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Review

Use of Marek’s disease vaccines: could they be driving the virus to increasing virulence?

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Pages 77-88 | Published online: 09 Jan 2014

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Read on this site (7)

A. Molouki, A. Ghalyanchilangeroudi, M. Abdoshah, A. Shoushtari, A. Abtin, F. Eshtartabadi, M. Mahmoudzadeh Akhijahani, Z. Ziafatikafi, S. S. Babaeimarzango, E. Allahyari, L. Ahmadzadeh, M. H. Fallah Mehrabadi, S. H. E. Lim, K. Rouhani, H. Hosseini & V. Nair. (2022) Report of a new meq gene size: The first study on genetic characterisation of Marek’s disease viruses circulating in Iranian commercial layer and backyard chicken. British Poultry Science 63:2, pages 142-149.
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Yasin Mohammed Yimer, Destaw Asfaw Ali, Belayneh Getachew Ayalew, Molalegne Bitew Asires & Esayas Gelaye. (2021) Pathogenicity of Field Marek’s Disease Virus Serotype-1 and Vaccine Efficacy Test in Chicken in Eastern Shewa Ethiopia. Veterinary Medicine: Research and Reports 12, pages 347-357.
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Sithara Ralapanawe, Stephen W. Walkden-Brown, Katrin G. Renz & A. F. M. Fakhrul Islam. (2016) Protection provided by Rispens CVI988 vaccine against Marek's disease virus isolates of different pathotypes and early prediction of vaccine take and MD outcome. Avian Pathology 45:1, pages 26-37.
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WilliamN. Mwangi, LorraineP. Smith, SusanJ. Baigent, AdrianL. Smith & Venugopal Nair. (2012) Induction of lymphomas by inoculation of Marek's disease virus-derived lymphoblastoid cell lines: prevention by CVI988 vaccination. Avian Pathology 41:6, pages 589-598.
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Kamran Haq, Thomas Fear, Abdelhakeem Ibraheem, Mohamed Faizal Abdul-Careem & Shayan Sharif. (2012) Influence of vaccination with CVI988/Rispens on load and replication of a very virulent Marek's disease virus strain in feathers of chickens. Avian Pathology 41:1, pages 69-75.
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Ekaterina Dudnikova, Svetlana Norkina, Anatoly Vlasov, Anna Slobodchuk, LucyF. Lee & RichardL. Witter. (2007) Evaluation of Marek's disease field isolates by the “best fit” pathotyping assay. Avian Pathology 36:2, pages 135-143.
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Articles from other publishers (71)

