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Special Focus Issue: Cancer Vaccines - Review

Strategies used for MUC1 immunotherapy: human clinical studies

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Pages 963-975 | Published online: 09 Jan 2014

Keep up to date with the latest research on this topic with citation updates for this article.

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Vivek P. Chavda, Melina Haritopoulou-Sinanidou, Rajashri Bezbaruah & Vasso Apostolopoulos. (2022) Vaccination efforts for Buruli ulcer. Expert Review of Vaccines 21:10, pages 1419-1428.
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Yonghui Liu, Zhaoyu Wang, Fan Yu, Mingjing Li, Haomiao Zhu, Kun Wang, Meng Meng & Wei Zhao. (2021) The Adjuvant of α-Galactosylceramide Presented by Gold Nanoparticles Enhances Antitumor Immune Responses of MUC1 Antigen-Based Tumor Vaccines. International Journal of Nanomedicine 16, pages 403-420.
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Stephen E Wright. (2012) Immunotherapy of breast cancer. Expert Opinion on Biological Therapy 12:4, pages 479-490.
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Pamela E Constantinou, Brian P Danysh, Neeraja Dharmaraj & Daniel D Carson. (2011) Transmembrane mucins as novel therapeutic targets. Expert Review of Endocrinology & Metabolism 6:6, pages 835-848.
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Silvia von Mensdorff-Pouilly. (2010) Vaccine-induced antibody responses in patients with carcinoma. Expert Review of Vaccines 9:6, pages 579-594.
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Choon-Kit Tang & Vasso Apostolopoulos. (2008) Strategies used for MUC1 immunotherapy: preclinical studies. Expert Review of Vaccines 7:7, pages 951-962.
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Articles from other publishers (56)

