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Persistent and recurrent Trichomonas vaginalis infections: epidemiology, treatment and management considerations

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Angel D. Herrera-España, Julio A. Aguiar-Pech, M. Elizbeth Alvarez-Sánchez, Victor E. Arana-Argáez, Cynthia K. Palomar-Gómez, Armin G. Jiménez-Ross, David Cáceres-Castillo, Rubén M. Carballo & Julio C. Torres-Romero. (2022) Lupeol acetate isolated from Chrysophyllum cainito L. fruit as a template for the synthesis of N-alkyl-arylsulfonamide derivatives and their synergistic effects with metronidazole against Trichomonas vaginalis. Natural Product Research 36:21, pages 5508-5516.
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Zhenchao Zhang, Xiaoxiao Song, Yangyang Deng, Yuhua Li, Fakun Li, Wanxin Sheng, Xiaowei Tian, Zhenke Yang, Xuefang Mei & Shuai Wang. (2023) Trichomonas vaginalis adhesion protein 65 (TvAP65) modulates parasite pathogenicity by interacting with host cell proteins. Acta Tropica 246, pages 106996.
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Alaa S Abd-El-Aziz, Amal M Youssef & Ahmad Abd-El-Aziz. 2023. Transition Metal-containing Dendrimers in Biomedicine. Transition Metal-containing Dendrimers in Biomedicine 249 308 .
Zhenchao Zhang, Yangyang Deng, Wanxin Sheng, Xiaoxiao Song, Yuhua Li, Fakun Li, Ying Pan, Xiaowei Tian, Zhenke Yang, Shuai Wang, Mingyong Wang & Xuefang Mei. (2023) The interaction between adhesion protein 33 (TvAP33) and BNIP3 mediates the adhesion and pathogenicity of Trichomonas vaginalis to host cells. Parasites & Vectors 16:1.
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Graziela Vargas Rigo, Júlia Biz Willig, Michael Devereux, Malachy McCann, André Luis Souza dos Santos & Tiana Tasca. (2023) Oxidative damage by 1,10-phenanthroline-5,6-dione and its silver and copper complexes lead to apoptotic-like death in Trichomonas vaginalis. Research in Microbiology 174:4, pages 104015.
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Candice J. McNeil, John C. Williamson & Christina A. Muzny. (2023) Successful Treatment of Persistent 5-Nitroimidazole–Resistant Trichomoniasis With an Extended Course of Oral Secnidazole Plus Intravaginal Boric Acid. Sexually Transmitted Diseases 50:4, pages 243-246.
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Anna Maya Powell, Isabella Sarria & Oluwatosin Goje. (2023) Microbiome and Vulvovaginitis. Obstetrics and Gynecology Clinics of North America.
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Mohammad Saleh Bahreini, Samaneh Sedghi, Yalda Badalzadeh, Mohammad Hossein Motazedian, Manouchehr Shirani, Sareh Sami Jahromi, Aref Teimouri, Mahmoud Agholi & Qasem Asgari. (2023) Molecular diagnosis of Trichomonas vaginalis in liquid-based Papanicolaou samples in Shiraz, southern Iran. BMC Women's Health 23:1.
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Beatriz Hernández-Ochoa, Víctor Martínez-Rosas, Laura Morales-Luna, Ernesto Calderón-Jaimes, Luz María Rocha-Ramírez, Daniel Ortega-Cuellar, Yadira Rufino-González, Abigail González-Valdez, Roberto Arreguin-Espinosa, Sergio Enríquez-Flores, Rosa Angélica Castillo-Rodríguez, Noemí Cárdenas-Rodríguez, Carlos Wong-Baeza, Isabel Baeza-Ramírez & Saúl Gómez-Manzo. (2022) Pyridyl Methylsulfinyl Benzimidazole Derivatives as Promising Agents against Giardia lamblia and Trichomonas vaginalis. Molecules 27:24, pages 8902.
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Mostafa M. Mostafa, Ayman Mahdy & Gamal Ghoniem. (2022) Updates on Sexually Transmitted Urethro-cystitis. Current Bladder Dysfunction Reports 17:3, pages 149-154.
