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Special Focus Issue: Cancer Vaccines - Perspective

Telomerase as a universal tumor antigen for cancer vaccines

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Pages 881-887 | Published online: 09 Jan 2014

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (9)

C. Riccay Elizondo, Jennifer D. Bright, Jennifer A. Byrne & Robert K. Bright. (2020) Analysis of the CD8+ IL-10+ T cell response elicited by vaccination with the oncogenic tumor-self protein D52. Human Vaccines & Immunotherapeutics 16:6, pages 1413-1423.
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Jessie Thalmensi, Elodie Pliquet, Christelle Liard, Marie Escande, Thomas Bestetti, Marion Julithe, Anna Kostrzak, Anne-Sophie Pailhes-Jimenez, Emanuèle Bourges, Maria Loustau, Julien Caumartin, Abderrahim Lachgar, Thierry Huet, Simon Wain-Hobson & Pierre Langlade-Demoyen. (2016) Anticancer DNA vaccine based on human telomerase reverse transcriptase generates a strong and specific T cell immune response. OncoImmunology 5:3.
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Erika Vacchelli, Fernando Aranda, Norma Bloy, Aitziber Buqué, Isabelle Cremer, Alexander Eggermont, Wolf Hervé Fridman, Jitka Fucikova, Jérôme Galon, Radek Spisek, Laurence Zitvogel, Guido Kroemer & Lorenzo Galluzzi. (2016) Trial Watch—Immunostimulation with cytokines in cancer therapy. OncoImmunology 5:2.
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Steffen Heeg. (2015) Variations in telomere maintenance and the role of telomerase inhibition in gastrointestinal cancer. Pharmacogenomics and Personalized Medicine 8, pages 171-180.
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Daniela Fenoglio, Alessia Parodi, Rosa Lavieri, Francesca Kalli, Francesca Ferrera, Augusto Tagliamacco, Andrea Guastalla, Maria Giuseppina Lamperti, Mauro Giacomini & Gilberto Filaci. (2015) Immunogenicity of GX301 cancer vaccine: Four (telomerase peptides) are better than one. Human Vaccines & Immunotherapeutics 11:4, pages 838-850.
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Robert K Bright, Jennifer D Bright & Jennifer A Byrne. (2014) Overexpressed oncogenic tumor-self antigens. Human Vaccines & Immunotherapeutics 10:11, pages 3297-3305.
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Daniela Fenoglio, Paolo Traverso, Alessia Parodi, Francesca Kalli, Maurizio Zanetti & Gilberto Filaci. (2013) Generation of more effective cancer vaccines. Human Vaccines & Immunotherapeutics 9:12, pages 2543-2547.
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Jennifer D Bright, Heather N Schultz, Jennifer A Byrne & Robert K Bright. (2013) Injection site and regulatory T cells influence durable vaccine-induced tumor immunity to an over-expressed self tumor associated antigen. OncoImmunology 2:7.
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Jon Amund Kyte. (2009) Cancer vaccination with telomerase peptide GV1001. Expert Opinion on Investigational Drugs 18:5, pages 687-694.
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Articles from other publishers (39)

Gilberto Filaci, Daniela Fenoglio, Franco Nolè, Elisa Zanardi, Laura Tomasello, Massimo Aglietta, Gianluca Del Conte, Joan Carles, Rafael Morales-Barrera, Pamela Guglielmini, Giorgio Scagliotti, Alessio Signori, Alessia Parodi, Francesca Kalli, Giuseppina Astone, Francesca Ferrera, Tiziana Altosole, Giuseppina Lamperti, Domenico Criscuolo, Francesco Gianese & Francesco Boccardo. (2021) Telomerase-based GX301 cancer vaccine in patients with metastatic castration-resistant prostate cancer: a randomized phase II trial. Cancer Immunology, Immunotherapy 70:12, pages 3679-3692.
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Robert H Vonderheide, Kimberly A Kraynyak, Anthony F Shields, Autumn J McRee, Jennifer M Johnson, Weijing Sun, Ashish V Chintakuntlawar, Jan Pawlicki, Albert J Sylvester, Trevor McMullan, Robert Samuels, Joseph J Kim, David Weiner, Jean D Boyer, Matthew P Morrow, Laurent Humeau & Jeffrey M Skolnik. (2021) Phase 1 study of safety, tolerability and immunogenicity of the human telomerase (hTERT)-encoded DNA plasmids INO-1400 and INO-1401 with or without IL-12 DNA plasmid INO-9012 in adult patients with solid tumors. Journal for ImmunoTherapy of Cancer 9:7, pages e003019.
