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Expert Review of Vaccines Volume 14, 2015 - Issue 8
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Review

The avian influenza vaccine Emerflu. Why did it fail?

Barnaby E YoungCommunicable Diseases Centre, Institute of Infectious Diseases and Epidemiology, Communicable Diseases Centre, 144 Moulmein Road, Singapore, SingaporeCorrespondence[email protected]
,
Sapna P SadaranganiDivision of Infectious Diseases, Mayo Clinic, Rochester, 200 First Street SW, Rochester, MN, USA
&
Yee Sin LeoCommunicable Diseases Centre, Institute of Infectious Diseases and Epidemiology, Communicable Diseases Centre, 144 Moulmein Road, Singapore, Singapore;
Pages 1125-1134 | Published online: 22 Jun 2015

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Tsai-Teng Tzeng, Kit Man Chai, I-Hua Chen, Ray-Yuan Chang, Jen-Ron Chiang & Shih-Jen Liu. (2023) A TLR9 agonist synergistically enhances protective immunity induced by an Alum-adjuvanted H7N9 inactivated whole-virion vaccine. Emerging Microbes & Infections 12:2.
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Yongping Ma. (2016) Recent advances in nontoxic Escherichia coli heat-labile toxin and its derivative adjuvants. Expert Review of Vaccines 15:11, pages 1361-1371.
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Noopur Bhatnagar, Ki-Hye Kim, Jeeva Subbiah, Bo Ryoung Park, Pengfei Wang, Harvinder Singh Gill, Bao-Zhong Wang & Sang-Moo Kang. (2022) Adjuvant Effects of a New Saponin Analog VSA-1 on Enhancing Homologous and Heterosubtypic Protection by Influenza Virus Vaccination. Vaccines 10:9, pages 1383.
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Noopur Bhatnagar, Ki-Hye Kim, Jeeva Subbiah, Bo Ryoung Park, Eun-Ju Ko, Baik-Lin Seong & Sang-Moo Kang. (2022) Comparison of the effects of different potent adjuvants on enhancing the immunogenicity and cross-protection by influenza virus vaccination in young and aged mice. Antiviral Research 197, pages 105229.
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Eun-Ju Ko, Youri Lee, Young-Tae Lee, Yu-Jin Kim, Ki-Hye Kim & Sang-Moo Kang. (2018) MPL and CpG combination adjuvants promote homologous and heterosubtypic cross protection of inactivated split influenza virus vaccine. Antiviral Research 156, pages 107-115.
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Neal Van Hoeven, Christopher B. Fox, Brian Granger, Tara Evers, Sharvari W. Joshi, Ghislain I. Nana, Sarah C. Evans, Susan Lin, Hong Liang, Li Liang, Rie Nakajima, Philip L. Felgner, Richard A. Bowen, Nicole Marlenee, Airn Hartwig, Susan L. Baldwin, Rhea N. Coler, Mark Tomai, James Elvecrog, Steven G. Reed & Darrick Carter. (2017) A Formulated TLR7/8 Agonist is a Flexible, Highly Potent and Effective Adjuvant for Pandemic Influenza Vaccines. Scientific Reports 7:1.
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Eun-Ju Ko, Young-Tae Lee, Ki-Hye Kim, Youri Lee, Yu-Jin Jung, Min-Chul Kim, Yu-Na Lee, Taeuk Kang & Sang-Moo Kang. (2017) Roles of Aluminum Hydroxide and Monophosphoryl Lipid A Adjuvants in Overcoming CD4+ T Cell Deficiency To Induce Isotype-Switched IgG Antibody Responses and Protection by T-Dependent Influenza Vaccine. The Journal of Immunology 198:1, pages 279-291.
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Eun-Ju Ko, Young-Tae Lee, Ki-Hye Kim, Yu-Jin Jung, Youri Lee, Timothy L. Denning & Sang-Moo Kang. (2016) Effects of MF59 Adjuvant on Induction of Isotype-Switched IgG Antibodies and Protection after Immunization with T-Dependent Influenza Virus Vaccine in the Absence of CD4 + T Cells . Journal of Virology 90:15, pages 6976-6988.
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