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Aminoglycoside toxicity in neonates: something to worry about?

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Aline Fuchs, Julia Bielicki, Shrey Mathur, Mike Sharland & Johannes N. Van Den Anker. (2018) Reviewing the WHO guidelines for antibiotic use for sepsis in neonates and children. Paediatrics and International Child Health 38:sup1, pages S3-S15.
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Anne Smits, Aida Kulo, John van den Anker & Karel Allegaert. (2017) The amikacin research program: a stepwise approach to validate dosing regimens in neonates. Expert Opinion on Drug Metabolism & Toxicology 13:2, pages 157-166.
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Janko Samardzic, Karel Allegaert, Mélanie Wilbaux, Marc Pfister & John N. van den Anker. (2016) Quantitative clinical pharmacology practice for optimal use of antibiotics during the neonatal period. Expert Opinion on Drug Metabolism & Toxicology 12:4, pages 367-375.
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Janko Samardzic, Mark A Turner, Ralph Bax & Karel Allegaert. (2015) Neonatal medicines research: challenges and opportunities. Expert Opinion on Drug Metabolism & Toxicology 11:7, pages 1041-1052.
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Articles from other publishers (49)

Karel Allegaert, Robert M. Ward & John N. Van Den Anker. 2024. Avery's Diseases of the Newborn. Avery's Diseases of the Newborn 253 265.e2 .
Jiaosheng Zhang, Wenshuang Zhang, Xiang Ma, Lanfang Tang, Daiyin Tian, Keye Wu, Yuejie Zheng, Kunling Shen, Jikui Deng & Yonghong Yang. (2022) Antimicrobial prescribing for children in China: data from point prevalence surveys in 18 tertiary centres in China in 2016–2017. BMJ Open 12:9, pages e059244.
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Caspar J. Hodiamont, Annemieke K. van den Broek, Suzanne L. de Vroom, Jan M. Prins, Ron A. A. Mathôt & Reinier M. van Hest. (2022) Clinical Pharmacokinetics of Gentamicin in Various Patient Populations and Consequences for Optimal Dosing for Gram-Negative Infections: An Updated Review. Clinical Pharmacokinetics 61:8, pages 1075-1094.
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Hiie Soeorg, Helgi Padari, Karin Kipper, Mari-Liis Ilmoja, Irja Lutsar & Tuuli Metsvaht. (2022) Pharmacokinetics of Gentamicin Components C1, C1a, and C2/C2a/C2b and Subsequent Decline in Glomerular Filtration Rate in Neonates. The AAPS Journal 24:4.
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Jinkyung Kim, Sriram Hemachandran, Alan G. Cheng & Anthony J. Ricci. (2022) Identifying targets to prevent aminoglycoside ototoxicity. Molecular and Cellular Neuroscience 120, pages 103722.
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Hanbing Yu, Deyu Ma, Bo Liu, Suqing Yang, Qiuxia Lin, Renlin Yu, Xiaojiong Jia, Siqiang Niu, Qun Zhang & Shifeng Huang. (2022) Differences in the Distribution of Species, Carbapenemases, Sequence Types, Antimicrobial Heteroresistance and Mortality Rates Between Pediatric and Adult Carbapenemase-Producing Enterobacterales in Bloodstream Infections. Frontiers in Medicine 9.
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Lijie Xu, Xuefang Cheng, Guanhua Zhu, Juanni Hu, Qin Li & Guorong Fan. (2022) Therapeutic drug monitoring of amikacin: quantification in plasma by liquid chromatography-tandem mass spectrometry and work experience of clinical pharmacists. European Journal of Hospital Pharmacy 29:e1, pages e77-e82.
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Veronika Rypdal, Sondre Jørandli, Dagny Hemmingsen, Marit Dahl Solbu & Claus Klingenberg. (2021) Exposure to an Extended-Interval, High-Dose Gentamicin Regimen in the Neonatal Period Is Not Associated With Long-Term Nephrotoxicity. Frontiers in Pediatrics 9.
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Paolo Paioni, Vera F. Jäggi, Romy Tilen, Michelle Seiler, Philipp Baumann, Dominic S. Bräm, Carole Jetzer, Robin T. U. Haid, Aljoscha N. Goetschi, Roland Goers, Daniel Müller, Diana Coman Schmid, Henriette E. Meyer zu Schwabedissen, Bernd Rinn, Christoph Berger & Stefanie D. Krämer. (2021) Gentamicin Population Pharmacokinetics in Pediatric Patients—A Prospective Study with Data Analysis Using the saemix Package in R. Pharmaceutics 13:10, pages 1596.