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Xing Chen, Wen‐Jian Tang, Jing Bo Shi, Ming Ming Liu & Xin‐Hua Liu. (2020) Therapeutic strategies for targeting telomerase in cancer. Medicinal Research Reviews 40:2, pages 532-585.
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Romain Loyon, Marine Jary, Bérengère Salomé, Alejandra Gomez-Cadena, Jeanne Galaine, Marie Kroemer, Pedro Romero, Sara Trabanelli, Olivier Adotévi, Christophe Borg & Camilla Jandus. (2019) Peripheral Innate Lymphoid Cells Are Increased in First Line Metastatic Colorectal Carcinoma Patients: A Negative Correlation With Th1 Immune Responses. Frontiers in Immunology 10.
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Jessie Thalmensi, Elodie Pliquet, Christelle Liard, Gabriel Chamel, Christine Kreuz, Thomas Bestetti, Marie Escande, Anna Kostrzak, Anne-Sophie Pailhes-Jimenez, Emmanuèle Bourges, Marion Julithe, Ludovic Bourre, Olivier Keravel, Pascal Clayette, Thierry Huet, Simon Wain-Hobson & Pierre Langlade-Demoyen. (2019) A DNA telomerase vaccine for canine cancer immunotherapy. Oncotarget 10:36, pages 3361-3372.
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Anke Vanderstraeten, Sandra Tuyaerts, Tina Everaert, Rieta Van Bree, Godelieve Verbist, Cathérine Luyten & Frederic Amant. (2016) In Vitro Assessment of the Expression and T Cell Immunogenicity of the Tumor-Associated Antigens BORIS, MUC1, hTERT, MAGE-A3 and Sp17 in Uterine Cancer. International Journal of Molecular Sciences 17:9, pages 1525.
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Yinnan Chen & Yanmin Zhang. (2016) Functional and mechanistic analysis of telomerase: An antitumor drug target. Pharmacology & Therapeutics 163, pages 24-47.
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Xuan Xiao, Yong Ni, Ying-Ming Jia, Min Zheng, Han-Fei Xu, Jun Xu & Chenzhong Liao. (2016) Identification of human telomerase inhibitors having the core of N -acyl-4,5-dihydropyrazole with anticancer effects. Bioorganic & Medicinal Chemistry Letters 26:6, pages 1508-1511.
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Malgorzata E. Wojtowicz, Barbara K. Dunn & Asad Umar. (2016) Immunologic approaches to cancer prevention—current status, challenges, and future perspectives. Seminars in Oncology 43:1, pages 161-172.
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Mikio Kajihara. (2016) Advances in inducing adaptive immunity using cell-based cancer vaccines: Clinical applications in pancreatic cancer. World Journal of Gastroenterology 22:18, pages 4446.
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Madhav V. Dhodapkar. 2016. Encyclopedia of Immunobiology. Encyclopedia of Immunobiology 420 425 .
Maria Tagliamonte, Annacarmen Petrizzo, Maria Napolitano, Antonio Luciano, Claudio Arra, Piera Maiolino, Francesco Izzo, Maria Lina Tornesello, Luigi Aurisicchio, Gennaro Ciliberto, Franco M. Buonaguro & Luigi Buonaguro. (2015) Novel metronomic chemotherapy and cancer vaccine combinatorial strategy for hepatocellular carcinoma in a mouse model. Cancer Immunology, Immunotherapy 64:10, pages 1305-1314.
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Yutaka Horiuchi, Akira Takagi, Tetsuya Uchida & Toshitaka Akatsuka. (2015) Targeting cryptic epitope with modified antigen coupled to the surface of liposomes induces strong antitumor CD8 T-cell immune responses in�vivo. Oncology Reports.
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Jeanne Galaine, Christophe Borg, Yann Godet & Olivier Adotévi. (2015) Interest of Tumor-Specific CD4 T Helper 1 Cells for Therapeutic Anticancer Vaccine. Vaccines 3:3, pages 490-502.
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Gavin C. Bowick. 2015. Vaccinology. Vaccinology 109 126 .
