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Expert Review of Vaccines Volume 5, 2006 - Issue 1
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Review

Progress towards an effective syphilis vaccine: the past, present and future

Paul A Cullen Australian Bacterial Pathogenesis Program, Victorian Bioinformatics Consortium, Department of Microbiology, Monash University, VIC 3800 Australia and Department of Medicine, University of Washington 1959 NE Pacific St. Room I-104G, Box 357185 Seattle, WA 98195, USA. [email protected]
&
Caroline E Cameron Department of Medicine, University of Washington, 1959 NE Pacific St. Room I-104E, Box 357185, Seattle, WA 98195, USA. [email protected]
Pages 67-80 | Published online: 09 Jan 2014

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Sijia Li, Weiwei Li, Yinqi Jin, Bin Wu & Yimou Wu. (2023) Advancements in the development of nucleic acid vaccines for syphilis prevention and control. Human Vaccines & Immunotherapeutics 19:2.
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James Oluwagbamigbe Fajemiroye, Andre Luis Elias Moreira, Célia Regina Malveste Ito, Elson Alves Costa, Rafaella Misael Queiroz, Ogbu John Ihayi, Caroline Vitória Moreira, Rafael Fernandes Costa, Claudia Carneiro Teixeira, Miguel Júnior Sordi Bortolini & Osmar Nascimento Silva. (2023) Advancing Syphilis Research: Exploring New Frontiers in Immunology and Pharmacological Interventions. Venereology 2:4, pages 147-163.
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Yuxing He, Dejun Chen, Yue Fu, Xinzhuo Huo, Feijun Zhao, Ling Yao, Xiuping Zhou, Pengfei Qi, Haoquan Yin, Longgu Cao, Hui Ling & Tiebing Zeng. (2023) Immunization with Tp0954, an adhesin of Treponema pallidum, provides protective efficacy in the rabbit model of experimental syphilis. Frontiers in Immunology 14.
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Sheila A. Lukehart, Barbara Molini, Alloysius Gomez, Charmie Godornes, Rebecca Hof, Mark C. Fernandez, Ragan A. Pitner, Sean A. Gray, Darrick Carter, Lorenzo Giacani & Caroline E. Cameron. (2022) Immunization with a tri-antigen syphilis vaccine significantly attenuates chancre development, reduces bacterial load, and inhibits dissemination of Treponema pallidum. Vaccine 40:52, pages 7676-7692.
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Man Xu, Yafeng Xie, Kang Zheng, Haodang Luo, Manyi Tan, Feijun Zhao, Tiebing Zeng & Yimou Wu. (2021) Two Potential Syphilis Vaccine Candidates Inhibit Dissemination of Treponema pallidum. Frontiers in Immunology 12.
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Valentina Marchese, Sarah Dal Zoppo, Virginia Quaresima, Benedetta Rossi & Alberto Matteelli. 2020. Sexually Transmitted Infections. Sexually Transmitted Infections 87 104 .
Miguel Pinto, Vítor Borges, Minia Antelo, Miguel Pinheiro, Alexandra Nunes, Jacinta Azevedo, Maria José Borrego, Joana Mendonça, Dina Carpinteiro, Luís Vieira & João Paulo Gomes. (2016) Genome-scale analysis of the non-cultivable Treponema pallidum reveals extensive within-patient genetic variation. Nature Microbiology 2:1.
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Arvind Anand, Morgan LeDoyt, Carson Karanian, Amit Luthra, Mary Koszelak-Rosenblum, Michael G. Malkowski, Robbins Puthenveetil, Olga Vinogradova & Justin D. Radolf. (2015) Bipartite Topology of Treponema pallidum Repeat Proteins C/D and I. Journal of Biological Chemistry 290:19, pages 12313-12331.
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Michael W. Russell, Judith Whittum-Hudson, Paul L. FidelJr.Jr., Edward W. HookIIIIII & Jiri Mestecky. 2015. Mucosal Immunology. Mucosal Immunology 2183 2214 .
Caroline E. Cameron & Sheila A. Lukehart. (2014) Current status of syphilis vaccine development: Need, challenges, prospects. Vaccine 32:14, pages 1602-1609.
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Lola V. Stamm & Rebecca L. Drapp. (2014) A synthetic lymph node containing inactivated Treponema pallidum cells elicits strong, antigen-specific humoral and cellular immune responses in mice . Pathogens and Disease 70:1, pages 88-94.
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Arvind Anand, Amit Luthra, Maxwell E. Edmond, Morgan Ledoyt, Melissa J. Caimano & Justin D. Radolf. (2013) The Major Outer Sheath Protein (Msp) of Treponema denticola Has a Bipartite Domain Architecture and Exists as Periplasmic and Outer Membrane-Spanning Conformers. Journal of Bacteriology 195:9, pages 2060-2071.
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Emily L. Ho & Sheila A. Lukehart. 2013. The Prokaryotes. The Prokaryotes 447 468 .
