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Special Focus Issue: Cancer Vaccines - Review

Cell fusion: from hybridoma to dendritic cell-based vaccine

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Pages 1055-1068 | Published online: 09 Jan 2014

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (7)

Laetitia Cicchelero, Sofie Denies, Bert Devriendt, Hilde de Rooster & Niek N Sanders. (2015) Can dendritic cells improve whole cancer cell vaccines based on immunogenically killed cancer cells?. OncoImmunology 4:12.
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Laetitia Cicchelero, Hilde de Rooster & Niek N Sanders. (2014) Various ways to improve whole cancer cell vaccines. Expert Review of Vaccines 13:6, pages 721-735.
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Shigeo Koido, Sadamu Homma, Masato Okamoto, Yoshihisa Namiki, Kazuki Takakura, Kan Uchiyama, Mikio Kajihara, Seiji Arihiro, Hiroo Imazu, Hiroshi Arakawa, Shin Kan, Hideo Komita, Masaki Ito, Toshifumi Ohkusa, Jianlin Gong & Hisao Tajiri. (2013) Fusions between dendritic cells and whole tumor cells as anticancer vaccines. OncoImmunology 2:5.
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Ayesha Murshid, Jianlin Gong, Mary Ann Stevenson & Stuart K Calderwood. (2011) Heat shock proteins and cancer vaccines: developments in the past decade and chaperoning in the decade to come. Expert Review of Vaccines 10:11, pages 1553-1568.
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Zhe Yu, Pengcheng Ren, Xudong Zhang, Ting Zhang & Bao’an Ma. (2009) Therapeutic potential of dendritic cell vaccines in sarcoma of the extremities. Expert Review of Anticancer Therapy 9:8, pages 1065-1071.
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Choon-Kit Tang, Maria Katsara & Vasso Apostolopoulos. (2008) Strategies used for MUC1 immunotherapy: human clinical studies. Expert Review of Vaccines 7:7, pages 963-975.
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Choon-Kit Tang & Vasso Apostolopoulos. (2008) Strategies used for MUC1 immunotherapy: preclinical studies. Expert Review of Vaccines 7:7, pages 951-962.
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Articles from other publishers (33)

