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The pediatric sepsis biomarker risk model: potential implications for sepsis therapy and biology

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Hector R. Wong, Keith R. Walley, Ville Pettilä, Nuala J. Meyer, James A. Russell, Sari Karlsson, Michael G. S. Shashaty & Christopher J. Lindsell. (2015) Comparing the prognostic performance of ASSIST to interleukin-6 and procalcitonin in patients with severe sepsis or septic shock. Biomarkers 20:2, pages 132-135.
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Mary Sandquist & Hector R Wong. (2014) Biomarkers of sepsis and their potential value in diagnosis, prognosis and treatment. Expert Review of Clinical Immunology 10:10, pages 1349-1356.
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Articles from other publishers (24)

Shannon Byler, Alexandra Baker, Eli Freiman, Joshua C. Herigon & Matthew A. Eisenberg. (2021) Utility of specific laboratory biomarkers to predict severe sepsis in pediatric patients with SIRS. The American Journal of Emergency Medicine 50, pages 778-783.
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Arturo Alejandro Canul-Euan, Gibran Zúñiga-González, Janelly Estefania Palacios-Luna, Rolando Maida-Claros, Néstor Fabián Díaz, Patricia Saltigeral-Tigeral, Perla Karina García-May, Oscar Díaz-Ruiz & Héctor Flores-Herrera. (2021) Increased Levels of Plasma Extracellular Heat-Shock Proteins 60 and 70 kDa Characterized Early-Onset Neonatal Sepsis. Frontiers in Pediatrics 9.
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Teresa Bleakly Kortz & Niranjan Kissoon. (2021) Predicting mortality in pediatric sepsis: A laudable but elusive goal. Jornal de Pediatria 97:3, pages 260-263.
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Yoshitaka HirasawaAtsushi FujiwaraKazuya TabataKenji YoshidaTsutomu NegamaTakayuki Anzai & Shin-ichi Sato. (2020) Evaluation of cytokine storms in a disseminated intravascular coagulation monkey model. Fundamental Toxicological Sciences 7:2, pages 105-114.
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Susan R. Conway & Hector R. Wong. (2020) Biomarker Panels in Critical Care. Critical Care Clinics 36:1, pages 89-104.
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Leonie S. Jochheim, Georgios Odysseos, Ana Hidalgo-Sastre, Suyang Zhong, Lina M. Staufer, Markus Kroiss, Derya Kabacaoglu, Sebastian Lange, Thomas Engleitner, Daniel Hartmann, Norbert Hüser, Katja Steiger, Roland M. Schmid, Bernhard Holzmann & Guido von Figura. (2019) The neuropeptide receptor subunit RAMP1 constrains the innate immune response during acute pancreatitis in mice. Pancreatology 19:4, pages 541-547.
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Vikhyat S. Bebarta, Normalynn Garrett, Joseph K. Maddry, Allyson Arana, Susan Boudreau, Maria Castaneda, Patricia Dixon & David A. Tanen. (2019) A prospective, randomized trial of intravenous hydroxocobalamin versus noradrenaline or saline for treatment of lipopolysaccharide-induced hypotension in a swine model. Clinical and Experimental Pharmacology and Physiology 46:3, pages 216-225.
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Balam Muñoz, Rocío Suárez-Sánchez, Oscar Hernández-Hernández, Rafael Franco-Cendejas, Hernán Cortés & Jonathan J. Magaña. (2019) From traditional biochemical signals to molecular markers for detection of sepsis after burn injuries. Burns 45:1, pages 16-31.
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Judith A. Guzman-Cottrill & Louise Elaine Vaz. 2018. Principles and Practice of Pediatric Infectious Diseases. Principles and Practice of Pediatric Infectious Diseases 98 102.e2 .
Hector R. Wong, Natalie Z. Cvijanovich, Nick Anas, Geoffrey L. Allen, Neal J. Thomas, Michael T. Bigham, Scott L. Weiss, Julie C. Fitzgerald, Paul A. Checchia, Keith Meyer, Michael Quasney, Mark Hall, Rainer Gedeit, Robert J. Freishtat, Jeffrey Nowak, Shekhar S. Raj, Shira Gertz, Jocelyn R. Grunwell & Christopher J. Lindsell. (2017) Improved Risk Stratification in Pediatric Septic Shock Using Both Protein and mRNA Biomarkers. PERSEVERE-XP. American Journal of Respiratory and Critical Care Medicine 196:4, pages 494-501.
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Mengshi Chen, Xiulan Lu, Li Hu, Pingping Liu, Wenjiao Zhao, Haipeng Yan, Liang Tang, Yimin Zhu, Zhenghui Xiao, Lizhang Chen & Hongzhuan Tan. (2017) Development and validation of a mortality risk model for pediatric sepsis. Medicine 96:20, pages e6923.
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Matt S. ZinterBenjamin E. OrwollAaron C. SpicerMustafa F. AlkhouliCarolyn S. CalfeeMichael A. MatthayAnil Sapru. (2017) Incorporating Inflammation into Mortality Risk in Pediatric Acute Respiratory Distress Syndrome. Critical Care Medicine 45:5, pages 858-866.
