-Roels, Maria Lattanzi, Claudia Dovali Solis, Mario Contorni, Marco Costantini, Luca Moraschini, Monia Bardelli, Sylvie Bertholet, Erica Borgogni, Francesca Buricchi, Rocco Cantisani, Elisa Faenzi, Oretta Finco, Rosanna Leuzzi, Mariagrazia Pizza, Domenico Rosa, Francesca Schiavetti, Anja Seubert, Fabiana Spensieri, Gianfranco Volpini, Luisanna Zedda, Giuseppe Del Giudice & Ilaria Galgani. (2018) A phase I, randomized, controlled, dose-ranging study of investigational acellular pertussis (aP) and reduced tetanus-diphtheria-acellular pertussis (TdaP) booster vaccines in adults. Human Vaccines & Immunotherapeutics 14:1, pages 45-58.
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Susanna Esposito & Nicola Principi$suffix/text()$suffix/text(). (2017) Strategies to develop vaccines of pediatric interest. Expert Review of Vaccines 16:2, pages 175-186.
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Chukiat Sirivichayakul, Pornthep Chanthavanich, Kriengsak Limkittikul, Claire-Anne Siegrist, Wassana Wijagkanalan, Pailinrut Chinwangso, Jean Petre, Pham Hong Thai, Mukesh Chauhan & Simonetta Viviani. (2017) Safety and immunogenicity of a combined Tetanus, Diphtheria, recombinant acellular Pertussis vaccine (TdaP) in healthy Thai adults. Human Vaccines & Immunotherapeutics 13:1, pages 136-143.
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Jan T Poolman. (2014) Pertussis vaccines. Expert Review of Vaccines 13:9, pages 1067-1069.
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Articles from other publishers (25)

Raphaël Esson, Stéphanie Falque, Eric Abachin, Steve George & Nolwenn Nougarede. (2023) Development of a droplet digital PCR for pertussis toxin locus copy number determination in a genetically-modified Bordetella pertussis strain. Biologicals 82, pages 101683.
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Xuanxuan Nian, Hongbo Liu, Mengyao Cai, Kai Duan & Xiaoming Yang. (2023) Coping Strategies for Pertussis Resurgence. Vaccines 11:5, pages 889.
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Kathryn M. Edwards, Michael D. Decker & F. Heath Damron. 2023. Plotkin's Vaccines. Plotkin's Vaccines 763 815.e19 .
Javier R. Jaldin‐Fincati, Serene Moussaoui, Maria Cecilia Gimenez, Cheuk Y. Ho, Charlene E. Lancaster, Roberto J. Botelho, Salvador F. Ausar, Roger H. Brookes & Mauricio R. Terebiznik. (2022) Aluminum hydroxide adjuvant diverts the uptake and trafficking of genetically detoxified pertussis toxin to lysosomes in macrophages. Molecular Microbiology 117:5, pages 1173-1195.
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Marta Prygiel, Ewa Mosiej, Paulina Górska & Aleksandra A Zasada. (2022) Diphtheria–tetanus–pertussis vaccine: past, current & future. Future Microbiology 17:3, pages 185-197.
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Atefeh Ghasemnejad, Samira Bazmara, Mahsa Shadmani & Kamran Pooshang Bagheri. (2021) Designing a New Multi-Epitope Pertussis Vaccine with Highly Population Coverage Based on a Novel Sequence and Structural Filtration Algorithm. IEEE/ACM Transactions on Computational Biology and Bioinformatics 18:5, pages 1885-1892.
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Alex-Mikael Barkoff, Aapo Knuutila, Jussi Mertsola & Qiushui He. (2021) Evaluation of Anti-PT Antibody Response after Pertussis Vaccination and Infection: The Importance of Both Quantity and Quality. Toxins 13:8, pages 508.
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Chandni Praveen, Sohini S. Bhatia, Robert C. Alaniz, Robert E. Droleskey, Noah D. Cohen, Palmy R. Jesudhasan & Suresh D. Pillai. (2021) Assessment of microbiological correlates and immunostimulatory potential of electron beam inactivated metabolically active yet non culturable (MAyNC) Salmonella Typhimurium. PLOS ONE 16:4, pages e0243417.
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M. Allison Wolf, Dylan T. Boehm, Megan A. DeJong, Ting Y. Wong, Emel Sen-Kilic, Jesse M. Hall, Catherine B. Blackwood, Kelly L. Weaver, Claire O. Kelly, Caleb A. Kisamore, Graham J. Bitzer, Justin R. Bevere, Mariette Barbier & F. Heath Damron. (2021) Intranasal Immunization with Acellular Pertussis Vaccines Results in Long-Term Immunity to Bordetella pertussis in Mice. Infection and Immunity 89:3.