Meng Wu, Qiang Ke, Jinhao Bi, Xinhao Li, Shuheng Huang, Zuohua Liu & Liangpeng Ge. (2022) Substantially Improved Electrofusion Efficiency of Hybridoma Cells: Based on the Combination of Nanosecond and Microsecond Pulses. Bioengineering 9:9, pages 450.
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Naotomo Tottori, Sora Sadamichi, Shinya Sakuma, Tomomi Tsubouchi & Yoko Yamanishi. (2022) On-chip Continuous Pairing, Separation and Electrofusion of Cells Using a Microdroplet. On-chip Continuous Pairing, Separation and Electrofusion of Cells Using a Microdroplet.
Hajer Fritah, Raphaël Rovelli, Cheryl Lai-Lai Chiang & Lana E. Kandalaft. (2022) The current clinical landscape of personalized cancer vaccines. Cancer Treatment Reviews 106, pages 102383.
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Xuan Mu & Yu Shrike Zhang. 2022. Engineering Technologies and Clinical Translation. Engineering Technologies and Clinical Translation 155 195 .
Jia Yang, Junjie Shangguan, Aydin Eresen, Yu Li, Jian Wang & Zhuoli Zhang. (2019) Dendritic cells in pancreatic cancer immunotherapy: Vaccines and combination immunotherapies. Pathology - Research and Practice 215:12, pages 152691.
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Weihua He, Liang Huang, Yongxiang Feng, Fei Liang, Wei Ding & Wenhui Wang. (2019) Highly integrated microfluidic device for cell pairing, fusion and culture. Biomicrofluidics 13:5.
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Masa Kanduser, Mojca Kokalj Imsirovic & Marko Usaj. (2019) The Effect of Lipid Antioxidant α-Tocopherol on Cell Viability and Electrofusion Yield of B16-F1 Cells In Vitro. The Journal of Membrane Biology 252:1, pages 105-114.
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Chuanwei Yang, James L. Murray & Nuhad K. Ibrahim. 2018. Immunology. Immunology 225 240 .
Shigeo Koido. (2016) Dendritic-Tumor Fusion Cell-Based Cancer Vaccines. International Journal of Molecular Sciences 17:6, pages 828.
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Mikio Kajihara, Kazuki Takakura, Tomoya Kanai, Zensho Ito, Keisuke Saito, Shinichiro Takami, Shigetaka Shimodaira, Masato Okamoto, Toshifumi Ohkusa & Shigeo Koido. (2016) Dendritic cell-based cancer immunotherapy for colorectal cancer. World Journal of Gastroenterology 22:17, pages 4275.
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Eran Ophir, Sara Bobisse, George Coukos, Alexandre Harari & Lana E. Kandalaft. (2016) Personalized approaches to active immunotherapy in cancer. Biochimica et Biophysica Acta (BBA) - Reviews on Cancer 1865:1, pages 72-82.
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Mikio Kajihara, Kazuki Takakura, Toshifumi Ohkusa & Shigeo Koido. (2015) The impact of dendritic cell–tumor fusion cells on cancer vaccines - past progress and future strategies. Immunotherapy 7:10, pages 1111-1122.
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Burak Dura & Joel Voldman. 2015. Cell Fusion. Cell Fusion 73 94 .
A Fujihira, T Suzuki, M O Chang, T Moriyama, M Kitajima & H Takaku. (2014) Antitumor effects of baculovirus-infected dendritic cells against human pancreatic carcinoma. Gene Therapy 21:9, pages 849-854.
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Shigeo Koido, Sadamu Homma, Shin Kan, Kazuki Takakura, Yoshihisa Namiki, Hiroko Kobayashi, Zensho Ito, Kan Uchiyama, Mikio Kajihara, Seiji Arihiro, Hiroshi Arakawa, Masato Okamoto, Toshifumi Ohkusa, Jianlin Gong & Hisao Tajiri. (2014) Induction of antigen-specific cytotoxic T lymphocytes by fusion cells generated from allogeneic plasmacytoid dendritic and tumor cells. International Journal of Oncology.
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Yunfei Zhang, Wen Luo, Yucai Wang, Yunyan Liu & Lianhe Zheng. (2014) Purified Dendritic Cell-Tumor Fusion Hybrids Supplemented with Non-Adherent Dendritic Cells Fraction Are Superior Activators of Antitumor Immunity. PLoS ONE 9:1, pages e86772.
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Yu. V. Bobryshev, V. P. Karagodin & A. N. Orekhov. (2013) Dendritic cells and their role in immune reactions of atherosclerosis. Cell and Tissue Biology 7:2, pages 113-125.
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Elena Niccolai, Domenico Prisco, Mario Milco D'Elios & Amedeo Amedei. (2013) What Is Recent in Pancreatic Cancer Immunotherapy?. BioMed Research International 2013, pages 1-14.
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Janos L Tanyi & Christina S Chu. (2012) Dendritic cell-based tumor vaccinations in epithelial ovarian cancer: a systematic review. Immunotherapy 4:10, pages 995-1009.