Luigi Buonaguro & Maria Tagliamonte. (2023) Peptide-based vaccine for cancer therapies. Frontiers in Immunology 14.
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Yicong Wang, Lifeng Liu & Yongai Yu. (2023) Mucins and mucinous ovarian carcinoma: Development, differential diagnosis, and treatment. Heliyon 9:8, pages e19221.
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Jing-Jing Du, Shi-Hao Zhou, Zi-Ru Cheng, Wen-Bo Xu, Ru-Yan Zhang, Long-Sheng Wang & Jun Guo. (2022) MUC1 Specific Immune Responses Enhanced by Coadministration of Liposomal DDA/MPLA and Lipoglycopeptide. Frontiers in Chemistry 10.
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Ayusha Dondulkar, Natasha Akojwar, Chanti Katta, Dharmendra K. Khatri, Neelesh K. Mehra, Shashi B. Singh & Jitender Madan. (2022) Inhalable Polymeric Micro and Nano-immunoadjuvants for Developing Therapeutic Vaccines in the Treatment of Non-small Cell Lung Cancer. Current Pharmaceutical Design 28:5, pages 395-409.
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Nicolas Jonckheere, Audrey Vincent, Bernadette Neve & Isabelle Van Seuningen. (2021) Mucin expression, epigenetic regulation and patient survival: A toolkit of prognostic biomarkers in epithelial cancers. Biochimica et Biophysica Acta (BBA) - Reviews on Cancer 1876:1, pages 188538.
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Nor Adzimah Johdi & Nur Fazilah Sukor. (2020) Colorectal Cancer Immunotherapy: Options and Strategies. Frontiers in Immunology 11.
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Bo Sun, Feifei Xu, Yuanyuan Zhang, Yechen Hu & Yun Chen. (2020) Dual-Probe Approach for Mass Spectrometric Quantification of MUC1-Specific Terminal Gal/GalNAc In Situ . Analytical Chemistry 92:12, pages 8340-8349.
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Jing-Jing Du, Chang-Wei Wang, Wen-Bo Xu, Lian Zhang, Yuan-Kai Tang, Shi-Hao Zhou, Xiao-Fei Gao, Guang-Fu Yang & Jun Guo. (2020) Multifunctional Protein Conjugates with Built-in Adjuvant (Adjuvant-Protein-Antigen) as Cancer Vaccines Boost Potent Immune Responses. iScience 23:3, pages 100935.
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Vanessa Barriga, Nyanbol Kuol, Kulmira Nurgali & Vasso Apostolopoulos. (2019) The Complex Interaction between the Tumor Micro-Environment and Immune Checkpoints in Breast Cancer. Cancers 11:8, pages 1205.
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Vasso Apostolopoulos. (2019) Cancer Vaccines: Research and Applications. Cancers 11:8, pages 1041.
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Hye-Youn Son, Vasso Apostolopoulos & Chul-Woo Kim. (2017) Mannosylated T/Tn with Freund’s adjuvant induces cellular immunity. International Journal of Immunopathology and Pharmacology 31, pages 039463201774250.
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Yan Tang, Xiuxia Cui, Han Xiao, Shengkun Qi, Xiaoping Hu, Qiong Yu, Guang Shi, Xue Zhang, Jiaying Gu, Yongli Yu, Liying Wang & Yarong Li. (2017) Binding of circulating anti-MUC1 antibody and serum MUC1 antigen in stage IV breast cancer. Molecular Medicine Reports.
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Juan Wang, Wei-hua Ni, Ke-bang Hu, Xiao-yu Zhai, Fei Xie, Jing Jie, Nan-nan Zhang, Li-na Jiang, Hong-yan Yuan & Gui-xiang Tai. (2017) Targeting MUC1 and JNK by RNA interference and inhibitor inhibit the development of hepatocellular carcinoma. Cancer Science 108:3, pages 504-511.
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Silvia von Mensdorff-Pouilly. 2017. Encyclopedia of Cancer. Encyclopedia of Cancer 657 668 .
Olivera Finn & Lixin Zhang. 2017. Cancer Therapeutic Targets. Cancer Therapeutic Targets 391 398 .
W. Fiedler, S. DeDosso, S. Cresta, J. Weidmann, A. Tessari, M. Salzberg, B. Dietrich, H. Baumeister, S. Goletz, L. Gianni & C. Sessa. (2016) A phase I study of PankoMab-GEX, a humanised glyco-optimised monoclonal antibody to a novel tumour-specific MUC1 glycopeptide epitope in patients with advanced carcinomas. European Journal of Cancer 63, pages 55-63.
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Haihong Zhang, Chenlu Liu, Fangfang Zhang, Fei Geng, Qiu Xia, Zhenzhen Lu, Ping Xu, Yu Xie, Hui Wu, Bin Yu, Jiaxin Wu, Xianghui Yu & Wei Kong. (2016) MUC1 and survivin combination tumor gene vaccine generates specific immune responses and anti-tumor effects in a murine melanoma model. Vaccine 34:24, pages 2648-2655.
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Boqi Hu, Juan Wang, Yingying Guo, Tanxiu Chen, Weihua Ni, Hongyan Yuan, Nannan Zhang, Fei Xie & Guixiang Tai. (2016) Pre-clinical toxicity and immunogenicity evaluation of a MUC1–MBP/BCG anti-tumor vaccine. International Immunopharmacology 33, pages 108-118.
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Fengtao You, Licui Jiang, Bozhen Zhang, Qiang Lu, Qiao Zhou, Xiaoyang Liao, Hong Wu, Kaiqi Du, Youcai Zhu, Huimin Meng, Zhishu Gong, Yunhui Zong, Lei Huang, Man Lu, Jirong Tang, Yafen Li, Xiaochen Zhai, Xiangling Wang, Sisi Ye, Dan Chen, Lei Yuan, Lin Qi & Lin Yang. (2016) Phase 1 clinical trial demonstrated that MUC1 positive metastatic seminal vesicle cancer can be effectively eradicated by modified Anti-MUC1 chimeric antigen receptor transduced T cells. Science China Life Sciences 59:4, pages 386-397.
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Vasso Apostolopoulos, Lily Stojanovska & Sharron E. Gargosky. (2015) MUC1 (CD227): a multi-tasked molecule. Cellular and Molecular Life Sciences 72:23, pages 4475-4500.