C. Rodríguez-Cerdeira & V.G. Silami-Lopes. (2012) Congenital Syphilis in the 21st Century. Actas Dermo-Sifiliográficas (English Edition) 103:8, pages 679-693.
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C. Rodríguez-Cerdeira & V.G. Silami-Lopes. (2012) Sífilis congénita en el siglo xxi. Actas Dermo-Sifiliográficas 103:8, pages 679-693.
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Eliahu Yuval Landau & Bezalel Wainrach. (2012) Sperm-mediated host-derived DNA transfer as a new mechanism for immune system evasion of sexually transmitted genital tract pathogens. Medical Hypotheses 79:3, pages 408-412.
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Arvind Anand, Amit Luthra, Star Dunham-Ems, Melissa J. Caimano, Carson Karanian, Morgan LeDoyt, Adriana R. Cruz, Juan C. Salazar & Justin D. Radolf. (2012) TprC/D (Tp0117/131), a Trimeric, Pore-Forming Rare Outer Membrane Protein of Treponema pallidum, Has a Bipartite Domain Structure. Journal of Bacteriology 194:9, pages 2321-2333.
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David J Wright, Steven J Norris, Rishi H‐P Dhillon & Diane G Edmondson. 2005. Encyclopedia of Life Sciences. Encyclopedia of Life Sciences.
Lola V. Stamm. 2012. The Pathogenic Spirochetes: strategies for evasion of host immunity and persistence. The Pathogenic Spirochetes: strategies for evasion of host immunity and persistence 213 228 .
Simon Houston & Caroline E. Cameron. 2012. The Pathogenic Spirochetes: strategies for evasion of host immunity and persistence. The Pathogenic Spirochetes: strategies for evasion of host immunity and persistence 3 18 .
Emily L. Ho & Sheila A. Lukehart. (2011) Syphilis: using modern approaches to understand an old disease. Journal of Clinical Investigation 121:12, pages 4584-4592.
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David L. Cox, Amit Luthra, Star Dunham-Ems, Daniel C. Desrosiers, Juan C. Salazar, Melissa J. Caimano & Justin D. Radolf. (2010) Surface Immunolabeling and Consensus Computational Framework To Identify Candidate Rare Outer Membrane Proteins of Treponema pallidum . Infection and Immunity 78:12, pages 5178-5194.
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Fraser Drummond, Rebecca Guy, John M Kaldor & Basil Donovan. (2010) The intersection between HIV and syphilis in men who have sex with men: some fresh perspectives. HIV Therapy 4:6, pages 661-673.
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Jun Liu, Jerrilyn K. Howell, Sherille D. Bradley, Yesha Zheng, Z. Hong Zhou & Steven J. Norris. (2010) Cellular Architecture of Treponema pallidum: Novel Flagellum, Periplasmic Cone, and Cell Envelope as Revealed by Cryo Electron Tomography. Journal of Molecular Biology 403:4, pages 546-561.
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Melanie A. McGill, Diane G. Edmondson, James A. Carroll, Richard G. Cook, Ralph S. Orkiszewski & Steven J. Norris. (2010) Characterization and Serologic Analysis of the Treponema pallidum Proteome . Infection and Immunity 78:6, pages 2631-2643.
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Jo L. Chung, Jian Sun, John Sidney, Alessandro Sette & Bjoern Peters. (2010) IMMUNOCAT—A Data Management System for Epitope Mapping Studies. Journal of Biomedicine and Biotechnology 2010, pages 1-8.
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Anna Litvak-Hinenzon & Lewi Stone. (2008) Spatio-temporal waves and targeted vaccination in recurrent epidemic network models. Journal of The Royal Society Interface 6:38, pages 749-760.
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Mary Beth Brinkman, Melanie A. McGill, Jonas Pettersson, Arthur Rogers, Petra Matějková, David Šmajs, George M. Weinstock, Steven J. Norris & Timothy Palzkill. (2008) A Novel Treponema pallidum Antigen, TP0136, Is an Outer Membrane Protein That Binds Human Fibronectin . Infection and Immunity 76:5, pages 1848-1857.
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Farol L. Tomson, Patrick G. Conley, Michael V. Norgard & Kayla E. Hagman. (2007) Assessment of cell-surface exposure and vaccinogenic potentials of Treponema pallidum candidate outer membrane proteins. Microbes and Infection 9:11, pages 1267-1275.
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Godfrey J.A. Walker & Damian G. Walker. (2007) Congenital syphilis: A continuing but neglected problem. Seminars in Fetal and Neonatal Medicine 12:3, pages 198-206.
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Peter J. Hotez & Meghan T. Ferris. (2006) The antipoverty vaccines. Vaccine 24:31-32, pages 5787-5799.
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