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Review

Acellular pertussis vaccines and the role of pertactin and fimbriae

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Pages 47-56 | Published online: 09 Jan 2014

Keep up to date with the latest research on this topic with citation updates for this article.

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Hamid Najminejad, Seyed Mehdi Kalantar, Ali Rezaei Mokarram, Mehran Dabaghian, Meghdad Abdollahpour-Alitappeh, Seyyed Mahmoud Ebrahimi, Majid Tebianian, Mahdi Fasihi Ramandi & Mohammad Hasan Sheikhha. (2019) Bordetella pertussis antigens encapsulated into N-trimethyl chitosan nanoparticulate systems as a novel intranasal pertussis vaccine. Artificial Cells, Nanomedicine, and Biotechnology 47:1, pages 2605-2611.
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Andrew R Gorringe & Thomas E Vaughan. (2014) Bordetella pertussis fimbriae (Fim): relevance for vaccines. Expert Review of Vaccines 13:10, pages 1205-1214.
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Nicolas Hegerle & Nicole Guiso. (2014) Bordetella pertussis and pertactin-deficient clinical isolates: lessons for pertussis vaccines. Expert Review of Vaccines 13:9, pages 1135-1146.
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Vincenzo Baldo, Paolo Bonanni, Marcela Castro, Giovanni Gabutti, Elisabetta Franco, Federico Marchetti, Rosa Prato & Francesco Vitale. (2014) Combined hexavalent diphtheria-tetanus-acellular pertussis-hepatitis B-inactivated poliovirus-Haemophilus influenzae type b vaccine; Infanrix™ hexa. Human Vaccines & Immunotherapeutics 10:1, pages 129-137.
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Daniel Cozens & Robert C Read. (2012) Anti-adhesion methods as novel therapeutics for bacterial infections. Expert Review of Anti-infective Therapy 10:12, pages 1457-1468.
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Jan T Poolman, Hans Hallander & Scott A Halperin. (2011) Pertussis vaccines: where to now?. Expert Review of Vaccines 10:11, pages 1497-1500.
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Teemu Kallonen & Qiushui He. (2009) Bordetella pertussis strain variation and evolution postvaccination. Expert Review of Vaccines 8:7, pages 863-875.
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Articles from other publishers (42)

