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Editorial

New strategies against Stenotrophomonas maltophilia: a serious worldwide intrinsically drug-resistant opportunistic pathogen

Keep up to date with the latest research on this topic with citation updates for this article.

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Thibaud Soumagne, Florence Levesque, Julie Milot, Krystelle Godbout, Yves Lacasse & François Maltais. (2021) Significance of Stenotrophomonas maltophilia When Detected in Sputum of Ambulatory Patients with COPD. International Journal of Chronic Obstructive Pulmonary Disease 16, pages 2895-2900.
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Lily Ho, Isabelle Jalbert, Kathleen Watt & Alex Hui. (2021) Current understanding and therapeutic management of contact lens associated sterile corneal infiltrates and microbial keratitis. Clinical and Experimental Optometry 104:3, pages 323-333.
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Samantha Flores-Treviño, Paola Bocanegra-Ibarias, Adrián Camacho-Ortiz, Rayo Morfín-Otero, Humberto Antonio Salazar-Sesatty & Elvira Garza-González. (2019) Stenotrophomonas maltophilia biofilm: its role in infectious diseases. Expert Review of Anti-infective Therapy 17:11, pages 877-893.
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Angelina Trifonova & Tanya Strateva. (2019) Stenotrophomonas maltophilia – a low-grade pathogen with numerous virulence factors. Infectious Diseases 51:3, pages 168-178.
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Luca Ruiu, Barbara Virdis, Maria Elena Mura, Ignazio Floris, Alberto Satta & Eustachio Tarasco. (2017) Oral insecticidal activity of new bacterial isolates against insects in two orders. Biocontrol Science and Technology 27:7, pages 886-902.
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Johannes B.J. Scholte, Tan Lai Zhou, Dennis C.J.J. Bergmans, Gernot G.U. Rohde, Bjorn Winkens, Helke A. Van Dessel, Tom P.J. Dormans, Catharina F.M. Linssen, Paul M.H.J. Roekaerts, Paul H.M. Savelkoul & Walther N.K.A. van Mook. (2016) Stenotrophomonas maltophilia ventilator-associated pneumonia. A retrospective matched case-control study. Infectious Diseases 48:10, pages 738-743.
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Articles from other publishers (82)

Meltem Yashar, Kerem Edip Basarir, Elif Seren Tanriverdi, Selcuk Celep, Leyla Sirekbasan, Erva Rakici, Nebahat Ejder, Eda Musellim, Aysegul Copur Cicek & Mesut Yilmaz. (2023) Stenotrophomonas maltophilia Outbreak Originating from a Pull-out Faucet in a Pediatric Intensive Care Unit in Turkey: Insights from Clinical Records and Molecular Typing. American Journal of Infection Control.
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Rebeca Vitória da Silva Lage de Miranda, Giovanna Merrelho Monteiro, Luciana Veloso da Costa, Milena Cristina Silva dos Santos, Cristhiane Moura Falavina dos Reis, Lygia Maria Paulo da Silva Braga, Stephen James Forsythe, Maria Helena Simões Villas Bôas & Marcelo Luiz Lima Brandão. (2023) Evaluation of phenotypical and genotypical methods for the identification and typing of Stenotrophomonas maltophilia isolated from a pharmaceutical facility . Journal of Applied Microbiology 134:10.
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Varsha V. Nair & Hugh D. C. Smyth. (2023) Inhalable Excipient-Free Dry Powder of Tigecycline for the Treatment of Pulmonary Infections. Molecular Pharmaceutics 20:9, pages 4640-4653.
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Ashlan J. Kunz Coyne, Shelbye Herbin, Kaylee Caniff & Michael J. Rybak. (2023) Steno‐sphere: Navigating the enigmatic world of emerging multidrug‐resistant Stenotrophomonas maltophilia . Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy 43:8, pages 833-846.
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Artur Serra Neto, Sirlei G. Marques, Maria Rosa Q. Bomfim, Silvio G. Monteiro, Rosangela C. de Souza & Rodolfo A. Nunes. (2023) Microbiological Analysis of Surgeons’ Hands in a Public Hospital in São Luis, Maranhão State, Brazil: A Cross-Sectional Study. Microorganisms 11:8, pages 1895.