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Abdelfattah Attallah, Mohamed El-Far, Camelia Abdel Malak, Khaled Farid, Mohamed Omran, Raida Yahya, Entsar Saad, Mohamed Albannan, Ahmed Attallah, Mohamed El Basuni, Islam Ali, Safaa Abed & Mohamed El Naggar. (2015) A simple diagnostic index comprising epithelial membrane antigen and fibronectin for hepatocellular carcinoma. Annals of Hepatology 14:6, pages 869-880.
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Krishna Pillai, Mohammad H. Pourgholami, Terence C. Chua & David L. Morris. (2015) MUC1 as a Potential Target in Anticancer Therapies. American Journal of Clinical Oncology 38:1, pages 108-118.
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Ryan Stevenson, Martin Goodman & Muhammad Wasif Saif. 2015. Cancer Immunology. Cancer Immunology 237 248 .
Tsukasa Tanida, Masahiro Tanemura, Eiji Miyoshi, Hiroaki Nagano, Kenta Furukawa, Yuji Nonaka, Hirofumi Akita, Naoki Hama, Hiroshi Wada, Koichi Kawamoto, Shogo Kobayashi, Hidetoshi Eguchi, Masaki Mori & Yuichiro Doki. (2014) Pancreatic cancer immunotherapy using a tumor lysate vaccine, engineered to express α-gal epitopes, targets pancreatic cancer stem cells. International Journal of Oncology.
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Nicolas Jonckheere, Nicolas Skrypek & Isabelle Van Seuningen. (2014) Mucins and tumor resistance to chemotherapeutic drugs. Biochimica et Biophysica Acta (BBA) - Reviews on Cancer 1846:1, pages 142-151.
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Riva Kovjazin, Galit Horn, Nechama I. Smorodinsky, Michael Y. Shapira & Lior Carmon. (2014) Cell Surface-Associated Anti-MUC1-Derived Signal Peptide Antibodies: Implications for Cancer Diagnostics and Therapy. PLoS ONE 9:1, pages e85400.
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David M. McDonald, Brendan L. Wilkinson, Leo Corcilius, Morten Thaysen-Andersen, Scott N. Byrne & Richard J. Payne. (2014) Synthesis and immunological evaluation of self-adjuvanting MUC1-macrophage activating lipopeptide 2 conjugate vaccine candidates. Chem. Commun. 50:71, pages 10273-10276.
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Silvia von Mensdorff-Pouilly. 2014. Encyclopedia of Cancer. Encyclopedia of Cancer 1 12 .
Xianling Cong. (2013) Antitumor effect of adenoviral vector prime protein boost immunity targeting the MUC1 VNTRs. Oncology Reports.
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Michael A. Morse, Donna Niedzwiecki, John L. Marshall, Christopher Garrett, David Z. Chang, Mebea Aklilu, Todd S. Crocenzi, David J. Cole, Sophie Dessureault, Amy C. Hobeika, Takuya Osada, Mark Onaitis, Bryan M. Clary, David Hsu, Gayathri R. Devi, Anuradha Bulusu, Robert P. Annechiarico, Vijaya Chadaram, Timothy M. Clay & H. Kim Lyerly. (2013) A Randomized Phase II Study of Immunization With Dendritic Cells Modified With Poxvectors Encoding CEA and MUC1 Compared With the Same Poxvectors Plus GM-CSF for Resected Metastatic Colorectal Cancer. Annals of Surgery 258:6, pages 879-886.
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Stamatis VassilarosAnastasios Tsibanis, Annivas Tsikkinis, Geoffrey A Pietersz, Ian FC McKenzie & Vasso Apostolopoulos. (2013) Up to 15-year clinical follow-up of a pilot Phase III immunotherapy study in stage II breast cancer patients using oxidized mannan–MUC1. Immunotherapy 5:11, pages 1177-1182.
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Nicolas Jonckheere, Nicolas Skrypek, Frédéric Frénois & Isabelle Van Seuningen. (2013) Membrane-bound mucin modular domains: From structure to function. Biochimie 95:6, pages 1077-1086.
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Takashi Kimura, John R. McKolanis, Lynda A. Dzubinski, Kazi Islam, Douglas M. Potter, Andres M. Salazar, Robert E. Schoen & Olivera J. Finn. (2013) MUC1 Vaccine for Individuals with Advanced Adenoma of the Colon: A Cancer Immunoprevention Feasibility Study. Cancer Prevention Research 6:1, pages 18-26.
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Elena Niccolai, Domenico Prisco, Mario Milco D'Elios & Amedeo Amedei. (2013) What Is Recent in Pancreatic Cancer Immunotherapy?. BioMed Research International 2013, pages 1-14.
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Olivera Finn & Lixin Zhang. 2016. Cancer Therapeutic Targets. Cancer Therapeutic Targets 1 8 .
Yu-Qian Wang, Hai-Hong Zhang, Chen-Lu Liu, Qiu Xia, Hui Wu, Xiang-Hui Yu & Wei Kong. (2012) Correlation Between Auto-antibodies to Survivin and MUC1 Variable Number Tandem Repeats in Colorectal Cancer. Asian Pacific Journal of Cancer Prevention 13:11, pages 5557-5562.
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Tharappel C. James & Ursula Bond. (2012) Molecular Mimics of the Tumour Antigen MUC1. PLoS ONE 7:11, pages e49728.
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RIVA KOVJAZIN, ANNA DUBNIK, GALIT HORN, NECHAMA I. SMORODINSKY, IZHAR HARDAN, MICHAEL YECHIEL SHAPIRA & LIOR CARMON. (2012) Autoantibodies against the signal peptide domain of MUC1 in patients with multiple myeloma: Implications for disease diagnosis and prognosis. Experimental and Therapeutic Medicine 3:6, pages 1092-1098.
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Neelima R. Mehta, Gregory T. Wurz, Rebekah A. Burich, Brittany E. Greenberg, Stephen Griffey, Audrey Gutierrez, Katie E. Bell, Jamie L. McCall, Michael Wolf & Michael DeGregorio. (2012) L-BLP25 Vaccine plus Letrozole Induces a TH1 Immune Response and Has Additive Antitumor Activity in MUC1-Expressing Mammary Tumors in Mice. Clinical Cancer Research 18:10, pages 2861-2871.
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Nicolas Jonckheere, Nicolas Skrypek & Isabelle Van Seuningen. (2010) Mucins and Pancreatic Cancer. Cancers 2:4, pages 1794-1812.
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