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David Avigan, Jacalyn Rosenblatt & Donald Kufe. (2012) Dendritic/Tumor Fusion Cells as Cancer Vaccines. Seminars in Oncology 39:3, pages 287-295.
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Desheng Weng, Baizheng Song, John Durfee, Valerie Sugiyama, Zhengrong Wu, Shigeo Koido, Stuart K. Calderwood & Jianlin Gong. (2011) Induction of cytotoxic T lymphocytes against ovarian cancer‐initiating cells. International Journal of Cancer 129:8, pages 1990-2001.
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Shigeo Koido, Sadamu Homma, Akitaka Takahara, Yoshihisa Namiki, Hideo Komita, Eijiro Nagasaki, Masaki Ito, Keisuke Nagatsuma, Kan Uchiyama, Kenichi Satoh, Toshifumi Ohkusa, Jianlin Gong & Hisao Tajiri. (2011) Immunologic Monitoring of Cellular Responses by Dendritic/Tumor Cell Fusion Vaccines. Journal of Biomedicine and Biotechnology 2011, pages 1-13.
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Shigeo Koido, Sadamu Homma, Akitaka Takahara, Yoshihisa Namiki, Shintaro Tsukinaga, Jimi Mitobe, Shunichi Odahara, Toyokazu Yukawa, Hiroshi Matsudaira, Keisuke Nagatsuma, Kan Uchiyama, Kenichi Satoh, Masaki Ito, Hideo Komita, Hiroshi Arakawa, Toshifumi Ohkusa, Jianlin Gong & Hisao Tajiri. (2011) Current Immunotherapeutic Approaches in Pancreatic Cancer. Clinical and Developmental Immunology 2011, pages 1-15.
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Amy Gottesman, Joseph Milazzo & Yuri Lazebnik. (2010) V-fusion: a convenient, nontoxic method for cell fusion. BioTechniques 49:4, pages 747-750.
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Ayesha Murshid, Jianlin Gong & Stuart K. Calderwood. (2010) Heat Shock Protein 90 Mediates Efficient Antigen Cross Presentation through the Scavenger Receptor Expressed by Endothelial Cells-I. The Journal of Immunology 185:5, pages 2903-2917.
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Shigeo Koido, Eiichi Hara, Sadamu Homma, Yoshihisa Namiki, Hideo Komita, Akitaka Takahara, Eijiro Nagasaki, Masaki Ito, Yukiko Sagawa, Makoto Mitsunaga, Kan Uchiyama, Kenichi Satoh, Seiji Arihiro, Toshifumi Ohkusa, Jianlin Gong & Hisao Tajiri. (2010) Dendritic/pancreatic carcinoma fusions for clinical use: Comparative functional analysis of healthy- versus patient-derived fusions. Clinical Immunology 135:3, pages 384-400.
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E Alvarez, E Moga, J Barquinero, J Sierra & J Briones. (2009) Dendritic and tumor cell fusions transduced with adenovirus encoding CD40L eradicate B-cell lymphoma and induce a Th17-type response. Gene Therapy 17:4, pages 469-477.
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Shigeo Koido, Sadamu Homma, Eiichi Hara, Yoshihisa Namiki, Toshifumi Ohkusa, Jianlin Gong & Hisao Tajiri. (2010) Antigen-Specific Polyclonal Cytotoxic T Lymphocytes Induced by Fusions of Dendritic Cells and Tumor Cells. Journal of Biomedicine and Biotechnology 2010, pages 1-12.
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Shigeo Koido, Sadamu Homma, Eiichi Hara, Yoshihisa Namiki, Akitaka Takahara, Hideo Komita, Eijiro Nagasaki, Masaki Ito, Toshifumi Ohkusa, Jianlin Gong & Hisao Tajiri. (2010) Regulation of Tumor Immunity by Tumor/Dendritic Cell Fusions. Clinical and Developmental Immunology 2010, pages 1-14.
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Jianlin Gong, Bangmin Zhu, Ayesha Murshid, Hideki Adachi, Baizheng Song, Allegra Lee, Chunlei Liu & Stuart K. Calderwood. (2009) T Cell Activation by Heat Shock Protein 70 Vaccine Requires TLR Signaling and Scavenger Receptor Expressed by Endothelial Cells-1. The Journal of Immunology 183:5, pages 3092-3098.
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Jing Ni, Britta Nolte, Annette Arnold, Philippe Fournier & Volker Schirrmacher. (2009) Targeting anti-tumor DNA vaccines to dendritic cells via a short CD11c promoter sequence. Vaccine 27:40, pages 5480-5487.
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Junfeng Liu, Zhixu He, Dong Shen, Jin Huang & Haowen Wang. (2009) The comparison of biologic characteristics between mice embryonic stem cells and bone marrow derived dendritic cells. Chinese Journal of Clinical Oncology 6:1, pages 51-54.
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Shigeo KoidoEiichi Hara, Sadamu Homma, Toshifumi Ohkusa, Jianlin Gong & Hisao Tajiri. (2009) Cancer immunotherapy by fusions of dendritic cells and tumor cells. Immunotherapy 1:1, pages 49-62.
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