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Martin Malý, Petr Kolenko, Jan Stránský, Leona Švecová, Jarmila Dušková, Tomáš Koval', Tereza Skálová, Mária Trundová, Kristýna Adámková, Jiří Černý, Paulína Božíková & Jan Dohnálek. (2023) Tetracycline-modifying enzyme Sm TetX from Stenotrophomonas maltophilia . Acta Crystallographica Section F Structural Biology Communications 79:7, pages 180-192.
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Uwe Mamat, Manuel Hein, Dörte Grella, Claire S. Taylor, Thomas Scholzen, Ifey Alio, Wolfgang R. Streit, Pol Huedo, Xavier Coves, Oscar Conchillo-Solé, Andromeda-Celeste Gómez, Isidre Gibert, Daniel Yero & Ulrich E. Schaible. (2023) Improved mini-Tn 7 Delivery Plasmids for Fluorescent Labeling of Stenotrophomonas maltophilia . Applied and Environmental Microbiology 89:6.
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Sani-e-Zehra Zaidi, Rahat Zaheer, Krysty Thomas, Sujeema Abeysekara, Travis Haight, Luke Saville, Matthew Stuart-Edwards, Athanasios Zovoilis & Tim A. McAllister. (2023) Genomic Characterization of Carbapenem-Resistant Bacteria from Beef Cattle Feedlots. Antibiotics 12:6, pages 960.
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Yiwei Wang, Yizhi Wang, Hechen Rong, Zhonghong Guo, Jie Xu & Xiaoping Huang. (2023) Risk factors of lower respiratory tract infection caused by Stenotrophomonas maltophilia: Systematic review and meta-analysis. Frontiers in Public Health 10.
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Taghreed A. Hafiz, Esraa Aldawood, Alaa Albloshi, Shahad S. Alghamdi, Murad A. Mubaraki, Ahmed S. Alyami & Marwh G. Aldriwesh. (2022) Stenotrophomonas maltophilia Epidemiology, Resistance Characteristics, and Clinical Outcomes: Understanding of the Recent Three Years’ Trends. Microorganisms 10:12, pages 2506.
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Olga M. Zając, Stefan Tyski & Agnieszka E. Laudy. (2022) The Contribution of Efflux Systems to Levofloxacin Resistance in Stenotrophomonas maltophilia Clinical Strains Isolated in Warsaw, Poland. Biology 11:7, pages 1044.
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Anusree Thenissery, Rithu Chandran, Rajasekhar Ravindran, Chintu Ravishankar & Jishnu Haridas Piriyath. (2022) Isolation and identification of emergent multidrug‐resistant Stenotrophomonas maltophilia from skin ulcers of Sarcoptes ‐infested pigs . Veterinary Record Case Reports 10:2.
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Amel Elsheredy, Azza Elsheikh, Abeer Ghazal & Sherine Shawky. (2022) Prevalence of trimethoprim/sulfamethoxazole resistance genes among Stenotrophomonas maltophilia clinical isolates in Egypt. Acta Microbiologica et Immunologica Hungarica 69:1, pages 56-60.
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Mohammed A. Almalki, Ashraf Y.Z. Khalifa & Yousef A. Alkhamis. (2022) In vitro Antibiosis of Chlorella vulgaris Extract against the Phytopathogen, Stenotrophomonas maltophilia. Journal of Pure and Applied Microbiology 16:1, pages 630-637.
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Lily Watson, Lisa Priestley, Stephen J Chapman, Monique I Andersson, Katie Jeffery & William G Flight. (2022) Clinical associations with carriage of pulmonary Stenotrophomonas maltophilia . Journal of the Royal College of Physicians of Edinburgh 52:1, pages 14-19.
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Eliana Alcaraz, Barbara Ghiglione, María Verónica Pineda, Andrea Mangano, José Di Conza & Beatriz Passerini de Rossi. (2022) AmpR is a dual regulator in Stenotrophomonas maltophilia with a positive role in β-lactam resistance and a negative role in virulence, biofilm and DSF production. Research in Microbiology 173:3, pages 103917.
