Advanced search
Publication Cover
Expert Review of Vaccines Volume 4, 2005 - Issue 1
Submit an article Journal homepage
90
Views
34
CrossRef citations to date
0
Altmetric
Review

Epidemiologic, immunologic and practical considerations in developing and evaluating a human hookworm vaccine

Simon Brooker London School of Hygiene and Tropical Medicine, Department of Infectious and Tropical Diseases, Keppel Street, London WC1E 7HT, UK; Sabin Vaccine Institute, Human Hookworm Vaccine Initiative, Bethesda MD, 20814, USA
,
Jeffrey M Bethony The George Washington University Medical Center, Department of Microbiology and Tropical Medicine, 2300 Eye Street NW, Washington, DC 20037, USA; Cellular and Molecular Immunology Laboratory, René Rachou Research Centre FIOCRUZ, Barro Preto – CEP 30190-002, Belo Horizonte, Brazil. Sabin Vaccine Institute, Human Hookworm Vaccine Initiative, Bethesda MD, 20814, USA
,
Laura C Rodrigues London School of Hygiene and Tropical Medicine, Department of Infectious and Tropical Diseases, Keppel Street, London WC1E 7HT, UK; Sabin Vaccine Institute, Human Hookworm Vaccine Initiative, Bethesda MD, 20814, USA
,
Neal Alexander London School of Hygiene and Tropical Medicine, Department of Infectious and Tropical Diseases, Keppel Street, London WC1E 7HT, UK; Sabin Vaccine Institute, Human Hookworm Vaccine Initiative, Bethesda MD, 20814, USA
,
Stefan M Geiger The George Washington University Medical Center, Department of Microbiology and Tropical Medicine, 2300 Eye Street NW, Washington, DC 20037, USA; Cellular and Molecular Immunology Laboratory, René Rachou Research Centre FIOCRUZ, Barro Preto – CEP 30190-002, Belo Horizonte, Brazil. Sabin Vaccine Institute, Human Hookworm Vaccine Initiative, Bethesda MD, 20814, USA; Eberhardt-Karls-Universitaet Tuebingen, Institut für Tropenmedizin, D-72074 Tuebingen, Germany
&
Peter J Hotez The George Washington University Medical Center, Department of Microbiology and Tropical Medicine, 2300 Eye Street NW, Washington, DC 20037, USA; Sabin Vaccine Institute, Human Hookworm Vaccine Initiative, Bethesda MD, 20814, USA. [email protected]
Pages 35-50 | Published online: 09 Jan 2014

Citations (34)

Keep up to date with the latest research on this topic with citation updates for this article.

Subscribe to citation updates

Read on this site (1)

Lin Wang & Chunpeng Fan. (2019) Sample size calculations for comparing two groups of count data. Journal of Biopharmaceutical Statistics 29:1, pages 115-127.
Read now

Articles from other publishers (33)