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Christopher A. Darlow, Renata M. A. da Costa, Sally Ellis, François Franceschi, Mike Sharland, Laura Piddock, Shampa Das & William Hope. (2021) Potential Antibiotics for the Treatment of Neonatal Sepsis Caused by Multidrug-Resistant Bacteria. Pediatric Drugs 23:5, pages 465-484.
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Kristin O’Connor, Mark W. Davies, Pieter Koorts, David W. Cartwright & Karen Whitfield. (2021) Gentamicin Dosing in Neonates with Normal Renal Function: Trough and Peak Levels. European Journal of Drug Metabolism and Pharmacokinetics 46:5, pages 677-684.
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Christopher A. Darlow, Fernando Docobo-Perez, Nicola Farrington, Adam Johnson, Laura McEntee, Jennifer Unsworth, Ana Jimenez-Valverde, Silke Gastine, Ruwanthi Kolamunnage-Dona, Renata M. A. de Costa, Sally Ellis, François Franceschi, Joseph F. Standing, Mike Sharland, Michael Neely, Laura Piddock, Shampa Das & William Hope. (2021) Amikacin Combined with Fosfomycin for Treatment of Neonatal Sepsis in the Setting of Highly Prevalent Antimicrobial Resistance. Antimicrobial Agents and Chemotherapy 65:7.
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Steven Kwasi Korang, Sanam Safi, Chiara Nava, Adrienne Gordon, Munish Gupta, Gorm Greisen, Ulrik Lausten-Thomsen & Janus C Jakobsen. (2021) Antibiotic regimens for early-onset neonatal sepsis. Cochrane Database of Systematic Reviews 2021:5.
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Emma J. Kenyon, Nerissa K. Kirkwood, Siân R. Kitcher, Richard J. Goodyear, Marco Derudas, Daire M. Cantillon, Sarah Baxendale, Antonio de la Vega de León, Virginia N. Mahieu, Richard T. Osgood, Charlotte Donald Wilson, James C. Bull, Simon J. Waddell, Tanya T. Whitfield, Simon E. Ward, Corné J. Kros & Guy P. Richardson. (2021) Identification of a series of hair-cell MET channel blockers that protect against aminoglycoside-induced ototoxicity. JCI Insight 6:7.
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S. D’Agate, F. Tshinanu Musuamba, E. Jacqz-Aigrain & O. Della Pasqua. (2021) Simplified Dosing Regimens for Gentamicin in Neonatal Sepsis. Frontiers in Pharmacology 12.
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Steven Kwasi Korang, Sanam Safi, Munish Gupta, Adrienne Gordon, Gorm Greisen, Ulrik Lausten-Thomsen & Janus C Jakobsen. (2021) Antibiotic regimens for early-onset neonatal sepsis. Cochrane Database of Systematic Reviews.
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Heidi J. Murphy, Brady Thomas, Brynna Van Wyk, Sarah B. Tierney, David T. Selewski & Jennifer G. Jetton. (2019) Nephrotoxic medications and acute kidney injury risk factors in the neonatal intensive care unit: clinical challenges for neonatologists and nephrologists. Pediatric Nephrology 35:11, pages 2077-2088.
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C. Vairo, J. Basas, M. Pastor, M. Palau, X. Gomis, B. Almirante, E. Gainza, R.M. Hernandez, M. Igartua, J. Gavaldà & G. Gainza. (2020) In vitro and in vivo antimicrobial activity of sodium colistimethate and amikacin-loaded nanostructured lipid carriers (NLC). Nanomedicine: Nanotechnology, Biology and Medicine 29, pages 102259.
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Rajakumar Marol, Rohitkumar Marol & Renuka Marol. (2020) Prevalence of urinary tract infection in febrile infants. Indian Journal of Child Health 07:02, pages 85-88.
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Dagny Hemmingsen, Camilla Mikalsen, Alexander Rydland Hansen, Jon Widding Fjalstad, Niels Christian Stenklev & Claus Klingenberg. (2020) Hearing in Schoolchildren After Neonatal Exposure to a High-Dose Gentamicin Regimen. Pediatrics 145:2.