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Mirna Samara Dié Alves, Ângela Sena-Lopes, Raquel Nascimento das Neves, Angela Maria Casaril, Micaela Domingues, Paloma Taborda Birmann, Emerson Teixeira da Silva, Marcus Vinicius Nora de Souza, Lucielli Savegnago & Sibele Borsuk. (2022) In vitro and in silico trichomonacidal activity of 2,8-bis(trifluoromethyl) quinoline analogs against Trichomonas vaginalis. Parasitology Research 121:9, pages 2697-2711.
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Andile Mtshali, Sinaye Ngcapu, Kavitha Govender, A. Willem Sturm, Prashini Moodley & Bronwyn C. Joubert. (2022) In Vitro Effect of 5-Nitroimidazole Drugs against Trichomonas vaginalis Clinical Isolates . Microbiology Spectrum 10:4.
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Balasubramaniam Mohankumar, R.K. Shandil, Shridhar Narayanan & Uma Maheswari Krishnan. (2022) Vaginosis: Advances in new therapeutic development and microbiome restoration. Microbial Pathogenesis 168, pages 105606.
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Valentina Margarita, Le Chi Cao, Nicholas P. Bailey, Thuy Ha Thi Ngoc, Thi Minh Chau Ngo, Phuong Anh Ton Nu, Nicia Diaz, Daniele Dessì, Robert P. Hirt, Pier Luigi Fiori & Paola Rappelli. (2022) Effect of the Symbiosis with Mycoplasma hominis and Candidatus Mycoplasma Girerdii on Trichomonas vaginalis Metronidazole Susceptibility. Antibiotics 11:6, pages 812.
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Helena Lucia Carneiro Santos & Karina M. Rebello. (2022) An Overview of Mucosa-Associated Protozoa: Challenges in Chemotherapy and Future Perspectives. Frontiers in Cellular and Infection Microbiology 12.
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Arlene C. Seña, Linda A. Goldstein, Gilbert Ramirez, Austin J. Parish & R. Scott McClelland. (2021) Bacterial Vaginosis and Its Association With Incident Trichomonas vaginalis Infections: A Systematic Review and Meta-Analysis. Sexually Transmitted Diseases 48:12, pages e192-e201.
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Koichiro Wada, Ryoichi Hamasuna, Takuya Sadahira, Motoo Araki & Shingo Yamamoto. (2021) UAA-AAUS guideline for M. genitalium and non-chlamydial non-gonococcal urethritis. Journal of Infection and Chemotherapy 27:10, pages 1384-1388.
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Kimberly A. Workowski, Laura H. Bachmann, Philip A. Chan, Christine M. Johnston, Christina A. Muzny, Ina Park, Hilary Reno, Jonathan M. Zenilman & Gail A. Bolan. (2021) Sexually Transmitted Infections Treatment Guidelines, 2021. MMWR. Recommendations and Reports 70:4, pages 1-187.
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Manal J. NattoFabian Hulpia, Eric R. KalkmanSusan BaillieAmani AlhejeliYukiko Miyamoto, Lars Eckmann, Serge Van Calenbergh & Harry P. de Koning. (2021) Deazapurine Nucleoside Analogues for the Treatment of Trichomonas vaginalis . ACS Infectious Diseases 7:6, pages 1752-1764.
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Nooshin Hashemi, Davood Ommi, Parya Kheyri, Faham Khamesipour, William N. Setzer & Marlene Benchimol. (2021) A review study on the anti-trichomonas activities of medicinal plants. International Journal for Parasitology: Drugs and Drug Resistance 15, pages 92-104.
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David Lloyd, Alan Chapman, Jayne E. Ellis, Kevin Hillman, Timothy A. Paget, Nigel Yarlett & Alan G. Williams. 2021. 163 240 .
M Sim, S Logan & LH Goh. (2020) Vaginal discharge: evaluation and management in primary care. Singapore Medical Journal, pages 297-301.
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Gweneth B. Lazenby, Allyson Hill, Jessica Tarleton & David Soper. (2020) Diagnosis, Treatment, Follow-up, and Persistence of Trichomonas vaginalis in Women 45 Years and Older According to HIV Status: A 10-Year Retrospective Cohort. Sexually Transmitted Diseases 47:5, pages 332-337.
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Tesia G. Kim, Marisa R. Young, Emily R. Goggins, Rachel E. Williams, Elena HogenEsch, Kimberly A. Workowski, Denise J. Jamieson & Lisa B. Haddad. (2020) Trichomonas vaginalis in Pregnancy. Obstetrics & Gynecology 135:5, pages 1136-1144.