Paul E.M. Fine, Kim Mulholland, J. Anthony Scott & W. John Edmunds. 2023. Plotkin's Vaccines. Plotkin's Vaccines 1603 1624.e8 .
Luisa Mourão Dias Magalhães, Livia Silva Araújo Passos, Ricardo Toshio Fujiwara & Lilian Lacerda Bueno. (2020) Immunopathology and modulation induced by hookworms: From understanding to intervention. Parasite Immunology 43:2.
Crossref
Severin Donald Kamdem, Francis Konhawa, Erve Martial Kuemkon, Leonel Meyo Kamguia, Gladys K. Tchanana, Frungwa Nche, Alim Oumarou, Mamadou Hamza, Yasmine Ouratou, Mariette Nzoku Tcheutchoua, René Ghislain Essomba, Marie Paule Ngogang, Michel Kengne, Palmer Masumbe Netongo, Bienvenu Etogo Ondigui, Marie Claire Okomo Assoumou, Frank Brombacher & Justin Komguep Nono. (2019) Negative Association of Interleukin-33 Plasma Levels and Schistosomiasis Infection in a Site of Polyparasitism in Rural Cameroon. Frontiers in Immunology 10.
Crossref
David Machin, Michael J. Campbell, Say Beng Tan & Sze Huey Tan. 2018. Sample Sizes for Clinical, Laboratory and Epidemiology Studies. Sample Sizes for Clinical, Laboratory and Epidemiology Studies 363 380 .
David Machin, Michael J. Campbell, Say Beng Tan & Sze Huey Tan. 2018. Sample Sizes for Clinical, Laboratory and Epidemiology Studies. Sample Sizes for Clinical, Laboratory and Epidemiology Studies 83 98 .
Paul E.M. Fine, Kim Mulholland, J. Anthony Scott & W. John Edmunds. 2018. Plotkin's Vaccines. Plotkin's Vaccines 1512 1531.e5 .
Hans J. Overgaard, Víctor Alberto Olano, Juan Felipe Jaramillo, María Inés Matiz, Diana Sarmiento, Thor Axel Stenström & Neal Alexander. (2017) A cross-sectional survey of Aedes aegypti immature abundance in urban and rural household containers in central Colombia. Parasites & Vectors 10:1.
Crossref
Hans J. Overgaard, Neal Alexander, Maria Ines Matiz, Juan Felipe Jaramillo, Victor Alberto Olano, Sandra Vargas, Diana Sarmiento, Audrey Lenhart & Thor Axel Stenström. (2016) A Cluster-Randomized Controlled Trial to Reduce Diarrheal Disease and Dengue Entomological Risk Factors in Rural Primary Schools in Colombia. PLOS Neglected Tropical Diseases 10:11, pages e0005106.
Crossref
Bonnie Cundill & Neal DE Alexander. (2015) Sample size calculations for skewed distributions. BMC Medical Research Methodology 15:1.
Crossref
Haiyuan ZhuHassan Lakkis. (2014) Authors' reply to comments on ‘Sample size calculation for comparing two negative binomial rates’. Statistics in Medicine 33:16, pages 2880-2880.
Crossref
H. Zhu & H. Lakkis. (2014) Comments on ‘Sample size calculation for comparing two negative binomial rates’. Statistics in Medicine 33:11, pages 1979-1979.
Crossref
Paul E.M. Fine & Kim Mulholland. 2013. Vaccines. Vaccines 1395 1412 .
Peter J. Hotez & Jeffrey M. Bethony. 2013. Vaccines. Vaccines 1154 1160 .
Hans J Overgaard, Neal Alexander, Maria Ines Mátiz, Juan Felipe Jaramillo, Victor Alberto Olano, Sandra Vargas, Diana Sarmiento, Audrey Lenhart, Razak Seidu & Thor Axel Stenström. (2012) Diarrhea and dengue control in rural primary schools in Colombia: study protocol for a randomized controlled trial. Trials 13:1.
Crossref
Neal Alexander, Bonnie Cundill, Lorenzo Sabatelli, Jeffrey M. Bethony, David Diemert, Peter Hotez, Peter G. Smith, Laura C. Rodrigues & Simon Brooker. (2011) Selection and quantification of infection endpoints for trials of vaccines against intestinal helminths. Vaccine 29:20, pages 3686-3694.
Crossref
L Sabatelli, A.C Ghani, L.C Rodrigues, P.J Hotez & S Brooker. (2008) Modelling heterogeneity and the impact of chemotherapy and vaccination against human hookworm. Journal of The Royal Society Interface 5:28, pages 1329-1341.
Crossref
S. Plotkin, D. J. Diemert, J. M. Bethony & P. J. Hotez. (2008) Hookworm Vaccines. Clinical Infectious Diseases 46:2, pages 282-288.
Crossref