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Irina Buchovec, Laurita Klimkaitė, Edita Sužiedėlienė & Saulius Bagdonas. (2022) Inactivation of Opportunistic Pathogens Acinetobacter baumannii and Stenotrophomonas maltophilia by Antimicrobial Photodynamic Therapy. Microorganisms 10:3, pages 506.
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Laila Chaoui, Taha Chouati, Imane Zalegh, Rajaa Ait Mhand, Fouad Mellouki & Naima Rhallabi. (2022) Identification and assessment of antimicrobial resistance bacteria in a hemodialysis water treatment system. Journal of Water and Health 20:2, pages 441-449.
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Sadia H Sarzynski, Sarah Warner, Junfeng Sun, Roland Matsouaka, John P Dekker, Ahmed Babiker, Willy Li, Yi Ling Lai, Robert L Danner, Vance G FowlerJrJr & Sameer S Kadri. (2022) Trimethoprim-Sulfamethoxazole Versus Levofloxacin for Stenotrophomonas maltophilia Infections: A Retrospective Comparative Effectiveness Study of Electronic Health Records from 154 US Hospitals . Open Forum Infectious Diseases 9:2.
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Rui-Xin Wu, Ching-Mei Yu, Sung-Teng Hsu & Ching Hsun Wang. (2022) Emergence of concurrent levofloxacin- and trimethoprim/sulfamethoxazole-resistant Stenotrophomonas maltophilia: Risk factors and antimicrobial sensitivity pattern analysis from a single medical center in Taiwan. Journal of Microbiology, Immunology and Infection 55:1, pages 107-113.
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Hira Saleem, Usman Ali Ashfaq, Habibullah Nadeem, Muhammad Zubair, Muhammad Hussnain Siddique & Ijaz Rasul. (2021) Subtractive genomics and molecular docking approach to identify drug targets against Stenotrophomonas maltophilia. PLOS ONE 16:12, pages e0261111.
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Ming Hu, Chuhao Li, Yang Xue, Anqun Hu, Shanshan Chen, Yufan Chen, Guangtao Lu, Xiaofan Zhou & Jianuan Zhou. (2021) Isolation, Characterization, and Genomic Investigation of a Phytopathogenic Strain of Stenotrophomonas maltophilia . Phytopathology® 111:11, pages 2088-2099.
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Rozina Tabassum, Ghulam Abbas & Syed Sikander Azam. (2021) Immunoinformatics based designing and simulation of multi-epitope vaccine against multi-drug resistant Stenotrophomonas maltophilia. Journal of Molecular Liquids 340, pages 116899.
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Chan-Ho Cho & Sang-Bumm Lee. (2021) Comparative Analysis of the Clinical Aspects and Treatment Outcomes of Stenotrophomonas maltophilia Keratitis and Pseudomonas aeruginosa Keratitis. Eye & Contact Lens: Science & Clinical Practice 47:8, pages 456-464.
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Pengjun Han, Yunjia Hu, Xiaoping An, Lihua Song, Huahao Fan & Yigang Tong. (2021) Biochemical and genomic characterization of a novel bacteriophage BUCT555 lysing Stenotrophomonas maltophilia. Virus Research 301, pages 198465.
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Prashant P. Patil, Sanjeet Kumar, Amandeep Kaur, Samriti Midha, Kanika Bansal & Prabhu B. Patil. (2021) Global transcriptome analysis of Stenotrophomonas maltophilia in response to growth at human body temperature. Microbial Genomics 7:7.
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Joanna S. Brooke. (2021) Advances in the Microbiology of Stenotrophomonas maltophilia. Clinical Microbiology Reviews 34:3.
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Akihiro Nakamura, Yoshiyuki Suzuki, Yasumitsu Sakamoto, Saori Roppongi, Chisato Kushibiki, Natsuri Yonezawa, Masato Takahashi, Yosuke Shida, Hiroaki Gouda, Takamasa Nonaka, Nobutada Tanaka & Wataru Ogasawara. (2021) Structural basis for an exceptionally strong preference for asparagine residue at the S2 subsite of Stenotrophomonas maltophilia dipeptidyl peptidase 7. Scientific Reports 11:1.