Danyal Imani, Tannaz Bahadori, Sedighe Ghourchian, Forough Golsaz-Shirazi, Masoumeh Douraghi, Mahmood Jeddi-Tehrani, Mohammad Mehdi Amiri & Fazel Shokri. (2023) Novel mouse monoclonal antibodies against Bordetella pertussis pertactin antigen with versatile applications. Journal of Microbiological Methods 211, pages 106786.
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Beatriz Miguelena Chamorro, Karelle De Luca, Gokul Swaminathan, Stéphanie Longet, Egbert Mundt & Stéphane Paul. (2023) Bordetella bronchiseptica and Bordetella pertussis: Similarities and Differences in Infection, Immuno-Modulation, and Vaccine Considerations. Clinical Microbiology Reviews.
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Nao Otsuka, Kentaro Koide, Masataka Goto, Kazunari Kamachi & Tsuyoshi Kenri. (2023) Fim3-dependent autoagglutination of Bordetella pertussis. Scientific Reports 13:1.
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Hanqing He, Yao Zhu, Mingjuan Jin, Yang Zhou, Xuewen Tang, Rui Yan, Xuan Deng & Kun Chen. (2022) The decline in immunity and circulation of pertussis among Chinese population during the COVID-19 pandemic: A cross-sectional sero-epidemiological study. Vaccine 40:48, pages 6956-6962.
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Md. Obayed Raihan, Brenna M. Espelien, Brett A. McGregor, Courtney Hanson, Afrina Brishti, Nathan A. Velaris, Travis D. Alvine, David S. Bradley, Matthew Nilles, Mikhail Y. Golovko, Junguk Hur & James E. Porter. (2022) Modulation of Inflammatory Signaling Molecules in Bordetella pertussis Antigen-Challenged Human Monocytes in Presence of Adrenergic Agonists. Vaccines 10:2, pages 321.
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Markus Knuf, Hervé Haas, Pilar Garcia-Corbeira, Elisa Turriani, Piyali Mukherjee, Winnie Janssens & Valérie Berlaimont. (2021) Hexavalent vaccines: What can we learn from head-to-head studies?. Vaccine 39:41, pages 6025-6036.
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Diana Keizner, Shakiba Ghaffari, Samaneh Beheshti, Elena Newman, David Tulumello, Marina Kirkitadze & Michael Leach. (2021) Quantitative microcapillary electrophoresis immunoassay (mCE IA) for end-to-end analysis of pertactin within in-process samples and Quadracel® vaccine. Journal of Pharmaceutical and Biomedical Analysis 204, pages 114284.
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Ting Y. Wong, Jesse M. Hall, Evan S. Nowak, Dylan T. Boehm, Laura A. Gonyar, Erik L. Hewlett, Joshua C. Eby, Mariette Barbier & F. Heath Damron. (2019) Analysis of the In Vivo Transcriptome of Bordetella pertussis during Infection of Mice . mSphere 4:2.
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Arezoo Asadi, Shabnam Razavi, Malihe Talebi & Mehrdad Gholami. (2018) A review on anti-adhesion therapies of bacterial diseases. Infection 47:1, pages 13-23.
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Anne Marie Queenan, David J. Dowling, Wing Ki Cheng, Kellen Faé, Jeffrey Fernandez, Peter J. Flynn, Sweta Joshi, Spencer E. Brightman, Juan Ramirez, Jan Serroyen, Selma Wiertsema, Alexandre Fortanier, Germie van den Dobbelsteen, Ofer Levy & Jan Poolman. (2019) Increasing FIM2/3 antigen-content improves efficacy of Bordetella pertussis vaccines in mice in vivo without altering vaccine-induced human reactogenicity biomarkers in vitro. Vaccine 37:1, pages 80-89.
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Anthony William MaressoAnthony William Maresso. 2019. Bacterial Virulence. Bacterial Virulence 177 194 .
Qing Chen, Gloria Lee, Candice Craig, Victoria Ng, Paul E. CarlsonJr.Jr., Deborah M. Hinton & Scott Stibitz. (2018) A Novel Bvg-Repressed Promoter Causes vrg -Like Transcription of fim3 but Does Not Result in the Production of Serotype 3 Fimbriae in Bvg − Mode Bordetella pertussis . Journal of Bacteriology 200:20.
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Christiane S. Eberhardt & Claire-Anne Siegrist. (2017) What Is Wrong with Pertussis Vaccine Immunity?. Cold Spring Harbor Perspectives in Biology 9:12, pages a029629.
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Julieanne L. Vo, Gabriela Constanza Martínez Ortiz, Pramod Subedi, Shivakumar Keerthikumar, Suresh Mathivanan, Jason J. Paxman & Begoña Heras. (2017) Autotransporter Adhesins in Escherichia coli Pathogenesis . PROTEOMICS 17:23-24, pages 1600431.
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Zenglan Li, Yan Zhang, Qi Wang, Zhengjun Li, Yongdong Liu, Songping Zhang, Guifeng Zhang, Guanghui Ma, Jian Luo & Zhiguo Su. (2016) Purification design and practice for pertactin, the third component of acellular pertussis vaccine, from Bordetella pertussis. Vaccine 34:34, pages 4032-4039.
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Azadeh Safarchi, Sophie Octavia, Laurence Don Wai Luu, Chin Yen Tay, Vitali Sintchenko, Nicholas Wood, Helen Marshall, Peter McIntyre & Ruiting Lan. (2015) Pertactin negative Bordetella pertussis demonstrates higher fitness under vaccine selection pressure in a mixed infection model. Vaccine 33:46, pages 6277-6281.
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Rita Austin & Tonya Shearin-Patterson. 2015. Practical Handbook of Microbiology, Third Edition. Practical Handbook of Microbiology, Third Edition 745 766 .
P Sumarno R, S Avanita A, Winarsih S, Hidayat S & Y Nurhidayati D. (2015) Haemaglutination of Shigella dysenteriae subunit pili protein with anti-haemaglutination of S. dysenteriae subunit pili protein as a molecule adhesion in mouse enterocytes. African Journal of Microbiology Research 9:11, pages 781-787.
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Na-Young Ha, Prashant Sharma, Gwanghun Kim, Yuri Kim, Chan-Ki Min, Myung-Sik Choi, Ik-Sang Kim & Nam-Hyuk Cho. (2015) Immunization with an Autotransporter Protein of Orientia tsutsugamushi Provides Protective Immunity against Scrub Typhus. PLOS Neglected Tropical Diseases 9:3, pages e0003585.