Tai-Yun Lin, Yu-Hsiu Su & Chin-kai Chuang. (2015) PTD-J domain acts as an antigen carrier for cell mediated immunity. Journal of Immunotherapy Applications 2:1, pages 1.
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Riccardo Dolcetti, Silvia Giunco, Jessica Dal Col, Andrea Celeghin, Katy Mastorci & Anita De Rossi. (2014) Epstein-Barr virus and telomerase: from cell immortalization to therapy. Infectious Agents and Cancer 9:1.
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Vijay Sekaran, Joana Soares & Michael B. Jarstfer. (2013) Telomere Maintenance as a Target for Drug Discovery. Journal of Medicinal Chemistry 57:3, pages 521-538.
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Christophe Y Calvet, Jessie Thalmensi, Christelle Liard, Elodie Pliquet, Thomas Bestetti, Thierry Huet, Pierre Langlade-Demoyen & Lluis M Mir. (2014) Optimization of a gene electrotransfer procedure for efficient intradermal immunization with an hTERT-based DNA vaccine in mice. Molecular Therapy - Methods & Clinical Development 1, pages 14045.
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Jian Yan, Panyupa Pankhong, Thomas H. Shin, Nyamekye Obeng-Adjei, Matthew P. Morrow, Jewell N. Walters, Amir S. Khan, Niranjan Y. Sardesai & David B. Weiner. (2013) Highly Optimized DNA Vaccine Targeting Human Telomerase Reverse Transcriptase Stimulates Potent Antitumor Immunity. Cancer Immunology Research 1:3, pages 179-189.
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Maria Ruden & Neelu Puri. (2013) Novel anticancer therapeutics targeting telomerase. Cancer Treatment Reviews 39:5, pages 444-456.
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Daniela Fenoglio, Paolo Traverso, Alessia Parodi, Laura Tomasello, Simone Negrini, Francesca Kalli, Florinda Battaglia, Francesca Ferrera, Stefania Sciallero, Giuseppe Murdaca, Maurizio Setti, Alberto Sobrero, Francesco Boccardo, Giuseppe Cittadini, Francesco Puppo, Domenico Criscuolo, Giorgio Carmignani, Francesco Indiveri & Gilberto Filaci. (2013) A multi-peptide, dual-adjuvant telomerase vaccine (GX301) is highly immunogenic in patients with prostate and renal cancer. Cancer Immunology, Immunotherapy 62:6, pages 1041-1052.
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Mingjun Wang, Bingnan Yin, Satoko Matsueda, Lijuan Deng, Ying Li, Wei Zhao, Jia Zou, Qingtian Li, Christopher Loo, Rong-Fu Wang & Helen Y. Wang. (2013) Identification of Special AT-Rich Sequence Binding Protein 1 as a Novel Tumor Antigen Recognized by CD8+ T Cells: Implication for Cancer Immunotherapy. PLoS ONE 8:2, pages e56730.
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Magalie Dosset, Yann Godet, Charline Vauchy, Laurent Beziaud, Yu Chun Lone, Christine Sedlik, Christelle Liard, Emeline Levionnois, Bertrand Clerc, Federico Sandoval, Etienne Daguindau, Simon Wain-Hobson, Eric Tartour, Pierre Langlade-Demoyen, Christophe Borg & Olivier Adotévi. (2012) Universal Cancer Peptide-Based Therapeutic Vaccine Breaks Tolerance against Telomerase and Eradicates Established Tumor. Clinical Cancer Research 18:22, pages 6284-6295.
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George V. Aslanidi, Angela E. Rivers, Luis Ortiz, Lakshmanan Govindasamy, Chen Ling, Giridhara R. Jayandharan, Sergei Zolotukhin, Mavis Agbandje-McKenna & Arun Srivastava. (2012) High-efficiency transduction of human monocyte-derived dendritic cells by capsid-modified recombinant AAV2 vectors. Vaccine 30:26, pages 3908-3917.
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Erik P. Winnikow, Lidia R. Medeiros, Maria I. Edelweiss, Daniela D. Rosa, Marcia Edelweiss, Priscyla W. Simões, Fábio R. Silva, Bruno R. Silva & Maria I. Rosa. (2012) Accuracy of telomerase in estimating breast cancer risk: A systematic review and meta-analysis. The Breast 21:1, pages 1-7.