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Amanda Dyson & Alison L. Kent. (2019) The Effect of Preterm Birth on Renal Development and Renal Health Outcome. NeoReviews 20:12, pages e725-e736.
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Jing Cui, Li Tang, Quan Hong, Shupeng Lin, Xuefeng Sun, Guangyan Cai, Xue-Yuan Bai & Xiangmei Chen. (2019) N-Acetylcysteine Ameliorates Gentamicin-Induced Nephrotoxicity by Enhancing Autophagy and Reducing Oxidative Damage in Miniature Pigs. Shock 52:6, pages 622-630.
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Ping Wang, Zhengmei Long, Zhengyu Yu, Ping Liu, Danna Wei, Qin Fang, Dan Ma & Jishi Wang. (2019) The efficacy of topical gentamycin application on prophylaxis and treatment of wound infection: A systematic review and meta‐analysis. International Journal of Clinical Practice 73:5, pages e13334.
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Huanju Bai, Xi Wang, Xue Gao, Jie Bing, Weiqian Wang, Xuebo Zhang, Chao Xi, Lingling Jiang, Xinwen Zhang, Zhongming Han, Shaoju Zeng & Jincao Xu. (2018) Study of the Mechanisms by Which Aminoglycoside Damage Is Prevented in Chick Embryonic Hair Cells. Journal of the Association for Research in Otolaryngology 20:1, pages 21-35.
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Andrew J Rogers, Daniel S Lockhart, Rebecca Clarke, Helen V Bennett, Yassar Kadoom, James E Turner, Matthew Dryden & Matthew A Crow. (2019) Rapid Rule Out of Culture-Negative Bloodstream Infections by Use of a Novel Approach to Universal Detection of Bacteria and Fungi. The Journal of Applied Laboratory Medicine 3:4, pages 534-544.
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Jing Fu, Zhongyuan Wu & Lijuan Zhang. 2019. Glycans and Glycosaminoglycans as Clinical Biomarkers and Therapeutics - Part B. Glycans and Glycosaminoglycans as Clinical Biomarkers and Therapeutics - Part B 487 522 .
Myda Khalid & Sharon P. Andreoli. 2019. Nephrology and Fluid/electrolyte Physiology. Nephrology and Fluid/electrolyte Physiology 291 314 .
Norberto Perico, David Askenazi, Monica Cortinovis & Giuseppe Remuzzi. (2018) Maternal and environmental risk factors for neonatal AKI and its long-term consequences. Nature Reviews Nephrology 14:11, pages 688-703.
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Jose Miguel Sequi Canet, Carlos Miguel Angelats Romero, Jose Miguel Sequi Sabater, Ana Miralles Torres, Miguel Boronat Garcia & Marta Gomez Delgado. (2018) Otoemisiones en los niños tratados con gentamicina de un hospital comarcal. Acta Otorrinolaringológica Española 69:5, pages 291-296.
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Jose Miguel Sequi Canet, Carlos Miguel Angelats Romero, Jose Miguel Sequi Sabater, Ana Miralles Torres, Miguel Boronat Garcia & Marta Gomez Delgado. (2018) Otoacoustic Emissions in Children Treated With Gentamicin in a Secondary Hospital. Acta Otorrinolaringologica (English Edition) 69:5, pages 291-296.
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Chloe Wilson, Jamie Duckers & Deepak Rajenderkumar. (2018) Unusual discovery of a vestibular schwannoma following eradication therapy for Mycobacterium abscessus . BMJ Case Reports, pages bcr-2018-225572.
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Tamara van Donge, Marc Pfister, Julia Bielicki, Chantal Csajka, Frederique Rodieux, John van den Anker & Aline Fuchs. (2018) Quantitative Analysis of Gentamicin Exposure in Neonates and Infants Calls into Question Its Current Dosing Recommendations. Antimicrobial Agents and Chemotherapy 62:4.
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Carolina Consuelo Llanos-Paez, Christine Staatz & Stefanie Hennig. (2017) Balancing Antibacterial Efficacy and Reduction in Renal Function to Optimise Initial Gentamicin Dosing in Paediatric Oncology Patients. The AAPS Journal 20:1.
