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Drug Profile

Rilpivirine: drug profile of a second-generation non-nucleoside reverse transcriptase HIV-inhibitor

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Molalign Tarekegn Minwagaw, Betelihem Belete Akenie, Desalew Salew Tewabe, Awoke Seyoum Tegegne & Tariku Belachew Beyene. (2021) Predictors of Poor Adherence to CART and Treatment Failure at Second-Line Regimens Among Adults in Public Hospitals of Amhara Region, North-Western Ethiopia: A Retrospective Cohort Study. Patient Preference and Adherence 15, pages 2855-2864.
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Vicente Soriano, Pablo Labarga, José V. Fernandez-Montero, Carmen de Mendoza, Laura Benítez-Gutiérrez, José M. Peña & Pablo Barreiro. (2017) Drug interactions in HIV-infected patients treated for hepatitis C. Expert Opinion on Drug Metabolism & Toxicology 13:8, pages 807-816.
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Isabella Esposito, Pablo Labarga, Pablo Barreiro, José V Fernandez-Montero, Carmen de Mendoza, Laura Benítez-Gutiérrez, José M Peña & Vicente Soriano. (2015) Dual antiviral therapy for HIV and hepatitis C – drug interactions and side effects. Expert Opinion on Drug Safety 14:9, pages 1421-1434.
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Zhao Wang, Prem Prakash Sharma, Brijesh Rathi, Minghui Xie, Erik De Clercq, Christophe Pannecouque, Dongwei Kang, Peng Zhan & Xinyong Liu. (2023) Escaping from Flatland: Multiparameter Optimization Leads to the Discovery of Novel Tetrahydropyrido[4,3- d ]pyrimidine Derivatives as Human Immunodeficiency Virus-1 Non-nucleoside Reverse Transcriptase Inhibitors with Superior Antiviral Activities against Non-nucleoside Reverse Transcriptase Inhibitor-Resistant Variants and Favorable Drug-like Profiles . Journal of Medicinal Chemistry 66:13, pages 8643-8665.
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Thomas Straubinger, Katherine Kay & Robert Bies. (2020) Modeling HIV Pre-Exposure Prophylaxis. Frontiers in Pharmacology 10.
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Carey Hwang, Ming-Tain Lai & Daria Hazuda. (2019) Rational Design of Doravirine: From Bench to Patients. ACS Infectious Diseases 6:1, pages 64-73.
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Ross D. CranstonCharlene S. DezzuttiAaron SiegelJarret EngstromCory ShetlerNicola Richardson-HarmanKaleab Z. AbebeDavid BackLaura ElseDeidre EganSaye KhooJames E. EganRonald StallPeter WilliamsRhonda M. BrandUrvi M. ParikhIan McGowan. (2019) A Multiple Dose Phase 1 Assessment of Rilpivirine Long Acting in a Model of Preexposure Prophylaxis Against HIV. AIDS Research and Human Retroviruses 35:9, pages 794-804.
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V. T. Valuev-Elliston & S. N. Kochetkov. (2018) Novel HIV-1 non-nucleoside reverse transcriptase inhibitors: A combinatorial approach. Biochemistry (Moscow) 82:13, pages 1716-1743.
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Lei Wei, Hui-Ling Wang, Li Huang, Chin-Ho Chen, Susan L. Morris-Natschke, Kuo-Hsiung Lee & Lan Xie. (2017) Drug-like property-driven optimization of 4-substituted 1,5-diarylanilines as potent HIV-1 non-nucleoside reverse transcriptase inhibitors against rilpivirine-resistant mutant virus. Bioorganic & Medicinal Chemistry Letters 27:12, pages 2788-2792.
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Ian McGowan, Charlene S Dezzutti, Aaron Siegel, Jarret Engstrom, Alexiy Nikiforov, Kathryn Duffill, Cory Shetler, Nicola Richardson-Harman, Kaleab Abebe, David Back, Laura Else, Deidre Egan, Saye Khoo, James E Egan, Ronald Stall, Peter E Williams, Khaleel K Rehman, Amy Adler, Rhonda M Brand, Beatrice Chen, Sharon Achilles & Ross D Cranston. (2016) Long-acting rilpivirine as potential pre-exposure prophylaxis for HIV-1 prevention (the MWRI-01 study): an open-label, phase 1, compartmental, pharmacokinetic and pharmacodynamic assessment. The Lancet HIV 3:12, pages e569-e578.
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Alejandro Sosnik. (2016) Drug self-assembly: A phenomenon at the nanometer scale with major impact in the structure–biological properties relationship and the treatment of disease. Progress in Materials Science 82, pages 39-82.
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Vincent Calvez, Anne-Genevieve Marcelin, Johan Vingerhoets, Andrew Hill, Blanca Hadacek & Christiane Moecklinghoff. (2015) Systematic Review to Determine the Prevalence of Transmitted Drug Resistance Mutations to Rilpivirine in HIV-Infected Treatment-Naive Persons. Antiviral Therapy 21:5, pages 405-412.
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Anna H. Tran, Brookie M. Best, Alice Stek, Jiajia Wang, Edmund V. Capparelli, Sandra K. Burchett, Regis Kreitchmann, Kittipong Rungruengthanakit, Kathleen George, Tim R. Cressey, Nahida Chakhtoura, Elizabeth Smith, David E. Shapiro & Mark Mirochnick. (2016) Pharmacokinetics of Rilpivirine in HIV-Infected Pregnant Women. JAIDS Journal of Acquired Immune Deficiency Syndromes 72:3, pages 289-296.
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Valeria Cozzi, Nitin Charbe, Sara Baldelli, Simone Castoldi, Chiara Atzori, Dario Cattaneo & Emilio Clementi. (2016) Development and Validation of a Chromatographic Ultraviolet Method for the Simultaneous Quantification of Dolutegravir and Rilpivirine in Human Plasma. Therapeutic Drug Monitoring 38:3, pages 407-413.
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Ruben Vardanyan & Victor Hruby. 2016. Synthesis of Best-Seller Drugs. Synthesis of Best-Seller Drugs 687 736 .
Ian McGowan. (2015) Injectable and implantable antiretroviral strategies for HIV prevention. Future Virology 10:10, pages 1163-1176.
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Martin Markowitz & Kathrine Meyers. (2015) Extending access with long-acting antiretroviral therapy. Current Opinion in HIV and AIDS 10:4, pages 216-218.
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Akil Jackson & Ian McGowan. (2015) Long-acting rilpivirine for HIV prevention. Current Opinion in HIV and AIDS 10:4, pages 253-257.
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