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S. W. Martin, L. Pawloski, M. Williams, K. Weening, C. DeBolt, X. Qin, L. Reynolds, C. Kenyon, G. Giambrone, K. Kudish, L. Miller, D. Selvage, A. Lee, T. H. Skoff, H. Kamiya, P. K. Cassiday, M. L. Tondella & T. A. Clark. (2014) Pertactin-Negative Bordetella pertussis Strains: Evidence for a Possible Selective Advantage. Clinical Infectious Diseases 60:2, pages 223-227.
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Shwu-Maan Lee, Vincent Turula, Bradford Powell, Mikkel Nissum, Mariagrazia Pizza, Claudia Magagnoli & Niranjan M. Kumar. 2015. Vaccine Analysis: Strategies, Principles, and Control. Vaccine Analysis: Strategies, Principles, and Control 187 270 .
Thomas E. Vaughan, Catherine B. Pratt, Katie Sealey, Andrew Preston, Norman K. Fry & Andrew R. Gorringe. (2014) Plasticity of fimbrial genotype and serotype within populations of Bordetella pertussis: analysis by paired flow cytometry and genome sequencing. Microbiology 160:9, pages 2030-2044.
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Qing Chen, Alice Boulanger, Deborah M. Hinton & Scott Stibitz. (2014) Strong inhibition of fimbrial 3 subunit gene transcription by a novel downstream repressive element in B ordetella pertussis . Molecular Microbiology 93:4, pages 748-758.
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Kerrie Vaughan, Emily Seymour, Bjoern Peters & Alessandro Sette. (2014) Substantial gaps in knowledge of Bordetella pertussis antibody and T cell epitopes relevant for natural immunity and vaccine efficacy. Human Immunology 75:5, pages 440-451.
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Derek S. Sarovich, Erin P. Price, Jessica R. Webb, Linda M. Ward, Marcos Y. Voutsinos, Apichai Tuanyok, Mark Mayo, Mirjam Kaestli & Bart J. Currie. (2014) Variable Virulence Factors in Burkholderia pseudomallei (Melioidosis) Associated with Human Disease. PLoS ONE 9:3, pages e91682.
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Hans Hallander, Abdolreza Advani, Frances Alexander, Lennart Gustafsson, Margaretha Ljungman, Catherine Pratt, Ian Hall & Andrew R. Gorringe. (2014) Antibody Responses to Bordetella pertussis Fim2 or Fim3 following Immunization with a Whole-Cell, Two-Component, or Five-Component Acellular Pertussis Vaccine and following Pertussis Disease in Children in Sweden in 1997 and 2007. Clinical and Vaccine Immunology 21:2, pages 165-173.
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Begoña HerasMakrina TotsikaKate M. PetersJason J. Paxman, Christine L. Gee, Russell J. Jarrott, Matthew A. PeruginiAndrew E. Whitten & Mark A. Schembri. (2013) The antigen 43 structure reveals a molecular Velcro-like mechanism of autotransporter-mediated bacterial clumping. Proceedings of the National Academy of Sciences 111:1, pages 457-462.
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Yusuke Miyaji, Nao Otsuka, Hiromi Toyoizumi-Ajisaka, Keigo Shibayama & Kazunari Kamachi. (2013) Genetic Analysis of Bordetella pertussis Isolates from the 2008–2010 Pertussis Epidemic in Japan. PLoS ONE 8:10, pages e77165.
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Birgit Thierry-Carstensen, Tine Dalby, Michael A. Stevner, John B. Robbins, Rachel Schneerson & Birger Trollfors. (2013) Experience with monocomponent acellular pertussis combination vaccines for infants, children, adolescents and adults—A review of safety, immunogenicity, efficacy and effectiveness studies and 15 years of field experience. Vaccine 31:45, pages 5178-5191.
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Françoise Vermeulen, Violette Dirix, Virginie Verscheure, Eliane Damis, Danièle Vermeylen, Camille Locht & Françoise Mascart. (2013) Persistence at one year of age of antigen-induced cellular immune responses in preterm infants vaccinated against whooping cough: Comparison of three different vaccines and effect of a booster dose. Vaccine 31:15, pages 1981-1986.
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Frances Alexander, Mary Matheson, Norman K. Fry, Briony Labram & Andrew R. Gorringe. (2012) Antibody Responses to Individual Bordetella pertussis Fimbrial Antigen Fim2 or Fim3 following Immunization with the Five-Component Acellular Pertussis Vaccine or to Pertussis Disease. Clinical and Vaccine Immunology 19:11, pages 1776-1783.
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Birgit Thierry-Carstensen, Karina Jordan, Hilde Hylland Uhlving, Tine Dalby, Charlotte Sørensen, Anders Mørup Jensen & Carsten Heilmann. (2012) A randomised, double-blind, non-inferiority clinical trial on the safety and immunogenicity of a tetanus, diphtheria and monocomponent acellular pertussis (TdaP) vaccine in comparison to a tetanus and diphtheria (Td) vaccine when given as booster vaccinations to healthy adults. Vaccine 30:37, pages 5464-5471.
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Na-Young Ha, Nam-Hyuk Cho, Yeon-Sook Kim, Myung-Sik Choi & Ik-Sang Kim. (2011) An Autotransporter Protein from Orientia tsutsugamushi Mediates Adherence to Nonphagocytic Host Cells . Infection and Immunity 79:4, pages 1718-1727.
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Sandra Morel, Philippe Denoël, Fabrice Godfroid, Caroline Cortvrindt, Nathalie Vanderheyde & Jan Poolman. (2011) Induction of Bordetella pertussis-specific immune memory by DTPa vaccines. Vaccine 29:18, pages 3449-3455.
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Estela M. Galván, Manoj Kumar Mohan Nair, Huaiqing Chen, Fabio Del Piero & Dieter M. Schifferli. (2010) Biosafety Level 2 Model of Pneumonic Plague and Protection Studies with F1 and Psa. Infection and Immunity 78:8, pages 3443-3453.
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HANS O. HALLANDER, MARGARETHA LJUNGMAN, MAJA JAHNMATZ, JANN STORSAETER, LENNART NILSSON & LENNART GUSTAFSSON. (2009) Should fimbriae be included in pertussis vaccines? Studies on ELISA IgG anti-Fim2/3 antibodies after vaccination and infection. APMIS 117:9, pages 660-671.
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Elizabeth M. Goebel, Xuqing Zhang & Eric T. Harvill. (2009) Bordetella pertussis Infection or Vaccination Substantially Protects Mice against B. bronchiseptica Infection. PLoS ONE 4:8, pages e6778.
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