ChengFei GE, HangQiong LU & ChangJun LIU. (2023) Progress in the evolution and vaccine research of Marek’s disease. SCIENTIA SINICA Vitae.
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Shaopeng Wu, Tian Ding, Hongxia Shao, Kun Qian, Jianqiang Ye & Aijian Qin. (2023) A quadruplex real-time PCR assay combined with a conventional PCR for the differential detection of Marek’s disease virus vaccines and field strains. Frontiers in Veterinary Science 10.
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Zheng-Hao Yu, Yan-Ping Zhang, Xing-Ge Lan, Ya-Nan Wang, Rong-Rong Guo, Kai Li, Li Gao, Xiao-Le Qi, Hong-Yu Cui, Xiao-Mei Wang, Yu-Long Gao & Chang-Jun Liu. (2023) Differences in Pathogenicity and Vaccine Resistance Discovered between Two Epidemic Strains of Marek’s Disease Virus in China. Viruses 15:4, pages 945.
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Mohammad Heidari, Huanmin Zhang, Lakshmi T Sunkara & Syed Mudasir Ahmad. (2023) Role of T Cells in Vaccine-Mediated Immunity against Marek’s Disease. Viruses 15:3, pages 648.
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Congsen Zheng, Zexian Liang, Qiaoer Lin, Meiting Chen, Chuanzhe Chang, Jun Zhou, Fan Yang, Yanfeng Chen, Mengmeng Zhao, Liangzong Huang & Limei Qin. (2023) Pathology, viremia, apoptosis during MDV latency in vaccinated chickens. Virology 579, pages 169-177.
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Suwarak Wannaratana, Wikanda Tunterak, Duangduean Prakairungnamthip, Jiroj Sasipreeyajan & Aunyaratana Thontiravong. (2022) Genetic characterization of Marek's disease virus in chickens in Thailand reveals a high genetic diversity of circulating strains. Transboundary and Emerging Diseases 69:6, pages 3771-3779.
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Alireza Abtin, Aidin Molouki, Fatemeh Eshtartabadi, Mohsen Mahmoudzadeh Akhijahani, Kiarash Roohani, Arash Ghalyanchilangeroudi, Swee Hua Erin Lim, Mohammad Abdoshah & Abdelhamid Shoushtari. (2022) Phylogenetic analyses on Marek’s disease virus circulating in Iranian backyard and commercial poultry indicate viruses of different origin. Brazilian Journal of Microbiology 53:3, pages 1683-1689.
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Ho Thi Viet Thu, Huynh Ngoc Trang, Nguyen Tran Phuoc Chien, Nguyen Trong Ngu & Nguyen Duc Hien. (2022) Occurrence of Marek's Disease in Backyard Chicken Flocks in Vietnam. Avian Diseases 66:2.
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Alec Steep, Evin Hildebrandt, Hongen Xu, Cari Hearn, Dmitrij Frishman, Masahiro Niikura, John R. Dunn, Taejoong Kim, Steven J. Conrad, William M. Muir & Hans H. Cheng. (2022) Identification and Validation of Ikaros (IKZF1) as a Cancer Driver Gene for Marek’s Disease Virus-Induced Lymphomas. Microorganisms 10:2, pages 401.
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Yu You, Tereza Vychodil, Giulia Aimola, Renato L. Previdelli, Thomas W. Göbel, Luca D. Bertzbach & Benedikt B. Kaufer. (2021) A Cell Culture System to Investigate Marek’s Disease Virus Integration into Host Chromosomes. Microorganisms 9:12, pages 2489.
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Yu You, Andelé M. Conradie, Ahmed Kheimar, Luca D. Bertzbach & Benedikt B. Kaufer. (2021) The Marek's Disease Virus Unique Gene MDV082 Is Dispensable for Virus Replication but Contributes to a Rapid Disease Onset. Journal of Virology 95:15.
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Maria Montoya & Elma Z. Tchilian. 2021. Veterinary Vaccines. Veterinary Vaccines 11 23 .
Yifei Liao, Kanika Bajwa, Sanjay M. Reddy & Blanca Lupiani. (2021) Methods for the Manipulation of Herpesvirus Genome and the Application to Marek’s Disease Virus Research. Microorganisms 9:6, pages 1260.
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Jegarubee Bavananthasivam, Mohammadali Alizadeh, Jake Astill, Nadiyah Alqazlan, Ayumi Matsuyama-Kato, Bahram Shojadoost, Khaled Taha-Abdelaziz & Shayan Sharif. (2021) Effects of administration of probiotic lactobacilli on immunity conferred by the herpesvirus of turkeys vaccine against challenge with a very virulent Marek’s disease virus in chickens. Vaccine 39:17, pages 2424-2433.