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Özlem Oyardi, Paul B Savage, Zayre Erturan & Cagla Bozkurt-Guzel. (2021) In vitro assessment of CSA-131 and CSA-131 poloxamer form for the treatment of Stenotrophomonas maltophilia infections in cystic fibrosis . Journal of Antimicrobial Chemotherapy 76:2, pages 443-450.
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Eliana Alcaraz, Daniela Centrón, Gabriela Camicia, María Paula Quiroga, José Di Conza & Beatriz Passerini de Rossi. (2021) Stenotrophomonas maltophilia phenotypic and genotypic features through 4-year cystic fibrosis lung colonization. Journal of Medical Microbiology 70:1.
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Laura Schages, Ralf Lucassen, Florian Wichern, Rainer Kalscheuer & Dirk Bockmühl. (2020) The Household Resistome: Frequency of β-Lactamases, Class 1 Integrons, and Antibiotic-Resistant Bacteria in the Domestic Environment and Their Reduction during Automated Dishwashing and Laundering. Applied and Environmental Microbiology 86:23.
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Michael J. Huchital, Jason Kim, Argirios Mantzoukas & Jeffrey V. Lucido. (2020) Insights for the Growth of Stenotrophomonas maltophilia in a Diabetic Patient with Long-Term Antibiotic Use: A Case Study. Journal of the American Podiatric Medical Association 110:5.
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K. Turnau, R.J. Jędrzejczyk, R. Ważny, D. Chlebda, M. Janicka, D. Pawcenis & T. Łojewski. (2020) Microbes of XVI century Arrases of Krakow Royal Castle. Microbiological Research 238, pages 126485.
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Xiaoping Zhang, Baodi Shang, Xiaoyi Li, Zhengyou Li & Sha Tao. (2020) Complete genome sequence data of multidrug-resistant Stenotrophomonas sp. strain SXG-1. Journal of Global Antimicrobial Resistance 22, pages 206-209.
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Shuo Shen, Wei Wu, D. Jay Grimes, Eric A. Saillant & Robert J. Griffitt. (2020) Community composition and antibiotic resistance of bacteria in bottlenose dolphins Tursiops truncatus – Potential impact of 2010 BP Oil Spill. Science of The Total Environment 732, pages 139125.
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Danielle L. Peters, Jaclyn G. McCutcheon & Jonathan J. Dennis. (2020) Characterization of Novel Broad-Host-Range Bacteriophage DLP3 Specific to Stenotrophomonas maltophilia as a Potential Therapeutic Agent. Frontiers in Microbiology 11.
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Daniel Yero, Pol Huedo, Oscar Conchillo-Solé, Sònia Martínez-Servat, Uwe Mamat, Xavier Coves, Ferran Llanas, Ignasi Roca, Jordi Vila, Ulrich E. Schaible, Xavier Daura & Isidre Gibert. (2020) Genetic Variants of the DSF Quorum Sensing System in Stenotrophomonas maltophilia Influence Virulence and Resistance Phenotypes Among Genotypically Diverse Clinical Isolates. Frontiers in Microbiology 11.
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Márió Gajdács & Edit Urbán. (2020) A 10-year single-center experience on Stenotrophomonas maltophilia resistotyping in Szeged, Hungary. European Journal of Microbiology and Immunology 10:2, pages 91-97.
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Mariana AM Ferreira, Maria LS Pereira & Kênia V dos Santos. (2020) Drug-induced tolerance: the effects of antibiotic pre-exposure in Stenotrophomonas maltophilia . Future Microbiology 15:7, pages 497-508.