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Andrew Medina-Marino, Maanda Mudau, Noah Kojima, Remco PH Peters, Ute D Feucht, Lindsey De Vos, Dawie Olivier, Christina A Muzny, James A McIntyre & Jeffrey D Klausner. (2020) Persistent Chlamydia trachomatis , Neisseria gonorrhoeae or Trichomonas vaginalis positivity after treatment among human immunodeficiency virus-infected pregnant women, South Africa . International Journal of STD & AIDS 31:4, pages 294-302.
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Hong-Ming Hsu, Yu-Hsin Huang, Sarita Aryal, Hsing-Wei Liu, Chinpan Chen, Shu-Hui Chen, Chien-Hsin Chu & Jung-Hsiang Tai. (2020) Endomembrane Protein Trafficking Regulated by a TvCyP2 Cyclophilin in the Protozoan Parasite, Trichomonas vaginalis. Scientific Reports 10:1.
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D.G. Kim, P.I. Kim, M.A. Gomberg & A.E. Guschin. (2020) Experience in the treatment of NGU in men associated with bacterial vaginosis in their sexual partners. Klinicheskaya dermatologiya i venerologiya 19:4, pages 520.
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Aliona S Rosca, Joana Castro, Lúcia G V Sousa & Nuno Cerca. (2020) Gardnerella and vaginal health: the truth is out there . FEMS Microbiology Reviews 44:1, pages 73-105.
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Nassib Abou Heidar, Aline Yaacoubian & Yaser El-Hout. 2020. The Surgical Management of Parasitic Diseases. The Surgical Management of Parasitic Diseases 293 308 .
Cynthia Alessio & Paul Nyirjesy. (2019) Management of Resistant Trichomoniasis. Current Infectious Disease Reports 21:9.
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Gilbert G G Donders, Kateryna Ruban, Christophe Depuydt, Gert Bellen, Davy Vanden Broeck, Jef Jonckheere & Yves Jacquemyn. (2019) Treatment Attitudes for Belgian Women With Persistent Trichomonas vaginalis Infection in the VlaResT Study. Clinical Infectious Diseases 68:9, pages 1575-1580.
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Antonio Salas, Matthew M. Hamill & Susan Tuddenham. (2019) Nitroimidazole Resistance in Trichomonas vaginalis Infection . JAMA Internal Medicine 179:2, pages 247.
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Angelica Montenegro Riestra, J. Andrés Valderrama, Kathryn A. Patras, Sharon D. Booth, Xing Yen Quek, Chih-Ming Tsai & Victor Nizet. (2019) <b><i>Trichomonas vaginalis</i></b> Induces NLRP3 Inflammasome Activation and Pyroptotic Cell Death in Human Macrophages. Journal of Innate Immunity 11:1, pages 86-98.
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Gweneth B. Lazenby, Lauren Thompson, Anna M. Powell & David E. Soper. (2019) Unexpected High Rates of Persistent Trichomonas vaginalis Infection in a Retrospective Cohort of Treated Pregnant Women. Sexually Transmitted Diseases 46:1, pages 2-8.
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Riccardo Bartoletti, Florian M.E. Wagenlehner, Truls Erik Bjerklund Johansen, Bela Köves, Tommaso Cai, Zafer Tandogdu & Gernot Bonkat. (2019) Management of Urethritis: Is It Still the Time for Empirical Antibiotic Treatments?. European Urology Focus 5:1, pages 29-35.
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N. Delshadi-Jahromi, R. Nazari-Vanani, H. Yadegari, N. Sattarahmady, G.R. Hatam & H. Heli. (2018) Label-free ultrasensitive electrochemical genosensing of Trichomonas vaginalis using anisotropic-shaped gold nanoparticles as a platform, a repeated sequence of the parasite DNA as a probe, and toluidine blue as a redox marker. Sensors and Actuators B: Chemical 273, pages 234-241.
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Saira Butt & Amir Tirmizi. (2018) Intravenous metronidazole, liquid tinidazole, and intra-vaginal boric acid to cure trichomonas in a patient with gastric bypass surgery. International Journal of STD & AIDS 29:8, pages 825-827.
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Agnieszka Beata Serwin, Violetta Bulhak-Koziol, Marianna Sokolowska, Daniel Golparian & Magnus Unemo. (2017) Trichomonas vaginalis is very rare among women with vaginal discharge in Podlaskie province, Poland . APMIS 125:9, pages 840-843.
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