Paul E.M. Fine & Kim Mulholland. 2008. Vaccines. Vaccines 1573 1592 .
Peter J. Hotez & Jeffrey M. Bethony. 2008. Vaccines. Vaccines 1295 1300 .
Michael Cappello & Peter J. Hotez. 2008. Principles and Practice of Pediatric Infectious Disease. Principles and Practice of Pediatric Infectious Disease 1296 1304 .
Neal Alexander, Jeff Bethony, Rodrigo Corrêa‐Oliveira, Laura C. Rodrigues, Peter Hotez & Simon Brooker. (2006) Repeatability of paired counts. Statistics in Medicine 26:19, pages 3566-3577.
Crossref
S. M. GEIGER, I. R. CALDAS, B. E. MC GLONE, A. C. CAMPI-AZEVEDO, L. M. DE OLIVEIRA, S. BROOKER, D. DIEMERT, R. CORRÊA-OLIVEIRA & J. M. BETHONY. (2007) Stage-specific immune responses in human Necator americanus infection. Parasite Immunology 29:7, pages 347-358.
Crossref
Ricardo T. Fujiwara, Bin Zhan, Susana Mendez, Alex Loukas, Lilian L. Bueno, Yan Wang, Jordan Plieskatt, Yelena Oksov, Sara Lustigman, Maria Elena Bottazzi, Peter Hotez & Jeffrey M. Bethony. (2007) Reduction of Worm Fecundity and Canine Host Blood Loss Mediates Protection against Hookworm Infection Elicited by Vaccination with Recombinant Ac- 16 . Clinical and Vaccine Immunology 14:3, pages 281-287.
Crossref
Alex Loukas, Jeffrey Bethony, Simon Brooker & Peter Hotez. (2006) Hookworm vaccines: past, present, and future. The Lancet Infectious Diseases 6:11, pages 733-741.
Crossref
J. M. BETHONY, A. LOUKAS, P. J. HOTEZ & D. P. KNOX. (2007) Vaccines against blood-feeding nematodes of humans and livestock. Parasitology 133:S2, pages S63-S79.
Crossref
R. T. FUJIWARA, S. M. GEIGER, J. BETHONY & S. MENDEZ. (2006) Comparative immunology of human and animal models of hookworm infection. Parasite Immunology 28:7, pages 285-293.
Crossref
Peter J. Hotez, Jeff Bethony, Maria Elena Bottazzi, Simon Brooker, David Diemert & Alex Loukas. (2006) New technologies for the control of human hookworm infection. Trends in Parasitology 22:7, pages 327-331.
Crossref
Peter J Hotez, David H Molyneux, Alan Fenwick, Eric Ottesen, Sonia Ehrlich Sachs & Jeffrey D Sachs. (2006) Incorporating a Rapid-Impact Package for Neglected Tropical Diseases with Programs for HIV/AIDS, Tuberculosis, and Malaria. PLoS Medicine 3:5, pages e102.
Crossref
Marco Albonico, Antonio Montresor, D.W.T. Crompton & Lorenzo Savioli. 2006. Control of Human Parasitic Diseases. Control of Human Parasitic Diseases 311 348 .
Alex Loukas, Jeffrey M Bethony, Susana Mendez, Ricardo T Fujiwara, Gaddam Narsa Goud, Najju Ranjit, Bin Zhan, Karen Jones, Maria Elena Bottazzi & Peter J Hotez. (2005) Vaccination with Recombinant Aspartic Hemoglobinase Reduces Parasite Load and Blood Loss after Hookworm Infection in Dogs. PLoS Medicine 2:10, pages e295.
Crossref
Jeffrey Bethony, Alex Loukas, Michael Smout, Simon Brooker, Susana Mendez, Jordan Plieskatt, Gaddam Goud, Maria Elena Bottazzi, Bin Zhan, Yan Wang, Angela Williamson, Sara Lustigman, Rodrigo Correa‐Oliveira, Shuhua Xiao & Peter J. Hotez. (2005) Antibodies against a secreted protein from hookworm larvae reduce the intensity of hookworm infection in humans and vaccinated laboratory animals. The FASEB Journal 19:12, pages 1743-1745.
Crossref
Gaddam Narsa Goud, Maria Elena Bottazzi, Bin Zhan, Susana Mendez, Vehid Deumic, Jordan Plieskatt, Sen Liu, Yan Wang, Lilian Bueno, Ricardo Fujiwara, Andre Samuel, So Yeong Ahn, Maneesha Solanki, Oluwatoyin A. Asojo, Jin Wang, Jeffrey M. Bethony, Alex Loukas, Michael Roy & Peter J. Hotez. (2005) Expression of the Necator americanus hookworm larval antigen Na-ASP-2 in Pichia pastoris and purification of the recombinant protein for use in human clinical trials. Vaccine 23:39, pages 4754-4764.
Crossref
Peter Hotez, Jeff Bethony, Simon Brooker & Marco Albonico. (2005) Eliminating neglected diseases in Africa. The Lancet 365:9477, pages 2089.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.