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Matthias I. Gröschel, Conor J. Meehan, Ivan Barilar, Margo Diricks, Aitor Gonzaga, Matthias Steglich, Oscar Conchillo-Solé, Isabell-Christin Scherer, Uwe Mamat, Christian F. Luz, Katrien De Bruyne, Christian Utpatel, Daniel Yero, Isidre Gibert, Xavier Daura, Stefanie Kampmeier, Nurdyana Abdul Rahman, Michael Kresken, Tjip S. van der Werf, Ifey Alio, Wolfgang R. Streit, Kai Zhou, Thomas Schwartz, John W. A. Rossen, Maha R. Farhat, Ulrich E. Schaible, Ulrich Nübel, Jan Rupp, Joerg Steinmann, Stefan Niemann & Thomas A. Kohl. (2020) The phylogenetic landscape and nosocomial spread of the multidrug-resistant opportunist Stenotrophomonas maltophilia. Nature Communications 11:1.
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Wafa Ibn Saied, Sybille Merceron, Carole Schwebel, Alban Le Monnier, Johana Oziel, Maité Garrouste-Orgeas, Guillaume Marcotte, Stéphane Ruckly, Bertrand Souweine, Michael Darmon, Lila Bouadma, Etienne de Montmollin, Bruno Mourvillier, Jean Reignier, Laurent Papazian, Shidasp Siami, Elie Azoulay, Jean-Pierre Bédos & Jean-Francois Timsit. (2020) Ventilator-associated pneumonia due to Stenotrophomonas maltophilia: Risk factors and outcome. Journal of Infection 80:3, pages 279-285.
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Marcelo Prates, Fernando Fernandes, Francisco Proença, Yashad Mussá, Ana Tavares & André Pereira. (2020) Oral Infection Caused by Stenotrophomonas maltophilia : A Rare Presentation of an Emerging Opportunistic Pathogen . Case Reports in Infectious Diseases 2020, pages 1-4.
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Márió Gajdács & Edit Urbán. (2019) Epidemiological Trends and Resistance Associated with Stenotrophomonas maltophilia Bacteremia: A 10-Year Retrospective Cohort Study in a Tertiary-Care Hospital in Hungary. Diseases 7:2, pages 41.
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Eliana Alcaraz, Carlos García, Laura Friedman & Beatriz Passerini de Rossi. (2019) The rpf /DSF signalling system of Stenotrophomonas maltophilia positively regulates biofilm formation, production of virulence-associated factors and β-lactamase induction . FEMS Microbiology Letters 366:6.
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Márió Gajdács & Edit Urbán. (2019) Prevalence and Antibiotic Resistance of Stenotrophomonas maltophilia in Respiratory Tract Samples: A 10-Year Epidemiological Snapshot . Health Services Research and Managerial Epidemiology 6, pages 233339281987077.
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Mohammadbagher Sharifkazemi, Mohammadhassan Nemati & Alireza Moarref. (2019) Stenotrophomonas maltophilia right‐sided endocarditis in an adult patient with uncorrected congenital heart disease. IDCases 17, pages e00562.
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Itay Tokatly Latzer, Gideon Paret, Marina Rubinstein, Nathan Keller, Galia BarkaiItai M. Pessach. (2018) Management of Stenotrophomonas maltophilia Infections in Critically Ill Children. Pediatric Infectious Disease Journal 37:10, pages 981-986.
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Prashant P. Patil, Sanjeet Kumar, Samriti MidhaVikas Gautam & Prabhu B. Patil. (2018) Taxonogenomics reveal multiple novel genomospecies associated with clinical isolates of Stenotrophomonas maltophilia. Microbial Genomics 4:8.
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Eliana Alcaraz, Carlos Garcia, Mariana Papalia, Carlos Vay, Laura Friedman & Beatriz Passerini de Rossi. (2018) Stenotrophomonas maltophilia isolated from patients exposed to invasive devices in a university hospital in Argentina: molecular typing, susceptibility and detection of potential virulence factors. Journal of Medical Microbiology 67:7, pages 992-1002.
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Jin Zhao, Yunxi Liu, Yi Liu, Dong Wang, Wentao Ni, Rui Wang, Youning Liu & Bo Zhang. (2018) Frequency and Genetic Determinants of Tigecycline Resistance in Clinically Isolated Stenotrophomonas maltophilia in Beijing, China. Frontiers in Microbiology 9.