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Karel Allegaert, Robert M. Ward & John N. Van Den Anker. 2018. Avery's Diseases of the Newborn. Avery's Diseases of the Newborn 419 431.e2 .
Pieter A. J. G. De Cock, Karel Allegaert, Matthew W. Linakis & Catherine M. T. Sherwin. 2018. Antibiotic Pharmacokinetic/Pharmacodynamic Considerations in the Critically Ill. Antibiotic Pharmacokinetic/Pharmacodynamic Considerations in the Critically Ill 239 263 .
Stephen J McWilliam, Daniel J Antoine, Rosalind L Smyth & Munir Pirmohamed. (2016) Aminoglycoside-induced nephrotoxicity in children. Pediatric Nephrology 32:11, pages 2015-2025.
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Y. Aujard. (2017) Infecciones neonatales bacterianas, micóticas y parasitarias. EMC - Pediatría 52:3, pages 1-23.
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Kostja Renko, Janine Martitz, Sandra Hybsier, Bjoern Heynisch, Linn Voss, Robert A. Everley, Steven P. Gygi, Mette Stoedter, Monika Wisniewska, Josef Köhrle, Vadim N. Gladyshev & Lutz Schomburg. (2017) Aminoglycoside-driven biosynthesis of selenium-deficient Selenoprotein P. Scientific Reports 7:1.
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L Oni, DB Hawcutt, MA Turner, MW Beresford, S McWilliam, C Barton, BK Park, P Murray, B Wilm, I Copple, R Floyd, M Peak, A Sharma & DJ Antoine. (2017) Optimising the use of medicines to reduce acute kidney injury in children and babies. Pharmacology & Therapeutics 174, pages 55-62.
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Elif Ece Doğan, Reha Erkoç, İskender Ekinci, Jamshid Hamdard, Barış Döner, Mehmet Ali Çıkrıkçıoğlu, Cumali Karatoprak, Ganime Çoban, Ömer Faruk Özer & Rümeyza Kazancıoğlu. (2017) Protective effect of dexpanthenol against nephrotoxic effect of amikacin: An experimental study. Biomedicine & Pharmacotherapy 89, pages 1409-1414.
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Eva Germovsek, Charlotte I Barker & Mike Sharland. (2017) What do I need to know about aminoglycoside antibiotics?. Archives of disease in childhood - Education & practice edition 102:2, pages 89-93.
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Alison Boast & Amanda Gwee. (2017) Absence of evidence: antimicrobial prescribing in neonates, elderly and pregnant women. Internal Medicine Journal 47:1, pages 13-15.
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Shripada C Rao, Ravisha Srinivasjois & Kwi Moon. (2016) One dose per day compared to multiple doses per day of gentamicin for treatment of suspected or proven sepsis in neonates. Cochrane Database of Systematic Reviews 2017:2.
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Jeffrey Gonzalez, John Ahern, Elizabeth Noyes, Michele Corriveau & Charles Mercier. (2016) Identification of Risk Factors for Elevated Neonatal Gentamicin Trough Concentrations. The Journal of Pediatric Pharmacology and Therapeutics 21:2, pages 133-139.
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DINGYUAN MA, JINGJING ZHANG, CHUNYU LUO, YING LIN, XIUQING JI, PING HU & ZHENGFENG XU. (2016) Genetic counseling for patients with nonsyndromic hearing impairment directed by gene analysis. Molecular Medicine Reports 13:3, pages 1967-1974.
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Fernando de Sá Del Fiol, Silvio Barberato-Filho, Cristiane de Cássia Bergamaschi, Luciane Cruz Lopes & Timothy P. Gauthier. (2016) Antibiotics and Breastfeeding. Chemotherapy 61:3, pages 134-143.
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Joseph B. Cantey, Amanda C. Farris & Sarah M. McCormick. (2015) Bacteremia in Early Infancy: Etiology and Management. Current Infectious Disease Reports 18:1.
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Margaret A. Kenna. (2015) Acquired Hearing Loss in Children. Otolaryngologic Clinics of North America 48:6, pages 933-953.
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Mohamed N. El-barbary, Rania I.H. Ismail & Adel A.A. Ibrahim. (2015) Gentamicin extended interval regimen and ototoxicity in neonates. International Journal of Pediatric Otorhinolaryngology 79:8, pages 1294-1298.
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