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Brian M. Olson & Douglas G. McNeel. (2011) CD8+ T cells specific for the androgen receptor are common in patients with prostate cancer and are able to lyse prostate tumor cells. Cancer Immunology, Immunotherapy 60:6, pages 781-792.
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Shigeo Koido, Sadamu Homma, Akitaka Takahara, Yoshihisa Namiki, Shintaro Tsukinaga, Jimi Mitobe, Shunichi Odahara, Toyokazu Yukawa, Hiroshi Matsudaira, Keisuke Nagatsuma, Kan Uchiyama, Kenichi Satoh, Masaki Ito, Hideo Komita, Hiroshi Arakawa, Toshifumi Ohkusa, Jianlin Gong & Hisao Tajiri. (2011) Current Immunotherapeutic Approaches in Pancreatic Cancer. Clinical and Developmental Immunology 2011, pages 1-15.
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Sylvie Rusakiewicz, Magalie Dosset, Karine Mollier, Philippe Souque, Pierre Charneau, Simon Wain-Hobson, Pierre Langlade-Demoyen & Olivier Adotévi. (2010) Immunogenicity of a recombinant lentiviral vector carrying human telomerase tumor antigen in HLA-B*0702 transgenic mice. Vaccine 28:38, pages 6374-6381.
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Daniel E. Speiser & Pedro Romero. (2010) Molecularly defined vaccines for cancer immunotherapy, and protective T cell immunity. Seminars in Immunology 22:3, pages 144-154.
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Vijay G. Sekaran, Joana Soares & Michael B. Jarstfer. (2010) Structures of telomerase subunits provide functional insights. Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics 1804:5, pages 1190-1201.
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Olivier AdotéviKarine MollierChristine Neuveut, Magalie DossetPatrice Ravel, Wolf-Hervé FridmanEric TartourPierre CharneauSimon Wain-HobsonPierre Langlade-Demoyen. (2010) Targeting human telomerase reverse transcriptase with recombinant lentivector is highly effective to stimulate antitumor CD8 T-cell immunity in vivo. Blood 115:15, pages 3025-3032.
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Vladimír Vonka. (2010) Immunotherapy of chronic myeloid leukemia: present state and future prospects. Immunotherapy 2:2, pages 227-241.
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Marcy A. Mitchell, Jay E. Johnson, Kara Pascarelli, Neil Beeharry, Maria Chiourea, Sarantis Gagos, Dina Lev, Margaret von Mehren, David Kipling & Dominique Broccoli. (2010) Doxorubicin Resistance in a Novel In vitro Model of Human Pleomorphic Liposarcoma Associated with Alternative Lengthening of Telomeres . Molecular Cancer Therapeutics 9:3, pages 682-692.
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Liyun Sang, James M. Roberts & Hilary A. Coller. (2010) Hijacking HES1: how tumors co-opt the anti-differentiation strategies of quiescent cells. Trends in Molecular Medicine 16:1, pages 17-26.
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Meng Dong, Thomas E. Mürdter & Ulrich Klotz. (2009) Telomeres and telomerase as novel drug targets: reflections on the 2009 Nobel Prize in Physiology or Medicine. European Journal of Clinical Pharmacology 66:1, pages 1-3.
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Mark M Aloysius, Alastair J Mc Kechnie, Richard A Robins, Chandan Verma, Jennifer M Eremin, Farzin Farzaneh, Nagy A Habib, Joti Bhalla, Nicola R Hardwick, Sukchai Satthaporn, Thiagarajan Sreenivasan, Mohammed El-Sheemy & Oleg Eremin. (2009) Generation in vivo of peptide-specific cytotoxic T cells and presence of regulatory T cells during vaccination with hTERT (class I and II) peptide-pulsed DCs. Journal of Translational Medicine 7:1.
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SunMi L. Palumbo, Scot W. Ebbinghaus & Laurence H. Hurley. (2009) Formation of a Unique End-to-End Stacked Pair of G-Quadruplexes in the hTERT Core Promoter with Implications for Inhibition of Telomerase by G-Quadruplex-Interactive Ligands. Journal of the American Chemical Society 131:31, pages 10878-10891.
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Laure Deville, Josette Hillion & Evelyne Ségal-Bendirdjian. (2009) Telomerase regulation in hematological cancers: A matter of stemness?. Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease 1792:4, pages 229-239.
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