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Mauro Geller, Carlos Pereira Nunes, Lisa Oliveira & Rafael Nigri. (2018) S. maltophilia pneumonia: A case report. Respiratory Medicine Case Reports 24, pages 44-45.
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Ashley L. DuMont & Nicholas P. Cianciotto. (2017) Stenotrophomonas maltophilia Serine Protease StmPr1 Induces Matrilysis, Anoikis, and Protease-Activated Receptor 2 Activation in Human Lung Epithelial Cells. Infection and Immunity 85:12.
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Ching-Hsun Wang, Jung-Chung Lin, Feng-Yee Chang, Ching-Mei Yu, Wei-San Lin & Kuo-Ming Yeh. (2017) Risk factors for hospital acquisition of trimethoprim–sulfamethoxazole resistant Stenotrophomonas maltophilia in adults: A matched case-control study. Journal of Microbiology, Immunology and Infection 50:5, pages 646-652.
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Luz E. Ochoa-Sánchez & Pablo Vinuesa. (2017) Evolutionary Genetic Analysis Uncovers Multiple Species with Distinct Habitat Preferences and Antibiotic Resistance Phenotypes in the Stenotrophomonas maltophilia Complex. Frontiers in Microbiology 8.
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Meng Wang, Minhua Huang, Junjie Zhang, Yi Ma, Shan Li & Jufang Wang. (2017) A novel secretion and online-cleavage strategy for production of cecropin A in Escherichia coli. Scientific Reports 7:1.
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Akira Fukuda, Masaru Usui, Hideyuki Wakao, Chanchai Boonla & Yutaka Tamura. (2017) Stenotrophomonas maltophilia is highly prevalent among houseflies (Musca domestica). Journal of Medical Microbiology 66:8, pages 1202-1206.
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Bin Cai, Roger Echols, Glenn Magee, Juan Camilo Arjona Ferreira, Gareth Morgan, Mari Ariyasu, Takuko Sawada & Tsutae “Den” Nagata. (2017) Prevalence of Carbapenem-Resistant Gram-Negative Infections in the United States Predominated by Acinetobacter baumannii and Pseudomonas aeruginosa. Open Forum Infectious Diseases 4:3.
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Megan Cross, Siji Rajan, Janine Chekaiban, Jake Saunders, Chloe Hamilton, Jeong-Sun Kim, Mark J. Coster, Robin B. Gasser & Andreas Hofmann. (2017) Enzyme characteristics of pathogen-specific trehalose-6-phosphate phosphatases. Scientific Reports 7:1.
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Dae Ro Lim, Jung Cheol Kuk, Taehyung Kim & Eung Jin Shin. (2017) Unusual case of rapid growing intraabdominal abscess caused by Stenotrophomonas maltophilia after laparoscopic appendectomy due to perforated appendicitis. Medicine 96:20, pages e6913.
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Adam M. Malinowski, Bryan M. McClarty, Carolyn Robinson, William Spear, Maria Sanchez, Timothy C. Sparkes & Joanna S. Brooke. (2017) Polysorbate 80 and polymyxin B inhibit Stenotrophomonas maltophilia biofilm. Diagnostic Microbiology and Infectious Disease 87:2, pages 154-156.
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MARJAN BIOČANIN, HAOWA MADI, ZORICA VASILJEVIĆ, MILAN KOJIĆ, BRANKO JOVČIĆ & JELENA LOZO. (2017) Temperature, pH and Trimethoprim-Sulfamethoxazole Are Potent Inhibitors of Biofilm Formation by Stenotrophomonas maltophilia Clinical Isolates . Polish Journal of Microbiology 66:4, pages 433-438.
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Oscar Conchillo-Solé, Daniel Yero, Xavier Coves, Pol Huedo, Sònia Martínez-Servat, Xavier Daura & Isidre Gibert. (2015) Draft Genome Sequence of Stenotrophomonas maltophilia Strain UV74 Reveals Extensive Variability within Its Genomic Group. Genome Announcements 3:3.
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