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Yifei Liao, Sanjay M. Reddy, Owais A. Khan, Aijun Sun & Blanca Lupiani. (2021) A Novel Effective and Safe Vaccine for Prevention of Marek’s Disease Caused by Infection with a Very Virulent Plus (vv+) Marek’s Disease Virus. Vaccines 9:2, pages 159.
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Andelé M. Conradie, Luca D. Bertzbach, Jakob Trimpert, Joseph N. Patria, Shiro Murata, Mark S. Parcells & Benedikt B. Kaufer. (2020) Distinct polymorphisms in a single herpesvirus gene are capable of enhancing virulence and mediating vaccinal resistance. PLOS Pathogens 16:12, pages e1009104.
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Sylvie Rémy, Gilles Le Pape, David Gourichon, Yannick Gardin & Caroline Denesvre. (2020) Chickens can durably clear herpesvirus vaccine infection in feathers while still carrying vaccine-induced antibodies. Veterinary Research 51:1.
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Yi Yang, Maoli Dong, Xiaoli Hao, Aijian Qin & Shaobin Shang. (2020) Revisiting cellular immune response to oncogenic Marek’s disease virus: the rising of avian T-cell immunity. Cellular and Molecular Life Sciences 77:16, pages 3103-3116.
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Luca D. Bertzbach, Andelé M. Conradie, Yu You & Benedikt B. Kaufer. (2020) Latest Insights into Marek’s Disease Virus Pathogenesis and Tumorigenesis. Cancers 12:3, pages 647.
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Junyan Lin, Yongxing Ai, Hongda Zhou, Yan Lv, Menghan Wang, Jiacui Xu, Cong Yu, Huanmin Zhang & Mengyun Wang. (2020) UL36 Encoded by Marek’s Disease Virus Exhibits Linkage-Specific Deubiquitinase Activity. International Journal of Molecular Sciences 21:5, pages 1783.
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Venugopal Nair, Isabel Gimeno, John Dunn, Guillermo Zavala, Susan M. Williams, Rodney L. Reece & Scott Hafner. 2020. Diseases of Poultry. Diseases of Poultry 548 715 .
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Luca Bertzbach, Florian Pfaff, Viktoria Pauker, Ahmed Kheimar, Dirk Höper, Sonja Härtle, Axel Karger & Benedikt Kaufer. (2019) The Transcriptional Landscape of Marek’s Disease Virus in Primary Chicken B Cells Reveals Novel Splice Variants and Genes. Viruses 11:3, pages 264.
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Luca D. Bertzbach, Maria LaparidouSonja Härtle, Robert J. Etches, Bernd KaspersBenjamin Schusser & Benedikt B. Kaufer. (2018) Unraveling the role of B cells in the pathogenesis of an oncogenic avian herpesvirus. Proceedings of the National Academy of Sciences 115:45, pages 11603-11607.
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Huimin Li, Jiaojiao Zhu, Minyi He, Qiong Luo, Fan Liu & Ruiai Chen. (2018) Marek’s Disease Virus Activates the PI3K/Akt Pathway Through Interaction of Its Protein Meq With the P85 Subunit of PI3K to Promote Viral Replication. Frontiers in Microbiology 9.
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Adrianna M.S. Laursen, Raveendra R. Kulkarni, Khaled Taha-Abdelaziz, Brandon L. Plattner, Leah R. Read & Shayan Sharif. (2018) Characterizaton of gamma delta T cells in Marek’s disease virus (Gallid herpesvirus 2) infection of chickens. Virology 522, pages 56-64.
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Kekungu-u Puro, Uttaran Bhattacharjee, Samprity Baruah, Arnab Sen, Samir Das, Sandeep Ghatak, Sunil Doley, Rajkumari Sanjukta & Ingudam Shakuntala. (2018) Characterization of Marek’s disease virus and phylogenetic analyses of meq gene from an outbreak in poultry in Meghalaya of Northeast India. VirusDisease 29:2, pages 167-172.
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Jing Zhou, Guo-Liang Zhao, Xiao-Man Wang, Xu-Sheng Du, Shuai Su, Chen-Gui Li, Venugopal Nair, Yong-Xiu Yao & Zi-Qiang Cheng. (2018) Synergistic Viral Replication of Marek’s Disease Virus and Avian Leukosis Virus Subgroup J is Responsible for the Enhanced Pathogenicity in the Superinfection of Chickens. Viruses 10:5, pages 271.
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Sonja Haertle, Ibrahim Alzuheir, Florian Busalt, Victoria Waters, Pete Kaiser & Benedikt B. Kaufer. (2017) Identification of the Receptor and Cellular Ortholog of the Marek's Disease Virus (MDV) CXC Chemokine. Frontiers in Microbiology 8.
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