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Helena Pereira da Silva Zamith, Rosely Oliveira Godinho, Valter Luiz da Costa Junior & Alexandre Pinto Corrado. (2021) The quantitative analysis of the mechanism involved in pertussis toxin-mediated cell clustering and its implications in the in vitro quality control of diphtheria tetanus and whole cell pertussis vaccines. Toxicology in Vitro 70, pages 105029.
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Jan T. Poolman. (2020) Expanding the role of bacterial vaccines into life-course vaccination strategies and prevention of antimicrobial-resistant infections. npj Vaccines 5:1.
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Salvador F. Ausar, Shaolong Zhu, Jessica Duprez, Michael Cohen, Thomas Bertrand, Valérie Steier, Derek J. Wilson, Stephen Li, Anthony Sheung, Roger H. Brookes, Artur Pedyczak, Alexey Rak & D. Andrew James. (2020) Genetically detoxified pertussis toxin displays near identical structure to its wild-type and exhibits robust immunogenicity. Communications Biology 3:1.
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Marta Prygiel, Ewa Mosiej & Aleksandra Anna Zasada. (2020) Causes Of Pertussis Incidence Increase. Postępy Mikrobiologii - Advancements of Microbiology 59:1, pages 11-24.
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Kevin Markey, Catpagavalli Asokanathan & Ian Feavers. (2019) Assays for Determining Pertussis Toxin Activity in Acellular Pertussis Vaccines. Toxins 11:7, pages 417.
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Susanna Esposito, Paola Stefanelli, Norman K. Fry, Giorgio Fedele, Qiushui He, Pauline Paterson, Tina Tan, Markus Knuf, Carlos Rodrigo, Catherine Weil Olivier, Katie L. Flanagan, Ivan Hung, Iria Lutsar, Kathryn Edwards, Miguel O'Ryan & Nicola Principi. (2019) Pertussis Prevention: Reasons for Resurgence, and Differences in the Current Acellular Pertussis Vaccines. Frontiers in Immunology 10.
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Daniela Hozbor. 2019. Pertussis Infection and Vaccines. Pertussis Infection and Vaccines 115 126 .
Christiane S. Eberhardt & Claire-Anne Siegrist. (2017) What Is Wrong with Pertussis Vaccine Immunity?. Cold Spring Harbor Perspectives in Biology 9:12, pages a029629.
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Nicolas Burdin, Lori Kestenbaum Handy & Stanley A. Plotkin. (2017) What Is Wrong with Pertussis Vaccine Immunity?. Cold Spring Harbor Perspectives in Biology 9:12, pages a029454.
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A.M. Harandi & N. Lycke. 2017. Immunopotentiators in Modern Vaccines. Immunopotentiators in Modern Vaccines 377 397 .
Mitra Saadatian-Elahi, Stanley Plotkin, Kingston H.G. Mills, Scott A. Halperin, Peter B. McIntyre, Valentina Picot, Jacques Louis & David R. Johnson. (2016) Pertussis: Biology, epidemiology and prevention. Vaccine 34:48, pages 5819-5826.
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Christiane S. Eberhardt, Geraldine Blanchard-Rohner, Barbara Lemaître, Meriem Boukrid, Christophe Combescure, Véronique Othenin-Girard, Antonina Chilin, Jean Petre, Begoña Martinez de Tejada & Claire-Anne Siegrist. (2016) Maternal Immunization Earlier in Pregnancy Maximizes Antibody Transfer and Expected Infant Seropositivity Against Pertussis. Clinical Infectious Diseases 62:7, pages 829-836.
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Matthew J. Bottomley, Rino Rappuoli & Oretta Finco. 2016. The Vaccine Book. The Vaccine Book 45 65 .
Nicholas H. Carbonetti. (2015) Contribution of pertussis toxin to the pathogenesis of pertussis disease: Graphical Abstract Figure.. Pathogens and Disease 73:8, pages ftv073.
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María Emilia Gaillard, Daniela Bottero, Griselda Moreno, Martin Rumbo & Daniela Hozbor. (2015) Strategies and new developments to control pertussis, an actual health problem: Graphical Abstract Figure.. Pathogens and Disease 73:8, pages ftv059.
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Beatris Mastelic Gavillet, Lucie Mondoulet, Véronique Dhelft, Christiane Sigrid Eberhardt, Floriane Auderset, Hong Thai Pham, Jean Petre, Paul-Henri Lambert, Pierre-Henri Benhamou & Claire-Anne Siegrist. (2015) Needle-free and adjuvant-free epicutaneous boosting of pertussis immunity: Preclinical proof of concept. Vaccine 33:30, pages 3450-3455.
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