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Katri V. Typpo, Hector R. Wong, Stacey D. Finley, Rodney C. Daniels, Andrew J. E. Seely & Jacques Lacroix. (2017) Monitoring Severity of Multiple Organ Dysfunction Syndrome. Pediatric Critical Care Medicine 18, pages S24-S31.
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Katri V. Typpo & Jacques R. Lacroix. (2017) Monitoring Severity of Multiple Organ Dysfunction Syndrome. Pediatric Critical Care Medicine 18, pages S17-S23.
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Tove Helldin, Anna-Karin Pernestig & Diana Tilevik. 2017. Digital Human Modeling. Applications in Health, Safety, Ergonomics, and Risk Management: Health and Safety. Digital Human Modeling. Applications in Health, Safety, Ergonomics, and Risk Management: Health and Safety 23 35 .
Hector R. Wong & Christopher J. Lindsell. (2016) An Enrichment Strategy For Sepsis Clinical Trials. Shock 46:6, pages 632-634.
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Hector R. Wong, Natalie Z. CvijanovichNick AnasGeoffrey L. AllenNeal J. ThomasMichael T. BighamScott L. WeissJulie FitzgeraldPaul A. ChecchiaKeith MeyerMichael QuasneyMark HallRainer GedeitRobert J. FreishtatJeffrey NowakShekhar S. RajShira GertzKelli HowardKelli HarmonPatrick LahniErin FrankKimberly W. HartTrung C. NguyenChristopher J. Lindsell. (2016) Pediatric Sepsis Biomarker Risk Model-II: Redefining the Pediatric Sepsis Biomarker Risk Model With Septic Shock Phenotype. Critical Care Medicine 44:11, pages 2010-2017.
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Derek S. Wheeler & Hector R. Wong. (2016) Sepsis in Pediatric Cardiac Intensive Care. Pediatric Critical Care Medicine 17, pages S266-S271.
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James J. Gilchrist, Jennifer N. Heath, Chisomo L. Msefula, Esther N. Gondwe, Vivek Naranbhai, Wilson Mandala, Jenny M. MacLennan, Elizabeth M. Molyneux, Stephen M. Graham, Mark T. Drayson, Malcolm E. Molyneux & Calman A. MacLennan. (2016) Cytokine Profiles during Invasive Nontyphoidal Salmonella Disease Predict Outcome in African Children. Clinical and Vaccine Immunology 23:7, pages 601-609.
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Hector R. Wong, Natalie Z. Cvijanovich, Nick Anas, Geoffrey L. Allen, Neal J. Thomas, Michael T. Bigham, Scott L. Weiss, Julie Fitzgerald, Paul A. Checchia, Keith Meyer, Michael Quasney, Mark Hall, Rainer Gedeit, Robert J. Freishtat, Jeffrey Nowak, Shekhar S. Raj, Shira Gertz, Kelli Howard, Kelli Harmon, Patrick Lahni, Erin Frank, Kimberly W. Hart & Christopher J. Lindsell. (2015) Prospective Testing and Redesign of a Temporal Biomarker Based Risk Model for Patients With Septic Shock: Implications for Septic Shock Biology. EBioMedicine 2:12, pages 2087-2093.
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Kevin O. Maher, Anthony C. Chang, Andrew Shin, Juliette Hunt & Hector R. Wong. (2015) Innovation in Pediatric Cardiac Intensive Care. World Journal for Pediatric and Congenital Heart Surgery 6:4, pages 588-596.
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Cristina Padre Cardoso, Argenil José de Assis de Oliveira, Fernando Antônio Botoni, Isabela Cristina Porto Rezende, Jose Carlos Alves-Filho, Fernando de Queiroz Cunha, Juliana de Assis Silva Gomes Estanislau, Luiz Alexandre Viana Magno & Fabricio Rios-Santos. (2015) Interleukin-10 rs1800896 and CXCR2 rs1126579 polymorphisms modulate the predisposition to septic shock. Memórias do Instituto Oswaldo Cruz 110:4, pages 453-460.
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Sarah J. Atkinson, Natalie Z. Cvijanovich, Neal J. Thomas, Geoffrey L. Allen, Nick Anas, Michael T. Bigham, Mark Hall, Robert J. Freishtat, Anita Sen, Keith Meyer, Paul A. Checchia, Thomas P. Shanley, Jeffrey Nowak, Michael Quasney, Scott L. Weiss, Sharon Banschbach, Eileen Beckman, Kelli Howard, Erin Frank, Kelli Harmon, Patrick Lahni, Christopher J. Lindsell & Hector R. Wong. (2014) Corticosteroids and Pediatric Septic Shock Outcomes: A Risk Stratified Analysis. PLoS ONE 9:11, pages e112702.
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Matt Zinter, Kayley Wong, Daniela Markovic, Matteo Pellegrini, Brunilda Balliu, Kinisha P. Gala, Lisa A. Asaro, Vinay Nadkarni, Patrick S. McQuillen, Sitaram Vangala, Pratik Sinha, Michael A. Matthay, Marc G. Jeschke, Michael S.D. Agus, Anil Sapru & CAF-PINT Investigators. (2022) Tight Glycemic Control Decreases Mortality Among Inflamed Critically Ill Children: Evidence for Heterogeneous Treatment Effects in Two Randomized Controlled Trials. SSRN Electronic Journal.
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